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Protein

Probable cation-transporting ATPase 13A5

Gene

Atp13a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4864-aspartylphosphate intermediateBy similarity1
Metal bindingi848MagnesiumBy similarity1
Metal bindingi852MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A5 (EC:3.6.3.-)
Alternative name(s):
P5-ATPase isoform 5
Gene namesi
Name:Atp13a5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2444068. Atp13a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei896 – 916HelicalSequence analysisAdd BLAST21
Transmembranei933 – 950HelicalSequence analysisAdd BLAST18
Transmembranei971 – 991HelicalSequence analysisAdd BLAST21
Transmembranei1040 – 1060HelicalSequence analysisAdd BLAST21
Transmembranei1075 – 1095HelicalSequence analysisAdd BLAST21
Transmembranei1113 – 1133HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371231 – 1216Probable cation-transporting ATPase 13A5Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi650N-linked (GlcNAc...)Sequence analysis1
Glycosylationi817N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3TYU2.
PRIDEiQ3TYU2.

PTM databases

iPTMnetiQ3TYU2.
PhosphoSitePlusiQ3TYU2.

Expressioni

Tissue specificityi

Specifically expressed in brain and stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000048939.
ExpressionAtlasiQ3TYU2. baseline and differential.
GenevisibleiQ3TYU2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075204.

Structurei

3D structure databases

ProteinModelPortaliQ3TYU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ3TYU2.
KOiK14951.
OMAiMENEMEI.
OrthoDBiEOG091G01IL.
PhylomeDBiQ3TYU2.
TreeFamiTF300331.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TYU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKSKKDGHQ AVLNEGEENE LEVFGYHTQN LRRALCLVTA ILTLGAVQLM
60 70 80 90 100
FYWRPEWWVW TSCIPCPLQE ADTILLRTTD EFRRYMRKKV FCLHLSTLKF
110 120 130 140 150
PISKNPEEPL VADHHSVINQ AVMKPELKLR CIQVQKIRYV WDFLKKRFQK
160 170 180 190 200
VGLLEDSNSC FDIHHTFGLG LTNEEQEVRR LVCGPNSIEV EIQPIWKLLV
210 220 230 240 250
KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV
260 270 280 290 300
KLHKLVEEHN KVQVTITVRD KGLQELESRL LVPGDILILP GKISLPCDAI
310 320 330 340 350
LIDGSCVVNE GMLTGESIPV TKTPLPQTEN TMPWKSHSLE DYRKHVLFCG
360 370 380 390 400
TEVIQVKPSA QGLVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYNDAFK
410 420 430 440 450
FMVFLACVGV VGFFYALGVY MYHEVPPRET ATMALILLSA TVPPVLPAAL
460 470 480 490 500
TIGNVYAQKR LKKEKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG
510 520 530 540 550
TVPTAGNCFQ AVHSFASGEA VPWGPLCAAM TSCHSLILLD GTIQGDPLDL
560 570 580 590 600
KMFEGTGWNM EDSQVASCKF GMADSSTVIK PGPKASQSPV DSITILRQFP
610 620 630 640 650
FSSGLQRMSV IAQLAGDLHL HVYMKGAPEM VARFCRSETV PKNFSQELRN
660 670 680 690 700
YTVQGFRVIA LAHKTLKMER LSDMDHLARE KVESELAFLG LLIMENRLKK
710 720 730 740 750
ETRPVLKELS EARIRTVMVT GDNLQTAITV AKNSEMIPVG SQVVIVEANE
760 770 780 790 800
PGDLVPASVT WQLVGTQEPG SGKKDTYIDI GNSSVPAGKG YHFAMSGKSY
810 820 830 840 850
QVLFHHFYSM LPQILVNGTI FARMSPGQKS SLVEEFQKLN YYVGMCGDGA
860 870 880 890 900
NDCGALKMAH AGISLSEQEA SVASPFTSKT ANIECVPHLI REGRAALVSS
910 920 930 940 950
FGVFKYLTMY GIIQFIGTSL LYWQLQLFGN YQYLLQDVAI TLMVSLTMSI
960 970 980 990 1000
NHAYPKLAPY RPAGQLLSPQ LLLSVFMNSC FTCIVQVCTF LTVKQQPWYC
1010 1020 1030 1040 1050
EVYKYSECFL VNQSNLSANV SLDRNWTGNA TLVPASVLSF EGTTLWPIVT
1060 1070 1080 1090 1100
FNCISAAFIF SKGKPFRKPI YANYLFSLLL ASAAGLTIFI LFCDFQDLYR
1110 1120 1130 1140 1150
KMEFIPTPTS WRVSILIAAF VQFCVAFFVE DAVLQNRELW LFIKKEFGFY
1160 1170 1180 1190 1200
SKSQYRILQR KLAEDSTWPP VNRTDYAVNG KNGFYVNRAY ESPEEVPKGK
1210
LKLEEQASEQ HFWTRL
Length:1,216
Mass (Da):136,760
Last modified:May 20, 2008 - v2
Checksum:i184884C18414B47A
GO
Isoform 2 (identifier: Q3TYU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-311: Missing.

