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Protein

Protein transport protein Sec31B

Gene

Sec31b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec31B
Alternative name(s):
SEC31-like protein 2
SEC31-related protein B
Gene namesi
Name:Sec31b
Synonyms:Gm341, Sec31l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2685187. Sec31b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951541 – 1158Protein transport protein Sec31BAdd BLAST1158

Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ3TZ89.
PaxDbiQ3TZ89.
PeptideAtlasiQ3TZ89.
PRIDEiQ3TZ89.

PTM databases

iPTMnetiQ3TZ89.
PhosphoSitePlusiQ3TZ89.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051984.
CleanExiMM_SEC31B.
ExpressionAtlasiQ3TZ89. baseline and differential.

Interactioni

Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13. Interacts with SEC31A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064900.

Structurei

3D structure databases

ProteinModelPortaliQ3TZ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 47WD 1Add BLAST44
Repeati65 – 110WD 2Add BLAST46
Repeati119 – 159WD 3Add BLAST41
Repeati166 – 206WD 4Add BLAST41
Repeati209 – 254WD 5Add BLAST46
Repeati258 – 298WD 6Add BLAST41
Repeati301 – 341WD 7Add BLAST41
Repeati376 – 407WD 8; interaction with SEC13PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi806 – 1052Pro-richAdd BLAST247

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0307. Eukaryota.
ENOG410XQ1D. LUCA.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiQ3TZ89.
KOiK14005.
OMAiITKDVDG.
OrthoDBiEOG091G01VB.
PhylomeDBiQ3TZ89.
TreeFamiTF313842.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TZ89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKELEKPA VQAWSPARQY PVYLATGTSA QQLDASFSTN ATLEIFEIDF
60 70 80 90 100
RDPSLDLKHK GILSVSSRFH KLIWGSFGSG LLENSGVIAG GGDNGTLTLY
110 120 130 140 150
NVTHVLSSGK EPLIAQKQKH TGAVRALDFN PFQGNLLASG ASDSEIFIWD
160 170 180 190 200
LNHLSVPMTP GPKSQNPPED IKALSWNLQV QHILASAHPS GKAVVWDLRK
210 220 230 240 250
NEPIIKVSSH SSRMNCSGLA WNPDIATQLV LCSEDDQLPV IQLWDLRFAS
260 270 280 290 300
SPLKVLESHS RGILSMSWNQ ADAELLLSTA KDSQIFCWNL SSSEVVYKLP
310 320 330 340 350
TQSSWCFDVQ WCPQSPPVFS AVSFDGWISL CSVMGRSWEA QHMRQADKVP
360 370 380 390 400
EQVAQASLIP PLKKPPKWMR RPAGGSFAFG GKLVTFGLPS IPVQPVAQAC
410 420 430 440 450
SRPVFISQVI TESEVLTRSV VLQEALGSGN LLNYCQSKVQ QASLPCEKIL
460 470 480 490 500
WQFLKVTLEQ DSRPKFLGLL GYSREELQKK VDTCLKSDSK SQESPQLEAV
510 520 530 540 550
DLKSDRAHSP CAQASKHTAK EASESSAFFD ELIPQNMTPW EIPTTEDTDG
560 570 580 590 600
LLSQALLLGE LRSAVELCLK EERFADAIIL AQAGDAELLK WTQERYLAKR
610 620 630 640 650
RTKTSSLLAC VVKKNWKDLV CACRLKNWRE ALALLLTYSG PEKFPELCDM
660 670 680 690 700
LGTRMEQEGG RALTSEARLC YVCSGSVERL VESWAKFQQA SSPMALQELM
710 720 730 740 750
EQVTVLSRSL ELLQGSNKMS PGPATTHRLT QYANLLAAQG SLATAMSFLP
760 770 780 790 800
SDCIQPGVQQ LRDRLFHAQG SAVLGQQAPA FPFPRVAVGA ALHSKETSSY
810 820 830 840 850
RRGLQPPQQV PAPSVRPRTT AQPSSVMPFS PSQPSPSQGS SDHRVLRPQA
860 870 880 890 900
ILPGHFVPGV RPALSPPQLS GGQSVPAVNP AGFCGAWPLP GPTPVMASPD
910 920 930 940 950
FMQPGSTHLP ETPRLLPLPP VGPPGPNPLS SQLPASPVTF SVAPPPGGPR
960 970 980 990 1000
APCSSALPSS GILATCPGPQ DSWKVSPASQ GNLQRKKLPE TFMPPAPITA
1010 1020 1030 1040 1050
PLRSLGPEPQ QALLPQPLVS SATLPPPGAP RECSLQQLQP LPPERTEKEL
1060 1070 1080 1090 1100
PPEHQCVKDS FEALLQRCSL TATDLKTKRK LEEAARRLEC LYEKLCEGTL
1110 1120 1130 1140 1150
SPHVLAGLHE VARCVDAGSF EQGLAVHAQV AGCSSFSEVS SFMPMLKAVL

