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Protein

26S proteasome non-ATPase regulatory subunit 1

Gene

Psmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-382556. ABC-family proteins mediated transport.
R-MMU-446652. Interleukin-1 signaling.
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-MMU-8941858. Regulation of RUNX3 expression and activity.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 1
Alternative name(s):
26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1
Gene namesi
Name:Psmd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917497. Psmd1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • membrane Source: MGI
  • proteasome accessory complex Source: UniProtKB
  • proteasome complex Source: MGI

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315981 – 95326S proteasome non-ATPase regulatory subunit 1Add BLAST953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei273PhosphothreonineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei310N6-acetyllysineCombined sources1
Modified residuei311PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei720N6-acetyllysineCombined sources1
Modified residuei830PhosphothreonineBy similarity1
Modified residuei834PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TXS7.
MaxQBiQ3TXS7.
PaxDbiQ3TXS7.
PeptideAtlasiQ3TXS7.
PRIDEiQ3TXS7.

PTM databases

iPTMnetiQ3TXS7.
PhosphoSitePlusiQ3TXS7.
SwissPalmiQ3TXS7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026229.
ExpressionAtlasiQ3TXS7. baseline and differential.
GenevisibleiQ3TXS7. MM.

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1. Interacts with ADRM1.By similarity

Protein-protein interaction databases

BioGridi213938. 6 interactors.
IntActiQ3TXS7. 6 interactors.
MINTiMINT-4433282.
STRINGi10090.ENSMUSP00000027432.

Structurei

3D structure databases

ProteinModelPortaliQ3TXS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati403 – 436PC 1Add BLAST34
Repeati441 – 474PC 2Add BLAST34
Repeati476 – 510PC 3Add BLAST35
Repeati511 – 545PC 4Add BLAST35
Repeati547 – 580PC 5Add BLAST34
Repeati581 – 616PC 6Add BLAST36
Repeati617 – 649PC 7Add BLAST33
Repeati651 – 685PC 8Add BLAST35
Repeati686 – 726PC 9Add BLAST41
Repeati729 – 761PC 10Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi936 – 943Poly-Glu8

Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2062. Eukaryota.
COG5116. LUCA.
GeneTreeiENSGT00550000074915.
HOGENOMiHOG000189403.
HOVERGENiHBG007543.
InParanoidiQ3TXS7.
KOiK03032.
OMAiRNCTIGL.
OrthoDBiEOG091G01IW.
PhylomeDBiQ3TXS7.
TreeFamiTF105742.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
PfamiView protein in Pfam
PF01851. PC_rep. 3 hits.
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q3TXS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITSAAGIIS LLDEEEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE
60 70 80 90 100
DEGFRSRQFA ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI
110 120 130 140 150
IAKCIDHYTK QCVENADLPE GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA
160 170 180 190 200
IGIALETRRL DVFEKTILES NDVPGMLAYS LKLCMSLMQN KQFRNKVLRV
210 220 230 240 250
LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED NLLMAYQICF
260 270 280 290 300
DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDPMETE
310 320 330 340 350
EKTASAVAGK TPDASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL
360 370 380 390 400
MILKNTKDAV RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA
410 420 430 440 450
KFTATASLGV IHKGHEKEAL QLMATYLPKD TSPGSAYQEG GGLYALGLIH
460 470 480 490 500
ANHGGDIIDY LLNQLKNASN DIVRHGGSLG LGLAAMGTAR QDVYDLLKTN
510 520 530 540 550
LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ HEKILRGLAV
560 570 580 590 600
GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR
610 620 630 640 650
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY
660 670 680 690 700
GAAMALGICC AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE
710 720 730 740 750
ITCPKVNQFR QLYSKVINDK HDDVMAKFGA ILAQGILDAG GHNVTISLQS
760 770 780 790 800
RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS LAYTPTCVIG LNKDLKMPKV
810 820 830 840 850
QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK KKEKEKEKKE
860 870 880 890 900
EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLSMTETCRY
910 920 930 940 950
QPFKPLSIGG IIILKDTSED VEELVEPVAA HGPKIEEEEQ EPEPPEPFEY

IDD
Length:953
Mass (Da):105,730
Last modified:October 11, 2005 - v1
Checksum:i40A72A08CFC778E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153386 mRNA. Translation: BAE31950.1.
AK159123 mRNA. Translation: BAE34838.1.
BC138526 mRNA. Translation: AAI38527.1.
BC138527 mRNA. Translation: AAI38528.1.
CCDSiCCDS15117.1.
RefSeqiNP_081633.1. NM_027357.2.
UniGeneiMm.280013.

Genome annotation databases

EnsembliENSMUST00000027432; ENSMUSP00000027432; ENSMUSG00000026229.
GeneIDi70247.
KEGGimmu:70247.
UCSCiuc007buy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153386 mRNA. Translation: BAE31950.1.
AK159123 mRNA. Translation: BAE34838.1.
BC138526 mRNA. Translation: AAI38527.1.
BC138527 mRNA. Translation: AAI38528.1.
CCDSiCCDS15117.1.
RefSeqiNP_081633.1. NM_027357.2.
UniGeneiMm.280013.

3D structure databases

ProteinModelPortaliQ3TXS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213938. 6 interactors.
IntActiQ3TXS7. 6 interactors.
MINTiMINT-4433282.
STRINGi10090.ENSMUSP00000027432.

PTM databases

iPTMnetiQ3TXS7.
PhosphoSitePlusiQ3TXS7.
SwissPalmiQ3TXS7.

Proteomic databases

EPDiQ3TXS7.
MaxQBiQ3TXS7.
PaxDbiQ3TXS7.
PeptideAtlasiQ3TXS7.
PRIDEiQ3TXS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027432; ENSMUSP00000027432; ENSMUSG00000026229.
GeneIDi70247.
KEGGimmu:70247.
UCSCiuc007buy.1. mouse.

Organism-specific databases

CTDi5707.
MGIiMGI:1917497. Psmd1.

Phylogenomic databases

eggNOGiKOG2062. Eukaryota.
COG5116. LUCA.
GeneTreeiENSGT00550000074915.
HOGENOMiHOG000189403.
HOVERGENiHBG007543.
InParanoidiQ3TXS7.
KOiK03032.
OMAiRNCTIGL.
OrthoDBiEOG091G01IW.
PhylomeDBiQ3TXS7.
TreeFamiTF105742.

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-382556. ABC-family proteins mediated transport.
R-MMU-446652. Interleukin-1 signaling.
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-MMU-8941858. Regulation of RUNX3 expression and activity.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiPR:Q3TXS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026229.
ExpressionAtlasiQ3TXS7. baseline and differential.
GenevisibleiQ3TXS7. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
PfamiView protein in Pfam
PF01851. PC_rep. 3 hits.
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPSMD1_MOUSE
AccessioniPrimary (citable) accession number: Q3TXS7
Secondary accession number(s): B2RRP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: June 7, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.