Q3U048 (Q3U048_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE34007.1

Gene names

Name:

Arhgef11 MGI 2441869

Organism

Mus musculus (Mouse) EMBL BAE34007.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1476 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS001331 Contains 1 PDZ (DHR) domain. RuleBase RU003354 Contains 1 PH domain.

Ontologies

Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1476	1	EMBL BAE34007.1

Sequences

	Sequence		Length	Mass (Da)
	Q3U048 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 8F688C105A716C58	FASTA	1,476	163,584
	10 20 30 40 50 60 MSIRLPHSID RLSSLSSLGD STPERTSPSH HRQPSDTSET TGLVQRCVII QKDQHGFGFT 70 80 90 100 110 120 VSGDRIVLVQ SVRPGGAAMR AGVKEGDRII KVNGTMVTNS SHLEVVKLIK SGAYVALTLL 130 140 150 160 170 180 GSSPSSIGVS GLQQNPSLSG GPRVNPTIPP PPPPPPLPPP QHITGPKPLQ DPEVQKHATQ 190 200 210 220 230 240 ILRNMLRQEE KELQDVLPLC GETSQRTCEG RLSVDSQEAD SGLDSGTERF PSISESLVNR 250 260 270 280 290 300 NSVLSDPGLD SPQTSPVILA RVGQHHRRQG SDAAVHPLNH QGIDQSPKPL IIGPEEDYDP 310 320 330 340 350 360 GYFNNESDII FQDLEKLKSH PAYLVVFLRY IFSQADPGPL LFYLCSEVYQ QTNPKDSRNL 370 380 390 400 410 420 GKDIWNIFLE KNAPLRVKIP EMLQAEIDLR LRNSEDPRSA LYEAQEAVMP EIQEQINDYR 430 440 450 460 470 480 SKRTLGLGSL YGENDLLDLD GDPLRERQMA EKQLAALGDI LSKYEEDRSA PMDFAVNTYM 490 500 510 520 530 540 SHTGIRLRES RPSSTAEKTQ SAPDKDKWLP FFPKTKKQSS NSKKEKDALE DKKRNPILRY 550 560 570 580 590 600 IGKPKSSSQS TFHIPLSPVE VKPGNVRNII QHFENSHQYD VPEPGTQRLS TGSFPEDLLE 610 620 630 640 650 660 SDSSRSEIRL GRSESLKGRE EMKRSRKAEN VPRSRSDVDM DAAAEATRLH QSASSSASSL 670 680 690 700 710 720 STRSLENPTP PFTPKMGRRS IESPNLGFCT DVILPHLLED DLGQLSDLEP EPEVQNWQHT 730 740 750 760 770 780 VGKDVVANLT QREIDRQEVI NELFVTEASH LRTLRVLDLI FYQRMKKENL MPREELARLF 790 800 810 820 830 840 PNLPELIEIH NSWCEAMKKL REEGPIIRDI SDLMLARFDG PAREELQQVA AQFCSYQSVA 850 860 870 880 890 900 LELIRTKQRK ESRFQLFMQE AESHPQCRRL QLRDLIISEM QRLTKYPLLL ENIIKHTAGG 910 920 930 940 950 960 TSEHEKLCRA RDQCREILKF VNEAVKQTEN RHRLEGYQKR LDATALERAS NPLAAEFKSL 970 980 990 1000 1010 1020 DLTTRKMIHE GPLTWRISKD KTLDLQVLLL EDLVVLLQRQ EEKLLLKCHS KTAVGSSDSK 1030 1040 1050 1060 1070 1080 QTFSPVLKLN AVLIRSVATD KRAFFIICTS ELGPPQIYEL VALTSSDKNI WMELLEEAVQ 1090 1100 1110 1120 1130 1140 NATKHPGDAP VLNHPSPPGS QEPAYQGSTS SRVEVNDSEV YPTEREPKKP SEGPGPEQRG 1150 1160 1170 1180 1190 1200 QDKQLLAQEG PEQEEDAEEL RALPCPPPSL DGENRGIRTR DPVLLALTGP LLMEGLADAA 1210 1220 1230 1240 1250 1260 LEDVENLRHL ILWSLLPGHT VKTQAAGEPE DDLTPTPSVV SITSHPWDPG SPGQAPAISD 1270 1280 1290 1300 1310 1320 NTQFPRPEGS QPEGEDVALC SLAHLPPRTR NSGIWDSPEL DRNPVEEASS SEPAGSYKVV 1330 1340 1350 1360 1370 1380 RKVSLLPGGG VGAAKVAGSN VTPALPESGQ SESELSEVEG GAQATGNCFY VSMPAEPLDS 1390 1400 1410 1420 1430 1440 STEPPGTPPS LSQCRSLPAW PTEPPQHRGV TGGQRSSLVL RDMGVIFHTI EQLTVKLHRL 1450 1460 1470 KDMELAHREL LNSLGGESSG GTTPVGSFHT EAARWT

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE34007.1. Tissue: Activated spleen EMBL BAE34007.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK157225 mRNA. Translation: BAE34007.1.
IPI	IPI00471007.
UniGene	Mm.287267.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008psl.1. mouse.
Organism-specific databases
MGI	MGI:2441869. Arhgef11.
Phylogenomic databases
HOGENOM	HOG000034045.
HOVERGEN	HBG101340.
Gene expression databases
Genevestigator	Q3U048.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR000342. Regulat_G_prot_signal. IPR015212. Regulat_G_prot_signal-like. IPR016137. Regulat_G_prot_signal_superfam. IPR015721. RhoGEF-like. [Graphical view]
PANTHER	PTHR22825. PTHR22825. 1 hit.
Pfam	PF00595. PDZ. 1 hit. PF09128. RGS-like. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. SM00233. PH. 1 hit. SM00315. RGS. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF50156. PDZ. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q3U048_MOUSE

Accession

Primary (citable) accession number: Q3U048

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)