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Protein

DNA mismatch repair protein

Gene

Msh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the post-replicative DNA mismatch repair system (MMR).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA repairUniRule annotation
LigandNucleotide-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair proteinUniRule annotation
Gene namesi
Name:Msh2Imported
ORF Names:mCG_15888Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101816 Msh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ3TZI5
PRIDEiQ3TZI5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024151
ExpressionAtlasiQ3TZI5 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3TZI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini743 – 759DNA_MISMATCH_REPAIR_2InterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili478 – 498Sequence analysisAdd BLAST21
Coiled coili553 – 576Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0219 Eukaryota
COG0249 LUCA
HOVERGENiHBG006399
KOiK08735
OMAiGDFYTAH
OrthoDBiEOG091G03SA

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
InterProiView protein in InterPro
IPR011184 DNA_mismatch_repair_Msh2
IPR007695 DNA_mismatch_repair_MutS-lik_N
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR016151 DNA_mismatch_repair_MutS_N
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR032642 Msh2
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR11361:SF35 PTHR11361:SF35, 1 hit
PfamiView protein in Pfam
PF01624 MutS_I, 1 hit
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF005813 MSH2, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
SSF53150 SSF53150, 2 hits
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TZI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQPKETLQ LEGAAEAGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA
60 70 80 90 100
LLAAREVFKT QGVIKYMGPA GSKTLQSVVL SKMNFESFVK DLLLVRQYRV
110 120 130 140 150
EVYKNKAGNK ASKENEWYLA FKASPGNLSQ FEDILFGNND MSASVGVMGI
160 170 180 190 200
KMAVVDGQRH VGVGYVDSTQ RKLGLCEFPE NDQFSNLEAL LIQIGPKECV
210 220 230 240 250
LPGGETTGDM GKLRQVIQRG GILITERKRA DFSTKDIYQD LNRLLKGKKG
260 270 280 290 300
EQINSAALPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM
310 320 330 340 350
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVNQWIKQPL
360 370 380 390 400
MDRNRIEERL NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN
410 420 430 440 450
LQDCYRLYQG INQLPSVIQA LEKYEGRHQA LLLAVFVTPL IDLRSDFSKF
460 470 480 490 500
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREVMDGLEK KMQSTLINAA
510 520 530 540 550
RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
560 570 580 590 600
FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
610 620 630 640 650
HLDAIVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDEVAF
660 670 680 690 700
IPNDVHFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA
710 720 730 740 750
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL
760 770 780 790 800
GRGTSTYDGF GLAWAISDYI ATKIGAFCMF ATHFHELTAL ANQIPTVNNL
810 820 830 840 850
HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPRHV IACAKQKALE
860 870 880 890 900
LEEFQNIGTS LGCDEAEPAA KRRCLEREQG EKIILEFLSK VKQVPFTAMS
910 920 930
EESISAKLKQ LKAEVVAKNN SFVNEIISRI KAPAP
Length:935
Mass (Da):104,151
Last modified:October 11, 2005 - v1
Checksum:i2111E9D5E3A8548A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157842 mRNA Translation: BAE34223.1
CH466537 Genomic DNA Translation: EDL38635.1
RefSeqiNP_032654.1, NM_008628.2
UniGeneiMm.4619

Genome annotation databases

GeneIDi17685
KEGGimmu:17685

Similar proteinsi

Entry informationi

Entry nameiQ3TZI5_MOUSE
AccessioniPrimary (citable) accession number: Q3TZI5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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