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Q3TXX4

- VGLU1_MOUSE

UniProt

Q3TXX4 - VGLU1_MOUSE

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Protein
Vesicular glutamate transporter 1
Gene
Slc17a7, Bnpi, Vglut1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.3 Publications

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: Ensembl
  2. sodium-dependent phosphate transmembrane transporter activity Source: Ensembl
  3. sodium:inorganic phosphate symporter activity Source: Ensembl

GO - Biological processi

  1. L-glutamate import Source: MGI
  2. long-term memory Source: MGI
  3. neurotransmitter transport Source: UniProtKB-KW
  4. regulation of excitatory postsynaptic membrane potential Source: MGI
  5. sequestering of neurotransmitter Source: MGI
  6. synaptic transmission Source: MGI
  7. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Neurotransmitter transport, Sensory transduction, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 1
Short name:
VGluT1
Alternative name(s):
Brain-specific Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 7
Gene namesi
Name:Slc17a7
Synonyms:Bnpi, Vglut1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1920211. Slc17a7.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane. Membrane; Multi-pass membrane protein Reviewed prediction. Cell junctionsynapsesynaptosome 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Topological domaini85 – 11632Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 1403Cytoplasmic Reviewed prediction
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Topological domaini162 – 1698Extracellular Reviewed prediction
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 20818Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 2367Extracellular Reviewed prediction
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Topological domaini258 – 30245Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Reviewed prediction
Add
BLAST
Topological domaini324 – 34118Extracellular Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 37816Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Topological domaini400 – 4012Extracellular Reviewed prediction
Transmembranei402 – 42221Helical; Reviewed prediction
Add
BLAST
Topological domaini423 – 43513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei436 – 45621Helical; Reviewed prediction
Add
BLAST
Topological domaini457 – 46913Extracellular Reviewed prediction
Add
BLAST
Transmembranei470 – 49021Helical; Reviewed prediction
Add
BLAST
Topological domaini491 – 56070Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cerebellar mossy fiber Source: MGI
  3. excitatory synapse Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. presynaptic active zone Source: BHF-UCL
  6. synapse Source: MGI
  7. synaptic vesicle Source: MGI
  8. synaptic vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Disruption phenotypei

Mice begin to die 3 weeks after birth. They exhibit a progressive neurological phenotype including blindness, loss of coordination and enhanced startle response. Glutamatergic neurotransmission is drastically reduced due to a decrease in the reserve pool of synaptic vesicles and reduced quantal size. Visual signaling from photoreceptors to retinal output neurons is impaired while photoentrainment and pupillary light responses remain intact.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Vesicular glutamate transporter 1
PRO_0000331612Add
BLAST

Proteomic databases

MaxQBiQ3TXX4.
PaxDbiQ3TXX4.
PRIDEiQ3TXX4.

PTM databases

PhosphoSiteiQ3TXX4.

Expressioni

Tissue specificityi

Expressed in hippocampus (at protein level). Expressed in the molecular layer of the cerebellum and in retina.3 Publications

Developmental stagei

Expression in brain increases progressively from four days to adulthood.2 Publications

Inductioni

Oscillates diurnally in synaptic vesicles (at protein level).

Gene expression databases

BgeeiQ3TXX4.
GenevestigatoriQ3TXX4.

Interactioni

Subunit structurei

Interacts with SHANK3.1 Publication

Protein-protein interaction databases

IntActiQ3TXX4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3TXX4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi530 – 55627Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00630000089608.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ3TXX4.
KOiK12302.
OMAiMHGHVVI.
OrthoDBiEOG789C9Z.
TreeFamiTF313535.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TXX4-1 [UniParc]FASTAAdd to Basket

