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Protein

Protein APCDD1

Gene

Apcdd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein APCDD1
Alternative name(s):
Adenomatosis polyposis coli down-regulated 1 protein homolog
Gene namesi
Name:Apcdd1Imported
Synonyms:Drapc11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3513977. Apcdd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 492ExtracellularSequence analysisAdd BLAST466
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514CytoplasmicSequence analysis1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000022752127 – 514Protein APCDD1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi319N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ3U128.
MaxQBiQ3U128.
PaxDbiQ3U128.
PRIDEiQ3U128.

PTM databases

iPTMnetiQ3U128.
PhosphoSitePlusiQ3U128.

Expressioni

Developmental stagei

Expressed during early development of the extraembryonic structures, nervous system, vascular system and inner ear. Also expressed in mesenchyme of various parts of the embryo and in adult hair follicles.1 Publication

Inductioni

APCDD1 is transcriptionally regulated by the CTNNB1/TF7L2 complex.By similarity

Gene expression databases

BgeeiENSMUSG00000071847.
CleanExiMM_APCDD1.
GenevisibleiQ3U128. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with LRP5 and WNT3A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094302.

Structurei

3D structure databases

ProteinModelPortaliQ3U128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APCDD1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGKQ. Eukaryota.
ENOG410XSNW. LUCA.
GeneTreeiENSGT00640000091492.
HOGENOMiHOG000033991.
HOVERGENiHBG060356.
InParanoidiQ3U128.
OMAiAIEGHWV.
OrthoDBiEOG091G081P.
PhylomeDBiQ3U128.
TreeFamiTF329491.

Family and domain databases

InterProiIPR029405. APCDD1.
[Graphical view]
PfamiPF14921. APCDDC. 2 hits.
[Graphical view]
SMARTiSM01352. APCDDC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVRRLLLG YLFPALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES
60 70 80 90 100
QCHHMLKHLH NGARITVQMP PTIEGHWVST GCEVRSGPEF MTRSYRFYNN
110 120 130 140 150
NTFKAYQFYY GSNRCTNPTY TLIIRGKIRL RQASWIIRGG TEADYQLHGV
160 170 180 190 200
QVICHTEAVA EQLSRLVNRT CPGFLAPGGP WVQDVAYDLW QEESNHECTK
210 220 230 240 250
AVNFAMHELQ LIRVEKQYPH HSLDHLVEEL FLGDIHTDAT QRVFYRPSSY
260 270 280 290 300
QPPLQNAKNH NHACIACRII FRSDEHHPPI LPPKADLTIG LHGEWVSQRC
310 320 330 340 350
EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPVCKHPTFT IYARGRYSRG
360 370 380 390 400
VLSSKVMGGT EFVFKVNHMK VTPMDAATAS LLNVFSGNEC GAEGSWQVGI
410 420 430 440 450
QQDVTHTNGC VALGIKLPHT EYEIFKMEQD TRGRYLLFNG QRPSDGSSPD
460 470 480 490 500
RPEKRATSYQ MPLVQCASSS PRAEELLEDS QGHLYGRAAG RTAGSLLLPA
510
FVSLWTLPHW RILR
Length:514
Mass (Da):58,638
Last modified:October 11, 2005 - v1
Checksum:i0657A8DF94C5F65E
GO

Sequence cautioni

The sequence BAE42770 differs from that shown. Reason: Erroneous termination at position 44. Translated as Trp.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156319 mRNA. Translation: BAE33672.1.
AK172004 mRNA. Translation: BAE42770.1. Sequence problems.
BC141269 mRNA. Translation: AAI41270.1.
BC141270 mRNA. Translation: AAI41271.1.
CCDSiCCDS37843.1.
RefSeqiNP_573500.2. NM_133237.3.
UniGeneiMm.391102.

Genome annotation databases

EnsembliENSMUST00000096554; ENSMUSP00000094302; ENSMUSG00000071847.
ENSMUST00000163716; ENSMUSP00000125868; ENSMUSG00000071847.
GeneIDi494504.
KEGGimmu:494504.
UCSCiuc008fdl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156319 mRNA. Translation: BAE33672.1.
AK172004 mRNA. Translation: BAE42770.1. Sequence problems.
BC141269 mRNA. Translation: AAI41270.1.
BC141270 mRNA. Translation: AAI41271.1.
CCDSiCCDS37843.1.
RefSeqiNP_573500.2. NM_133237.3.
UniGeneiMm.391102.

3D structure databases

ProteinModelPortaliQ3U128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094302.

PTM databases

iPTMnetiQ3U128.
PhosphoSitePlusiQ3U128.

Proteomic databases

EPDiQ3U128.
MaxQBiQ3U128.
PaxDbiQ3U128.
PRIDEiQ3U128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096554; ENSMUSP00000094302; ENSMUSG00000071847.
ENSMUST00000163716; ENSMUSP00000125868; ENSMUSG00000071847.
GeneIDi494504.
KEGGimmu:494504.
UCSCiuc008fdl.1. mouse.

Organism-specific databases

CTDi147495.
MGIiMGI:3513977. Apcdd1.

Phylogenomic databases

eggNOGiENOG410IGKQ. Eukaryota.
ENOG410XSNW. LUCA.
GeneTreeiENSGT00640000091492.
HOGENOMiHOG000033991.
HOVERGENiHBG060356.
InParanoidiQ3U128.
OMAiAIEGHWV.
OrthoDBiEOG091G081P.
PhylomeDBiQ3U128.
TreeFamiTF329491.

Miscellaneous databases

ChiTaRSiApcdd1. mouse.
PROiQ3U128.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071847.
CleanExiMM_APCDD1.
GenevisibleiQ3U128. MM.

Family and domain databases

InterProiIPR029405. APCDD1.
[Graphical view]
PfamiPF14921. APCDDC. 2 hits.
[Graphical view]
SMARTiSM01352. APCDDC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPCD1_MOUSE
AccessioniPrimary (citable) accession number: Q3U128
Secondary accession number(s): B2RUN4, Q3TA99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.