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Protein

Protein APCDD1

Gene

Apcdd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein APCDD1
Alternative name(s):
Adenomatosis polyposis coli down-regulated 1 protein homolog
Gene namesi
Name:Apcdd1Imported
Synonyms:Drapc11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3513977. Apcdd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 492466ExtracellularSequence analysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence analysisAdd
BLAST
Topological domaini514 – 5141CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 514488Protein APCDD1PRO_0000227521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ3U128.
MaxQBiQ3U128.
PaxDbiQ3U128.
PRIDEiQ3U128.

PTM databases

iPTMnetiQ3U128.
PhosphoSiteiQ3U128.

Expressioni

Developmental stagei

Expressed during early development of the extraembryonic structures, nervous system, vascular system and inner ear. Also expressed in mesenchyme of various parts of the embryo and in adult hair follicles.1 Publication

Inductioni

APCDD1 is transcriptionally regulated by the CTNNB1/TF7L2 complex.By similarity

Gene expression databases

BgeeiQ3U128.
CleanExiMM_APCDD1.
GenevisibleiQ3U128. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with LRP5 and WNT3A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094302.

Family & Domainsi

Sequence similaritiesi

Belongs to the APCDD1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGKQ. Eukaryota.
ENOG410XSNW. LUCA.
GeneTreeiENSGT00640000091492.
HOGENOMiHOG000033991.
HOVERGENiHBG060356.
InParanoidiQ3U128.
OMAiAIEGHWV.
OrthoDBiEOG7PK8Z4.
PhylomeDBiQ3U128.
TreeFamiTF329491.

Family and domain databases

InterProiIPR029405. APCDD1.
[Graphical view]
PfamiPF14921. APCDDC. 2 hits.
[Graphical view]
SMARTiSM01352. APCDDC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVRRLLLG YLFPALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES
60 70 80 90 100
QCHHMLKHLH NGARITVQMP PTIEGHWVST GCEVRSGPEF MTRSYRFYNN
110 120 130 140 150
NTFKAYQFYY GSNRCTNPTY TLIIRGKIRL RQASWIIRGG TEADYQLHGV
160 170 180 190 200
QVICHTEAVA EQLSRLVNRT CPGFLAPGGP WVQDVAYDLW QEESNHECTK
210 220 230 240 250
AVNFAMHELQ LIRVEKQYPH HSLDHLVEEL FLGDIHTDAT QRVFYRPSSY
260 270 280 290 300
QPPLQNAKNH NHACIACRII FRSDEHHPPI LPPKADLTIG LHGEWVSQRC
310 320 330 340 350
EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPVCKHPTFT IYARGRYSRG
360 370 380 390 400
VLSSKVMGGT EFVFKVNHMK VTPMDAATAS LLNVFSGNEC GAEGSWQVGI
410 420 430 440 450
QQDVTHTNGC VALGIKLPHT EYEIFKMEQD TRGRYLLFNG QRPSDGSSPD
460 470 480 490 500
RPEKRATSYQ MPLVQCASSS PRAEELLEDS QGHLYGRAAG RTAGSLLLPA
510
FVSLWTLPHW RILR
Length:514
Mass (Da):58,638
Last modified:October 11, 2005 - v1
Checksum:i0657A8DF94C5F65E
GO

Sequence cautioni

The sequence BAE42770.1 differs from that shown. Reason: Erroneous termination at position 44. Translated as Trp.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156319 mRNA. Translation: BAE33672.1.
AK172004 mRNA. Translation: BAE42770.1. Sequence problems.
BC141269 mRNA. Translation: AAI41270.1.
BC141270 mRNA. Translation: AAI41271.1.
CCDSiCCDS37843.1.
RefSeqiNP_573500.2. NM_133237.3.
UniGeneiMm.391102.

Genome annotation databases

EnsembliENSMUST00000096554; ENSMUSP00000094302; ENSMUSG00000071847.
ENSMUST00000163716; ENSMUSP00000125868; ENSMUSG00000071847.
GeneIDi494504.
KEGGimmu:494504.
UCSCiuc008fdl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156319 mRNA. Translation: BAE33672.1.
AK172004 mRNA. Translation: BAE42770.1. Sequence problems.
BC141269 mRNA. Translation: AAI41270.1.
BC141270 mRNA. Translation: AAI41271.1.
CCDSiCCDS37843.1.
RefSeqiNP_573500.2. NM_133237.3.
UniGeneiMm.391102.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094302.

PTM databases

iPTMnetiQ3U128.
PhosphoSiteiQ3U128.

Proteomic databases

EPDiQ3U128.
MaxQBiQ3U128.
PaxDbiQ3U128.
PRIDEiQ3U128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096554; ENSMUSP00000094302; ENSMUSG00000071847.
ENSMUST00000163716; ENSMUSP00000125868; ENSMUSG00000071847.
GeneIDi494504.
KEGGimmu:494504.
UCSCiuc008fdl.1. mouse.

Organism-specific databases

CTDi147495.
MGIiMGI:3513977. Apcdd1.

Phylogenomic databases

eggNOGiENOG410IGKQ. Eukaryota.
ENOG410XSNW. LUCA.
GeneTreeiENSGT00640000091492.
HOGENOMiHOG000033991.
HOVERGENiHBG060356.
InParanoidiQ3U128.
OMAiAIEGHWV.
OrthoDBiEOG7PK8Z4.
PhylomeDBiQ3U128.
TreeFamiTF329491.

Miscellaneous databases

ChiTaRSiApcdd1. mouse.
PROiQ3U128.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U128.
CleanExiMM_APCDD1.
GenevisibleiQ3U128. MM.

Family and domain databases

InterProiIPR029405. APCDD1.
[Graphical view]
PfamiPF14921. APCDDC. 2 hits.
[Graphical view]
SMARTiSM01352. APCDDC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NODImported.
    Tissue: SpleenImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Drapc1 expression during mouse embryonic development."
    Jukkola T., Sinjushina N., Partanen J.
    Gene Expr. Patterns 4:755-762(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiAPCD1_MOUSE
AccessioniPrimary (citable) accession number: Q3U128
Secondary accession number(s): B2RUN4, Q3TA99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.