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Q3TYD6

- LMTK2_MOUSE

UniProt

Q3TYD6 - LMTK2_MOUSE

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Protein

Serine/threonine-protein kinase LMTK2

Gene

Lmtk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphorylates PPP1C, phosphorylase b and CFTR.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671ATPPROSITE-ProRule annotation
Active sitei264 – 2641Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1509ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein phosphatase inhibitor activity Source: Ensembl
  3. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. early endosome to late endosome transport Source: Ensembl
  3. endocytic recycling Source: Ensembl
  4. nervous system development Source: MGI
  5. neurotrophin TRK receptor signaling pathway Source: MGI
  6. peptidyl-serine phosphorylation Source: Ensembl
  7. peptidyl-threonine phosphorylation Source: Ensembl
  8. protein autophosphorylation Source: MGI
  9. receptor recycling Source: Ensembl
  10. transferrin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK2 (EC:2.7.11.1)
Alternative name(s):
Brain-enriched kinase
Lemur tyrosine kinase 2
Gene namesi
Name:Lmtk2
Synonyms:Brek, Kiaa1079
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:3036247. Lmtk2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 4110LumenalSequence Analysis
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Topological domaini63 – 14711409CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. early endosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. perinuclear region of cytoplasm Source: Ensembl
  6. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14711471Serine/threonine-protein kinase LMTK2PRO_0000259459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei781 – 7811Phosphoserine1 Publication
Modified residuei783 – 7831Phosphothreonine1 Publication

Post-translational modificationi

Autophosphorylated. Phosphorylated (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3TYD6.
PaxDbiQ3TYD6.
PRIDEiQ3TYD6.

PTM databases

PhosphoSiteiQ3TYD6.

Expressioni

Tissue specificityi

Mainly expressed in brain, especially in the olfactory bulb, olfactory tubercle, hippocampus, striatum, cerebellum and cerebral cortex. Weakly expressed in skeletal muscle and not expressed in liver.1 Publication

Developmental stagei

Expression observed during all tested stages from embryonic day 18 (E18) to postnatal week 6, but it was especially high during the early postnatal stage (postnatal weeks 0-2).1 Publication

Gene expression databases

BgeeiQ3TYD6.
CleanExiMM_LMTK2.
GenevestigatoriQ3TYD6.

Interactioni

Subunit structurei

Interacts with PPP1C and inhibitor-2.By similarity

Protein-protein interaction databases

IntActiQ3TYD6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3TYD6.
SMRiQ3TYD6. Positions 128-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 406271Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091449.
HOGENOMiHOG000252999.
HOVERGENiHBG081920.
InParanoidiQ3TYD6.
KOiK08898.
OMAiNLESPEW.
OrthoDBiEOG7HTHG4.
TreeFamiTF332280.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TYD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGPPASPPP PMLLLLLLLT VGCARAAPLP QTGAGEVPVV EVPSLFVILS
60 70 80 90 100
VCSLLILIVL IANCVSCCKD PEIDFKEFED NFDDEIDFTP PAEDTPSIQS
110 120 130 140 150
PAEVFTLSVP NISLPAPSQF QASVEGLKSQ VARHSLNYIQ EIGSGWFGKV
160 170 180 190 200
LLGETYTGTS VARVIVKELK VSASPKEQDT FLKSGEPYYI LQHPNVLQCV
210 220 230 240 250
GQCVEAIPYL LVFEFCDLGD LKAYLHNEQE HVRGDSQTML LQRMACEIAA
260 270 280 290 300
GLAAMHKLHF LHSDLALRNC YLTSDLNVKV GDYGIGFSRY KEDYIETDDK
310 320 330 340 350
KVFPLRWTAP ELVTSFQDRL LTADQTKYSN IWSLGVTLWE LFNNAAQPYA
360 370 380 390 400
NLSDLDVLNQ VIRERDMKLP KPQLEQPYSD RWYEVLQFCW LPPDKRPAAE
410 420 430 440 450
DVHRLLTYLR MQSQRDSEVD FEQQWTALKP DTNSRDASSS AAFPILDHFA
460 470 480 490 500
RDRLGREMEE VLTVTETSQG LSFEYVWEAA KHDHFDEQGR GHPDEALSYS
510 520 530 540 550
SMFFPVEVFE NSLSDPGPGK QDDSGQEVPV RAPGVVPVFD AHNLSVGSDY
560 570 580 590 600
YIQLEEKSSS NLGLDPPALL TTEVDKLERA GAEEPRTEED FFQSSAHPKE
610 620 630 640 650
ASSTEDSRAT SIPGSPFNLF SDLDKADDLP SHQKIFDLME LNGVQADFKP
660 670 680 690 700
AILSSSLDDP KDTCQSDKEK PHKLLDQGPL CLSESLLHQD HFDPLSVQEL
710 720 730 740 750
SENFLFLQEK NLLKGSLTTK EQVSDLQTEL KNAGFTSALL ESPQRGSESS
760 770 780 790 800
ELEFLENTLD FPLSQGDTRG QNEGAGVRRH SGTSPQASPA LLTEEGSPTA
810 820 830 840 850
PTDPILKPEE TKSFRDVRVP EDSICLELGP DPVTVGVEIP ATDAKTLDGG
860 870 880 890 900
NRPPDVTCQS KEALSLTNRH PILVNDITAQ GSVESCLPES RQDLQNEPFS
910 920 930 940 950
EDPLSVSSLE KHSEAAETLN QLNSKAAPED AALASALSSD STSQDSLLED
960 970 980 990 1000
SLSTPIPTSE QSVETPDSLD SVDVREALLE SLGSHTPRKL LPPDKPADSG
1010 1020 1030 1040 1050
YETENLESPE WTLHPAPEGT ADSDAAAAGD SGHSSLPPNP VIVISDAGDG
1060 1070 1080 1090 1100
HRGAEGPPQS FTLGPQSSYR DSAYFSDNDS EPDKKPEEVP GTSANALVLV
1110 1120 1130 1140 1150
KGQSPPESVV PEESSDVREG CLEAPQDKPD QSRVSTLQNS CHSELQETLQ
1160 1170 1180 1190 1200
PTPADASRES CPVNDEASSP LSLLNSEPSS CDDLDTQEDR PCTLASTGTN
1210 1220 1230 1240 1250
TNELLAYMSS TLDKSLPSHL ESSKLKEPDI EGKYLGKLCV SGMLDLSEDG
1260 1270 1280 1290 1300
MDADEEDENS DDSDEDLRAF NLHSLSSESE DDTEHPVPII VSNDDGRHLR
1310 1320 1330 1340 1350
SLLKPSAAEA IEQLPEDWKK EKKAVTFFDD VTVYLFDQET PTKELGHCGG
1360 1370 1380 1390 1400
EAHGPGPSSP AASSSSPYLG RCMNSESSTD EEGGGFEWDD DFSPDPFMSK
1410 1420 1430 1440 1450
TTSLLGSKPS LQTSKYFSPP PPARSAEQSW PHVSPCSRFS ISPANIASFS
1460 1470
LTHLTDSDIE QGGSSEDGDK D
Length:1,471
Mass (Da):160,508
Last modified:July 27, 2011 - v3
Checksum:i13C0C905F585D23F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti421 – 4211F → L in BAE34627. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB288872 mRNA. Translation: BAF64833.1.
AK039738 mRNA. Translation: BAC30433.1.
AK158724 mRNA. Translation: BAE34627.1.
AK129279 mRNA. Translation: BAC98089.2.
BC058653 mRNA. Translation: AAH58653.1.
CCDSiCCDS39376.1.
RefSeqiNP_001074578.1. NM_001081109.1.
UniGeneiMm.288726.

