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Q3U0V1

- FUBP2_MOUSE

UniProt

Q3U0V1 - FUBP2_MOUSE

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Protein

Far upstream element-binding protein 2

Gene

Khsrp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. mRNA binding Source: MGI

GO - Biological processi

  1. mRNA catabolic process Source: MGI
  2. mRNA processing Source: UniProtKB-KW
  3. mRNA transport Source: UniProtKB-KW
  4. regulation of miRNA metabolic process Source: MGI
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. RNA splicing Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198696. KSRP destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Far upstream element-binding protein 2
Short name:
FUSE-binding protein 2
Alternative name(s):
KH type-splicing regulatory protein
Short name:
KSRP
Gene namesi
Name:Khsrp
Synonyms:Fubp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1336214. Khsrp.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.By similarity

GO - Cellular componenti

  1. cytoplasmic stress granule Source: MGI
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 748747Far upstream element-binding protein 2PRO_0000298678Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei88 – 881N6-acetyllysine1 Publication
Modified residuei101 – 1011PhosphothreonineBy similarity
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei185 – 1851Phosphoserine1 Publication
Modified residuei194 – 1941PhosphoserineBy similarity
Modified residuei275 – 2751PhosphoserineBy similarity
Modified residuei481 – 4811PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3U0V1.
PaxDbiQ3U0V1.
PRIDEiQ3U0V1.

PTM databases

PhosphoSiteiQ3U0V1.

Expressioni

Gene expression databases

BgeeiQ3U0V1.
CleanExiMM_KHSRP.
ExpressionAtlasiQ3U0V1. baseline and differential.
GenevestigatoriQ3U0V1.

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN (By similarity).By similarity

Protein-protein interaction databases

BioGridi200927. 1 interaction.
IntActiQ3U0V1. 1 interaction.
STRINGi10090.ENSMUSP00000007814.

Structurei

3D structure databases

ProteinModelPortaliQ3U0V1.
SMRiQ3U0V1. Positions 131-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 20965KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini234 – 30067KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 38765KH 3PROSITE-ProRule annotationAdd
BLAST
Domaini425 – 49268KH 4PROSITE-ProRule annotationAdd
BLAST
Repeati572 – 583121Add
BLAST
Repeati618 – 629122Add
BLAST
Repeati644 – 655123Add
BLAST
Repeati674 – 685124Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni572 – 6851144 X 12 AA imperfect repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 6862Gly/Pro-richAdd
BLAST
Compositional biasi69 – 497429Gly-richAdd
BLAST
Compositional biasi499 – 613115Ala/Gly/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the KHSRP family.Curated
Contains 4 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG300923.
GeneTreeiENSGT00730000110664.
HOGENOMiHOG000231552.
HOVERGENiHBG000625.
InParanoidiQ3U0V1.
KOiK13210.
OMAiGPMGPFN.
OrthoDBiEOG77Q4WB.
TreeFamiTF313654.

Family and domain databases

Gene3Di3.30.1370.10. 4 hits.
InterProiIPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view]
SMARTiSM00322. KH. 4 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 4 hits.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50084. KH_TYPE_1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U0V1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDYNTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP
60 70 80 90 100
GGGGASGGPS QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN
110 120 130 140 150
TPDFGFGGQK RQLEDGDQPD SKKLASQGDS IGSQLGPIHP PPRTSMTEEY
160 170 180 190 200
RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ ISPDSGGLPE RSVSLTGAPE
210 220 230 240 250
SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM IPAGKAGLVI
260 270 280 290 300
GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV
310 320 330 340 350
MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ
360 370 380 390 400
NDAGVRIQFK QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG
410 420 430 440 450
PPGAPGMPPG GRGRGRGQGN WGPPGGEMTF SIPTHKCGLV IGRGGENVKA
460 470 480 490 500
INQQTGAFVE ISRQLPPNGD PNFKLFVIRG SPQQIDHAKQ LIEEKIEGPL
510 520 530 540 550
CPVGPGPGGP GPAGPMGPFN PGPFNQGPPG APPHAGGPPP HQYPPQGWGN
560 570 580 590 600
TYPQWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA
610 620 630 640 650
APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE
660 670 680 690 700
EYYKKQAQVA TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ
710 720 730 740
PPPTQQGQQQ ASGNCHPPPP PFSFQPPATV HPALVGSAGN PFPCGVCP
Length:748
Mass (Da):76,775
Last modified:July 27, 2011 - v2
Checksum:i0699217B3E1E54A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871I → F in BAE33750. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK156541 mRNA. Translation: BAE33750.1.
CT571247 Genomic DNA. No translation available.
BC064454 mRNA. Translation: AAH64454.1.
BC108414 mRNA. Translation: AAI08415.1.
CCDSiCCDS50157.1.
RefSeqiNP_034743.3. NM_010613.3.
UniGeneiMm.34296.

Genome annotation databases

EnsembliENSMUST00000007814; ENSMUSP00000007814; ENSMUSG00000007670.
GeneIDi16549.
KEGGimmu:16549.
UCSCiuc008ddr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK156541 mRNA. Translation: BAE33750.1 .
CT571247 Genomic DNA. No translation available.
BC064454 mRNA. Translation: AAH64454.1 .
BC108414 mRNA. Translation: AAI08415.1 .
CCDSi CCDS50157.1.
RefSeqi NP_034743.3. NM_010613.3.
UniGenei Mm.34296.

3D structure databases

ProteinModelPortali Q3U0V1.
SMRi Q3U0V1. Positions 131-504.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200927. 1 interaction.
IntActi Q3U0V1. 1 interaction.
STRINGi 10090.ENSMUSP00000007814.

PTM databases

PhosphoSitei Q3U0V1.

Proteomic databases

MaxQBi Q3U0V1.
PaxDbi Q3U0V1.
PRIDEi Q3U0V1.

Protocols and materials databases

DNASUi 16549.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007814 ; ENSMUSP00000007814 ; ENSMUSG00000007670 .
GeneIDi 16549.
KEGGi mmu:16549.
UCSCi uc008ddr.2. mouse.

Organism-specific databases

CTDi 8570.
MGIi MGI:1336214. Khsrp.

Phylogenomic databases

eggNOGi NOG300923.
GeneTreei ENSGT00730000110664.
HOGENOMi HOG000231552.
HOVERGENi HBG000625.
InParanoidi Q3U0V1.
KOi K13210.
OMAi GPMGPFN.
OrthoDBi EOG77Q4WB.
TreeFami TF313654.

Enzyme and pathway databases

Reactomei REACT_198696. KSRP destabilizes mRNA.

Miscellaneous databases

NextBioi 290019.
PROi Q3U0V1.
SOURCEi Search...

Gene expression databases

Bgeei Q3U0V1.
CleanExi MM_KHSRP.
ExpressionAtlasi Q3U0V1. baseline and differential.
Genevestigatori Q3U0V1.

Family and domain databases

Gene3Di 3.30.1370.10. 4 hits.
InterProi IPR015096. DUF1897.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF09005. DUF1897. 2 hits.
PF00013. KH_1. 4 hits.
[Graphical view ]
SMARTi SM00322. KH. 4 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 4 hits.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50084. KH_TYPE_1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-748.
    Strain: C57BL/6.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiFUBP2_MOUSE
AccessioniPrimary (citable) accession number: Q3U0V1
Secondary accession number(s): E9QKH3, Q2VPQ6, Q6P2L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3