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Protein

E3 ubiquitin-protein ligase MARCH9

Gene

March9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 162RING-CH-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MARCH9 (EC:6.3.2.-)
Alternative name(s):
Membrane-associated RING finger protein 9
Membrane-associated RING-CH protein IX
Short name:
MARCH-IX
Gene namesi
Name:March9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2446144. March9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742831 – 348E3 ubiquitin-protein ligase MARCH9Add BLAST348

Proteomic databases

PaxDbiQ3TZ87.
PRIDEiQ3TZ87.

PTM databases

PhosphoSitePlusiQ3TZ87.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040502.
CleanExiMM_MARCH9.
GenevisibleiQ3TZ87. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041581.

Structurei

3D structure databases

ProteinModelPortaliQ3TZ87.
SMRiQ3TZ87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 39Poly-Gly8
Compositional biasi74 – 89Pro-richAdd BLAST16

Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity.

Sequence similaritiesi

Contains 1 RING-CH-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 162RING-CH-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1609. Eukaryota.
COG5183. LUCA.
GeneTreeiENSGT00730000110738.
HOGENOMiHOG000113484.
HOVERGENiHBG052412.
InParanoidiQ3TZ87.
KOiK10659.
OMAiCSKGKLE.
OrthoDBiEOG091G0JT5.
TreeFamiTF319557.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033275. MARCH-like.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR23012. PTHR23012. 1 hit.
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TZ87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSRLRMFL NELKLLVLTG GGRPRAEPQP RGGGGGGCGW APFAGCSARD
60 70 80 90 100
GDGDEEEYYG SEPRARGLAG DKEPRAGPPP PPAPPPPPPG ALDALSLSSS
110 120 130 140 150
LDSGLRTPQC RICFQGPEQG ELLSPCRCDG SVRCTHQPCL IRWISERGSW
160 170 180 190 200
SCELCYFKYQ VLAISTKNPL QWQAISLTVI EKVQIAAIVL GSLFLVASIS
210 220 230 240 250
WLIWSSLSPS AKWQRQDLLF QICYGMYGFM DVVCIGLIVH EGSSVYRIFK
260 270 280 290 300
RWQAVNQQWK VLNYDKTKDV GGDTGGGAAG KPGPRTSRTS PPAGAPTRPP
310 320 330 340
AAQRMRMRTL LPQRCGYTIL HLLGQLRPPD ARSSSHSGRE VVMRVTTV
Length:348
Mass (Da):37,888
Last modified:October 11, 2005 - v1
Checksum:i0062DB303278CD17
GO

Sequence cautioni

The sequence AAH19560 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158026 mRNA. Translation: BAE34323.1.
BC019560 mRNA. Translation: AAH19560.1. Different initiation.
CCDSiCCDS24225.1.
RefSeqiNP_001028434.1. NM_001033262.2.
UniGeneiMm.37892.

Genome annotation databases

EnsembliENSMUST00000040307; ENSMUSP00000041581; ENSMUSG00000040502.
GeneIDi216438.
KEGGimmu:216438.
UCSCiuc007hhu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158026 mRNA. Translation: BAE34323.1.
BC019560 mRNA. Translation: AAH19560.1. Different initiation.
CCDSiCCDS24225.1.
RefSeqiNP_001028434.1. NM_001033262.2.
UniGeneiMm.37892.

3D structure databases

ProteinModelPortaliQ3TZ87.
SMRiQ3TZ87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041581.

PTM databases

PhosphoSitePlusiQ3TZ87.

Proteomic databases

PaxDbiQ3TZ87.
PRIDEiQ3TZ87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040307; ENSMUSP00000041581; ENSMUSG00000040502.
GeneIDi216438.
KEGGimmu:216438.
UCSCiuc007hhu.1. mouse.

Organism-specific databases

CTDi92979.
MGIiMGI:2446144. March9.

Phylogenomic databases

eggNOGiKOG1609. Eukaryota.
COG5183. LUCA.
GeneTreeiENSGT00730000110738.
HOGENOMiHOG000113484.
HOVERGENiHBG052412.
InParanoidiQ3TZ87.
KOiK10659.
OMAiCSKGKLE.
OrthoDBiEOG091G0JT5.
TreeFamiTF319557.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ3TZ87.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040502.
CleanExiMM_MARCH9.
GenevisibleiQ3TZ87. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033275. MARCH-like.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR23012. PTHR23012. 1 hit.
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMARH9_MOUSE
AccessioniPrimary (citable) accession number: Q3TZ87
Secondary accession number(s): Q8VCL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.