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Protein

Arylsulfatase G

Gene

Arsg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441CalciumBy similarity
Metal bindingi45 – 451CalciumBy similarity
Metal bindingi84 – 841Calcium; via 3-oxoalanineBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Active sitei139 – 1391By similarity
Binding sitei162 – 1621SubstrateBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Metal bindingi302 – 3021CalciumBy similarity
Metal bindingi303 – 3031CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase G (EC:3.1.6.-)
Short name:
ASG
Gene namesi
Name:Arsg
Synonyms:Kiaa1001
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921258. Arsg.

Subcellular locationi

  • Lysosome

  • Note: Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 525509Arylsulfatase GPRO_0000238663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 8413-oxoalanine (Cys)By similarity
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3TYD4.
PaxDbiQ3TYD4.
PeptideAtlasiQ3TYD4.
PRIDEiQ3TYD4.

Expressioni

Gene expression databases

BgeeiQ3TYD4.
CleanExiMM_ARSG.
GenevisibleiQ3TYD4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020928.

Structurei

3D structure databases

ProteinModelPortaliQ3TYD4.
SMRiQ3TYD4. Positions 36-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOVERGENiHBG004283.
InParanoidiQ3TYD4.
KOiK12381.
OMAiCCNPYQI.
OrthoDBiEOG7QZG9J.
PhylomeDBiQ3TYD4.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TYD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWLFLKVLL VGMAFSGFFY PLVDFSISGK TRAPQPNIVI ILADDMGWGD
60 70 80 90 100
LGANWAETKD TTNLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN
110 120 130 140 150
GVTHNFAVTS VGGLPVNETT LAEVLRQEGY VTAMIGKWHL GHHGSYHPNF
160 170 180 190 200
RGFDYYFGIP YSNDMGCTDA PGYNYPPCPA CPQRDGLWRN PGRDCYTDVA
210 220 230 240 250
LPLYENLNIV EQPVNLSGLA QKYAERAVEF IEQASTSGRP FLLYVGLAHM
260 270 280 290 300
HVPLSVTPPL AHPQRQSLYR ASLREMDSLV GQIKDKVDHV ARENTLLWFT
310 320 330 340 350
GDNGPWAQKC ELAGSVGPFF GLWQTHQGGS PTKQTTWEGG HRVPALAYWP
360 370 380 390 400
GRVPANVTST ALLSLLDIFP TVIALAGASL PPNRKFDGRD VSEVLFGKSQ
410 420 430 440 450
MGHRVLFHPN SGAAGEYGAL QTVRLNHYKA FYITGGAKAC DGSVGPEQHH
460 470 480 490 500
VAPLIFNLED AADEGMPLQK GSPEYQEVLQ QVTRALADVL QDIADDNSSR
510 520
ADYTQDPSVI PCCNPYQTTC RCQPV
Length:525
Mass (Da):57,434
Last modified:October 11, 2005 - v1
Checksum:iFA319206459D1B2B
GO
Isoform 2 (identifier: Q3TYD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     324-327: QTHQ → MIKI

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):21,778
Checksum:i1C56A85519841355
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221A → V in AAH84731 (PubMed:15489334).Curated
Sequence conflicti247 – 2471L → Q in BAB31086 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 323323Missing in isoform 2. 1 PublicationVSP_018628Add
BLAST
Alternative sequencei324 – 3274QTHQ → MIKI in isoform 2. 1 PublicationVSP_018629

