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Unreviewed, UniProtKB/TrEMBL Q3TYB0 (Q3TYB0_MOUSE)

Last modified February 9, 2010. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAE34653.1
Submitted name:
    Lymphoid enhancer binding factor 1, isoform CRA_a EMBL EDL12204.1
Gene names
Name: Lef1 MGI 96770
ORF Names: mCG_10208 EMBL EDL12204.1
OrganismMus musculus (Mouse) EMBL BAE34653.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

Ontologies

Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Inferred from mutant phenotype. Source: MGI

cell development

Inferred from genetic interaction. Source: MGI

chorio-allantoic fusion

Inferred from genetic interaction. Source: MGI

dentate gyrus development

Inferred from mutant phenotype. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction. Source: MGI

kidney development

Inferred from electronic annotation. Source: Compara

mammary gland development

Inferred from mutant phenotype. Source: MGI

negative regulation of striated muscle tissue development

Inferred from direct assay. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

odontogenesis of dentine-containing tooth

Inferred from mutant phenotype. Source: MGI

paraxial mesoderm formation

Inferred from genetic interaction. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

regulation of Wnt receptor signaling pathway

Inferred from genetic interaction. Source: MGI

response to lithium ion

Inferred from electronic annotation. Source: Compara

response to organic cyclic substance

Inferred from electronic annotation. Source: Compara

skin development

Inferred from electronic annotation. Source: Compara

somitogenesis

Inferred from genetic interaction. Source: MGI

   Cellular componentcytoplasm

Inferred from direct assay. Source: MGI

transcription factor complex

Inferred from physical interaction. Source: MGI

   Molecular functionRNA polymerase II transcription factor activity, enhancer binding

Inferred from genetic interaction. Source: MGI

chromatin binding

Inferred from direct assay. Source: MGI

protein binding

Inferred from electronic annotation. Source: Compara

sequence-specific DNA binding

Inferred from electronic annotation. Source: Compara

transcription activator activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3TYB0-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 0CA01B6C528FD7FA

FASTA39744,059
        10         20         30         40         50         60 
MPQLSGGGGG GDPELCATDE MIPFKDEGDP QKEKIFAEIS HPEEEGDLAD IKSSLVNESE 

        70         80         90        100        110        120 
IIPASNGHEV VRQAPSSQEP YHDKAREHPD EGKHPDGGLY NKGPSYSSYS GYIMMPNMNS 

       130        140        150        160        170        180 
DPYMSNGSLS PPIPRTSNKV PVVQPSHAVH PLTPLITYSD EHFSPGSHPS HIPSDVNSKQ 

       190        200        210        220        230        240 
GMSRHPPAPE IPTFYPLSPG GVGQITPPIG WQGQPVYPIT GGFRQPYPSS LSGDTSMSRF 

       250        260        270        280        290        300 
SHHMIPGPPG PHTTGIPHPA IVTPQVKQEH PHTDSDLMHV KPQHEQRKEQ EPKRPHIKKP 

       310        320        330        340        350        360 
LNAFMLYMKE MRANVVAECT LKESAAINQI LGRRWHALSR EEQAKYYELA RKERQLHMQL 

       370        380        390 
YPGWSARDNY GKKKKRKREK LQESTSGTGP RMTAAYI 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE34653.1.
Tissue: Visual cortex EMBL BAE34653.1.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL12204.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL12204.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK158769 mRNA. Translation: BAE34653.1.
CH466532 Genomic DNA. Translation: EDL12204.1.
IPIIPI00119934.
RefSeqNP_034833.2.
UniGeneMm.255219

3D structure databases

SMRQ3TYB0. Positions 2-59, 296-371.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3TYB0.

Proteomic databases

PRIDEQ3TYB0.

Genome annotation databases

EnsemblENSMUST00000029611; ENSMUSP00000029611; ENSMUSG00000027985; Mus musculus. [Genome view]
GeneID16842.
KEGGmmu:16842.

Organism-specific databases

CTD16842.
MGIMGI:96770. Lef1.

Phylogenomic databases

HOVERGENQ3TYB0.
InParanoidQ3TYB0.
OMAGYSGYIM.
PhylomeDBQ3TYB0.

Gene expression databases

ArrayExpressQ3TYB0.
BgeeQ3TYB0.
GenevestigatorQ3TYB0.

Family and domain databases

InterProIPR013558. CTNNB1_bd_N.
IPR000910. HMG_HMG1/HMG2.
IPR009071. HMG_superfamily.
[Graphical view]
Gene3DG3DSA:1.10.30.10. HMG-box. 1 hit.
PfamPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio290768.
SOURCESearch...

Entry information

Entry nameQ3TYB0_MOUSE
AccessionPrimary (citable) accession number: Q3TYB0
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information