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Protein
Submitted name:

Ral guanine nucleotide dissociation stimulator

Gene

Ralgds

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ral guanine nucleotide dissociation stimulatorImported
Gene namesi
Name:RalgdsImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107485. Ralgds.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000026821.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097812.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 249138N-terminal Ras-GEFInterPro annotationAdd
BLAST
Domaini379 – 641263Ras-GEFInterPro annotationAdd
BLAST
Domaini791 – 87888Ras-associatingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
GeneTreeiENSGT00810000125349.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
OMAiCKVRTIK.
OrthoDBiEOG091G0761.
TreeFamiTF315204.

Family and domain databases

CDDicd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR015758. RalGDS.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF35. PTHR23113:SF35. 4 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TWC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRMWAEAA GPIGGTEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF
60 70 80 90 100
TQLDPDLPRL ESSTQEIGEE LINGVIYSIS LRKVQLHQGA TKGQRWLGCE
110 120 130 140 150
NESALNLYET CKVRTVKAGT LEKLVEHLVP AFQGSDLSYV TVFLCTYRAF
160 170 180 190 200
TTTQQVLDLL FKRYGRCDAL TASSRYGCIL PYSSEDGGPQ DQLKNAISSI
210 220 230 240 250
LGTWLDQYSE DFCQPPDFPC LKQLVAYVQL NMPGSDLERR AHLLLAQLED
260 270 280 290 300
LEPSEAESEA LSPAPVLSLK PASQLEPALL LTPSQVVTST PVREPAAAPV
310 320 330 340 350
PVLASSPVVA PAPELEPVPE PPQEPEPSLA LAPELEPAVS QSLELESAPV
360 370 380 390 400
PTPALEPSWS LPEATENGLT EKPHLLLFPP DLVAEQFTLM DAELFKKVVP
410 420 430 440 450
YHCLGSIWSQ RDKKGKEHLA PTIRATVAQF NNVANCVITT CLGDQSMKAP
460 470 480 490 500
DRARVVEHWI EVARECRALK NFSSLYAILS ALQSNAIHRL KKTWEEVSRD
510 520 530 540 550
SFRVFQKLSE IFSDENNYSL SRELLIKEGT SKFATLEMNP RRAQRRQKET
560 570 580 590 600
GVIQGTVPYL GTFLTDLVML DTAMKDYLYG RLINFEKRRK EFEVIAQIKL
610 620 630 640 650
LQSACNNYSI APEEHFGTWF RAMERLSEAE SYTLSCELEP PSESASNTLR
660 670 680 690 700
SKKSTAIVKR WSDRQAPSTE LSTSSSAHSK SCDQLRCSPY LGSGDITDAL
710 720 730 740 750
SVHSAGSSSS DVEEINMSFV PESPDGQEKK FWESASQSSP ETSGISSASS
760 770 780 790 800
STSSSSASTT PVSTTRTHKR SVSGVCSYSS SLPLYNQQVG DCCIIRVSLD
810 820 830 840 850
VDNGNMYKSI LVTSQDKAPT VIRKAMDKHN LDEDEPEDYE LVQIISEDHK
860 870 880 890 900
LKIPENANVF YAMNSTANYD FILKKRTFTK GAKVKHGASS TLPRMKQKGL

RIAKGIF
Length:907
Mass (Da):100,207
Last modified:October 11, 2005 - v1
Checksum:i2CD533100ADCEF2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772249 Genomic DNA. No translation available.
AK159754 mRNA. Translation: BAE35345.1.
RefSeqiNP_001139307.1. NM_001145835.1.
UniGeneiMm.5236.

Genome annotation databases

EnsembliENSMUST00000100241; ENSMUSP00000097812; ENSMUSG00000026821.
GeneIDi19730.
UCSCiuc008iyo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772249 Genomic DNA. No translation available.
AK159754 mRNA. Translation: BAE35345.1.
RefSeqiNP_001139307.1. NM_001145835.1.
UniGeneiMm.5236.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100241; ENSMUSP00000097812; ENSMUSG00000026821.
GeneIDi19730.
UCSCiuc008iyo.2. mouse.

Organism-specific databases

CTDi5900.
MGIiMGI:107485. Ralgds.

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
GeneTreeiENSGT00810000125349.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
OMAiCKVRTIK.
OrthoDBiEOG091G0761.
TreeFamiTF315204.

Miscellaneous databases

ChiTaRSiRalgds. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026821.

Family and domain databases

CDDicd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR015758. RalGDS.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF35. PTHR23113:SF35. 4 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TWC1_MOUSE
AccessioniPrimary (citable) accession number: Q3TWC1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.