Q3TVP5 (F105A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM105A

Gene names

Name:

Fam105a

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM105 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3TVP5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q3TVP5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     114-163: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Protein FAM105A		PRO_0000274405
Natural variations
	Alternative sequence	114 – 163	50	Missing in isoform 2.		VSP_022738
Experimental info
	Sequence conflict	173	1	G → S in BAE29828. Ref.1
	Sequence conflict	173	1	G → S in BAE30963. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: DCCB7047E1CFDF30	FASTA	353	41,576
	10 20 30 40 50 60 MEAPRSAPRE RERARTTSGS DQVHSWILVT SQVLSAAWRI ARAFVMTTLS PLSATFSYFR 70 80 90 100 110 120 SLYLYLGHQL KWWIGYLQRK FKRNLSVEAE VDLLSYCARE WKGEAPRARL MRKAYEELFW 130 140 150 160 170 180 RHHIKCVRAV KRDNYDALRS VLFQIFSQGL SFPSWMKEKD IVKLPEKLLF SQGCNWIQQY 190 200 210 220 230 240 SFGPEKYTGS NVFGKLRKCV ELLKLQWTEF SGMRDHHKRG SMCNSLFSDA ILECKLYEAL 250 260 270 280 290 300 KFLMLYQVTE AYEQMKTNKV IPSLFRLLFS RESSPDPLSF MMNHLNSIGD TCGLDQIDMF 310 320 330 340 350 ILGYSLQVKI KVFRLFKFNS RDFAVCYPEE PLREWPEISL LTENGHHYHI PVF
	Isoform 2 [UniParc]. Checksum: AEDCEB97D6B8EC58	FASTA	303	35,507
	10 20 30 40 50 60 MEAPRSAPRE RERARTTSGS DQVHSWILVT SQVLSAAWRI ARAFVMTTLS PLSATFSYFR 70 80 90 100 110 120 SLYLYLGHQL KWWIGYLQRK FKRNLSVEAE VDLLSYCARE WKGEAPRARL MRKLPEKLLF 130 140 150 160 170 180 SQGCNWIQQY SFGPEKYTGS NVFGKLRKCV ELLKLQWTEF SGMRDHHKRG SMCNSLFSDA 190 200 210 220 230 240 ILECKLYEAL KFLMLYQVTE AYEQMKTNKV IPSLFRLLFS RESSPDPLSF MMNHLNSIGD 250 260 270 280 290 300 TCGLDQIDMF ILGYSLQVKI KVFRLFKFNS RDFAVCYPEE PLREWPEISL LTENGHHYHI PVF

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK150760 mRNA. Translation: BAE29828.1. AK152120 mRNA. Translation: BAE30963.1. AK152590 mRNA. Translation: BAE31339.1. AK160030 mRNA. Translation: BAE35573.1. BC052328 mRNA. Translation: AAH52328.1.
IPI	IPI00330614. IPI00653413.
RefSeq	NP_001229352.1. NM_001242423.1. NP_938043.1. NM_198301.2.
UniGene	Mm.266485.
3D structure databases
ProteinModelPortal	Q3TVP5.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000066783.
PTM databases
PhosphoSite	Q3TVP5.
Proteomic databases
PRIDE	Q3TVP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000100739; ENSMUSP00000098305; ENSMUSG00000056069.
GeneID	223433.
KEGG	mmu:223433.
UCSC	uc007vjs.1. mouse. uc007vjt.1. mouse.
Organism-specific databases
CTD	54491.
MGI	MGI:2687281. Fam105a.
Phylogenomic databases
eggNOG	NOG38836.
GeneTree	ENSGT00390000009802.
HOGENOM	HOG000294085.
HOVERGEN	HBG059856.
InParanoid	Q3TVP5.
OMA	HLNSVGD.
OrthoDB	EOG4894MP.
Gene expression databases
Bgee	Q3TVP5.
Genevestigator	Q3TVP5.
Family and domain databases
InterPro	IPR023235. FAM105. IPR023236. FAM105A. [Graphical view]
PRINTS	PR02055. PROTEINF105. PR02056. PROTEINF105A.
ProtoNet	Search...
Other
NextBio	376710.
SOURCE	Search...

Entry information

Entry name

F105A_MOUSE

Accession

Primary (citable) accession number: Q3TVP5
Secondary accession number(s): Q3U8Q4, Q80WP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program