Show »
Length:905
Mass (Da):100,867
Checksum:iBF799AEEBBB6B5B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1072A → T in AAI15740 (PubMed:15489334).Curated1
Sequence conflicti1079L → V in BAE34470 (PubMed:16141072).Curated1
Sequence conflicti1130E → V in BAC38770 (PubMed:16141072).Curated1
Sequence conflicti1214T → A in BAE34470 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339241 – 311Missing in isoform 2. 1 PublicationAdd BLAST311

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083121 mRNA. Translation: BAC38770.1.
AK158355 mRNA. Translation: BAE34470.1.
BC115739 mRNA. Translation: AAI15740.1.
CCDSiCCDS28095.1. [Q3TYU2-1]
RefSeqiNP_001271304.1. NM_001284375.1.
NP_783581.2. NM_175650.4. [Q3TYU2-1]
UniGeneiMm.9823.

Genome annotation databases

EnsembliENSMUST00000075806; ENSMUSP00000075204; ENSMUSG00000048939. [Q3TYU2-1]
GeneIDi268878.
KEGGimmu:268878.
UCSCiuc007yvy.2. mouse. [Q3TYU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083121 mRNA. Translation: BAC38770.1.
AK158355 mRNA. Translation: BAE34470.1.
BC115739 mRNA. Translation: AAI15740.1.
CCDSiCCDS28095.1. [Q3TYU2-1]
RefSeqiNP_001271304.1. NM_001284375.1.
NP_783581.2. NM_175650.4. [Q3TYU2-1]
UniGeneiMm.9823.

3D structure databases

ProteinModelPortaliQ3TYU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075204.

PTM databases

iPTMnetiQ3TYU2.
PhosphoSitePlusiQ3TYU2.

Proteomic databases

PaxDbiQ3TYU2.
PRIDEiQ3TYU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075806; ENSMUSP00000075204; ENSMUSG00000048939. [Q3TYU2-1]
GeneIDi268878.
KEGGimmu:268878.
UCSCiuc007yvy.2. mouse. [Q3TYU2-1]

Organism-specific databases

CTDi344905.
MGIiMGI:2444068. Atp13a5.

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ3TYU2.
KOiK14951.
OMAiMENEMEI.
OrthoDBiEOG091G01IL.
PhylomeDBiQ3TYU2.
TreeFamiTF300331.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp13a5. mouse.
PROiQ3TYU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048939.
ExpressionAtlasiQ3TYU2. baseline and differential.
GenevisibleiQ3TYU2. MM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT135_MOUSE
AccessioniPrimary (citable) accession number: Q3TYU2
Secondary accession number(s): Q14BM0, Q8BUP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.