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Protein

Zinc finger protein 746

Gene

Znf746

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri454 – 479C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri517 – 539C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 746
Gene namesi
Name:Znf746
Synonyms:Zfp746
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916478. Zfp746.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537291 – 652Zinc finger protein 746Add BLAST652

Post-translational modificationi

Ubiquitinated by PARK2. 'Lys-48'-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may play a key role in regulation of neuron death (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ3U133.
PeptideAtlasiQ3U133.
PRIDEiQ3U133.

PTM databases

iPTMnetiQ3U133.
PhosphoSitePlusiQ3U133.

Expressioni

Tissue specificityi

Widely expressed. In brain, it is heterogeneously distributed throughout the brain and localizes to neurons, including substantia nigra pars compacta dopamine-containing neurons. Weakly expressed in cerebellum and midbrain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000057691.
CleanExiMM_ZFP746.
ExpressionAtlasiQ3U133. baseline and differential.
GenevisibleiQ3U133. MM.

Interactioni

Subunit structurei

Interacts (via C2H2-type zinc fingers) with PARK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Park2Q9WVS62EBI-3862590,EBI-973635

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ3U133. 1 interactor.
STRINGi10090.ENSMUSP00000072868.

Structurei

3D structure databases

ProteinModelPortaliQ3U133.
SMRiQ3U133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 167KRABPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 92Sequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 7Poly-Ala6
Compositional biasi477 – 508Gly-richAdd BLAST32

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri454 – 479C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri517 – 539C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
ENOG41112U5. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG062119.
InParanoidiQ3U133.
KOiK09228.
OMAiSAHQRSC.
OrthoDBiEOG091G0P6J.
TreeFamiTF337777.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 4 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAAAPIS PWTMAATIQA MERKIESQAA RLLSLEGRTG MAEKKLADCE
60 70 80 90 100
KTAVEFSNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN RNFWILRLPP
110 120 130 140 150
GSKGEVPKEW GKLEDWQKEL YKHVMRGNYE TLVSLDYAIS KPEVLSQIEQ
160 170 180 190 200
GKEPCTWRRT GPKVPEVPVD PSPGSGAPVP APDLLMQIKQ EGELQLQEQQ
210 220 230 240 250
ALGVEAWAAG QPDIGEEPWG LSQLDSGAGD ISTDATSGVH SNFSTTIPPT
260 270 280 290 300
SWQADLPPHH PSSACSDGTL KLNTAASTEA DVKIVIKTEV QEEEVVATPV
310 320 330 340 350
HPTDLEAHGT LFAPGQATRF FPSPVQEGAW ESQGSSFPSQ DPVLGLREPT
360 370 380 390 400
RPERDIGELS PAIAQEEAPA GDWLFGGVRW GWNFRCKPPV GLNPRTVPEG
410 420 430 440 450
LPFSSPDNGE AILDPSQAPR PFNDPCKYPG RTKGFGHKPG LKKHPAAPPG
460 470 480 490 500
GRPFTCATCG KSFQLQVSLS AHQRSCGLSD GAATGAASTT TGGGGGGSGG
510 520 530 540 550
GGGSSGGGSS ARDSSALRCG ECGRCFTRPA HLIRHRMLHT GERPFPCTEC
560 570 580 590 600
EKRFTERSKL IDHYRTHTGV RPFTCTVCGK SFIRKDHLRK HQRNHPAVAK
610 620 630 640 650
APAHGQPLPP LPAPPDPFKS PAAKGPMAST DLVTDWTCGL SVLGPSDGGG

DL
Length:652
Mass (Da):69,821
Last modified:July 27, 2011 - v3
Checksum:i680CFF21F30CEDE0
GO

Sequence cautioni

The sequence BAE33667 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490T → A in BAE33667 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156312 mRNA. Translation: BAE33667.1. Different initiation.
AC166290 Genomic DNA. No translation available.
CCDSiCCDS51762.1.
RefSeqiNP_001156947.1. NM_001163475.1.
UniGeneiMm.207555.

Genome annotation databases

EnsembliENSMUST00000073124; ENSMUSP00000072868; ENSMUSG00000057691.
GeneIDi69228.
KEGGimmu:69228.
UCSCiuc009btv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156312 mRNA. Translation: BAE33667.1. Different initiation.
AC166290 Genomic DNA. No translation available.
CCDSiCCDS51762.1.
RefSeqiNP_001156947.1. NM_001163475.1.
UniGeneiMm.207555.

3D structure databases

ProteinModelPortaliQ3U133.
SMRiQ3U133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3U133. 1 interactor.
STRINGi10090.ENSMUSP00000072868.

PTM databases

iPTMnetiQ3U133.
PhosphoSitePlusiQ3U133.

Proteomic databases

PaxDbiQ3U133.
PeptideAtlasiQ3U133.
PRIDEiQ3U133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073124; ENSMUSP00000072868; ENSMUSG00000057691.
GeneIDi69228.
KEGGimmu:69228.
UCSCiuc009btv.2. mouse.

Organism-specific databases

CTDi69228.
MGIiMGI:1916478. Zfp746.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
ENOG41112U5. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG062119.
InParanoidiQ3U133.
KOiK09228.
OMAiSAHQRSC.
OrthoDBiEOG091G0P6J.
TreeFamiTF337777.

Miscellaneous databases

PROiQ3U133.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057691.
CleanExiMM_ZFP746.
ExpressionAtlasiQ3U133. baseline and differential.
GenevisibleiQ3U133. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 4 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN746_MOUSE
AccessioniPrimary (citable) accession number: Q3U133
Secondary accession number(s): E9QPR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.