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Protein

WD repeat-containing protein 70

Gene

Wdr70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 70
Gene namesi
Name:Wdr70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921020 Wdr70

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051451 – 657WD repeat-containing protein 70Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei455N6-acetyllysineBy similarity1
Modified residuei582PhosphothreonineBy similarity1
Cross-linki593Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei624PhosphoserineBy similarity1
Modified residuei641PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3TWF6
MaxQBiQ3TWF6
PaxDbiQ3TWF6
PRIDEiQ3TWF6

2D gel databases

REPRODUCTION-2DPAGEiIPI00464325

PTM databases

iPTMnetiQ3TWF6
PhosphoSitePlusiQ3TWF6

Expressioni

Gene expression databases

CleanExiMM_WDR70

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3TWF6, 1 interactor
MINTiQ3TWF6
STRINGi10090.ENSMUSP00000037340

Structurei

3D structure databases

ProteinModelPortaliQ3TWF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati183 – 222WD 1Add BLAST40
Repeati230 – 271WD 2Add BLAST42
Repeati284 – 324WD 3Add BLAST41
Repeati333 – 372WD 4Add BLAST40
Repeati379 – 418WD 5Add BLAST40
Repeati424 – 469WD 6Add BLAST46
Repeati472 – 511WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 115Ser-richAdd BLAST31

Sequence similaritiesi

Belongs to the WD repeat GAD-1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0772 Eukaryota
ENOG410XP76 LUCA
HOGENOMiHOG000172867
HOVERGENiHBG108671
InParanoidiQ3TWF6
PhylomeDBiQ3TWF6

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TWF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSGTSEVT GADTAGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA
60 70 80 90 100
VERSRKTLEA REKEEEMNRE KELRKQIEDM EPAPSSSSAA RERSQSSCRD
110 120 130 140 150
TSSSDSESDD SSDSSDDELI GPPLPPKMVG ESVTTVDEGT LGPLPPPLCE
160 170 180 190 200
EGEDDDDDEL DDEGEEDNPV QRIPDSHEIT LRHGTKTVSA LGLDPSGARL
210 220 230 240 250
VTGGYDYDVK FWDFAGMDAS FKAFRSLQPC ECHQIKSLQY SNTGDMILVV
260 270 280 290 300
SGSSQAKVID RDGFEVMECI KGDQYIVDMA NTKGHTAMLH TDSWHPKIKG
310 320 330 340 350
EFMTCSNDAT VRLWEVENPK KQKSVFKPRT MQGKKVIPTT CTYSRDGNLV
360 370 380 390 400
AAACQNGSIQ IWDRNLTVHP KFHYKQAHDP GTDTSCVAFS YDGNVLASRG
410 420 430 440 450
GDDTLKLWDV RQFNKPLFSA SDLPTLFPMT DCCFSPDDKL IVTGTSVQRG
460 470 480 490 500
CGSGKLVFLE RRTFQRVYEI HITDASVVRC LWHPKLNQIM VGTGNGLAKV
510 520 530 540 550
YYDPNKSQRG AKLCVVKTQR KAKQAETLTQ DYIITPHALP MFREPRQRST
560 570 580 590 600
RKQLEKDRLD PLKSHKPEPP VAGPGRGGRV GTHGGTLSSY IVKNIALDKT
610 620 630 640 650
DDSNPREAIL RHAKAAEDNP YWVSPAYSKT QPKTMFAQVE SDDEESKNEP

EWKKRKI
Length:657
Mass (Da):73,119
Last modified:October 11, 2005 - v1
Checksum:i79499A0A83C53B73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159714 mRNA Translation: BAE35310.1
CCDSiCCDS37033.1
RefSeqiNP_001074871.1, NM_001081402.1
UniGeneiMm.321312

Genome annotation databases

GeneIDi545085

Similar proteinsi

Entry informationi

Entry nameiWDR70_MOUSE
AccessioniPrimary (citable) accession number: Q3TWF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health