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018132 mRNA. Translation: BAB31086.1.
AK158726 mRNA. Translation: BAE34629.1.
AL645791 Genomic DNA. Translation: CAM25215.1.
AL645791 Genomic DNA. Translation: CAM25216.1.
BC022158 mRNA. Translation: AAH22158.1.
BC039629 mRNA. Translation: AAH39629.1.
BC084731 mRNA. Translation: AAH84731.1.
AK173082 mRNA. Translation: BAD32360.1.
BN000747 mRNA. Translation: CAI84993.1.
CCDSiCCDS25581.1. [Q3TYD4-1]
CCDS48971.1. [Q3TYD4-2]
RefSeqiNP_001159649.1. NM_001166177.1. [Q3TYD4-2]
NP_082986.3. NM_028710.3. [Q3TYD4-1]
XP_006534410.1. XM_006534347.2. [Q3TYD4-1]
XP_006534411.1. XM_006534348.2. [Q3TYD4-1]
XP_006534412.1. XM_006534349.2. [Q3TYD4-1]
XP_006534413.1. XM_006534350.2. [Q3TYD4-1]
UniGeneiMm.482224.

Genome annotation databases

EnsembliENSMUST00000020928; ENSMUSP00000020928; ENSMUSG00000020604. [Q3TYD4-1]
ENSMUST00000106696; ENSMUSP00000102307; ENSMUSG00000020604. [Q3TYD4-2]
ENSMUST00000106697; ENSMUSP00000102308; ENSMUSG00000020604. [Q3TYD4-1]
GeneIDi74008.
KEGGimmu:74008.
UCSCiuc007mcn.1. mouse. [Q3TYD4-1]
uc007mcp.2. mouse. [Q3TYD4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018132 mRNA. Translation: BAB31086.1.
AK158726 mRNA. Translation: BAE34629.1.
AL645791 Genomic DNA. Translation: CAM25215.1.
AL645791 Genomic DNA. Translation: CAM25216.1.
BC022158 mRNA. Translation: AAH22158.1.
BC039629 mRNA. Translation: AAH39629.1.
BC084731 mRNA. Translation: AAH84731.1.
AK173082 mRNA. Translation: BAD32360.1.
BN000747 mRNA. Translation: CAI84993.1.
CCDSiCCDS25581.1. [Q3TYD4-1]
CCDS48971.1. [Q3TYD4-2]
RefSeqiNP_001159649.1. NM_001166177.1. [Q3TYD4-2]
NP_082986.3. NM_028710.3. [Q3TYD4-1]
XP_006534410.1. XM_006534347.2. [Q3TYD4-1]
XP_006534411.1. XM_006534348.2. [Q3TYD4-1]
XP_006534412.1. XM_006534349.2. [Q3TYD4-1]
XP_006534413.1. XM_006534350.2. [Q3TYD4-1]
UniGeneiMm.482224.

3D structure databases

ProteinModelPortaliQ3TYD4.
SMRiQ3TYD4. Positions 36-515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020928.

Proteomic databases

MaxQBiQ3TYD4.
PaxDbiQ3TYD4.
PeptideAtlasiQ3TYD4.
PRIDEiQ3TYD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020928; ENSMUSP00000020928; ENSMUSG00000020604. [Q3TYD4-1]
ENSMUST00000106696; ENSMUSP00000102307; ENSMUSG00000020604. [Q3TYD4-2]
ENSMUST00000106697; ENSMUSP00000102308; ENSMUSG00000020604. [Q3TYD4-1]
GeneIDi74008.
KEGGimmu:74008.
UCSCiuc007mcn.1. mouse. [Q3TYD4-1]
uc007mcp.2. mouse. [Q3TYD4-2]

Organism-specific databases

CTDi22901.
MGIiMGI:1921258. Arsg.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOVERGENiHBG004283.
InParanoidiQ3TYD4.
KOiK12381.
OMAiCCNPYQI.
OrthoDBiEOG7QZG9J.
PhylomeDBiQ3TYD4.

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-1663150. The activation of arylsulfatases.

Miscellaneous databases

PROiQ3TYD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TYD4.
CleanExiMM_ARSG.
GenevisibleiQ3TYD4. MM.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Visual cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Kidney and Liver.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-525 (ISOFORM 1).
  5. "Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."
    Sardiello M., Annunziata I., Roma G., Ballabio A.
    Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiARSG_MOUSE
AccessioniPrimary (citable) accession number: Q3TYD4
Secondary accession number(s): B1AT67
, B1AT68, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.