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Protein

Arylsulfatase G

Gene

Arsg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44CalciumBy similarity1
Metal bindingi45CalciumBy similarity1
Metal bindingi84Calcium; via 3-oxoalanineBy similarity1
Binding sitei137SubstrateBy similarity1
Active sitei139By similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi302CalciumBy similarity1
Metal bindingi303CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase G (EC:3.1.6.-)
Short name:
ASG
Gene namesi
Name:Arsg
Synonyms:Kiaa1001
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921258. Arsg.

Subcellular locationi

  • Lysosome

  • Note: Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000023866317 – 525Arylsulfatase GAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei843-oxoalanine (Cys)By similarity1
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3TYD4.
PeptideAtlasiQ3TYD4.
PRIDEiQ3TYD4.

PTM databases

PhosphoSitePlusiQ3TYD4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020604.
CleanExiMM_ARSG.
GenevisibleiQ3TYD4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020928.

Structurei

3D structure databases

ProteinModelPortaliQ3TYD4.
SMRiQ3TYD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOVERGENiHBG004283.
InParanoidiQ3TYD4.
KOiK12381.
OMAiCCNPYQI.
OrthoDBiEOG091G041Y.
PhylomeDBiQ3TYD4.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TYD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWLFLKVLL VGMAFSGFFY PLVDFSISGK TRAPQPNIVI ILADDMGWGD
60 70 80 90 100
LGANWAETKD TTNLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN
110 120 130 140 150
GVTHNFAVTS VGGLPVNETT LAEVLRQEGY VTAMIGKWHL GHHGSYHPNF
160 170 180 190 200
RGFDYYFGIP YSNDMGCTDA PGYNYPPCPA CPQRDGLWRN PGRDCYTDVA
210 220 230 240 250
LPLYENLNIV EQPVNLSGLA QKYAERAVEF IEQASTSGRP FLLYVGLAHM
260 270 280 290 300
HVPLSVTPPL AHPQRQSLYR ASLREMDSLV GQIKDKVDHV ARENTLLWFT
310 320 330 340 350
GDNGPWAQKC ELAGSVGPFF GLWQTHQGGS PTKQTTWEGG HRVPALAYWP
360 370 380 390 400
GRVPANVTST ALLSLLDIFP TVIALAGASL PPNRKFDGRD VSEVLFGKSQ
410 420 430 440 450
MGHRVLFHPN SGAAGEYGAL QTVRLNHYKA FYITGGAKAC DGSVGPEQHH
460 470 480 490 500
VAPLIFNLED AADEGMPLQK GSPEYQEVLQ QVTRALADVL QDIADDNSSR
510 520
ADYTQDPSVI PCCNPYQTTC RCQPV
Length:525
Mass (Da):57,434
Last modified:October 11, 2005 - v1
Checksum:iFA319206459D1B2B
GO
Isoform 2 (identifier: Q3TYD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     324-327: QTHQ → MIKI

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):21,778
Checksum:i1C56A85519841355
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122A → V in AAH84731 (PubMed:15489334).Curated1
Sequence conflicti247L → Q in BAB31086 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186281 – 323Missing in isoform 2. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_018629324 – 327QTHQ → MIKI in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018132 mRNA. Translation: BAB31086.1.
AK158726 mRNA. Translation: BAE34629.1.
AL645791 Genomic DNA. Translation: CAM25215.1.
AL645791 Genomic DNA. Translation: CAM25216.1.
BC022158 mRNA. Translation: AAH22158.1.
BC039629 mRNA. Translation: AAH39629.1.
BC084731 mRNA. Translation: AAH84731.1.
AK173082 mRNA. Translation: BAD32360.1.
BN000747 mRNA. Translation: CAI84993.1.
CCDSiCCDS25581.1. [Q3TYD4-1]
CCDS48971.1. [Q3TYD4-2]
RefSeqiNP_001159649.1. NM_001166177.1. [Q3TYD4-2]
NP_082986.3. NM_028710.3. [Q3TYD4-1]
XP_006534411.1. XM_006534348.2. [Q3TYD4-1]
XP_006534412.1. XM_006534349.3. [Q3TYD4-1]
XP_006534413.1. XM_006534350.3. [Q3TYD4-1]
XP_017170289.1. XM_017314800.1. [Q3TYD4-1]
XP_017170290.1. XM_017314801.1. [Q3TYD4-1]
UniGeneiMm.482224.

