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Q3U0V1

- FUBP2_MOUSE

UniProt

Q3U0V1 - FUBP2_MOUSE

Protein

Far upstream element-binding protein 2

Gene

Khsrp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. mRNA binding Source: MGI

    GO - Biological processi

    1. mRNA catabolic process Source: MGI
    2. mRNA processing Source: UniProtKB-KW
    3. mRNA transport Source: UniProtKB-KW
    4. regulation of miRNA metabolic process Source: MGI
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. RNA splicing Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198696. KSRP destabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Far upstream element-binding protein 2
    Short name:
    FUSE-binding protein 2
    Alternative name(s):
    KH type-splicing regulatory protein
    Short name:
    KSRP
    Gene namesi
    Name:Khsrp
    Synonyms:Fubp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1336214. Khsrp.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.By similarity

    GO - Cellular componenti

    1. cytoplasmic stress granule Source: MGI
    2. cytosol Source: Reactome
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 748747Far upstream element-binding protein 2PRO_0000298678Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei88 – 881N6-acetyllysine1 Publication
    Modified residuei101 – 1011PhosphothreonineBy similarity
    Modified residuei182 – 1821Phosphoserine1 Publication
    Modified residuei185 – 1851Phosphoserine1 Publication
    Modified residuei194 – 1941PhosphoserineBy similarity
    Modified residuei275 – 2751PhosphoserineBy similarity
    Modified residuei481 – 4811PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ3U0V1.
    PaxDbiQ3U0V1.
    PRIDEiQ3U0V1.

    PTM databases

    PhosphoSiteiQ3U0V1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3U0V1.
    BgeeiQ3U0V1.
    CleanExiMM_KHSRP.
    GenevestigatoriQ3U0V1.

    Interactioni

    Subunit structurei

    Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200927. 1 interaction.
    IntActiQ3U0V1. 1 interaction.
    STRINGi10090.ENSMUSP00000007814.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U0V1.
    SMRiQ3U0V1. Positions 131-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 20965KH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini234 – 30067KH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini323 – 38765KH 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 49268KH 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati572 – 583121Add
    BLAST
    Repeati618 – 629122Add
    BLAST
    Repeati644 – 655123Add
    BLAST
    Repeati674 – 685124Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni572 – 6851144 X 12 AA imperfect repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 6862Gly/Pro-richAdd
    BLAST
    Compositional biasi69 – 497429Gly-richAdd
    BLAST
    Compositional biasi499 – 613115Ala/Gly/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KHSRP family.Curated
    Contains 4 KH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG300923.
    GeneTreeiENSGT00730000110664.
    HOGENOMiHOG000231552.
    HOVERGENiHBG000625.
    InParanoidiQ3U0V1.
    KOiK13210.
    OMAiGPMGPFN.
    OrthoDBiEOG77Q4WB.
    TreeFamiTF313654.

    Family and domain databases

    Gene3Di3.30.1370.10. 4 hits.
    InterProiIPR015096. DUF1897.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF09005. DUF1897. 2 hits.
    PF00013. KH_1. 4 hits.
    [Graphical view]
    SMARTiSM00322. KH. 4 hits.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 4 hits.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50084. KH_TYPE_1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3U0V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDYNTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP    50
    GGGGASGGPS QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN 100
    TPDFGFGGQK RQLEDGDQPD SKKLASQGDS IGSQLGPIHP PPRTSMTEEY 150
    RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ ISPDSGGLPE RSVSLTGAPE 200
    SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM IPAGKAGLVI 250
    GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV 300
    MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ 350
    NDAGVRIQFK QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG 400
    PPGAPGMPPG GRGRGRGQGN WGPPGGEMTF SIPTHKCGLV IGRGGENVKA 450
    INQQTGAFVE ISRQLPPNGD PNFKLFVIRG SPQQIDHAKQ LIEEKIEGPL 500
    CPVGPGPGGP GPAGPMGPFN PGPFNQGPPG APPHAGGPPP HQYPPQGWGN 550
    TYPQWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA 600
    APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE 650
    EYYKKQAQVA TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ 700
    PPPTQQGQQQ ASGNCHPPPP PFSFQPPATV HPALVGSAGN PFPCGVCP 748
    Length:748
    Mass (Da):76,775
    Last modified:July 27, 2011 - v2
    Checksum:i0699217B3E1E54A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti387 – 3871I → F in BAE33750. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK156541 mRNA. Translation: BAE33750.1.
    CT571247 Genomic DNA. No translation available.
    BC064454 mRNA. Translation: AAH64454.1.
    BC108414 mRNA. Translation: AAI08415.1.
    CCDSiCCDS50157.1.
    RefSeqiNP_034743.3. NM_010613.3.
    UniGeneiMm.34296.

    Genome annotation databases

    EnsembliENSMUST00000007814; ENSMUSP00000007814; ENSMUSG00000007670.
    GeneIDi16549.
    KEGGimmu:16549.
    UCSCiuc008ddr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK156541 mRNA. Translation: BAE33750.1 .
    CT571247 Genomic DNA. No translation available.
    BC064454 mRNA. Translation: AAH64454.1 .
    BC108414 mRNA. Translation: AAI08415.1 .
    CCDSi CCDS50157.1.
    RefSeqi NP_034743.3. NM_010613.3.
    UniGenei Mm.34296.

    3D structure databases

    ProteinModelPortali Q3U0V1.
    SMRi Q3U0V1. Positions 131-504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200927. 1 interaction.
    IntActi Q3U0V1. 1 interaction.
    STRINGi 10090.ENSMUSP00000007814.

    PTM databases

    PhosphoSitei Q3U0V1.

    Proteomic databases

    MaxQBi Q3U0V1.
    PaxDbi Q3U0V1.
    PRIDEi Q3U0V1.

    Protocols and materials databases

    DNASUi 16549.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007814 ; ENSMUSP00000007814 ; ENSMUSG00000007670 .
    GeneIDi 16549.
    KEGGi mmu:16549.
    UCSCi uc008ddr.2. mouse.

    Organism-specific databases

    CTDi 8570.
    MGIi MGI:1336214. Khsrp.

    Phylogenomic databases

    eggNOGi NOG300923.
    GeneTreei ENSGT00730000110664.
    HOGENOMi HOG000231552.
    HOVERGENi HBG000625.
    InParanoidi Q3U0V1.
    KOi K13210.
    OMAi GPMGPFN.
    OrthoDBi EOG77Q4WB.
    TreeFami TF313654.

    Enzyme and pathway databases

    Reactomei REACT_198696. KSRP destabilizes mRNA.

    Miscellaneous databases

    NextBioi 290019.
    PROi Q3U0V1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3U0V1.
    Bgeei Q3U0V1.
    CleanExi MM_KHSRP.
    Genevestigatori Q3U0V1.

    Family and domain databases

    Gene3Di 3.30.1370.10. 4 hits.
    InterProi IPR015096. DUF1897.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF09005. DUF1897. 2 hits.
    PF00013. KH_1. 4 hits.
    [Graphical view ]
    SMARTi SM00322. KH. 4 hits.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 4 hits.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50084. KH_TYPE_1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-748.
      Strain: C57BL/6.
      Tissue: Brain.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiFUBP2_MOUSE
    AccessioniPrimary (citable) accession number: Q3U0V1
    Secondary accession number(s): E9QKH3, Q2VPQ6, Q6P2L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3