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Protein

Apoptosis-inducing factor 3

Gene

Aifm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi111Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi128Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi131Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1
Binding sitei235FADSequence analysis1
Binding sitei240FADSequence analysis1
Binding sitei270FAD; via amide nitrogen and carbonyl oxygenSequence analysis1
Binding sitei467FADSequence analysis1
Binding sitei514FAD; via carbonyl oxygenSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 205FADSequence analysis5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Electron transport, Transport
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-inducing factor 3 (EC:1.-.-.-)
Alternative name(s):
Apoptosis-inducing factor-like protein
Gene namesi
Name:Aifm3
Synonyms:Aifl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1919418 Aifm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002556611 – 605Apoptosis-inducing factor 3Add BLAST605

Proteomic databases

PaxDbiQ3TY86
PeptideAtlasiQ3TY86
PRIDEiQ3TY86

PTM databases

iPTMnetiQ3TY86
PhosphoSitePlusiQ3TY86

Expressioni

Gene expression databases

BgeeiENSMUSG00000022763
GenevisibleiQ3TY86 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023448

Structurei

3D structure databases

ProteinModelPortaliQ3TY86
SMRiQ3TY86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 165RieskePROSITE-ProRule annotationAdd BLAST96

Domaini

The Rieske domain induces apoptosis.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1336 Eukaryota
COG0446 LUCA
COG2146 LUCA
GeneTreeiENSGT00530000063416
HOGENOMiHOG000276711
HOVERGENiHBG052926
InParanoidiQ3TY86
OMAiGAQLRYC
OrthoDBiEOG091G07EG
PhylomeDBiQ3TY86
TreeFamiTF314028

Family and domain databases

Gene3Di2.102.10.10, 1 hit
3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR028202 Reductase_C
IPR017941 Rieske_2Fe-2S
IPR036922 Rieske_2Fe-2S_sf
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF14759 Reductase_C, 1 hit
PF00355 Rieske, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF50022 SSF50022, 1 hit
SSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
PROSITEiView protein in PROSITE
PS51296 RIESKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TY86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGCFSKPKP VELKIEVVLP EKERGKEELS ASGKGSPRGY QGNGTARHFH
60 70 80 90 100
AEERLPTPQP YPSPQDCVEA TVCHVKDLEN GQMREVELGW GKVLLVKDNG
110 120 130 140 150
EFHALGHKCP HYGAPLVKGV LSRGRVRCPW HGACFNISTG DLEDFPGLDS
160 170 180 190 200
LHKFQVKIEK EKVTIRASKQ ALQLQRRTKV MAKCISPSAG HSSSTNVLIV
210 220 230 240 250
GAGAAGLVCA ETLRQEGFSD RIVLCTLDRH LPYDRAKLSK SLDAQPEQLA
260 270 280 290 300
LRPKEFFRAY GIEMLTEAQV VTVDVRNKKV VFKDGFKLEY SKLLLAPGSS
310 320 330 340 350
PKTLTCKGKD VENVFTIRTP EDANRVLRLA RGRNAVVVGA GFLGMEVAAY
360 370 380 390 400
LTEKAHSVSV VELEETPFRR FLGERVGRAL MKMFENNRVK FYMQTEVSEL
410 420 430 440 450
RAQEGKLQEV VLKSSKVLRA DVCVLGIGAV PATGFLRQSG IGLDSRGFIP
460 470 480 490 500
VNKMMQTNVP GVFAAGDAVT FPLAWRNNRK VNIPHWQMAH AQGRVAAQNM
510 520 530 540 550
LAQEAEINTV PYLWTAMFGK SLRYAGYGEG FDDVIIQGDL EELKFVAFYT
560 570 580 590 600
KSDEVIAVAS MNYDPIVSKV AEVLASGRAI RKREVELFML HSKTGDMSWL

TGKGS
Length:605
Mass (Da):66,792
Last modified:October 11, 2005 - v1
Checksum:iD4811CB2B2CD0739
GO
Isoform 2 (identifier: Q3TY86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-593: Missing.

Note: No experimental confirmation available.
Show »
Length:598
Mass (Da):65,935
Checksum:iAF9A044EC3E59579
GO
Isoform 3 (identifier: Q3TY86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     494-500: RVAAQNM → MASPEAS
     501-605: Missing.

Note: May be due to intron retention.
Show »
Length:500
Mass (Da):55,040
Checksum:i2A456EA3D4E8B4EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138S → T in BAC33988 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021304494 – 500RVAAQNM → MASPEAS in isoform 3. 2 Publications7
Alternative sequenceiVSP_021305501 – 605Missing in isoform 3. 2 PublicationsAdd BLAST105
Alternative sequenceiVSP_021306587 – 593Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049928 mRNA Translation: BAC33988.1
AK158809 mRNA Translation: BAE34677.1
BC096476 mRNA Translation: AAH96476.1
BC120685 mRNA Translation: AAI20686.1
CCDSiCCDS28003.1 [Q3TY86-2]
CCDS79430.1 [Q3TY86-1]
RefSeqiNP_001277999.1, NM_001291070.1 [Q3TY86-1]
NP_780387.2, NM_175178.4 [Q3TY86-2]
XP_006522655.1, XM_006522592.3 [Q3TY86-1]
UniGeneiMm.40038

Genome annotation databases

EnsembliENSMUST00000023448; ENSMUSP00000023448; ENSMUSG00000022763 [Q3TY86-2]
ENSMUST00000115685; ENSMUSP00000111349; ENSMUSG00000022763 [Q3TY86-1]
GeneIDi72168
KEGGimmu:72168
UCSCiuc007ykw.2 mouse [Q3TY86-1]
uc007ykx.2 mouse [Q3TY86-3]
uc007yky.2 mouse [Q3TY86-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAIFM3_MOUSE
AccessioniPrimary (citable) accession number: Q3TY86
Secondary accession number(s): Q0VBD6, Q4VAA4, Q8BWV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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