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Q3TZM9

- ALG11_MOUSE

UniProt

Q3TZM9 - ALG11_MOUSE

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

Alg11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain By similarity.By similarity

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT4. Glycosyltransferase Family 4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Asparagine-linked glycosylation protein 11 homolog
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:Alg11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2142632. Alg11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000295617Add
    BLAST

    Proteomic databases

    PaxDbiQ3TZM9.
    PRIDEiQ3TZM9.

    PTM databases

    PhosphoSiteiQ3TZM9.

    Expressioni

    Gene expression databases

    BgeeiQ3TZM9.
    GenevestigatoriQ3TZM9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ3TZM9. 1 interaction.
    MINTiMINT-5043664.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TZM9.
    SMRiQ3TZM9. Positions 251-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    GeneTreeiENSGT00550000075118.
    HOGENOMiHOG000209670.
    HOVERGENiHBG057178.
    InParanoidiQ3TZM9.
    KOiK03844.
    OMAiGTVILAH.
    OrthoDBiEOG7FFMRF.
    PhylomeDBiQ3TZM9.
    TreeFamiTF313056.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3TZM9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADTGSWCV YAVLRFFYSL FFPGLMICGV LCVYLVIGLW VIRWHLQRKK    50
    KSVSTSKNGK EQTVVAFFHP YCNAGGGGER VLWCALRALQ KKYPEAVYVV 100
    YTGDINVSGQ QILDGAFRRF NIKLAHPVQF VFLRKRYLVE DSRYPHFTLL 150
    GQSLGSILLG WEALMQRVPD VYIDSMGYAF TLPLFKYVGG CRVGSYVHYP 200
    TISTDMLSVV KNQNPGFNNA AFISRNALLS KAKLIYYYLF AFVYGLVGSC 250
    SDIVMVNSSW TLNHILSLWK VGHCTNIVYP PCDVQTFLDI PLHEKKVTPG 300
    HLLVSIGQFR PEKNHALQIK AFAKLLNEKA AELGHSLKLV LIGGCRNKDD 350
    EFRVNQLRSL SENLGVQENV EFKINISFDE LKNYLSEATI GLHTMWNEHF 400
    GIGVVECMAA GTVILAHNSG GPKLDIVIPH EGQITGFLAE SEEGYADSMA 450
    HILSLSAEER LQIRKNARAS ISRFSDQEFE VAFLCSMEKL LT 492
    Length:492
    Mass (Da):55,270
    Last modified:October 11, 2005 - v1
    Checksum:iE8347784DC963823
    GO
    Isoform 2 (identifier: Q3TZM9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-134: Missing.

    Show »
    Length:450
    Mass (Da):50,446
    Checksum:i6308A07260BD2004
    GO
    Isoform 3 (identifier: Q3TZM9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-164: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:328
    Mass (Da):36,597
    Checksum:i08BF59F5E13E558C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 164164Missing in isoform 3. 1 PublicationVSP_026941Add
    BLAST
    Alternative sequencei93 – 13442Missing in isoform 2. 1 PublicationVSP_026940Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK046475 mRNA. Translation: BAC32746.1.
    AK157746 mRNA. Translation: BAE34179.1.
    BC061469 mRNA. Translation: AAH61469.1.
    CCDSiCCDS40292.1. [Q3TZM9-2]
    CCDS57613.1. [Q3TZM9-1]
    RefSeqiNP_001230090.1. NM_001243161.1. [Q3TZM9-1]
    NP_898965.1. NM_183142.4. [Q3TZM9-2]
    UniGeneiMm.267439.
    Mm.446082.

    Genome annotation databases

    EnsembliENSMUST00000072572; ENSMUSP00000072382; ENSMUSG00000063362. [Q3TZM9-1]
    ENSMUST00000110737; ENSMUSP00000106365; ENSMUSG00000063362. [Q3TZM9-2]
    GeneIDi207958.
    KEGGimmu:207958.
    UCSCiuc009lcl.2. mouse. [Q3TZM9-2]
    uc009lcm.2. mouse. [Q3TZM9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK046475 mRNA. Translation: BAC32746.1 .
    AK157746 mRNA. Translation: BAE34179.1 .
    BC061469 mRNA. Translation: AAH61469.1 .
    CCDSi CCDS40292.1. [Q3TZM9-2 ]
    CCDS57613.1. [Q3TZM9-1 ]
    RefSeqi NP_001230090.1. NM_001243161.1. [Q3TZM9-1 ]
    NP_898965.1. NM_183142.4. [Q3TZM9-2 ]
    UniGenei Mm.267439.
    Mm.446082.

    3D structure databases

    ProteinModelPortali Q3TZM9.
    SMRi Q3TZM9. Positions 251-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3TZM9. 1 interaction.
    MINTi MINT-5043664.

    Protein family/group databases

    CAZyi GT4. Glycosyltransferase Family 4.

    PTM databases

    PhosphoSitei Q3TZM9.

    Proteomic databases

    PaxDbi Q3TZM9.
    PRIDEi Q3TZM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072572 ; ENSMUSP00000072382 ; ENSMUSG00000063362 . [Q3TZM9-1 ]
    ENSMUST00000110737 ; ENSMUSP00000106365 ; ENSMUSG00000063362 . [Q3TZM9-2 ]
    GeneIDi 207958.
    KEGGi mmu:207958.
    UCSCi uc009lcl.2. mouse. [Q3TZM9-2 ]
    uc009lcm.2. mouse. [Q3TZM9-1 ]

    Organism-specific databases

    CTDi 440138.
    MGIi MGI:2142632. Alg11.

    Phylogenomic databases

    eggNOGi COG0438.
    GeneTreei ENSGT00550000075118.
    HOGENOMi HOG000209670.
    HOVERGENi HBG057178.
    InParanoidi Q3TZM9.
    KOi K03844.
    OMAi GTVILAH.
    OrthoDBi EOG7FFMRF.
    PhylomeDBi Q3TZM9.
    TreeFami TF313056.

    Miscellaneous databases

    NextBioi 372104.
    PROi Q3TZM9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TZM9.
    Genevestigatori Q3TZM9.

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina and Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiALG11_MOUSE
    AccessioniPrimary (citable) accession number: Q3TZM9
    Secondary accession number(s): Q6P7W8, Q8BL38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3