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Protein

WD repeat-containing protein 70

Gene

Wdr70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 70
Gene namesi
Name:Wdr70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921020. Wdr70.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657WD repeat-containing protein 70PRO_0000305145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki299 – 299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei455 – 4551N6-acetyllysineBy similarity
Modified residuei582 – 5821PhosphothreonineBy similarity
Modified residuei624 – 6241PhosphoserineBy similarity
Modified residuei641 – 6411PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3TWF6.
MaxQBiQ3TWF6.
PaxDbiQ3TWF6.
PRIDEiQ3TWF6.

2D gel databases

REPRODUCTION-2DPAGEIPI00464325.

PTM databases

iPTMnetiQ3TWF6.
PhosphoSiteiQ3TWF6.

Expressioni

Gene expression databases

CleanExiMM_WDR70.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3TWF6. 1 interaction.
STRINGi10090.ENSMUSP00000037340.

Structurei

3D structure databases

ProteinModelPortaliQ3TWF6.
SMRiQ3TWF6. Positions 178-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati183 – 22240WD 1Add
BLAST
Repeati230 – 27142WD 2Add
BLAST
Repeati284 – 32441WD 3Add
BLAST
Repeati333 – 37240WD 4Add
BLAST
Repeati379 – 41840WD 5Add
BLAST
Repeati424 – 46946WD 6Add
BLAST
Repeati472 – 51140WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 11531Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat GAD-1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0772. Eukaryota.
ENOG410XP76. LUCA.
HOGENOMiHOG000172867.
HOVERGENiHBG108671.
InParanoidiQ3TWF6.
PhylomeDBiQ3TWF6.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TWF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSGTSEVT GADTAGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA
60 70 80 90 100
VERSRKTLEA REKEEEMNRE KELRKQIEDM EPAPSSSSAA RERSQSSCRD
110 120 130 140 150
TSSSDSESDD SSDSSDDELI GPPLPPKMVG ESVTTVDEGT LGPLPPPLCE
160 170 180 190 200
EGEDDDDDEL DDEGEEDNPV QRIPDSHEIT LRHGTKTVSA LGLDPSGARL
210 220 230 240 250
VTGGYDYDVK FWDFAGMDAS FKAFRSLQPC ECHQIKSLQY SNTGDMILVV
260 270 280 290 300
SGSSQAKVID RDGFEVMECI KGDQYIVDMA NTKGHTAMLH TDSWHPKIKG
310 320 330 340 350
EFMTCSNDAT VRLWEVENPK KQKSVFKPRT MQGKKVIPTT CTYSRDGNLV
360 370 380 390 400
AAACQNGSIQ IWDRNLTVHP KFHYKQAHDP GTDTSCVAFS YDGNVLASRG
410 420 430 440 450
GDDTLKLWDV RQFNKPLFSA SDLPTLFPMT DCCFSPDDKL IVTGTSVQRG
460 470 480 490 500
CGSGKLVFLE RRTFQRVYEI HITDASVVRC LWHPKLNQIM VGTGNGLAKV
510 520 530 540 550
YYDPNKSQRG AKLCVVKTQR KAKQAETLTQ DYIITPHALP MFREPRQRST
560 570 580 590 600
RKQLEKDRLD PLKSHKPEPP VAGPGRGGRV GTHGGTLSSY IVKNIALDKT
610 620 630 640 650
DDSNPREAIL RHAKAAEDNP YWVSPAYSKT QPKTMFAQVE SDDEESKNEP

EWKKRKI
Length:657
Mass (Da):73,119
Last modified:October 11, 2005 - v1
Checksum:i79499A0A83C53B73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159714 mRNA. Translation: BAE35310.1.
CCDSiCCDS37033.1.
UniGeneiMm.321312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159714 mRNA. Translation: BAE35310.1.
CCDSiCCDS37033.1.
UniGeneiMm.321312.

3D structure databases

ProteinModelPortaliQ3TWF6.
SMRiQ3TWF6. Positions 178-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TWF6. 1 interaction.
STRINGi10090.ENSMUSP00000037340.

PTM databases

iPTMnetiQ3TWF6.
PhosphoSiteiQ3TWF6.

2D gel databases

REPRODUCTION-2DPAGEIPI00464325.

Proteomic databases

EPDiQ3TWF6.
MaxQBiQ3TWF6.
PaxDbiQ3TWF6.
PRIDEiQ3TWF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1921020. Wdr70.

Phylogenomic databases

eggNOGiKOG0772. Eukaryota.
ENOG410XP76. LUCA.
HOGENOMiHOG000172867.
HOVERGENiHBG108671.
InParanoidiQ3TWF6.
PhylomeDBiQ3TWF6.

Miscellaneous databases

ChiTaRSiWdr70. mouse.
PROiQ3TWF6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_WDR70.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiWDR70_MOUSE
AccessioniPrimary (citable) accession number: Q3TWF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.