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Q3U0K8

- OGFD1_MOUSE

UniProt

Q3U0K8 - OGFD1_MOUSE

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Protein

Prolyl 3-hydroxylase OGFOD1

Gene

Ogfod1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation (By similarity).By similarity

Catalytic activityi

Peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.

Cofactori

Protein has several cofactor binding sites:
  • Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe(2+) ion per subunit.PROSITE-ProRule annotation
  • L-ascorbateBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi155 – 1551IronPROSITE-ProRule annotation
Metal bindingi157 – 1571IronPROSITE-ProRule annotation
Metal bindingi218 – 2181IronPROSITE-ProRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. L-ascorbic acid binding Source: UniProtKB-KW
  3. peptidyl-proline 3-dioxygenase activity Source: UniProtKB
  4. peptidyl-proline dioxygenase activity Source: UniProtKB

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. protein hydroxylation Source: UniProtKB
  3. regulation of translational termination Source: UniProtKB
  4. stress granule assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding, Vitamin C

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl 3-hydroxylase OGFOD1 (EC:1.14.11.-)
Alternative name(s):
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
Gene namesi
Name:Ogfod1
Synonyms:Kiaa1612
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2442978. Ogfod1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasmic stress granule Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Prolyl 3-hydroxylase OGFOD1PRO_0000288975Add
BLAST

Proteomic databases

MaxQBiQ3U0K8.
PaxDbiQ3U0K8.
PRIDEiQ3U0K8.

PTM databases

PhosphoSiteiQ3U0K8.

Expressioni

Gene expression databases

BgeeiQ3U0K8.
ExpressionAtlasiQ3U0K8. baseline.
GenevestigatoriQ3U0K8.

Interactioni

Protein-protein interaction databases

BioGridi234757. 1 interaction.
STRINGi10090.ENSMUSP00000105183.

Structurei

3D structure databases

ProteinModelPortaliQ3U0K8.
SMRiQ3U0K8. Positions 72-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 239103Fe2OG dioxygenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TPA1 family.Curated
Contains 1 Fe2OG dioxygenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3751.
GeneTreeiENSGT00390000002349.
HOGENOMiHOG000007015.
HOVERGENiHBG056995.
InParanoidiQ3U0K8.
OMAiFSFVYYE.
OrthoDBiEOG7FBRHW.
PhylomeDBiQ3U0K8.
TreeFamiTF105920.

Family and domain databases

InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR019601. Oxoglutarate/Fe-dep_Oase_C.
IPR006620. Pro_4_hyd_alph.
[Graphical view]
PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
PF10637. Ofd1_CTDD. 1 hit.
[Graphical view]
SMARTiSM00702. P4Hc. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3U0K8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGKRPADPG PARPMKKGKK QVSAEFSDAV TEEILRKQVA EAWSCRTPFS
60 70 80 90 100
HEAIALDMDP FLHCVIPNFI QSQDFLEGLH KELLSLDFHE KYNDLYKFQQ
110 120 130 140 150
SDDLKNRKEP HISALRKLMF EDFRAWLSKV SGIDLEPTID MSCAKYEFTD
160 170 180 190 200
ALLCHDDELE GRRIAFILYL VPSWDRDLGG TLDLYDTDEH LQPKQIVKSL
210 220 230 240 250
IPSWNKLVFF EVSPVSFHQV SEVLSEETSR LSISGWFYGP SLTRPPTYFE
260 270 280 290 300
PPIPRNPHIP QDHEILYEWI NPAYLEMDYQ MQIQEEFEER SEILLKEFLK
310 320 330 340 350
PEKFAEVCEA LEKGDVEWKS HGPPNKRFYE KAEENNLPDV LKECMGLFRS
360 370 380 390 400
EALFLLLSNL TGLKLHFLAP SEDDETEEKG EGETASAAAG TEEGTSRRPS
410 420 430 440 450
GPENNQVAAG SHSQENGEQA DPEAQEEEAK KESSVPMCQG ELRRWKTGHY
460 470 480 490 500
TLVHDNTKTE FALDLFLYCG CEGWEPEYGG FTSYIAKGED EELLIVNPEN
510 520 530 540
NSLALVYRDR ETLRFVKHIN HRSLEQSKAF PSRSGFWDFA FIYYE
Length:545
Mass (Da):62,734
Last modified:October 11, 2005 - v1
Checksum:i92F376ABC86CB410
GO
Isoform 2 (identifier: Q3U0K8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-262: Missing.

Show »
Length:502
Mass (Da):57,854
Checksum:iB726F1A267873FC9
GO
Isoform 3 (identifier: Q3U0K8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.

Note: No experimental confirmation available.

