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Protein
Submitted name:

Interleukin 1 alpha

Gene

Il1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation, MitogenUniRule annotation, PyrogenUniRule annotation

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 1 alphaImported
Submitted name:
Interleukin 1 alpha, isoform CRA_bImported
Gene namesi
Name:Il1aImported
ORF Names:mCG_20997Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96542. Il1a.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000027399.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028882.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110IL1_propepInterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOVERGENiHBG002432.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG091G0MAP.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U0Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ
60 70 80 90 100
FVSLRTSETS KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL
110 120 130 140 150
QSITHDLEET IQPRSAPYTY QSDLRYKLMK LVRQKFVMND SLNQTIYQDV
160 170 180 190 200
DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD SKYPVTLKIS DSQLFVSAQG
210 220 230 240 250
EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA AYPELFIATK
260 270
EQSRVHLARG LPSMTDFQIS
Length:270
Mass (Da):31,023
Last modified:October 11, 2005 - v1
Checksum:i7F60AC4F330D5B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902318 Genomic DNA. Translation: AAX90603.1.
AK156449 mRNA. Translation: BAE33715.1.
CH466519 Genomic DNA. Translation: EDL28237.1.
RefSeqiNP_034684.2. NM_010554.4.
XP_006498856.1. XM_006498793.3.
UniGeneiMm.15534.

Genome annotation databases

GeneIDi16175.
KEGGimmu:16175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902318 Genomic DNA. Translation: AAX90603.1.
AK156449 mRNA. Translation: BAE33715.1.
CH466519 Genomic DNA. Translation: EDL28237.1.
RefSeqiNP_034684.2. NM_010554.4.
XP_006498856.1. XM_006498793.3.
UniGeneiMm.15534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16175.
KEGGimmu:16175.

Organism-specific databases

CTDi3552.
MGIiMGI:96542. Il1a.

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
HOVERGENiHBG002432.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG091G0MAP.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027399.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U0Y6_MOUSE
AccessioniPrimary (citable) accession number: Q3U0Y6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.