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Protein

Serine/arginine-rich splicing factor 6

Gene

Srsf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.
R-MMU-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 6
Alternative name(s):
Pre-mRNA-splicing factor SRP55
Splicing factor, arginine/serine-rich 6
Gene namesi
Name:Srsf6
Synonyms:Sfrs6, Srp55
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915246. Srsf6.

Subcellular locationi

  • Nucleus 1 Publication
  • Nucleus speckle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004260951 – 339Serine/arginine-rich splicing factor 6Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei81PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei165N6-acetyllysineCombined sources1
Modified residuei297PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei303Phosphoserine; by DYRK1ABy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei316PhosphoserineBy similarity1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TWW8.
MaxQBiQ3TWW8.
PaxDbiQ3TWW8.
PeptideAtlasiQ3TWW8.
PRIDEiQ3TWW8.

PTM databases

iPTMnetiQ3TWW8.
PhosphoSitePlusiQ3TWW8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016921.
ExpressionAtlasiQ3TWW8. baseline and differential.
GenevisibleiQ3TWW8. MM.

Interactioni

Subunit structurei

Binds SREK1/SFRS12. Interacts with DYRK1A (By similarity).By similarity

Protein-protein interaction databases

BioGridi212588. 1 interactor.
IntActiQ3TWW8. 2 interactors.
MINTiMINT-1868150.
STRINGi10090.ENSMUSP00000119065.

Structurei

3D structure databases

ProteinModelPortaliQ3TWW8.
SMRiQ3TWW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini110 – 183RRM 2PROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 90Gly-rich (hinge region)4
Compositional biasi184 – 338Arg/Ser-rich (RS domain)Add BLAST155

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00700000104103.
HOGENOMiHOG000276234.
HOVERGENiHBG002295.
InParanoidiQ3TWW8.
KOiK12893.
OMAiRDGYSYS.
OrthoDBiEOG091G0R9W.
PhylomeDBiQ3TWW8.
TreeFamiTF351335.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TWW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVYIGRLS YNVREKDIQR FFSGYGRLLE IDLKNGYGFV EFEDSRDADD
60 70 80 90 100
AVYELNSKEL CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD
110 120 130 140 150
KYGPPVRTEY RLIVENLSSR CSWQDLKDFM RQAGEVTYAD AHKERTNEGV
160 170 180 190 200
IEFRSYSDMK RALDKLDGTE INGRNIRLIE DKPRTSHRRS YSGSRSRSRS
210 220 230 240 250
RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG RKSRSKSKSK
260 270 280 290 300
PKSDRGSHSH SRSRSKDKYG KSRSRSRSRS PKENGKGDIK SKSRSRSQSR
310 320 330
SHSPLPAPPS KARSMSPPPK RASRSRSRSR SRSRSSSRD
Length:339
Mass (Da):39,025
Last modified:October 11, 2005 - v1
Checksum:iAE8B6650D7294A0D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201R → K in BAB23599 (PubMed:16141072).Curated1
Sequence conflicti230S → G in BAE27050 (PubMed:16141072).Curated1
Sequence conflicti299S → P in BAE27050 (PubMed:16141072).Curated1
Sequence conflicti319P → T in AAH12039 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004831 mRNA. Translation: BAB23599.1.
AK133872 mRNA. Translation: BAE21902.1.
AK146293 mRNA. Translation: BAE27050.1.
AK159519 mRNA. Translation: BAE35148.1.
AL590418 Genomic DNA. No translation available.
AL606473 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06308.1.
BC012039 mRNA. Translation: AAH12039.1.
CCDSiCCDS17002.1.
RefSeqiNP_080775.3. NM_026499.4.
UniGeneiMm.24042.

Genome annotation databases

EnsembliENSMUST00000130411; ENSMUSP00000119065; ENSMUSG00000016921.
GeneIDi67996.
KEGGimmu:67996.
UCSCiuc008nsc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004831 mRNA. Translation: BAB23599.1.
AK133872 mRNA. Translation: BAE21902.1.
AK146293 mRNA. Translation: BAE27050.1.
AK159519 mRNA. Translation: BAE35148.1.
AL590418 Genomic DNA. No translation available.
AL606473 Genomic DNA. No translation available.
CH466551 Genomic DNA. Translation: EDL06308.1.
BC012039 mRNA. Translation: AAH12039.1.
CCDSiCCDS17002.1.
RefSeqiNP_080775.3. NM_026499.4.
UniGeneiMm.24042.

3D structure databases

ProteinModelPortaliQ3TWW8.
SMRiQ3TWW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212588. 1 interactor.
IntActiQ3TWW8. 2 interactors.
MINTiMINT-1868150.
STRINGi10090.ENSMUSP00000119065.

PTM databases

iPTMnetiQ3TWW8.
PhosphoSitePlusiQ3TWW8.

Proteomic databases

EPDiQ3TWW8.
MaxQBiQ3TWW8.
PaxDbiQ3TWW8.
PeptideAtlasiQ3TWW8.
PRIDEiQ3TWW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130411; ENSMUSP00000119065; ENSMUSG00000016921.
GeneIDi67996.
KEGGimmu:67996.
UCSCiuc008nsc.2. mouse.

Organism-specific databases

CTDi6431.
MGIiMGI:1915246. Srsf6.

Phylogenomic databases

eggNOGiKOG0106. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00700000104103.
HOGENOMiHOG000276234.
HOVERGENiHBG002295.
InParanoidiQ3TWW8.
KOiK12893.
OMAiRDGYSYS.
OrthoDBiEOG091G0R9W.
PhylomeDBiQ3TWW8.
TreeFamiTF351335.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.
R-MMU-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiSrsf6. mouse.
PROiQ3TWW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016921.
ExpressionAtlasiQ3TWW8. baseline and differential.
GenevisibleiQ3TWW8. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRSF6_MOUSE
AccessioniPrimary (citable) accession number: Q3TWW8
Secondary accession number(s): Q3UJV5, Q921K3, Q9DBP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.