TIAHKLQG
Length:1,158
Mass (Da):125,633
Last modified:July 10, 2007 - v2
Checksum:i86EE5CD7F518691B
GO
Isoform 2 (identifier: Q3TZ89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:1,001
Mass (Da):108,639
Checksum:i642DDDCD22E409A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275L → P in BAE34320 (PubMed:16141072).Curated1
Sequence conflicti334M → I in BAE34320 (PubMed:16141072).Curated1
Sequence conflicti438K → R in BAE34320 (PubMed:16141072).Curated1
Sequence conflicti847R → G in BAE34320 (PubMed:16141072).Curated1
Sequence conflicti897A → E in BAE34320 (PubMed:16141072).Curated1
Sequence conflicti1046T → A in BAE34320 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0267641 – 157Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158017 mRNA. Translation: BAE34320.1.
AC151478 Genomic DNA. No translation available.
BC042701 mRNA. Translation: AAH42701.1.
CCDSiCCDS37997.1. [Q3TZ89-1]
RefSeqiNP_001028515.1. NM_001033343.1. [Q3TZ89-1]
UniGeneiMm.329873.

Genome annotation databases

EnsembliENSMUST00000063632; ENSMUSP00000064900; ENSMUSG00000051984. [Q3TZ89-1]
ENSMUST00000111985; ENSMUSP00000107616; ENSMUSG00000051984. [Q3TZ89-2]
GeneIDi240667.
KEGGimmu:240667.
UCSCiuc008hpu.1. mouse. [Q3TZ89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158017 mRNA. Translation: BAE34320.1.
AC151478 Genomic DNA. No translation available.
BC042701 mRNA. Translation: AAH42701.1.
CCDSiCCDS37997.1. [Q3TZ89-1]
RefSeqiNP_001028515.1. NM_001033343.1. [Q3TZ89-1]
UniGeneiMm.329873.

3D structure databases

ProteinModelPortaliQ3TZ89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064900.

PTM databases

iPTMnetiQ3TZ89.
PhosphoSitePlusiQ3TZ89.

Proteomic databases

MaxQBiQ3TZ89.
PaxDbiQ3TZ89.
PeptideAtlasiQ3TZ89.
PRIDEiQ3TZ89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063632; ENSMUSP00000064900; ENSMUSG00000051984. [Q3TZ89-1]
ENSMUST00000111985; ENSMUSP00000107616; ENSMUSG00000051984. [Q3TZ89-2]
GeneIDi240667.
KEGGimmu:240667.
UCSCiuc008hpu.1. mouse. [Q3TZ89-1]

Organism-specific databases

CTDi25956.
MGIiMGI:2685187. Sec31b.

Phylogenomic databases

eggNOGiKOG0307. Eukaryota.
ENOG410XQ1D. LUCA.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiQ3TZ89.
KOiK14005.
OMAiITKDVDG.
OrthoDBiEOG091G01VB.
PhylomeDBiQ3TZ89.
TreeFamiTF313842.

Miscellaneous databases

PROiQ3TZ89.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051984.
CleanExiMM_SEC31B.
ExpressionAtlasiQ3TZ89. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC31B_MOUSE
AccessioniPrimary (citable) accession number: Q3TZ89
Secondary accession number(s): Q811L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.