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Protein

Protein HEXIM2

Gene

Hexim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HEXIM2
Gene namesi
Name:Hexim2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918309 Hexim2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052681 – 313Protein HEXIM2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3TVI4
PaxDbiQ3TVI4
PeptideAtlasiQ3TVI4
PRIDEiQ3TVI4

PTM databases

iPTMnetiQ3TVI4
PhosphoSitePlusiQ3TVI4

Expressioni

Gene expression databases

BgeeiENSMUSG00000043372
CleanExiMM_HEXIM2
ExpressionAtlasiQ3TVI4 baseline and differential
GenevisibleiQ3TVI4 MM

Interactioni

Subunit structurei

Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with CCNT2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3TVI4, 1 interactor
STRINGi10090.ENSMUSP00000053678

Structurei

3D structure databases

ProteinModelPortaliQ3TVI4
SMRiQ3TVI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 142Interaction with P-TEFbBy similarity4
Regioni225 – 286Interaction with CCNT1, HEXIM1 and HEXIM2By similarityAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 276Sequence analysisAdd BLAST70

Domaini

The coiled-coil domain mediates oligomerization.By similarity

Sequence similaritiesi

Belongs to the HEXIM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH8I Eukaryota
ENOG4111K9Z LUCA
GeneTreeiENSGT00390000002808
HOGENOMiHOG000060338
HOVERGENiHBG107976
InParanoidiQ3TVI4
KOiK15189
OMAiPCRQVEE
OrthoDBiEOG091G0Y9A
PhylomeDBiQ3TVI4
TreeFamiTF336851

Family and domain databases

InterProiView protein in InterPro
IPR024872 HEXIM
IPR024876 HEXIM2
PANTHERiPTHR13469 PTHR13469, 1 hit
PTHR13469:SF3 PTHR13469:SF3, 1 hit
PfamiView protein in Pfam
PF15313 HEXIM, 1 hit
PRINTSiPR02094 HEXIMFAMILY

Sequencei

Sequence statusi: Complete.

Q3TVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVNHTNCN TASPAALEEA KTSGGLRSPQ IAHEPHDFGG SQLLPSGQEI
60 70 80 90 100
QSEDEGTVPA GDGSSCNIRG SRTQSPGGCS VEAVLARKKH RRRPSKRKRH
110 120 130 140 150
WRPYLELSWA EKQQRDERQS QRASRVREEM FAKGQPLAPY NTTQFLMNDR
160 170 180 190 200
DLEEPNLDVL HGPSHSGSGG ENEAGDSDGQ GRAHGEFQQR DFSEAYERYH
210 220 230 240 250
TESLQGRSKQ ELVRDYLDLE RRLSQAEQET RRLRQLQGCS SRQPCQQVEE
260 270 280 290 300
LAAEVERLRT ENQRLRQENE MWNREGGYCD QEKPASEGTP WPKVEAPFQT
310
HTGQLGHREA GDR
Length:313
Mass (Da):35,397
Last modified:October 11, 2005 - v1
Checksum:i37DC31F063D7C60A
GO

Sequence cautioni

The sequence BAB30344 differs from that shown. Reason: Frameshift at positions 93 and 99.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016624 mRNA Translation: BAB30344.1 Frameshift.
AK140145 mRNA Translation: BAE24255.1
AK160110 mRNA Translation: BAE35634.1
AL662804, AL731805 Genomic DNA Translation: CAM21575.1
AL731805, AL662804 Genomic DNA Translation: CAM22096.1
BC026458 mRNA Translation: AAH26458.1
BC115597 mRNA Translation: AAI15598.1
BC115598 mRNA Translation: AAI15599.1
CCDSiCCDS25514.1
RefSeqiNP_001123987.1, NM_001130515.1
NP_001123988.1, NM_001130516.1
NP_081934.1, NM_027658.2
XP_006534291.1, XM_006534228.2
XP_006534292.1, XM_006534229.2
XP_006534293.1, XM_006534230.2
XP_006534294.1, XM_006534231.3
UniGeneiMm.273871

Genome annotation databases

EnsembliENSMUST00000062530; ENSMUSP00000053678; ENSMUSG00000043372
ENSMUST00000107037; ENSMUSP00000102652; ENSMUSG00000043372
GeneIDi71059
KEGGimmu:71059
UCSCiuc007ltp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHEXI2_MOUSE
AccessioniPrimary (citable) accession number: Q3TVI4
Secondary accession number(s): Q9D4C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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