Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RuvB-like helicase

Gene

Ruvbl2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotationSAAS annotation, Hydrolase
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicaseUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:Ruvbl2Imported
ORF Names:mCG_23165Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1342299. Ruvbl2.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ3TXT7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003868.
ExpressionAtlasiQ3TXT7. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ3TXT7. 1 interactor.
MINTiMINT-8174138.
STRINGi10090.ENSMUSP00000033087.

Structurei

3D structure databases

SMRiQ3TXT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 361AAAInterPro annotationAdd BLAST293

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2680. Eukaryota.
COG1224. LUCA.
HOVERGENiHBG054186.
KOiK11338.
OMAiYDAMGAQ.
OrthoDBiEOG091G07C9.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiView protein in Pfam
PF06068. TIP49. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TXT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVAATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL
60 70 80 90 100
AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF
110 120 130 140 150
TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP
160 170 180 190 200
ATGTGSKVGK LTLKTTEMET IYDLGTKMIE SLTKDKVQAG DVITIDKATG
210 220 230 240 250
KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH TVSLHEIDVI
260 270 280 290 300
NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE
310 320 330 340 350
VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL
360 370 380 390 400
LDRLLIVSTS PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR
410 420 430 440 450
YAIQLITAAS LVCRKRKGTE VQVDDIKRVY SLFLDESRST QYMKEYQDAF
460
LFNELKGETM DTS
Length:463
Mass (Da):51,113
Last modified:October 11, 2005 - v1
Checksum:i419D779972933308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115809 mRNA. Translation: AAI15810.1.
BC116693 mRNA. Translation: AAI16694.1.
AK144156 mRNA. Translation: BAE25736.1.
AK159112 mRNA. Translation: BAE34828.1.
CH466603 Genomic DNA. Translation: EDL22854.1.
RefSeqiNP_035434.1. NM_011304.3.
XP_006540785.1. XM_006540722.1.
XP_006540786.1. XM_006540723.3.
UniGeneiMm.34410.

Genome annotation databases

GeneIDi20174.
KEGGimmu:20174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115809 mRNA. Translation: AAI15810.1.
BC116693 mRNA. Translation: AAI16694.1.
AK144156 mRNA. Translation: BAE25736.1.
AK159112 mRNA. Translation: BAE34828.1.
CH466603 Genomic DNA. Translation: EDL22854.1.
RefSeqiNP_035434.1. NM_011304.3.
XP_006540785.1. XM_006540722.1.
XP_006540786.1. XM_006540723.3.
UniGeneiMm.34410.

3D structure databases

SMRiQ3TXT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TXT7. 1 interactor.
MINTiMINT-8174138.
STRINGi10090.ENSMUSP00000033087.

Proteomic databases

PeptideAtlasiQ3TXT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20174.
KEGGimmu:20174.

Organism-specific databases

CTDi10856.
MGIiMGI:1342299. Ruvbl2.

Phylogenomic databases

eggNOGiKOG2680. Eukaryota.
COG1224. LUCA.
HOVERGENiHBG054186.
KOiK11338.
OMAiYDAMGAQ.
OrthoDBiEOG091G07C9.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003868.
ExpressionAtlasiQ3TXT7. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiView protein in Pfam
PF06068. TIP49. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TXT7_MOUSE
AccessioniPrimary (citable) accession number: Q3TXT7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 15, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.