Genome annotation databases

EnsembliENSMUST00000020928; ENSMUSP00000020928; ENSMUSG00000020604. [Q3TYD4-1]
ENSMUST00000106696; ENSMUSP00000102307; ENSMUSG00000020604. [Q3TYD4-2]
ENSMUST00000106697; ENSMUSP00000102308; ENSMUSG00000020604. [Q3TYD4-1]
GeneIDi74008.
KEGGimmu:74008.
UCSCiuc007mcn.1. mouse. [Q3TYD4-1]
uc007mcp.2. mouse. [Q3TYD4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018132 mRNA. Translation: BAB31086.1.
AK158726 mRNA. Translation: BAE34629.1.
AL645791 Genomic DNA. Translation: CAM25215.1.
AL645791 Genomic DNA. Translation: CAM25216.1.
BC022158 mRNA. Translation: AAH22158.1.
BC039629 mRNA. Translation: AAH39629.1.
BC084731 mRNA. Translation: AAH84731.1.
AK173082 mRNA. Translation: BAD32360.1.
BN000747 mRNA. Translation: CAI84993.1.
CCDSiCCDS25581.1. [Q3TYD4-1]
CCDS48971.1. [Q3TYD4-2]
RefSeqiNP_001159649.1. NM_001166177.1. [Q3TYD4-2]
NP_082986.3. NM_028710.3. [Q3TYD4-1]
XP_006534411.1. XM_006534348.2. [Q3TYD4-1]
XP_006534412.1. XM_006534349.3. [Q3TYD4-1]
XP_006534413.1. XM_006534350.3. [Q3TYD4-1]
XP_017170289.1. XM_017314800.1. [Q3TYD4-1]
XP_017170290.1. XM_017314801.1. [Q3TYD4-1]
UniGeneiMm.482224.

3D structure databases

ProteinModelPortaliQ3TYD4.
SMRiQ3TYD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020928.

PTM databases

PhosphoSitePlusiQ3TYD4.

Proteomic databases

PaxDbiQ3TYD4.
PeptideAtlasiQ3TYD4.
PRIDEiQ3TYD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020928; ENSMUSP00000020928; ENSMUSG00000020604. [Q3TYD4-1]
ENSMUST00000106696; ENSMUSP00000102307; ENSMUSG00000020604. [Q3TYD4-2]
ENSMUST00000106697; ENSMUSP00000102308; ENSMUSG00000020604. [Q3TYD4-1]
GeneIDi74008.
KEGGimmu:74008.
UCSCiuc007mcn.1. mouse. [Q3TYD4-1]
uc007mcp.2. mouse. [Q3TYD4-2]

Organism-specific databases

CTDi22901.
MGIiMGI:1921258. Arsg.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOVERGENiHBG004283.
InParanoidiQ3TYD4.
KOiK12381.
OMAiCCNPYQI.
OrthoDBiEOG091G041Y.
PhylomeDBiQ3TYD4.

Enzyme and pathway databases

ReactomeiR-MMU-1660662. Glycosphingolipid metabolism.
R-MMU-1663150. The activation of arylsulfatases.

Miscellaneous databases

PROiQ3TYD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020604.
CleanExiMM_ARSG.
GenevisibleiQ3TYD4. MM.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSG_MOUSE
AccessioniPrimary (citable) accession number: Q3TYD4
Secondary accession number(s): B1AT67
, B1AT68, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.