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Q3TYD6

- LMTK2_MOUSE

UniProt

Q3TYD6 - LMTK2_MOUSE

Protein

Serine/threonine-protein kinase LMTK2

Gene

Lmtk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Phosphorylates PPP1C, phosphorylase b and CFTR.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei167 – 1671ATPPROSITE-ProRule annotation
    Active sitei264 – 2641Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi142 – 1509ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein phosphatase inhibitor activity Source: Ensembl
    3. protein serine/threonine kinase activity Source: MGI
    4. protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: MGI
    2. early endosome to late endosome transport Source: Ensembl
    3. endocytic recycling Source: Ensembl
    4. nervous system development Source: MGI
    5. neurotrophin TRK receptor signaling pathway Source: MGI
    6. peptidyl-serine phosphorylation Source: Ensembl
    7. peptidyl-threonine phosphorylation Source: Ensembl
    8. protein autophosphorylation Source: MGI
    9. receptor recycling Source: Ensembl
    10. transferrin transport Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase LMTK2 (EC:2.7.11.1)
    Alternative name(s):
    Brain-enriched kinase
    Lemur tyrosine kinase 2
    Gene namesi
    Name:Lmtk2
    Synonyms:Brek, Kiaa1079
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:3036247. Lmtk2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. early endosome Source: Ensembl
    3. Golgi apparatus Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. perinuclear region of cytoplasm Source: Ensembl
    6. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14711471Serine/threonine-protein kinase LMTK2PRO_0000259459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei781 – 7811Phosphoserine2 Publications
    Modified residuei783 – 7831Phosphothreonine2 Publications

    Post-translational modificationi

    Autophosphorylated. Phosphorylated By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ3TYD6.
    PRIDEiQ3TYD6.

    PTM databases

    PhosphoSiteiQ3TYD6.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain, especially in the olfactory bulb, olfactory tubercle, hippocampus, striatum, cerebellum and cerebral cortex. Weakly expressed in skeletal muscle and not expressed in liver.1 Publication

    Developmental stagei

    Expression observed during all tested stages from embryonic day 18 (E18) to postnatal week 6, but it was especially high during the early postnatal stage (postnatal weeks 0-2).1 Publication

    Gene expression databases

    BgeeiQ3TYD6.
    CleanExiMM_LMTK2.
    GenevestigatoriQ3TYD6.

    Interactioni

    Subunit structurei

    Interacts with PPP1C and inhibitor-2.By similarity

    Protein-protein interaction databases

    IntActiQ3TYD6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TYD6.
    SMRiQ3TYD6. Positions 128-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 4110LumenalSequence Analysis
    Topological domaini63 – 14711409CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 406271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00640000091449.
    HOGENOMiHOG000252999.
    HOVERGENiHBG081920.
    InParanoidiA6BLY9.
    KOiK08898.
    OMAiNLESPEW.
    OrthoDBiEOG7HTHG4.
    TreeFamiTF332280.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TYD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGPPASPPP PMLLLLLLLT VGCARAAPLP QTGAGEVPVV EVPSLFVILS     50
    VCSLLILIVL IANCVSCCKD PEIDFKEFED NFDDEIDFTP PAEDTPSIQS 100
    PAEVFTLSVP NISLPAPSQF QASVEGLKSQ VARHSLNYIQ EIGSGWFGKV 150
    LLGETYTGTS VARVIVKELK VSASPKEQDT FLKSGEPYYI LQHPNVLQCV 200
    GQCVEAIPYL LVFEFCDLGD LKAYLHNEQE HVRGDSQTML LQRMACEIAA 250
    GLAAMHKLHF LHSDLALRNC YLTSDLNVKV GDYGIGFSRY KEDYIETDDK 300
    KVFPLRWTAP ELVTSFQDRL LTADQTKYSN IWSLGVTLWE LFNNAAQPYA 350
    NLSDLDVLNQ VIRERDMKLP KPQLEQPYSD RWYEVLQFCW LPPDKRPAAE 400
    DVHRLLTYLR MQSQRDSEVD FEQQWTALKP DTNSRDASSS AAFPILDHFA 450
    RDRLGREMEE VLTVTETSQG LSFEYVWEAA KHDHFDEQGR GHPDEALSYS 500
    SMFFPVEVFE NSLSDPGPGK QDDSGQEVPV RAPGVVPVFD AHNLSVGSDY 550
    YIQLEEKSSS NLGLDPPALL TTEVDKLERA GAEEPRTEED FFQSSAHPKE 600
    ASSTEDSRAT SIPGSPFNLF SDLDKADDLP SHQKIFDLME LNGVQADFKP 650
    AILSSSLDDP KDTCQSDKEK PHKLLDQGPL CLSESLLHQD HFDPLSVQEL 700
    SENFLFLQEK NLLKGSLTTK EQVSDLQTEL KNAGFTSALL ESPQRGSESS 750
    ELEFLENTLD FPLSQGDTRG QNEGAGVRRH SGTSPQASPA LLTEEGSPTA 800
    PTDPILKPEE TKSFRDVRVP EDSICLELGP DPVTVGVEIP ATDAKTLDGG 850
    NRPPDVTCQS KEALSLTNRH PILVNDITAQ GSVESCLPES RQDLQNEPFS 900
    EDPLSVSSLE KHSEAAETLN QLNSKAAPED AALASALSSD STSQDSLLED 950
    SLSTPIPTSE QSVETPDSLD SVDVREALLE SLGSHTPRKL LPPDKPADSG 1000
    YETENLESPE WTLHPAPEGT ADSDAAAAGD SGHSSLPPNP VIVISDAGDG 1050
    HRGAEGPPQS FTLGPQSSYR DSAYFSDNDS EPDKKPEEVP GTSANALVLV 1100
    KGQSPPESVV PEESSDVREG CLEAPQDKPD QSRVSTLQNS CHSELQETLQ 1150
    PTPADASRES CPVNDEASSP LSLLNSEPSS CDDLDTQEDR PCTLASTGTN 1200
    TNELLAYMSS TLDKSLPSHL ESSKLKEPDI EGKYLGKLCV SGMLDLSEDG 1250
    MDADEEDENS DDSDEDLRAF NLHSLSSESE DDTEHPVPII VSNDDGRHLR 1300
    SLLKPSAAEA IEQLPEDWKK EKKAVTFFDD VTVYLFDQET PTKELGHCGG 1350
    EAHGPGPSSP AASSSSPYLG RCMNSESSTD EEGGGFEWDD DFSPDPFMSK 1400
    TTSLLGSKPS LQTSKYFSPP PPARSAEQSW PHVSPCSRFS ISPANIASFS 1450
    LTHLTDSDIE QGGSSEDGDK D 1471
    Length:1,471
    Mass (Da):160,508
    Last modified:July 27, 2011 - v3
    Checksum:i13C0C905F585D23F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti421 – 4211F → L in BAE34627. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB288872 mRNA. Translation: BAF64833.1.
    AK039738 mRNA. Translation: BAC30433.1.
    AK158724 mRNA. Translation: BAE34627.1.
    AK129279 mRNA. Translation: BAC98089.2.
    BC058653 mRNA. Translation: AAH58653.1.
    CCDSiCCDS39376.1.
    RefSeqiNP_001074578.1. NM_001081109.1.
    UniGeneiMm.288726.

