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Protein

Methyltransferase-like protein 4

Gene

Mettl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 4 (EC:2.1.1.-)
Gene namesi
Name:Mettl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924031. Mettl4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Methyltransferase-like protein 4PRO_0000251226Add
BLAST

Proteomic databases

PaxDbiQ3U034.
PRIDEiQ3U034.

PTM databases

iPTMnetiQ3U034.
PhosphoSiteiQ3U034.

Expressioni

Gene expression databases

BgeeiQ3U034.
CleanExiMM_METTL4.
GenevisibleiQ3U034. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127142.

Structurei

3D structure databases

ProteinModelPortaliQ3U034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2356. Eukaryota.
ENOG410Y4SI. LUCA.
GeneTreeiENSGT00390000016237.
HOGENOMiHOG000113569.
HOVERGENiHBG078120.
InParanoidiQ3U034.
OMAiKRCVVFN.
OrthoDBiEOG7PGDR5.
PhylomeDBiQ3U034.
TreeFamiTF314410.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVHHLPPG WLLDHLSFIN KVNYQLCQHQ ESFCSKNNPT SSVYMDSLQL
60 70 80 90 100
DPGSPFGAPA MCFAPDFTTV SGNDDEGSCE VITEKYVFRS ELFNVTKPYI
110 120 130 140 150
VPAVHKERQQ SNKNENLVTD YKQEVSVSVG KKRKRCIAFN QGELDAMEYH
160 170 180 190 200
TKIRELILDG SSKLIQEGLR SGFLYPLVEK QDGSSGCITL PLDACNLSEL
210 220 230 240 250
CEMAKHLPSL NEMELQTLQL MGDDVSVIEL DLSSQIIENN SSFSKMITLM
260 270 280 290 300
GQKYLLPPQS SFLLSDISCM QPLLNCGKTF DAIVIDPPWE NKSVKRSNRY
310 320 330 340 350
SSLSPQQIKR MPIPKLAAAD CLIVTWVTNR QKHLCFVKEE LYPSWSVEVV
360 370 380 390 400
AEWYWVKITN SGEFVFPLDS PHKKPYECLV LGRVKEKTPL ALRNPDVRIP
410 420 430 440 450
PVPDQKLIVS VPCVLHSHKP PLTEVLRDYI KPGGQCLELF ARNLQPGWMS
460 470
WGNEVLKFQH MDYFIALESG C
Length:471
Mass (Da):53,306
Last modified:October 11, 2005 - v1
Checksum:i66C93ADF8FC0A43F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157268 mRNA. Translation: BAE34021.1.
CCDSiCCDS29030.1.
RefSeqiNP_795891.2. NM_176917.4.
XP_006525168.1. XM_006525105.2.
XP_006525169.1. XM_006525106.2.
UniGeneiMm.139146.
Mm.486648.

Genome annotation databases

EnsembliENSMUST00000171284; ENSMUSP00000127142; ENSMUSG00000055660.
GeneIDi76781.
KEGGimmu:76781.
UCSCiuc008dwk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157268 mRNA. Translation: BAE34021.1.
CCDSiCCDS29030.1.
RefSeqiNP_795891.2. NM_176917.4.
XP_006525168.1. XM_006525105.2.
XP_006525169.1. XM_006525106.2.
UniGeneiMm.139146.
Mm.486648.

3D structure databases

ProteinModelPortaliQ3U034.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127142.

PTM databases

iPTMnetiQ3U034.
PhosphoSiteiQ3U034.

Proteomic databases

PaxDbiQ3U034.
PRIDEiQ3U034.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171284; ENSMUSP00000127142; ENSMUSG00000055660.
GeneIDi76781.
KEGGimmu:76781.
UCSCiuc008dwk.1. mouse.

Organism-specific databases

CTDi64863.
MGIiMGI:1924031. Mettl4.

Phylogenomic databases

eggNOGiKOG2356. Eukaryota.
ENOG410Y4SI. LUCA.
GeneTreeiENSGT00390000016237.
HOGENOMiHOG000113569.
HOVERGENiHBG078120.
InParanoidiQ3U034.
OMAiKRCVVFN.
OrthoDBiEOG7PGDR5.
PhylomeDBiQ3U034.
TreeFamiTF314410.

Miscellaneous databases

NextBioi345789.
PROiQ3U034.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U034.
CleanExiMM_METTL4.
GenevisibleiQ3U034. MM.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.

Entry informationi

Entry nameiMETL4_MOUSE
AccessioniPrimary (citable) accession number: Q3U034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.