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Protein

Cyclin-dependent kinase-like 4

Gene

Cdkl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 4 (EC:2.7.11.22)
Gene namesi
Name:Cdkl4
Synonyms:Gm942
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3587025. Cdkl4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858251 – 342Cyclin-dependent kinase-like 4Add BLAST342

Proteomic databases

MaxQBiQ3TZA2.
PaxDbiQ3TZA2.
PRIDEiQ3TZA2.

PTM databases

iPTMnetiQ3TZA2.
PhosphoSitePlusiQ3TZA2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033966.
CleanExiMM_CDKL4.
GenevisibleiQ3TZA2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083732.

Structurei

3D structure databases

ProteinModelPortaliQ3TZA2.
SMRiQ3TZA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ3TZA2.
KOiK08824.
OMAiRNETQTS.
OrthoDBiEOG091G0BZP.
PhylomeDBiQ3TZA2.
TreeFamiTF101031.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TZA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYEKLAKI GEGSYGVVFK CRNKSSGQVV AIKKFVESED DRVVRKIALR
60 70 80 90 100
EIRMLKQLKH PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVSD
110 120 130 140 150
GVIKSVLWQT LQALNFCHKH NCIHRDVKPE NILITKQGMI KICDFGFARI
160 170 180 190 200
LIPGDAYTDY VATRWYRAPE LLVGDTKYGS SVDVWAVGCV FAELLTGQPL
210 220 230 240 250
WPGKSDVDQL YLIIRTLGKL IPRHQSIFRS NQFFRGISIP EPEDMETLEE
260 270 280 290 300
KFSNVQPVAL SFMKGCLKMN PDERLTCAQL LDSAYFESFQ EDQMKRKARS
310 320 330 340
EGRSRRRQQN QLLPLIPGSH ISPTPDGRKQ VVQLKFDHLP NI
Length:342
Mass (Da):39,446
Last modified:October 11, 2005 - v1
Checksum:i384426A832F4D7C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157995 mRNA. Translation: BAE34307.1.
BC138986 mRNA. Translation: AAI38987.1.
BC138988 mRNA. Translation: AAI38989.1.
CCDSiCCDS28992.1.
RefSeqiNP_001028615.1. NM_001033443.4.
XP_006524589.1. XM_006524526.1.
XP_006524590.1. XM_006524527.3.
XP_011244823.1. XM_011246521.2.
UniGeneiMm.329216.

Genome annotation databases

EnsembliENSMUST00000086545; ENSMUSP00000083732; ENSMUSG00000033966.
GeneIDi381113.
KEGGimmu:381113.
UCSCiuc008dri.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDKL4_MOUSE
AccessioniPrimary (citable) accession number: Q3TZA2
Secondary accession number(s): B2RSS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: July 5, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families