« Hide

MEFRQEEFRK LAGRALGRLH RLLEKRQEGA ETLELSADGR PVTTHTRDPP    50
VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG 100
HVVVQKAQFN WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA 150
IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP 200
LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL 250
FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPVTK FNTPWRRFFT 300
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV 350
MTIIVPIGGQ IADFLRSRHI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS 400
KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM 450
VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP 500
EEMSEEKCGF VGHDQLAGSD ESEMEDEAEP PGAPPAPPPS YGATHSTVQP 550
PRPPPPVRDY 560
Length:560
Mass (Da):61,637
Last modified:July 27, 2011 - v2
Checksum:iE866668F606B8305
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti500 – 5001P → Q in BAE34790. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK159064 mRNA. Translation: BAE34790.1.
AC149868 Genomic DNA. No translation available.
CCDSiCCDS52244.1.
RefSeqiNP_892038.2. NM_182993.2.
UniGeneiMm.255631.

Genome annotation databases

EnsembliENSMUST00000085374; ENSMUSP00000082489; ENSMUSG00000070570.
GeneIDi72961.
KEGGimmu:72961.
UCSCiuc009gtx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK159064 mRNA. Translation: BAE34790.1 .
AC149868 Genomic DNA. No translation available.
CCDSi CCDS52244.1.
RefSeqi NP_892038.2. NM_182993.2.
UniGenei Mm.255631.

3D structure databases

ProteinModelPortali Q3TXX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3TXX4. 1 interaction.

PTM databases

PhosphoSitei Q3TXX4.

Proteomic databases

MaxQBi Q3TXX4.
PaxDbi Q3TXX4.
PRIDEi Q3TXX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085374 ; ENSMUSP00000082489 ; ENSMUSG00000070570 .
GeneIDi 72961.
KEGGi mmu:72961.
UCSCi uc009gtx.2. mouse.

Organism-specific databases

CTDi 57030.
MGIi MGI:1920211. Slc17a7.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00630000089608.
HOGENOMi HOG000230812.
HOVERGENi HBG008834.
InParanoidi Q3TXX4.
KOi K12302.
OMAi MHGHVVI.
OrthoDBi EOG789C9Z.
TreeFami TF313535.

Miscellaneous databases

ChiTaRSi SLC17A7. mouse.
NextBioi 337233.
PROi Q3TXX4.
SOURCEi Search...

Gene expression databases

Bgeei Q3TXX4.
Genevestigatori Q3TXX4.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Visual cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons."
    Schaefer M.K.-H., Varoqui H., Defamie N., Weihe E., Erickson J.D.
    J. Biol. Chem. 277:50734-50748(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. "An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size."
    Wojcik S.M., Rhee J.S., Herzog E., Sigler A., Jahn R., Takamori S., Brose N., Rosenmund C.
    Proc. Natl. Acad. Sci. U.S.A. 101:7158-7163(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  5. "Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites."
    Fremeau R.T. Jr., Kam K., Qureshi T., Johnson J., Copenhagen D.R., Storm-Mathisen J., Chaudhry F.A., Nicoll R.A., Edwards R.H.
    Science 304:1815-1819(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  6. "Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus."
    Herzog E., Takamori S., Jahn R., Brose N., Wojcik S.M.
    J. Neurochem. 99:1011-1018(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2."
    Yelamanchili S.V., Pendyala G., Brunk I., Darna M., Albrecht U., Ahnert-Hilger G.
    J. Biol. Chem. 281:15671-15679(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions."
    Johnson J., Fremeau R.T. Jr., Duncan J.L., Renteria R.C., Yang H., Hua Z., Liu X., LaVail M.M., Edwards R.H., Copenhagen D.R.
    J. Neurosci. 27:7245-7255(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties."
    Han K., Holder J.L. Jr., Schaaf C.P., Lu H., Chen H., Kang H., Tang J., Wu Z., Hao S., Cheung S.W., Yu P., Sun H., Breman A.M., Patel A., Lu H.C., Zoghbi H.Y.
    Nature 503:72-77(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHANK3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiVGLU1_MOUSE
AccessioniPrimary (citable) accession number: Q3TXX4
Secondary accession number(s): E9QMT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi