Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3U0K8

- OGFD1_MOUSE

UniProt

Q3U0K8 - OGFD1_MOUSE

Protein

Prolyl 3-hydroxylase OGFOD1

Gene

Ogfod1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation By similarity.By similarity

    Catalytic activityi

    Peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.

    Cofactori

    Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation
    Ascorbate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi155 – 1551IronPROSITE-ProRule annotation
    Metal bindingi157 – 1571IronPROSITE-ProRule annotation
    Metal bindingi218 – 2181IronPROSITE-ProRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. L-ascorbic acid binding Source: UniProtKB-KW
    3. peptidyl-proline 3-dioxygenase activity Source: UniProtKB
    4. peptidyl-proline dioxygenase activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. peptidyl-proline hydroxylation Source: GOC
    3. protein hydroxylation Source: UniProtKB
    4. regulation of translational termination Source: UniProtKB
    5. stress granule assembly Source: UniProtKB

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding, Vitamin C

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prolyl 3-hydroxylase OGFOD1 (EC:1.14.11.-)
    Alternative name(s):
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
    Gene namesi
    Name:Ogfod1
    Synonyms:Kiaa1612
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2442978. Ogfod1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasmic stress granule Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 545545Prolyl 3-hydroxylase OGFOD1PRO_0000288975Add
    BLAST

    Proteomic databases

    MaxQBiQ3U0K8.
    PaxDbiQ3U0K8.
    PRIDEiQ3U0K8.

    PTM databases

    PhosphoSiteiQ3U0K8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3U0K8.
    BgeeiQ3U0K8.
    GenevestigatoriQ3U0K8.

    Interactioni

    Protein-protein interaction databases

    BioGridi234757. 1 interaction.
    STRINGi10090.ENSMUSP00000105183.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U0K8.
    SMRiQ3U0K8. Positions 72-329, 441-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini137 – 239103Fe2OG dioxygenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TPA1 family.Curated
    Contains 1 Fe2OG dioxygenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3751.
    GeneTreeiENSGT00390000002349.
    HOGENOMiHOG000007015.
    HOVERGENiHBG056995.
    InParanoidiQ3U0K8.
    OMAiFSFVYYE.
    OrthoDBiEOG7FBRHW.
    PhylomeDBiQ3U0K8.
    TreeFamiTF105920.

    Family and domain databases

    InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
    IPR019601. Oxoglutarate/Fe-dep_Oase_C.
    IPR006620. Pro_4_hyd_alph.
    [Graphical view]
    PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
    PF10637. Ofd1_CTDD. 1 hit.
    [Graphical view]
    SMARTiSM00702. P4Hc. 1 hit.
    [Graphical view]
    PROSITEiPS51471. FE2OG_OXY. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3U0K8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGKRPADPG PARPMKKGKK QVSAEFSDAV TEEILRKQVA EAWSCRTPFS    50
    HEAIALDMDP FLHCVIPNFI QSQDFLEGLH KELLSLDFHE KYNDLYKFQQ 100
    SDDLKNRKEP HISALRKLMF EDFRAWLSKV SGIDLEPTID MSCAKYEFTD 150
    ALLCHDDELE GRRIAFILYL VPSWDRDLGG TLDLYDTDEH LQPKQIVKSL 200
    IPSWNKLVFF EVSPVSFHQV SEVLSEETSR LSISGWFYGP SLTRPPTYFE 250
    PPIPRNPHIP QDHEILYEWI NPAYLEMDYQ MQIQEEFEER SEILLKEFLK 300
    PEKFAEVCEA LEKGDVEWKS HGPPNKRFYE KAEENNLPDV LKECMGLFRS 350
    EALFLLLSNL TGLKLHFLAP SEDDETEEKG EGETASAAAG TEEGTSRRPS 400
    GPENNQVAAG SHSQENGEQA DPEAQEEEAK KESSVPMCQG ELRRWKTGHY 450
    TLVHDNTKTE FALDLFLYCG CEGWEPEYGG FTSYIAKGED EELLIVNPEN 500
    NSLALVYRDR ETLRFVKHIN HRSLEQSKAF PSRSGFWDFA FIYYE 545
    Length:545
    Mass (Da):62,734
    Last modified:October 11, 2005 - v1
    Checksum:i92F376ABC86CB410
    GO
    Isoform 2 (identifier: Q3U0K8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-262: Missing.

    Show »
    Length:502
    Mass (Da):57,854
    Checksum:iB726F1A267873FC9
    GO
    Isoform 3 (identifier: Q3U0K8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:544
    Mass (Da):62,605
    Checksum:iCE6A47CC524D6948
    GO

    Sequence cautioni

    The sequence AAH40267.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121A → V in BAE38717. (PubMed:16141072)Curated
    Sequence conflicti48 – 481P → S in BAE38717. (PubMed:16141072)Curated
    Sequence conflicti58 – 581M → V in BAE38717. (PubMed:16141072)Curated
    Sequence conflicti80 – 801H → Q in BAE38717. (PubMed:16141072)Curated
    Sequence conflicti397 – 3971R → Q in BAE38717. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 521Missing in isoform 3. 1 PublicationVSP_025853
    Alternative sequencei220 – 26243Missing in isoform 2. 2 PublicationsVSP_025854Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK156765 mRNA. Translation: BAE33844.1.
    AK164189 mRNA. Translation: BAE37671.1.
    AK166343 mRNA. Translation: BAE38717.1.
    BC040267 mRNA. Translation: AAH40267.1. Different initiation.
    AK122532 mRNA. Translation: BAC65814.1.
    CCDSiCCDS22535.2. [Q3U0K8-1]
    CCDS52636.1. [Q3U0K8-2]
    RefSeqiNP_001087226.1. NM_001093757.1. [Q3U0K8-2]
    NP_808435.3. NM_177767.4. [Q3U0K8-1]
    UniGeneiMm.251085.

    Genome annotation databases

    EnsembliENSMUST00000093301; ENSMUSP00000090991; ENSMUSG00000033009. [Q3U0K8-2]
    ENSMUST00000109556; ENSMUSP00000105183; ENSMUSG00000033009. [Q3U0K8-1]
    GeneIDi270086.
    KEGGimmu:270086.
    UCSCiuc009mvq.1. mouse. [Q3U0K8-1]
    uc009mvr.1. mouse. [Q3U0K8-2]
    uc012gim.1. mouse. [Q3U0K8-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK156765 mRNA. Translation: BAE33844.1 .
    AK164189 mRNA. Translation: BAE37671.1 .
    AK166343 mRNA. Translation: BAE38717.1 .
    BC040267 mRNA. Translation: AAH40267.1 . Different initiation.
    AK122532 mRNA. Translation: BAC65814.1 .
    CCDSi CCDS22535.2. [Q3U0K8-1 ]
    CCDS52636.1. [Q3U0K8-2 ]
    RefSeqi NP_001087226.1. NM_001093757.1. [Q3U0K8-2 ]
    NP_808435.3. NM_177767.4. [Q3U0K8-1 ]
    UniGenei Mm.251085.

    3D structure databases

    ProteinModelPortali Q3U0K8.
    SMRi Q3U0K8. Positions 72-329, 441-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234757. 1 interaction.
    STRINGi 10090.ENSMUSP00000105183.

    PTM databases

    PhosphoSitei Q3U0K8.

    Proteomic databases

    MaxQBi Q3U0K8.
    PaxDbi Q3U0K8.
    PRIDEi Q3U0K8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000093301 ; ENSMUSP00000090991 ; ENSMUSG00000033009 . [Q3U0K8-2 ]
    ENSMUST00000109556 ; ENSMUSP00000105183 ; ENSMUSG00000033009 . [Q3U0K8-1 ]
    GeneIDi 270086.
    KEGGi mmu:270086.
    UCSCi uc009mvq.1. mouse. [Q3U0K8-1 ]
    uc009mvr.1. mouse. [Q3U0K8-2 ]
    uc012gim.1. mouse. [Q3U0K8-3 ]

    Organism-specific databases

    CTDi 55239.
    MGIi MGI:2442978. Ogfod1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG3751.
    GeneTreei ENSGT00390000002349.
    HOGENOMi HOG000007015.
    HOVERGENi HBG056995.
    InParanoidi Q3U0K8.
    OMAi FSFVYYE.
    OrthoDBi EOG7FBRHW.
    PhylomeDBi Q3U0K8.
    TreeFami TF105920.

    Miscellaneous databases

    NextBioi 393192.
    PROi Q3U0K8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3U0K8.
    Bgeei Q3U0K8.
    Genevestigatori Q3U0K8.

    Family and domain databases

    InterProi IPR005123. Oxoglu/Fe-dep_dioxygenase.
    IPR019601. Oxoglutarate/Fe-dep_Oase_C.
    IPR006620. Pro_4_hyd_alph.
    [Graphical view ]
    Pfami PF13640. 2OG-FeII_Oxy_3. 1 hit.
    PF10637. Ofd1_CTDD. 1 hit.
    [Graphical view ]
    SMARTi SM00702. P4Hc. 1 hit.
    [Graphical view ]
    PROSITEi PS51471. FE2OG_OXY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-545 (ISOFORM 2).
      Strain: C57BL/6J and NOD.
      Tissue: Hippocampus, Mammary gland and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-545 (ISOFORM 3).
      Tissue: Brain.

    Entry informationi

    Entry nameiOGFD1_MOUSE
    AccessioniPrimary (citable) accession number: Q3U0K8
    Secondary accession number(s): Q3TLS5
    , Q3TPR4, Q80TB3, Q8CFR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3