Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/arginine-rich splicing factor 6

Gene

Srsf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.
R-MMU-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 6
Alternative name(s):
Pre-mRNA-splicing factor SRP55
Splicing factor, arginine/serine-rich 6
Gene namesi
Name:Srsf6
Synonyms:Sfrs6, Srp55
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915246. Srsf6.

Subcellular locationi

  • Nucleus 1 Publication
  • Nucleus speckle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Serine/arginine-rich splicing factor 6PRO_0000426095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei165 – 1651N6-acetyllysineCombined sources
Modified residuei299 – 2991PhosphoserineBy similarity
Modified residuei303 – 3031Phosphoserine; by DYRK1ABy similarity
Modified residuei314 – 3141PhosphoserineCombined sources
Modified residuei316 – 3161PhosphoserineBy similarity

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TWW8.
MaxQBiQ3TWW8.
PaxDbiQ3TWW8.
PRIDEiQ3TWW8.

PTM databases

iPTMnetiQ3TWW8.

Expressioni

Gene expression databases

ExpressionAtlasiQ3TWW8. baseline and differential.
GenevisibleiQ3TWW8. MM.

Interactioni

Subunit structurei

Binds SREK1/SFRS12. Interacts with DYRK1A (By similarity).By similarity

Protein-protein interaction databases

BioGridi212588. 1 interaction.
IntActiQ3TWW8. 1 interaction.
MINTiMINT-1868150.
STRINGi10090.ENSMUSP00000119065.

Structurei

3D structure databases

ProteinModelPortaliQ3TWW8.
SMRiQ3TWW8. Positions 3-83, 99-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7271RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini110 – 18374RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi87 – 904Gly-rich (hinge region)
Compositional biasi184 – 338155Arg/Ser-rich (RS domain)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00700000104103.
HOGENOMiHOG000276234.
HOVERGENiHBG002295.
InParanoidiQ3TWW8.
KOiK12893.
OMAiRDGYSYS.
OrthoDBiEOG7H1JPR.
PhylomeDBiQ3TWW8.
TreeFamiTF351335.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TWW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVYIGRLS YNVREKDIQR FFSGYGRLLE IDLKNGYGFV EFEDSRDADD
60 70 80 90 100
AVYELNSKEL CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD
110 120 130 140 150
KYGPPVRTEY RLIVENLSSR CSWQDLKDFM RQAGEVTYAD AHKERTNEGV
160 170 180 190 200
IEFRSYSDMK RALDKLDGTE INGRNIRLIE DKPRTSHRRS YSGSRSRSRS
210 220 230 240 250
RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG RKSRSKSKSK
260 270 280 290 300
PKSDRGSHSH SRSRSKDKYG KSRSRSRSRS PKENGKGDIK SKSRSRSQSR
310 320 330
SHSPLPAPPS KARSMSPPPK RASRSRSRSR SRSRSSSRD
Length:339
Mass (Da):39,025
Last modified:October 11, 2005 - v1
Checksum:iAE8B6650D7294A0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011R → K in BAB23599 (PubMed:16141072).Curated
Sequence conflicti230 – 2301S → G in BAE27050 (PubMed:16141072).Curated
Sequence conflicti299 – 2991S → P in BAE27050 (PubMed:16141072).Curated
Sequence conflicti319 – 3191P → T in AAH12039 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004831 mRNA. Translation: BAB23599.1.
AK133872 mRNA. Translation: BAE21902.1.
AK146293 mRNA. Translation: BAE27050.1.
AK159519 mRNA. Translation: BAE35148.1.
AL590418 Genomic DNA. No translation available.
AL606473 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06308.1.
BC012039 mRNA. Translation: AAH12039.1.
CCDSiCCDS17002.1.
RefSeqiNP_080775.3. NM_026499.4.
UniGeneiMm.24042.

Genome annotation databases

EnsembliENSMUST00000130411; ENSMUSP00000119065; ENSMUSG00000016921.
GeneIDi67996.
KEGGimmu:67996.
UCSCiuc008nsc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004831 mRNA. Translation: BAB23599.1.
AK133872 mRNA. Translation: BAE21902.1.
AK146293 mRNA. Translation: BAE27050.1.
AK159519 mRNA. Translation: BAE35148.1.
AL590418 Genomic DNA. No translation available.
AL606473 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06308.1.
BC012039 mRNA. Translation: AAH12039.1.
CCDSiCCDS17002.1.
RefSeqiNP_080775.3. NM_026499.4.
UniGeneiMm.24042.

3D structure databases

ProteinModelPortaliQ3TWW8.
SMRiQ3TWW8. Positions 3-83, 99-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212588. 1 interaction.
IntActiQ3TWW8. 1 interaction.
MINTiMINT-1868150.
STRINGi10090.ENSMUSP00000119065.

PTM databases

iPTMnetiQ3TWW8.

Proteomic databases

EPDiQ3TWW8.
MaxQBiQ3TWW8.
PaxDbiQ3TWW8.
PRIDEiQ3TWW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130411; ENSMUSP00000119065; ENSMUSG00000016921.
GeneIDi67996.
KEGGimmu:67996.
UCSCiuc008nsc.2. mouse.

Organism-specific databases

CTDi6431.
MGIiMGI:1915246. Srsf6.

Phylogenomic databases

eggNOGiKOG0106. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00700000104103.
HOGENOMiHOG000276234.
HOVERGENiHBG002295.
InParanoidiQ3TWW8.
KOiK12893.
OMAiRDGYSYS.
OrthoDBiEOG7H1JPR.
PhylomeDBiQ3TWW8.
TreeFamiTF351335.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.
R-MMU-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiSrsf6. mouse.
PROiQ3TWW8.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ3TWW8. baseline and differential.
GenevisibleiQ3TWW8. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Embryo and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing."
    Tran Q., Roesser J.R.
    Biochemistry 42:951-957(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Pancreas, Spleen and Testis.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSRSF6_MOUSE
AccessioniPrimary (citable) accession number: Q3TWW8
Secondary accession number(s): Q3UJV5, Q921K3, Q9DBP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.