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Protein

Solute carrier family 25 member 33

Gene

Slc25a33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 33
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917806. Slc25a33.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei49 – 65Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917861 – 320Solute carrier family 25 member 33Add BLAST320

Proteomic databases

MaxQBiQ3TZX3.
PaxDbiQ3TZX3.
PeptideAtlasiQ3TZX3.
PRIDEiQ3TZX3.

PTM databases

PhosphoSitePlusiQ3TZX3.
SwissPalmiQ3TZX3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028982.
CleanExiMM_SLC25A33.
GenevisibleiQ3TZX3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101311.

Structurei

3D structure databases

ProteinModelPortaliQ3TZX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 118Solcar 1Add BLAST110
Repeati126 – 213Solcar 2Add BLAST88
Repeati231 – 315Solcar 3Add BLAST85

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757. Eukaryota.
ENOG410XS20. LUCA.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
HOVERGENiHBG059891.
InParanoidiQ3TZX3.
KOiK15116.
OMAiYLLEDHA.
OrthoDBiEOG091G0BCW.
PhylomeDBiQ3TZX3.
TreeFamiTF314220.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TZX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTQQKEN TLLHLFAGGC GGTVGAIFTC PLEVIKTRLQ SSRLALRTVY
60 70 80 90 100
YPQVHLGTIS GAGMVRPTSV TPGLLQVLKS ILEKEGPKSL FRGLGPNLVG
110 120 130 140 150
VAPSRAVYFA CYSKAKEQFN GIFVPNSNTV HILSAGSAAF VTNTLMNPIW
160 170 180 190 200
MVKTRMQLER KVRGCKQMNT LQCARRVYQT EGVRGFYRGL TASYAGISET
210 220 230 240 250
IICFAIYESL KKCLKDAPIV SSTDGAEKSS SGFFGLMAAA AVSKGCASCI
260 270 280 290 300
AYPHEVIRTR LREEGSKYRS FVQTARLVFR EEGYLAFYRG LFAQLIRQIP
310 320
NTAIVLSTYE FIVYLLGERA
Length:320
Mass (Da):35,064
Last modified:October 11, 2005 - v1
Checksum:i39D2EB15037D2AEC
GO

Sequence cautioni

The sequence BAB30846 differs from that shown. Reason: Frameshift at position 260.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31P → H in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti122I → V in AAH11293 (PubMed:15489334).Curated1
Sequence conflicti129T → N in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti154T → K in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti189G → V in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti293A → T in BAB30846 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017628 mRNA. Translation: BAB30846.1. Frameshift.
AK157423 mRNA. Translation: BAE34084.1.
AL626808 Genomic DNA. Translation: CAM22695.1.
BC011293 mRNA. Translation: AAH11293.1.
CCDSiCCDS38976.1.
RefSeqiNP_081736.2. NM_027460.2.
UniGeneiMm.41877.

Genome annotation databases

EnsembliENSMUST00000105686; ENSMUSP00000101311; ENSMUSG00000028982.
GeneIDi70556.
KEGGimmu:70556.
UCSCiuc008vxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017628 mRNA. Translation: BAB30846.1. Frameshift.
AK157423 mRNA. Translation: BAE34084.1.
AL626808 Genomic DNA. Translation: CAM22695.1.
BC011293 mRNA. Translation: AAH11293.1.
CCDSiCCDS38976.1.
RefSeqiNP_081736.2. NM_027460.2.
UniGeneiMm.41877.

3D structure databases

ProteinModelPortaliQ3TZX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101311.

PTM databases

PhosphoSitePlusiQ3TZX3.
SwissPalmiQ3TZX3.

Proteomic databases

MaxQBiQ3TZX3.
PaxDbiQ3TZX3.
PeptideAtlasiQ3TZX3.
PRIDEiQ3TZX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105686; ENSMUSP00000101311; ENSMUSG00000028982.
GeneIDi70556.
KEGGimmu:70556.
UCSCiuc008vxe.1. mouse.

Organism-specific databases

CTDi84275.
MGIiMGI:1917806. Slc25a33.

Phylogenomic databases

eggNOGiKOG0757. Eukaryota.
ENOG410XS20. LUCA.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
HOVERGENiHBG059891.
InParanoidiQ3TZX3.
KOiK15116.
OMAiYLLEDHA.
OrthoDBiEOG091G0BCW.
PhylomeDBiQ3TZX3.
TreeFamiTF314220.

Miscellaneous databases

PROiQ3TZX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028982.
CleanExiMM_SLC25A33.
GenevisibleiQ3TZX3. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2533_MOUSE
AccessioniPrimary (citable) accession number: Q3TZX3
Secondary accession number(s): Q921P8, Q9CYJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.