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Protein

TBC1 domain family member 2B

Gene

Tbc1d2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 2B
Gene namesi
Name:Tbc1d2b
Synonyms:Kiaa1055
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914266. Tbc1d2b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965TBC1 domain family member 2BPRO_0000315714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei959 – 9591PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3U0J8.
MaxQBiQ3U0J8.
PaxDbiQ3U0J8.
PRIDEiQ3U0J8.

PTM databases

iPTMnetiQ3U0J8.
PhosphoSiteiQ3U0J8.

Expressioni

Gene expression databases

BgeeiQ3U0J8.
CleanExiMM_TBC1D2B.
ExpressionAtlasiQ3U0J8. baseline and differential.
GenevisibleiQ3U0J8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045413.

Structurei

3D structure databases

ProteinModelPortaliQ3U0J8.
SMRiQ3U0J8. Positions 30-143, 597-908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 139106PHPROSITE-ProRule annotationAdd
BLAST
Domaini664 – 858195Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili339 – 537199Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000049204.
HOVERGENiHBG059233.
InParanoidiQ3U0J8.
OMAiNSLDMVK.
OrthoDBiEOG7PK8XW.
PhylomeDBiQ3U0J8.
TreeFamiTF317336.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U0J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAGDGVEE SCSGGEGAVP GTGSEAGAVA GREPSRLCGY LQKLSGKGPL
60 70 80 90 100
RGYRSRWFVF DSRRCYLYYF KSPQDALPLG HLDIADACFS YQGRDEAAEP
110 120 130 140 150
GADPPTHFQV HSAGAVTVLK APNRELMTYW LQELQQKRWE YCNSLDMMKW
160 170 180 190 200
DSRTSPTPGD FPKGLVARDT TDIISQHPNP SAEKARTVLA VEAAPGELVG
210 220 230 240 250
DRAAHQPAPG HPNPINFYSL KQWGNELKNS MSSFRPGRGH SESRRTVFYT
260 270 280 290 300
NEEWELLDPP PKDLEESLVP EERKKPMPEG SKGVASSGFP FEFGRNPYKG
310 320 330 340 350
KRPLKDIIGS YKNRHSSSDP LLEGTATSSG SSGGPTKPVP EMQLQIQSQQ
360 370 380 390 400
EELEQLKKDL SSQKELIRLL QQTVRSSQYD KYFTNPQISQ GVPGDTLELL
410 420 430 440 450
HQKDEQILGL SGQLERFGLE KESLQQEVRT LKSKVGELNE RLGMLMETIQ
460 470 480 490 500
AKDEVIIKLS ACEGSVSSPT LGPSSPLAIP ASKDQLELDR LKDSLQGYKS
510 520 530 540 550
QNKFLNKEIL ELSALRRNAE RRERDLMAKY SSLEAKLCQV ESKYLILLQE
560 570 580 590 600
MKTPVCSEEQ GPARDVIAQL LEDALQVESQ EQPEQAFVKP HLVSEFDIYG
610 620 630 640 650
FRTVPDDDEE EKLVAKVRAL DLKTLYLTDN QEVSTGVKWE NYFASTMNRE
660 670 680 690 700
MACSPELKNL IRAGIPHEHR SKVWKWCVDR HTRKFKDSME PDYFQTLLQK
710 720 730 740 750
ALEKQNPASK QIELDLLRTL PNNKHYSSPT SEGIQKLRSV LLAFSWRNPD
760 770 780 790 800
IGYCQGLNRL VAVALLYLDQ EDAFWCLVTI VEVFMPRDYY TKTLLGSQVD
810 820 830 840 850
QRVFRDLLSE KLPRLHTHFE QYKVDYTLIT FNWFLVVFVD SVVSDILFKI
860 870 880 890 900
WDSFLYEGPK VIFRFALALF KYKEEEILKL QDSMSIFKYL RYFTRTILDA
910 920 930 940 950
RKLISISFGD LNPFPLRQIR NRRAYHLEKV RLELTELEAI REDFLRERDT
960
SPDKGELVSD EEEDT
Length:965
Mass (Da):109,950
Last modified:January 15, 2008 - v2
Checksum:i3329196304E487E4
GO

Sequence cautioni

The sequence BAC98083.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti719 – 7191T → A in BAE33855 (PubMed:16141072).Curated
Sequence conflicti865 – 8651F → L in BAE33855 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129273 mRNA. Translation: BAC98083.1. Different initiation.
AK156788 mRNA. Translation: BAE33855.1.
BC056467 mRNA. Translation: AAH56467.2.
BC108420 mRNA. Translation: AAI08421.1.
CCDSiCCDS23401.1.
RefSeqiNP_919315.2. NM_194334.2.
UniGeneiMm.335347.

Genome annotation databases

EnsembliENSMUST00000041767; ENSMUSP00000045413; ENSMUSG00000037410.
GeneIDi67016.
KEGGimmu:67016.
UCSCiuc009rac.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129273 mRNA. Translation: BAC98083.1. Different initiation.
AK156788 mRNA. Translation: BAE33855.1.
BC056467 mRNA. Translation: AAH56467.2.
BC108420 mRNA. Translation: AAI08421.1.
CCDSiCCDS23401.1.
RefSeqiNP_919315.2. NM_194334.2.
UniGeneiMm.335347.

3D structure databases

ProteinModelPortaliQ3U0J8.
SMRiQ3U0J8. Positions 30-143, 597-908.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045413.

PTM databases

iPTMnetiQ3U0J8.
PhosphoSiteiQ3U0J8.

Proteomic databases

EPDiQ3U0J8.
MaxQBiQ3U0J8.
PaxDbiQ3U0J8.
PRIDEiQ3U0J8.

Protocols and materials databases

DNASUi67016.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041767; ENSMUSP00000045413; ENSMUSG00000037410.
GeneIDi67016.
KEGGimmu:67016.
UCSCiuc009rac.1. mouse.

Organism-specific databases

CTDi23102.
MGIiMGI:1914266. Tbc1d2b.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000049204.
HOVERGENiHBG059233.
InParanoidiQ3U0J8.
OMAiNSLDMVK.
OrthoDBiEOG7PK8XW.
PhylomeDBiQ3U0J8.
TreeFamiTF317336.

Miscellaneous databases

NextBioi323318.
PROiQ3U0J8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U0J8.
CleanExiMM_TBC1D2B.
ExpressionAtlasiQ3U0J8. baseline and differential.
GenevisibleiQ3U0J8. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 447-965.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-959, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTBD2B_MOUSE
AccessioniPrimary (citable) accession number: Q3U0J8
Secondary accession number(s): Q2VPQ4, Q6PHN8, Q6ZPZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 16, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.