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Protein
Submitted name:

Hepatic triacylglycerol lipase

Gene

Lipc

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84NucleophileUniRule annotation1
Active sitei110Charge relay systemUniRule annotation1
Active sitei195Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHERimouse-1hlip. Hepatic_Lipase.

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatic triacylglycerol lipaseImported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:LipcImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96216. Lipc.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000032207.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034731.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 402PLATInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IIHP. Eukaryota.
ENOG4110MCZ. LUCA.
GeneTreeiENSGT00760000119069.
HOVERGENiHBG002259.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR002333. Lipase_hep.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiView protein in Pfam
PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiView protein in SMART
SM00308. LH2. 1 hit.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS50095. PLAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TYU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIHGWSVDG LLENWIWKIV SALKSRQSQP VNVGLVDWIS LAYQHYTIAV
60 70 80 90 100
QNTRIVGQDV AALLLWLEES AKFSRSKVHL IGYSLGAHVS GFAGSSMDGK
110 120 130 140 150
NKIGRITGLD PAGPMFEGTS PNERLSPDDA NFVDAIHTFT REHMGLSVGI
160 170 180 190 200
KQPIAHYDFY PNGGSFQPGC HFLELYKHIA EHGLNAITQT IKCAHERSVH
210 220 230 240 250
LFIDSLQHSD LQSIGFQCSD MGSFSQGLCL SCKKGRCNTL GYDIRKDRSG
260 270 280 290 300
KSKRLFLITR AQSPFKVYHY QFKIQFINQI EKPVEPTFTM SLLGTKEEIK
310 320 330 340 350
RIPITLGEGI TSNKTYSFLI TLDKDIGELI LLKFKWENSA VWANVWNTVQ
360 370 380 390 400
TIMLWGIEPH HSGLILKTIW VKAGETQQRM TFCPENLDDL QLHPSQEKVF
410 420
VNCEVKSKRL TESKEQMSQE THAKK
Length:425
Mass (Da):48,009
Last modified:October 11, 2005 - v1
Checksum:i095637E1F3DB2B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137843 Genomic DNA. No translation available.
CT025701 Genomic DNA. No translation available.
AK158285 mRNA. Translation: BAE34446.1.
AK158360 mRNA. Translation: BAE34472.1.
RefSeqiNP_001311402.1. NM_001324473.1.
UniGeneiMm.390187.

Genome annotation databases

EnsembliENSMUST00000216798; ENSMUSP00000149185; ENSMUSG00000032207.
GeneIDi15450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137843 Genomic DNA. No translation available.
CT025701 Genomic DNA. No translation available.
AK158285 mRNA. Translation: BAE34446.1.
AK158360 mRNA. Translation: BAE34472.1.
RefSeqiNP_001311402.1. NM_001324473.1.
UniGeneiMm.390187.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034731.

Protein family/group databases

ESTHERimouse-1hlip. Hepatic_Lipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000216798; ENSMUSP00000149185; ENSMUSG00000032207.
GeneIDi15450.

Organism-specific databases

CTDi3990.
MGIiMGI:96216. Lipc.

Phylogenomic databases

eggNOGiENOG410IIHP. Eukaryota.
ENOG4110MCZ. LUCA.
GeneTreeiENSGT00760000119069.
HOVERGENiHBG002259.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032207.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR002333. Lipase_hep.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiView protein in Pfam
PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiView protein in SMART
SM00308. LH2. 1 hit.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS50095. PLAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TYU0_MOUSE
AccessioniPrimary (citable) accession number: Q3TYU0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 15, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.