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Q3TZ86

- Q3TZ86_MOUSE

UniProt

Q3TZ86 - Q3TZ86_MOUSE

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Protein
Submitted name:

C5a anaphylatoxin chemotactic receptor 1

Gene

C5ar1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. C5a anaphylatoxin receptor activity Source: MGI
  2. complement component C5a receptor activity Source: Ensembl

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. cell proliferation in hindbrain Source: Ensembl
  3. defense response to Gram-positive bacterium Source: MGI
  4. inflammatory response Source: Ensembl
  5. mRNA transcription from RNA polymerase II promoter Source: Ensembl
  6. negative regulation of neuron apoptotic process Source: Ensembl
  7. neutrophil chemotaxis Source: MGI
  8. organ regeneration Source: Ensembl
  9. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  10. positive regulation of epithelial cell proliferation Source: Ensembl
  11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  12. response to lipopolysaccharide Source: Ensembl
  13. response to peptidoglycan Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
C5a anaphylatoxin chemotactic receptor 1Imported
Submitted name:
C5a anaphylatoxin receptorImported
Submitted name:
Complement component 5a receptor 1Imported
Gene namesi
Name:C5ar1Imported
Synonyms:C5r1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:88232. C5ar1.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cell surface Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ3TZ86.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107547.
KOiK04010.
OMAiYINCCIN.
OrthoDBiEOG71P2BC.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF28. PTHR24225:SF28. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TZ86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPIDNSSFE INYDHYGTMD PNIPADGIHL PKRQPGDVAA LIIYSVVFLV
60 70 80 90 100
GVPGNALVVW VTAFEARRAV NAIWFLNLAV ADLLSCLALP VLFTTVLNHN
110 120 130 140 150
YWYFDATACI VLPSLILLNM YASILLLATI SADRFLLVFK PIWCQKVRGT
160 170 180 190 200
GLAWMACGVA WVLALLLTIP SFVYREAYKD FYSEHTVCGI NYGGGSFPKE
210 220 230 240 250
KAVAILRLMV GFVLPLLTLN ICYTFLLLRT WSRKATRSTK TLKVVMAVVI
260 270 280 290 300
CFFIFWLPYQ VTGVMIAWLP PSSPTLKRVE KLNSLCVSLA YINCCVNPII
310 320 330 340 350
YVMAGQGFHG RLLRSLPSII RNALSEDSVG RDSKTFTPST TDTSTRKSQA

V
Length:351
Mass (Da):39,023
Last modified:October 11, 2005 - v1
Checksum:i1186314DBAECC8F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156630 Genomic DNA. No translation available.
BC125641 mRNA. Translation: AAI25642.1.
BC125643 mRNA. Translation: AAI25644.1.
AY220494 mRNA. Translation: AAP50849.1.
AK158027 mRNA. Translation: BAE34324.1.
RefSeqiNP_001167021.1. NM_001173550.1.
NP_031603.2. NM_007577.4.
UniGeneiMm.247623.

Genome annotation databases

EnsembliENSMUST00000050770; ENSMUSP00000060003; ENSMUSG00000049130.
ENSMUST00000168818; ENSMUSP00000129972; ENSMUSG00000049130.
GeneIDi12273.
KEGGimmu:12273.
UCSCiuc009fhl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156630 Genomic DNA. No translation available.
BC125641 mRNA. Translation: AAI25642.1 .
BC125643 mRNA. Translation: AAI25644.1 .
AY220494 mRNA. Translation: AAP50849.1 .
AK158027 mRNA. Translation: BAE34324.1 .
RefSeqi NP_001167021.1. NM_001173550.1.
NP_031603.2. NM_007577.4.
UniGenei Mm.247623.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 32.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050770 ; ENSMUSP00000060003 ; ENSMUSG00000049130 .
ENSMUST00000168818 ; ENSMUSP00000129972 ; ENSMUSG00000049130 .
GeneIDi 12273.
KEGGi mmu:12273.
UCSCi uc009fhl.2. mouse.

Organism-specific databases

CTDi 728.
MGIi MGI:88232. C5ar1.

Phylogenomic databases

GeneTreei ENSGT00760000118990.
HOGENOMi HOG000234122.
HOVERGENi HBG107547.
KOi K04010.
OMAi YINCCIN.
OrthoDBi EOG71P2BC.
TreeFami TF330976.

Miscellaneous databases

NextBioi 280732.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3TZ86.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF28. PTHR24225:SF28. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01104. ANPHYLATOXNR.
PR00426. C5ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  8. "Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction."
    Waters S.M., Brodbeck R.M., Steflik J., Yu J., Baltazar C., Peck A.E., Severance D., Zhang L.Y., Currie K., Chenard B.L., Hutchison A.J., Maynard G., Krause J.E.
    J. Biol. Chem. 280:40617-40623(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  11. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  13. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TZ86_MOUSE
AccessioniPrimary (citable) accession number: Q3TZ86
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3