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Q3TZM9 (ALG11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:Alg11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain By similarity.

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3TZM9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3TZM9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-134: Missing.
Isoform 3 (identifier: Q3TZM9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000295617

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane234 – 25421Helical; Potential

Natural variations

Alternative sequence1 – 164164Missing in isoform 3.
VSP_026941
Alternative sequence93 – 13442Missing in isoform 2.
VSP_026940

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: E8347784DC963823

FASTA49255,270
        10         20         30         40         50         60 
MAADTGSWCV YAVLRFFYSL FFPGLMICGV LCVYLVIGLW VIRWHLQRKK KSVSTSKNGK 

        70         80         90        100        110        120 
EQTVVAFFHP YCNAGGGGER VLWCALRALQ KKYPEAVYVV YTGDINVSGQ QILDGAFRRF 

       130        140        150        160        170        180 
NIKLAHPVQF VFLRKRYLVE DSRYPHFTLL GQSLGSILLG WEALMQRVPD VYIDSMGYAF 

       190        200        210        220        230        240 
TLPLFKYVGG CRVGSYVHYP TISTDMLSVV KNQNPGFNNA AFISRNALLS KAKLIYYYLF 

       250        260        270        280        290        300 
AFVYGLVGSC SDIVMVNSSW TLNHILSLWK VGHCTNIVYP PCDVQTFLDI PLHEKKVTPG 

       310        320        330        340        350        360 
HLLVSIGQFR PEKNHALQIK AFAKLLNEKA AELGHSLKLV LIGGCRNKDD EFRVNQLRSL 

       370        380        390        400        410        420 
SENLGVQENV EFKINISFDE LKNYLSEATI GLHTMWNEHF GIGVVECMAA GTVILAHNSG 

       430        440        450        460        470        480 
GPKLDIVIPH EGQITGFLAE SEEGYADSMA HILSLSAEER LQIRKNARAS ISRFSDQEFE 

       490 
VAFLCSMEKL LT 

« Hide

Isoform 2 [UniParc].

Checksum: 6308A07260BD2004
Show »

FASTA45050,446
Isoform 3 [UniParc].

Checksum: 08BF59F5E13E558C
Show »

FASTA32836,597

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Corpora quadrigemina and Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK046475 mRNA. Translation: BAC32746.1.
AK157746 mRNA. Translation: BAE34179.1.
BC061469 mRNA. Translation: AAH61469.1.
RefSeqNP_001230090.1. NM_001243161.1.
NP_898965.1. NM_183142.4.
UniGeneMm.267439.
Mm.446082.

3D structure databases

ProteinModelPortalQ3TZM9.
SMRQ3TZM9. Positions 251-475.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3TZM9. 1 interaction.
MINTMINT-5043664.

Protein family/group databases

CAZyGT4. Glycosyltransferase Family 4.

PTM databases

PhosphoSiteQ3TZM9.

Proteomic databases

PaxDbQ3TZM9.
PRIDEQ3TZM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072572; ENSMUSP00000072382; ENSMUSG00000063362. [Q3TZM9-1]
ENSMUST00000110737; ENSMUSP00000106365; ENSMUSG00000063362. [Q3TZM9-2]
GeneID207958.
KEGGmmu:207958.
UCSCuc009lcl.2. mouse. [Q3TZM9-2]
uc009lcm.2. mouse. [Q3TZM9-1]

Organism-specific databases

CTD440138.
MGIMGI:2142632. Alg11.

Phylogenomic databases

eggNOGCOG0438.
GeneTreeENSGT00550000075118.
HOGENOMHOG000209670.
HOVERGENHBG057178.
InParanoidQ3TZM9.
KOK03844.
OMAMAHILSM.
OrthoDBEOG7FFMRF.
PhylomeDBQ3TZM9.
TreeFamTF313056.

Gene expression databases

BgeeQ3TZM9.
GenevestigatorQ3TZM9.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372104.
PROQ3TZM9.
SOURCESearch...

Entry information

Entry nameALG11_MOUSE
AccessionPrimary (citable) accession number: Q3TZM9
Secondary accession number(s): Q6P7W8, Q8BL38
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot