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Q3TZ86

- Q3TZ86_MOUSE

UniProt

Q3TZ86 - Q3TZ86_MOUSE

Protein
Submitted name:

C5a anaphylatoxin chemotactic receptor 1

Gene

C5ar1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. C5a anaphylatoxin receptor activity Source: MGI
    2. complement component C5a receptor activity Source: Ensembl

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. cell proliferation in hindbrain Source: Ensembl
    3. defense response to Gram-positive bacterium Source: MGI
    4. inflammatory response Source: Ensembl
    5. mRNA transcription from RNA polymerase II promoter Source: Ensembl
    6. negative regulation of neuron apoptotic process Source: Ensembl
    7. neutrophil chemotaxis Source: MGI
    8. organ regeneration Source: Ensembl
    9. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    10. positive regulation of epithelial cell proliferation Source: Ensembl
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. response to lipopolysaccharide Source: Ensembl
    13. response to peptidoglycan Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    C5a anaphylatoxin chemotactic receptor 1Imported
    Submitted name:
    C5a anaphylatoxin receptorImported
    Submitted name:
    Complement component 5a receptor 1Imported
    Gene namesi
    Name:C5ar1Imported
    Synonyms:C5r1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88232. C5ar1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cell surface Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ3TZ86.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110299.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107547.
    InParanoidiQ3TZ86.
    KOiK04010.
    OMAiYINCCIN.
    OrthoDBiEOG71P2BC.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001274. Anaphtx_C5AR1/C5AR2.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF28. PTHR24225:SF28. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01104. ANPHYLATOXNR.
    PR00426. C5ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TZ86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPIDNSSFE INYDHYGTMD PNIPADGIHL PKRQPGDVAA LIIYSVVFLV    50
    GVPGNALVVW VTAFEARRAV NAIWFLNLAV ADLLSCLALP VLFTTVLNHN 100
    YWYFDATACI VLPSLILLNM YASILLLATI SADRFLLVFK PIWCQKVRGT 150
    GLAWMACGVA WVLALLLTIP SFVYREAYKD FYSEHTVCGI NYGGGSFPKE 200
    KAVAILRLMV GFVLPLLTLN ICYTFLLLRT WSRKATRSTK TLKVVMAVVI 250
    CFFIFWLPYQ VTGVMIAWLP PSSPTLKRVE KLNSLCVSLA YINCCVNPII 300
    YVMAGQGFHG RLLRSLPSII RNALSEDSVG RDSKTFTPST TDTSTRKSQA 350
    V 351
    Length:351
    Mass (Da):39,023
    Last modified:October 11, 2005 - v1
    Checksum:i1186314DBAECC8F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156630 Genomic DNA. No translation available.
    BC125641 mRNA. Translation: AAI25642.1.
    BC125643 mRNA. Translation: AAI25644.1.
    AY220494 mRNA. Translation: AAP50849.1.
    AK158027 mRNA. Translation: BAE34324.1.
    RefSeqiNP_001167021.1. NM_001173550.1.
    NP_031603.2. NM_007577.4.
    UniGeneiMm.247623.

    Genome annotation databases

    EnsembliENSMUST00000050770; ENSMUSP00000060003; ENSMUSG00000049130.
    ENSMUST00000168818; ENSMUSP00000129972; ENSMUSG00000049130.
    GeneIDi12273.
    KEGGimmu:12273.
    UCSCiuc009fhl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156630 Genomic DNA. No translation available.
    BC125641 mRNA. Translation: AAI25642.1 .
    BC125643 mRNA. Translation: AAI25644.1 .
    AY220494 mRNA. Translation: AAP50849.1 .
    AK158027 mRNA. Translation: BAE34324.1 .
    RefSeqi NP_001167021.1. NM_001173550.1.
    NP_031603.2. NM_007577.4.
    UniGenei Mm.247623.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 32.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050770 ; ENSMUSP00000060003 ; ENSMUSG00000049130 .
    ENSMUST00000168818 ; ENSMUSP00000129972 ; ENSMUSG00000049130 .
    GeneIDi 12273.
    KEGGi mmu:12273.
    UCSCi uc009fhl.2. mouse.

    Organism-specific databases

    CTDi 728.
    MGIi MGI:88232. C5ar1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110299.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107547.
    InParanoidi Q3TZ86.
    KOi K04010.
    OMAi YINCCIN.
    OrthoDBi EOG71P2BC.
    TreeFami TF330976.

    Miscellaneous databases

    NextBioi 280732.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3TZ86.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001274. Anaphtx_C5AR1/C5AR2.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF28. PTHR24225:SF28. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01104. ANPHYLATOXNR.
    PR00426. C5ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    8. "Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction."
      Waters S.M., Brodbeck R.M., Steflik J., Yu J., Baltazar C., Peck A.E., Severance D., Zhang L.Y., Currie K., Chenard B.L., Hutchison A.J., Maynard G., Krause J.E.
      J. Biol. Chem. 280:40617-40623(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    9. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    10. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Inner earImported.
    11. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    13. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3TZ86_MOUSE
    AccessioniPrimary (citable) accession number: Q3TZ86
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3