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Q3TZM9

- ALG11_MOUSE

UniProt

Q3TZM9 - ALG11_MOUSE

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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene
Alg11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain By similarity.

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Asparagine-linked glycosylation protein 11 homolog
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:Alg11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2142632. Alg11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000295617Add
BLAST

Proteomic databases

PaxDbiQ3TZM9.
PRIDEiQ3TZM9.

PTM databases

PhosphoSiteiQ3TZM9.

Expressioni

Gene expression databases

BgeeiQ3TZM9.
GenevestigatoriQ3TZM9.

Interactioni

Protein-protein interaction databases

IntActiQ3TZM9. 1 interaction.
MINTiMINT-5043664.

Structurei

3D structure databases

ProteinModelPortaliQ3TZM9.
SMRiQ3TZM9. Positions 251-475.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00550000075118.
HOGENOMiHOG000209670.
HOVERGENiHBG057178.
InParanoidiQ3TZM9.
KOiK03844.
OMAiGTVILAH.
OrthoDBiEOG7FFMRF.
PhylomeDBiQ3TZM9.
TreeFamiTF313056.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TZM9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAADTGSWCV YAVLRFFYSL FFPGLMICGV LCVYLVIGLW VIRWHLQRKK    50
KSVSTSKNGK EQTVVAFFHP YCNAGGGGER VLWCALRALQ KKYPEAVYVV 100
YTGDINVSGQ QILDGAFRRF NIKLAHPVQF VFLRKRYLVE DSRYPHFTLL 150
GQSLGSILLG WEALMQRVPD VYIDSMGYAF TLPLFKYVGG CRVGSYVHYP 200
TISTDMLSVV KNQNPGFNNA AFISRNALLS KAKLIYYYLF AFVYGLVGSC 250
SDIVMVNSSW TLNHILSLWK VGHCTNIVYP PCDVQTFLDI PLHEKKVTPG 300
HLLVSIGQFR PEKNHALQIK AFAKLLNEKA AELGHSLKLV LIGGCRNKDD 350
EFRVNQLRSL SENLGVQENV EFKINISFDE LKNYLSEATI GLHTMWNEHF 400
GIGVVECMAA GTVILAHNSG GPKLDIVIPH EGQITGFLAE SEEGYADSMA 450
HILSLSAEER LQIRKNARAS ISRFSDQEFE VAFLCSMEKL LT 492
Length:492
Mass (Da):55,270
Last modified:October 11, 2005 - v1
Checksum:iE8347784DC963823
GO
Isoform 2 (identifier: Q3TZM9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-134: Missing.

Show »
Length:450
Mass (Da):50,446
Checksum:i6308A07260BD2004
GO
Isoform 3 (identifier: Q3TZM9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: No experimental confirmation available.

Show »
Length:328
Mass (Da):36,597
Checksum:i08BF59F5E13E558C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 164164Missing in isoform 3. VSP_026941Add
BLAST
Alternative sequencei93 – 13442Missing in isoform 2. VSP_026940Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046475 mRNA. Translation: BAC32746.1.
AK157746 mRNA. Translation: BAE34179.1.
BC061469 mRNA. Translation: AAH61469.1.
CCDSiCCDS40292.1. [Q3TZM9-2]
CCDS57613.1. [Q3TZM9-1]
RefSeqiNP_001230090.1. NM_001243161.1. [Q3TZM9-1]
NP_898965.1. NM_183142.4. [Q3TZM9-2]
UniGeneiMm.267439.
Mm.446082.

Genome annotation databases

EnsembliENSMUST00000072572; ENSMUSP00000072382; ENSMUSG00000063362. [Q3TZM9-1]
ENSMUST00000110737; ENSMUSP00000106365; ENSMUSG00000063362. [Q3TZM9-2]
GeneIDi207958.
KEGGimmu:207958.
UCSCiuc009lcl.2. mouse. [Q3TZM9-2]
uc009lcm.2. mouse. [Q3TZM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046475 mRNA. Translation: BAC32746.1 .
AK157746 mRNA. Translation: BAE34179.1 .
BC061469 mRNA. Translation: AAH61469.1 .
CCDSi CCDS40292.1. [Q3TZM9-2 ]
CCDS57613.1. [Q3TZM9-1 ]
RefSeqi NP_001230090.1. NM_001243161.1. [Q3TZM9-1 ]
NP_898965.1. NM_183142.4. [Q3TZM9-2 ]
UniGenei Mm.267439.
Mm.446082.

3D structure databases

ProteinModelPortali Q3TZM9.
SMRi Q3TZM9. Positions 251-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3TZM9. 1 interaction.
MINTi MINT-5043664.

Protein family/group databases

CAZyi GT4. Glycosyltransferase Family 4.

PTM databases

PhosphoSitei Q3TZM9.

Proteomic databases

PaxDbi Q3TZM9.
PRIDEi Q3TZM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072572 ; ENSMUSP00000072382 ; ENSMUSG00000063362 . [Q3TZM9-1 ]
ENSMUST00000110737 ; ENSMUSP00000106365 ; ENSMUSG00000063362 . [Q3TZM9-2 ]
GeneIDi 207958.
KEGGi mmu:207958.
UCSCi uc009lcl.2. mouse. [Q3TZM9-2 ]
uc009lcm.2. mouse. [Q3TZM9-1 ]

Organism-specific databases

CTDi 440138.
MGIi MGI:2142632. Alg11.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00550000075118.
HOGENOMi HOG000209670.
HOVERGENi HBG057178.
InParanoidi Q3TZM9.
KOi K03844.
OMAi GTVILAH.
OrthoDBi EOG7FFMRF.
PhylomeDBi Q3TZM9.
TreeFami TF313056.

Miscellaneous databases

NextBioi 372104.
PROi Q3TZM9.
SOURCEi Search...

Gene expression databases

Bgeei Q3TZM9.
Genevestigatori Q3TZM9.

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiALG11_MOUSE
AccessioniPrimary (citable) accession number: Q3TZM9
Secondary accession number(s): Q6P7W8, Q8BL38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi