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Protein

Zinc finger protein 746

Gene

Znf746

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri454 – 479C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri517 – 539C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 746
Gene namesi
Name:Znf746
Synonyms:Zfp746
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916478 Zfp746

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537291 – 652Zinc finger protein 746Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ3U133
PaxDbiQ3U133
PeptideAtlasiQ3U133
PRIDEiQ3U133

PTM databases

iPTMnetiQ3U133
PhosphoSitePlusiQ3U133

Expressioni

Tissue specificityi

Widely expressed. In brain, it is heterogeneously distributed throughout the brain and localizes to neurons, including substantia nigra pars compacta dopamine-containing neurons. Weakly expressed in cerebellum and midbrain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000057691
CleanExiMM_ZFP746
ExpressionAtlasiQ3U133 baseline and differential
GenevisibleiQ3U133 MM

Interactioni

Subunit structurei

Interacts (via C2H2-type zinc fingers) with PRKN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PrknQ9WVS62EBI-3862590,EBI-973635

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi213305, 1 interactor
IntActiQ3U133, 1 interactor
STRINGi10090.ENSMUSP00000072868

Structurei

3D structure databases

ProteinModelPortaliQ3U133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 167KRABPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 92Sequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 7Poly-Ala6
Compositional biasi477 – 508Gly-richAdd BLAST32

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri454 – 479C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri517 – 539C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
ENOG41112U5 LUCA
GeneTreeiENSGT00530000063032
HOGENOMiHOG000013125
HOVERGENiHBG062119
InParanoidiQ3U133
KOiK09228
OMAiKYPGRTK
OrthoDBiEOG091G0P6J
TreeFamiTF337777

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR022137 DUF3669_Znf
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12417 DUF3669, 1 hit
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q3U133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAAAPIS PWTMAATIQA MERKIESQAA RLLSLEGRTG MAEKKLADCE
60 70 80 90 100
KTAVEFSNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN RNFWILRLPP
110 120 130 140 150
GSKGEVPKEW GKLEDWQKEL YKHVMRGNYE TLVSLDYAIS KPEVLSQIEQ
160 170 180 190 200
GKEPCTWRRT GPKVPEVPVD PSPGSGAPVP APDLLMQIKQ EGELQLQEQQ
210 220 230 240 250
ALGVEAWAAG QPDIGEEPWG LSQLDSGAGD ISTDATSGVH SNFSTTIPPT
260 270 280 290 300
SWQADLPPHH PSSACSDGTL KLNTAASTEA DVKIVIKTEV QEEEVVATPV
310 320 330 340 350
HPTDLEAHGT LFAPGQATRF FPSPVQEGAW ESQGSSFPSQ DPVLGLREPT
360 370 380 390 400
RPERDIGELS PAIAQEEAPA GDWLFGGVRW GWNFRCKPPV GLNPRTVPEG
410 420 430 440 450
LPFSSPDNGE AILDPSQAPR PFNDPCKYPG RTKGFGHKPG LKKHPAAPPG
460 470 480 490 500
GRPFTCATCG KSFQLQVSLS AHQRSCGLSD GAATGAASTT TGGGGGGSGG
510 520 530 540 550
GGGSSGGGSS ARDSSALRCG ECGRCFTRPA HLIRHRMLHT GERPFPCTEC
560 570 580 590 600
EKRFTERSKL IDHYRTHTGV RPFTCTVCGK SFIRKDHLRK HQRNHPAVAK
610 620 630 640 650
APAHGQPLPP LPAPPDPFKS PAAKGPMAST DLVTDWTCGL SVLGPSDGGG

DL
Length:652
Mass (Da):69,821
Last modified:July 27, 2011 - v3
Checksum:i680CFF21F30CEDE0
GO

Sequence cautioni

The sequence BAE33667 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490T → A in BAE33667 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156312 mRNA Translation: BAE33667.1 Different initiation.
AC166290 Genomic DNA No translation available.
CCDSiCCDS51762.1
RefSeqiNP_001156947.1, NM_001163475.1
UniGeneiMm.207555

Genome annotation databases

EnsembliENSMUST00000073124; ENSMUSP00000072868; ENSMUSG00000057691
GeneIDi69228
KEGGimmu:69228
UCSCiuc009btv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZN746_MOUSE
AccessioniPrimary (citable) accession number: Q3U133
Secondary accession number(s): E9QPR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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