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Protein

DNA mismatch repair protein

Gene

Msh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the post-replicative DNA mismatch repair system (MMR).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA repairUniRule annotation
LigandNucleotide-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair proteinUniRule annotation
Gene namesi
Name:Msh2Imported
ORF Names:mCG_15888Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101816. Msh2.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ3TZI5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024151.
ExpressionAtlasiQ3TZI5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024967.

Structurei

3D structure databases

ProteinModelPortaliQ3TZI5.
SMRiQ3TZI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini743 – 759DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili553 – 576Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0219. Eukaryota.
COG0249. LUCA.
HOVERGENiHBG006399.
KOiK08735.
OMAiNDWYLAY.
OrthoDBiEOG091G03SA.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
InterProiView protein in InterPro
IPR011184. DNA_mismatch_repair_MutS.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11361:SF118. PTHR11361:SF118. 1 hit.
PfamiView protein in Pfam
PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiView protein in SMART
SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 2 hits.
PROSITEiView protein in PROSITE
PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TZI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQPKETLQ LEGAAEAGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA
60 70 80 90 100
LLAAREVFKT QGVIKYMGPA GSKTLQSVVL SKMNFESFVK DLLLVRQYRV
110 120 130 140 150
EVYKNKAGNK ASKENEWYLA FKASPGNLSQ FEDILFGNND MSASVGVMGI
160 170 180 190 200
KMAVVDGQRH VGVGYVDSTQ RKLGLCEFPE NDQFSNLEAL LIQIGPKECV
210 220 230 240 250
LPGGETTGDM GKLRQVIQRG GILITERKRA DFSTKDIYQD LNRLLKGKKG
260 270 280 290 300
EQINSAALPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM
310 320 330 340 350
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVNQWIKQPL
360 370 380 390 400
MDRNRIEERL NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN
410 420 430 440 450
LQDCYRLYQG INQLPSVIQA LEKYEGRHQA LLLAVFVTPL IDLRSDFSKF
460 470 480 490 500
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREVMDGLEK KMQSTLINAA
510 520 530 540 550
RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
560 570 580 590 600
FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
610 620 630 640 650
HLDAIVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDEVAF
660 670 680 690 700
IPNDVHFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA
710 720 730 740 750
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL
760 770 780 790 800
GRGTSTYDGF GLAWAISDYI ATKIGAFCMF ATHFHELTAL ANQIPTVNNL
810 820 830 840 850
HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPRHV IACAKQKALE
860 870 880 890 900
LEEFQNIGTS LGCDEAEPAA KRRCLEREQG EKIILEFLSK VKQVPFTAMS
910 920 930
EESISAKLKQ LKAEVVAKNN SFVNEIISRI KAPAP
Length:935
Mass (Da):104,151
Last modified:October 11, 2005 - v1
Checksum:i2111E9D5E3A8548A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157842 mRNA. Translation: BAE34223.1.
CH466537 Genomic DNA. Translation: EDL38635.1.
RefSeqiNP_032654.1. NM_008628.2.
UniGeneiMm.4619.

Genome annotation databases

GeneIDi17685.
KEGGimmu:17685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157842 mRNA. Translation: BAE34223.1.
CH466537 Genomic DNA. Translation: EDL38635.1.
RefSeqiNP_032654.1. NM_008628.2.
UniGeneiMm.4619.

3D structure databases

ProteinModelPortaliQ3TZI5.
SMRiQ3TZI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024967.

Proteomic databases

MaxQBiQ3TZI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17685.
KEGGimmu:17685.

Organism-specific databases

CTDi4436.
MGIiMGI:101816. Msh2.

Phylogenomic databases

eggNOGiKOG0219. Eukaryota.
COG0249. LUCA.
HOVERGENiHBG006399.
KOiK08735.
OMAiNDWYLAY.
OrthoDBiEOG091G03SA.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024151.
ExpressionAtlasiQ3TZI5. baseline and differential.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
InterProiView protein in InterPro
IPR011184. DNA_mismatch_repair_MutS.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11361:SF118. PTHR11361:SF118. 1 hit.
PfamiView protein in Pfam
PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiView protein in SMART
SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 2 hits.
PROSITEiView protein in PROSITE
PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TZI5_MOUSE
AccessioniPrimary (citable) accession number: Q3TZI5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 12, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.