    Genome annotation databases

    EnsembliENSMUST00000041804; ENSMUSP00000048238; ENSMUSG00000038970.
    GeneIDi231876.
    KEGGimmu:231876.
    UCSCiuc009alg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB288872 mRNA. Translation: BAF64833.1 .
    AK039738 mRNA. Translation: BAC30433.1 .
    AK158724 mRNA. Translation: BAE34627.1 .
    AK129279 mRNA. Translation: BAC98089.2 .
    BC058653 mRNA. Translation: AAH58653.1 .
    CCDSi CCDS39376.1.
    RefSeqi NP_001074578.1. NM_001081109.1.
    UniGenei Mm.288726.

    3D structure databases

    ProteinModelPortali Q3TYD6.
    SMRi Q3TYD6. Positions 128-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3TYD6. 1 interaction.

    PTM databases

    PhosphoSitei Q3TYD6.

    Proteomic databases

    PaxDbi Q3TYD6.
    PRIDEi Q3TYD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041804 ; ENSMUSP00000048238 ; ENSMUSG00000038970 .
    GeneIDi 231876.
    KEGGi mmu:231876.
    UCSCi uc009alg.1. mouse.

    Organism-specific databases

    CTDi 22853.
    MGIi MGI:3036247. Lmtk2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00640000091449.
    HOGENOMi HOG000252999.
    HOVERGENi HBG081920.
    InParanoidi A6BLY9.
    KOi K08898.
    OMAi NLESPEW.
    OrthoDBi EOG7HTHG4.
    TreeFami TF332280.

    Miscellaneous databases

    NextBioi 380841.
    PROi Q3TYD6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TYD6.
    CleanExi MM_LMTK2.
    Genevestigatori Q3TYD6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family."
      Tomomura M., Morita N., Yoshikawa F., Konishi A., Akiyama H., Furuichi T., Kamiguchi H.
      Neuroscience 148:510-521(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-632 AND 1263-1471.
      Strain: C57BL/6J.
      Tissue: Spinal cord and Visual cortex.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 410-1471.
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1253-1471.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling."
      Kawa S., Fujimoto J., Tezuka T., Nakazawa T., Yamamoto T.
      Genes Cells 9:219-232(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, PHOSPHORYLATION, CHARACTERIZATION, DEVELOPMENTAL STAGE.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781 AND THR-783, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLMTK2_MOUSE
    AccessioniPrimary (citable) accession number: Q3TYD6
    Secondary accession number(s): A6BLY9
    , Q6PDK6, Q6ZPY9, Q8CA34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3