Genome annotation databases

EnsembliENSMUST00000041804; ENSMUSP00000048238; ENSMUSG00000038970.
GeneIDi231876.
KEGGimmu:231876.
UCSCiuc009alg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB288872 mRNA. Translation: BAF64833.1 .
AK039738 mRNA. Translation: BAC30433.1 .
AK158724 mRNA. Translation: BAE34627.1 .
AK129279 mRNA. Translation: BAC98089.2 .
BC058653 mRNA. Translation: AAH58653.1 .
CCDSi CCDS39376.1.
RefSeqi NP_001074578.1. NM_001081109.1.
UniGenei Mm.288726.

3D structure databases

ProteinModelPortali Q3TYD6.
SMRi Q3TYD6. Positions 128-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3TYD6. 1 interaction.

PTM databases

PhosphoSitei Q3TYD6.

Proteomic databases

MaxQBi Q3TYD6.
PaxDbi Q3TYD6.
PRIDEi Q3TYD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041804 ; ENSMUSP00000048238 ; ENSMUSG00000038970 .
GeneIDi 231876.
KEGGi mmu:231876.
UCSCi uc009alg.1. mouse.

Organism-specific databases

CTDi 22853.
MGIi MGI:3036247. Lmtk2.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091449.
HOGENOMi HOG000252999.
HOVERGENi HBG081920.
InParanoidi Q3TYD6.
KOi K08898.
OMAi NLESPEW.
OrthoDBi EOG7HTHG4.
TreeFami TF332280.

Miscellaneous databases

NextBioi 380841.
PROi Q3TYD6.
SOURCEi Search...

Gene expression databases

Bgeei Q3TYD6.
CleanExi MM_LMTK2.
Genevestigatori Q3TYD6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family."
    Tomomura M., Morita N., Yoshikawa F., Konishi A., Akiyama H., Furuichi T., Kamiguchi H.
    Neuroscience 148:510-521(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-632 AND 1263-1471.
    Strain: C57BL/6J.
    Tissue: Spinal cord and Visual cortex.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 410-1471.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1253-1471.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling."
    Kawa S., Fujimoto J., Tezuka T., Nakazawa T., Yamamoto T.
    Genes Cells 9:219-232(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, PHOSPHORYLATION, CHARACTERIZATION, DEVELOPMENTAL STAGE.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781 AND THR-783, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLMTK2_MOUSE
AccessioniPrimary (citable) accession number: Q3TYD6
Secondary accession number(s): A6BLY9
, Q6PDK6, Q6ZPY9, Q8CA34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3