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Q3TVI4 (HEXI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein HEXIM2
Gene names
Name:Hexim2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation By similarity.

Subunit structure

Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs By similarity.

Subcellular location

Nucleus By similarity.

Domain

The coiled-coil domain mediates oligomerization By similarity.

Sequence similarities

Belongs to the HEXIM family.

Sequence caution

The sequence BAB30344.1 differs from that shown. Reason: Frameshift at positions 93 and 99.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Protein HEXIM2
PRO_0000305268

Regions

Region139 – 1424Interaction with P-TEFb By similarity
Region225 – 28662Interaction with CCNT1, HEXIM1 and HEXIM2 By similarity
Coiled coil207 – 27670 Potential

Amino acid modifications

Modified residue281Phosphoserine By similarity
Modified residue521Phosphoserine By similarity
Modified residue751Phosphoserine By similarity
Modified residue801Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3TVI4 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 37DC31F063D7C60A

FASTA31335,397
        10         20         30         40         50         60 
MATVNHTNCN TASPAALEEA KTSGGLRSPQ IAHEPHDFGG SQLLPSGQEI QSEDEGTVPA 

        70         80         90        100        110        120 
GDGSSCNIRG SRTQSPGGCS VEAVLARKKH RRRPSKRKRH WRPYLELSWA EKQQRDERQS 

       130        140        150        160        170        180 
QRASRVREEM FAKGQPLAPY NTTQFLMNDR DLEEPNLDVL HGPSHSGSGG ENEAGDSDGQ 

       190        200        210        220        230        240 
GRAHGEFQQR DFSEAYERYH TESLQGRSKQ ELVRDYLDLE RRLSQAEQET RRLRQLQGCS 

       250        260        270        280        290        300 
SRQPCQQVEE LAAEVERLRT ENQRLRQENE MWNREGGYCD QEKPASEGTP WPKVEAPFQT 

       310 
HTGQLGHREA GDR 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Corpora quadrigemina and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK016624 mRNA. Translation: BAB30344.1. Frameshift.
AK140145 mRNA. Translation: BAE24255.1.
AK160110 mRNA. Translation: BAE35634.1.
AL662804, AL731805 Genomic DNA. Translation: CAM21575.1.
AL731805, AL662804 Genomic DNA. Translation: CAM22096.1.
BC026458 mRNA. Translation: AAH26458.1.
BC115597 mRNA. Translation: AAI15598.1.
BC115598 mRNA. Translation: AAI15599.1.
CCDSCCDS25514.1.
RefSeqNP_001123987.1. NM_001130515.1.
NP_001123988.1. NM_001130516.1.
NP_081934.1. NM_027658.2.
XP_006534291.1. XM_006534228.1.
XP_006534292.1. XM_006534229.1.
XP_006534293.1. XM_006534230.1.
XP_006534294.1. XM_006534231.1.
UniGeneMm.273871.

3D structure databases

ProteinModelPortalQ3TVI4.
SMRQ3TVI4. Positions 186-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3TVI4. 1 interaction.

PTM databases

PhosphoSiteQ3TVI4.

Proteomic databases

PRIDEQ3TVI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062530; ENSMUSP00000053678; ENSMUSG00000043372.
ENSMUST00000107037; ENSMUSP00000102652; ENSMUSG00000043372.
GeneID71059.
KEGGmmu:71059.
UCSCuc007ltp.2. mouse.

Organism-specific databases

CTD124790.
MGIMGI:1918309. Hexim2.

Phylogenomic databases

eggNOGNOG72325.
GeneTreeENSGT00390000002808.
HOGENOMHOG000060338.
HOVERGENHBG107976.
InParanoidQ3TVI4.
KOK15189.
OMAPCRQVEE.
PhylomeDBQ3TVI4.
TreeFamTF336851.

Gene expression databases

BgeeQ3TVI4.
CleanExMM_HEXIM2.
GenevestigatorQ3TVI4.

Family and domain databases

InterProIPR024872. HEXIM.
IPR024876. HEXIM2.
[Graphical view]
PANTHERPTHR13469. PTHR13469. 1 hit.
PTHR13469:SF3. PTHR13469:SF3. 1 hit.
PfamPF15313. HEXIM. 1 hit.
[Graphical view]
PRINTSPR02094. HEXIMFAMILY.
ProtoNetSearch...

Other

NextBio332919.
PROQ3TVI4.
SOURCESearch...

Entry information

Entry nameHEXI2_MOUSE
AccessionPrimary (citable) accession number: Q3TVI4
Secondary accession number(s): Q9D4C7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot