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Protein

UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

Gene

Uap1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125UTPBy similarity1
Binding sitei199UTPBy similarity1
Binding sitei225UTP; via amide nitrogenBy similarity1
Binding sitei226SubstrateBy similarity1
Binding sitei256UTPBy similarity1
Binding sitei380UTPBy similarity1
Binding sitei410SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC:2.7.7.-)
Gene namesi
Name:Uap1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443318. Uap1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245811 – 507UDP-N-acetylhexosamine pyrophosphorylase-like protein 1Add BLAST507

Proteomic databases

EPDiQ3TW96.
MaxQBiQ3TW96.
PaxDbiQ3TW96.
PeptideAtlasiQ3TW96.
PRIDEiQ3TW96.

PTM databases

iPTMnetiQ3TW96.
PhosphoSitePlusiQ3TW96.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026956.
GenevisibleiQ3TW96. MM.

Interactioni

Protein-protein interaction databases

BioGridi230646. 1 interactor.
STRINGi10090.ENSMUSP00000099989.

Structurei

3D structure databases

ProteinModelPortaliQ3TW96.
SMRiQ3TW96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 114UTP bindingBy similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 114Substrate binding4
Motifi306 – 307Substrate binding2

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2388. Eukaryota.
COG4284. LUCA.
GeneTreeiENSGT00390000010072.
HOVERGENiHBG018024.
InParanoidiQ3TW96.
KOiK00972.
OMAiVEYSEVE.
OrthoDBiEOG091G05FO.
PhylomeDBiQ3TW96.
TreeFamiTF300611.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TW96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSERDVRAQ LQRAGQDHLL RFYADLAPEA RAALLAELAS LEADALREHC
60 70 80 90 100
QRAAAAGALA PGPLPDLAAR LQPLPPERVG SAIRCDQETR LRWEEEGFRQ
110 120 130 140 150
ISLNKVAVLL LAGGQGTRLG VTYPKGMYQV GLPSQKTLYQ LQAERIRRVQ
160 170 180 190 200
QLADQRQGTH CTVPWYIMTS EFTLGPTIKF FKEHDFFHLD PTNVVLFEQR
210 220 230 240 250
MLPAVTFEGK AILERKDKVA MAPDGNGGLY CALADHQILE DMKQRGVEFV
260 270 280 290 300
HVYCVDNILV RLADPVFIGF CVLQGADCGA KVVEKAYPEE PVGVVCQVDG
310 320 330 340 350
VPQVVEYSEI SPEIAGQLGA DGGLLYNAGN ICNHFFTRGF LDVVTREFEP
360 370 380 390 400
LLRLHVAMKK VPYVDEEGNL VKPLRPNGIK MEKFVFDVFQ FAKNFVAFEV
410 420 430 440 450
CREEEFSPLK NDDTADRDNP STCRRALLAQ HYRWALQAGA RFLDVHGVQL
460 470 480 490 500
TEQSGMLPNG DPPAICEISP LVSYSGEGLE MYLQGRQLQS PFILDEDQAR

LLRPQDC
Length:507
Mass (Da):56,614
Last modified:October 11, 2005 - v1
Checksum:iF4972BE7DBA6C1A1
GO
Isoform 2 (identifier: Q3TW96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,968
Checksum:i0C399AC539E3D445
GO

Sequence cautioni

The sequence AAH43307 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD21409 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322811 – 126Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151942 mRNA. Translation: BAE30818.1.
AK159787 mRNA. Translation: BAE35370.1.
AK168977 mRNA. Translation: BAE40778.1.
AL732557 Genomic DNA. Translation: CAM25608.1.
BC043307 mRNA. Translation: AAH43307.1. Different initiation.
BC068207 mRNA. Translation: AAH68207.1.
BC130030 mRNA. Translation: AAI30031.1.
AK131159 Transcribed RNA. Translation: BAD21409.1. Sequence problems.
CCDSiCCDS15767.1. [Q3TW96-1]
RefSeqiNP_001028465.1. NM_001033293.2. [Q3TW96-1]
UniGeneiMm.33797.

Genome annotation databases

EnsembliENSMUST00000102925; ENSMUSP00000099989; ENSMUSG00000026956. [Q3TW96-1]
GeneIDi227620.
KEGGimmu:227620.
UCSCiuc008irr.1. mouse. [Q3TW96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151942 mRNA. Translation: BAE30818.1.
AK159787 mRNA. Translation: BAE35370.1.
AK168977 mRNA. Translation: BAE40778.1.
AL732557 Genomic DNA. Translation: CAM25608.1.
BC043307 mRNA. Translation: AAH43307.1. Different initiation.
BC068207 mRNA. Translation: AAH68207.1.
BC130030 mRNA. Translation: AAI30031.1.
AK131159 Transcribed RNA. Translation: BAD21409.1. Sequence problems.
CCDSiCCDS15767.1. [Q3TW96-1]
RefSeqiNP_001028465.1. NM_001033293.2. [Q3TW96-1]
UniGeneiMm.33797.

3D structure databases

ProteinModelPortaliQ3TW96.
SMRiQ3TW96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230646. 1 interactor.
STRINGi10090.ENSMUSP00000099989.

PTM databases

iPTMnetiQ3TW96.
PhosphoSitePlusiQ3TW96.

Proteomic databases

EPDiQ3TW96.
MaxQBiQ3TW96.
PaxDbiQ3TW96.
PeptideAtlasiQ3TW96.
PRIDEiQ3TW96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102925; ENSMUSP00000099989; ENSMUSG00000026956. [Q3TW96-1]
GeneIDi227620.
KEGGimmu:227620.
UCSCiuc008irr.1. mouse. [Q3TW96-1]

Organism-specific databases

CTDi91373.
MGIiMGI:2443318. Uap1l1.

Phylogenomic databases

eggNOGiKOG2388. Eukaryota.
COG4284. LUCA.
GeneTreeiENSGT00390000010072.
HOVERGENiHBG018024.
InParanoidiQ3TW96.
KOiK00972.
OMAiVEYSEVE.
OrthoDBiEOG091G05FO.
PhylomeDBiQ3TW96.
TreeFamiTF300611.

Miscellaneous databases

ChiTaRSiUap1l1. mouse.
PROiQ3TW96.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026956.
GenevisibleiQ3TW96. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUAP1L_MOUSE
AccessioniPrimary (citable) accession number: Q3TW96
Secondary accession number(s): A1L3D3
, Q6KAP8, Q6NVB6, Q80XP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.