Show »
Length:544
Mass (Da):62,605
Checksum:iCE6A47CC524D6948
GO

Sequence cautioni

The sequence AAH40267.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → V in BAE38717. (PubMed:16141072)Curated
Sequence conflicti48 – 481P → S in BAE38717. (PubMed:16141072)Curated
Sequence conflicti58 – 581M → V in BAE38717. (PubMed:16141072)Curated
Sequence conflicti80 – 801H → Q in BAE38717. (PubMed:16141072)Curated
Sequence conflicti397 – 3971R → Q in BAE38717. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 521Missing in isoform 3. 1 PublicationVSP_025853
Alternative sequencei220 – 26243Missing in isoform 2. 2 PublicationsVSP_025854Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156765 mRNA. Translation: BAE33844.1.
AK164189 mRNA. Translation: BAE37671.1.
AK166343 mRNA. Translation: BAE38717.1.
BC040267 mRNA. Translation: AAH40267.1. Different initiation.
AK122532 mRNA. Translation: BAC65814.1.
CCDSiCCDS22535.2. [Q3U0K8-1]
CCDS52636.1. [Q3U0K8-2]
RefSeqiNP_001087226.1. NM_001093757.1. [Q3U0K8-2]
NP_808435.3. NM_177767.4. [Q3U0K8-1]
UniGeneiMm.251085.

Genome annotation databases

EnsembliENSMUST00000093301; ENSMUSP00000090991; ENSMUSG00000033009. [Q3U0K8-2]
ENSMUST00000109556; ENSMUSP00000105183; ENSMUSG00000033009. [Q3U0K8-1]
GeneIDi270086.
KEGGimmu:270086.
UCSCiuc009mvq.1. mouse. [Q3U0K8-1]
uc009mvr.1. mouse. [Q3U0K8-2]
uc012gim.1. mouse. [Q3U0K8-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156765 mRNA. Translation: BAE33844.1 .
AK164189 mRNA. Translation: BAE37671.1 .
AK166343 mRNA. Translation: BAE38717.1 .
BC040267 mRNA. Translation: AAH40267.1 . Different initiation.
AK122532 mRNA. Translation: BAC65814.1 .
CCDSi CCDS22535.2. [Q3U0K8-1 ]
CCDS52636.1. [Q3U0K8-2 ]
RefSeqi NP_001087226.1. NM_001093757.1. [Q3U0K8-2 ]
NP_808435.3. NM_177767.4. [Q3U0K8-1 ]
UniGenei Mm.251085.

3D structure databases

ProteinModelPortali Q3U0K8.
SMRi Q3U0K8. Positions 72-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234757. 1 interaction.
STRINGi 10090.ENSMUSP00000105183.

PTM databases

PhosphoSitei Q3U0K8.

Proteomic databases

MaxQBi Q3U0K8.
PaxDbi Q3U0K8.
PRIDEi Q3U0K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000093301 ; ENSMUSP00000090991 ; ENSMUSG00000033009 . [Q3U0K8-2 ]
ENSMUST00000109556 ; ENSMUSP00000105183 ; ENSMUSG00000033009 . [Q3U0K8-1 ]
GeneIDi 270086.
KEGGi mmu:270086.
UCSCi uc009mvq.1. mouse. [Q3U0K8-1 ]
uc009mvr.1. mouse. [Q3U0K8-2 ]
uc012gim.1. mouse. [Q3U0K8-3 ]

Organism-specific databases

CTDi 55239.
MGIi MGI:2442978. Ogfod1.
Rougei Search...

Phylogenomic databases

eggNOGi COG3751.
GeneTreei ENSGT00390000002349.
HOGENOMi HOG000007015.
HOVERGENi HBG056995.
InParanoidi Q3U0K8.
OMAi FSFVYYE.
OrthoDBi EOG7FBRHW.
PhylomeDBi Q3U0K8.
TreeFami TF105920.

Miscellaneous databases

NextBioi 393192.
PROi Q3U0K8.
SOURCEi Search...

Gene expression databases

Bgeei Q3U0K8.
ExpressionAtlasi Q3U0K8. baseline.
Genevestigatori Q3U0K8.

Family and domain databases

InterProi IPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR019601. Oxoglutarate/Fe-dep_Oase_C.
IPR006620. Pro_4_hyd_alph.
[Graphical view ]
Pfami PF13640. 2OG-FeII_Oxy_3. 1 hit.
PF10637. Ofd1_CTDD. 1 hit.
[Graphical view ]
SMARTi SM00702. P4Hc. 1 hit.
[Graphical view ]
PROSITEi PS51471. FE2OG_OXY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-545 (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Hippocampus, Mammary gland and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-545 (ISOFORM 3).
    Tissue: Brain.

Entry informationi

Entry nameiOGFD1_MOUSE
AccessioniPrimary (citable) accession number: Q3U0K8
Secondary accession number(s): Q3TLS5
, Q3TPR4, Q80TB3, Q8CFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3