Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein HEXIM2

Gene

Hexim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HEXIM2
Gene namesi
Name:Hexim2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918309. Hexim2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052681 – 313Protein HEXIM2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3TVI4.
PaxDbiQ3TVI4.
PeptideAtlasiQ3TVI4.
PRIDEiQ3TVI4.

PTM databases

iPTMnetiQ3TVI4.
PhosphoSitePlusiQ3TVI4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043372.
CleanExiMM_HEXIM2.
ExpressionAtlasiQ3TVI4. baseline and differential.
GenevisibleiQ3TVI4. MM.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with CCNT2.By similarity

Protein-protein interaction databases

IntActiQ3TVI4. 1 interactor.
STRINGi10090.ENSMUSP00000053678.

Structurei

3D structure databases

ProteinModelPortaliQ3TVI4.
SMRiQ3TVI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 142Interaction with P-TEFbBy similarity4
Regioni225 – 286Interaction with CCNT1, HEXIM1 and HEXIM2By similarityAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 276Sequence analysisAdd BLAST70

Domaini

The coiled-coil domain mediates oligomerization.By similarity

Sequence similaritiesi

Belongs to the HEXIM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH8I. Eukaryota.
ENOG4111K9Z. LUCA.
GeneTreeiENSGT00390000002808.
HOGENOMiHOG000060338.
HOVERGENiHBG107976.
InParanoidiQ3TVI4.
KOiK15189.
OMAiPCRQVEE.
OrthoDBiEOG091G0Y9A.
PhylomeDBiQ3TVI4.
TreeFamiTF336851.

Family and domain databases

InterProiIPR024872. HEXIM.
[Graphical view]
PfamiPF15313. HEXIM. 1 hit.
[Graphical view]
PRINTSiPR02094. HEXIMFAMILY.

Sequencei

Sequence statusi: Complete.

Q3TVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVNHTNCN TASPAALEEA KTSGGLRSPQ IAHEPHDFGG SQLLPSGQEI
60 70 80 90 100
QSEDEGTVPA GDGSSCNIRG SRTQSPGGCS VEAVLARKKH RRRPSKRKRH
110 120 130 140 150
WRPYLELSWA EKQQRDERQS QRASRVREEM FAKGQPLAPY NTTQFLMNDR
160 170 180 190 200
DLEEPNLDVL HGPSHSGSGG ENEAGDSDGQ GRAHGEFQQR DFSEAYERYH
210 220 230 240 250
TESLQGRSKQ ELVRDYLDLE RRLSQAEQET RRLRQLQGCS SRQPCQQVEE
260 270 280 290 300
LAAEVERLRT ENQRLRQENE MWNREGGYCD QEKPASEGTP WPKVEAPFQT
310
HTGQLGHREA GDR
Length:313
Mass (Da):35,397
Last modified:October 11, 2005 - v1
Checksum:i37DC31F063D7C60A
GO

Sequence cautioni

The sequence BAB30344 differs from that shown. Reason: Frameshift at positions 93 and 99.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016624 mRNA. Translation: BAB30344.1. Frameshift.
AK140145 mRNA. Translation: BAE24255.1.
AK160110 mRNA. Translation: BAE35634.1.
AL662804, AL731805 Genomic DNA. Translation: CAM21575.1.
AL731805, AL662804 Genomic DNA. Translation: CAM22096.1.
BC026458 mRNA. Translation: AAH26458.1.
BC115597 mRNA. Translation: AAI15598.1.
BC115598 mRNA. Translation: AAI15599.1.
CCDSiCCDS25514.1.
RefSeqiNP_001123987.1. NM_001130515.1.
NP_001123988.1. NM_001130516.1.
NP_081934.1. NM_027658.2.
XP_006534291.1. XM_006534228.2.
XP_006534292.1. XM_006534229.2.
XP_006534293.1. XM_006534230.2.
XP_006534294.1. XM_006534231.3.
UniGeneiMm.273871.

Genome annotation databases

EnsembliENSMUST00000062530; ENSMUSP00000053678; ENSMUSG00000043372.
ENSMUST00000107037; ENSMUSP00000102652; ENSMUSG00000043372.
GeneIDi71059.
KEGGimmu:71059.
UCSCiuc007ltp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016624 mRNA. Translation: BAB30344.1. Frameshift.
AK140145 mRNA. Translation: BAE24255.1.
AK160110 mRNA. Translation: BAE35634.1.
AL662804, AL731805 Genomic DNA. Translation: CAM21575.1.
AL731805, AL662804 Genomic DNA. Translation: CAM22096.1.
BC026458 mRNA. Translation: AAH26458.1.
BC115597 mRNA. Translation: AAI15598.1.
BC115598 mRNA. Translation: AAI15599.1.
CCDSiCCDS25514.1.
RefSeqiNP_001123987.1. NM_001130515.1.
NP_001123988.1. NM_001130516.1.
NP_081934.1. NM_027658.2.
XP_006534291.1. XM_006534228.2.
XP_006534292.1. XM_006534229.2.
XP_006534293.1. XM_006534230.2.
XP_006534294.1. XM_006534231.3.
UniGeneiMm.273871.

3D structure databases

ProteinModelPortaliQ3TVI4.
SMRiQ3TVI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TVI4. 1 interactor.
STRINGi10090.ENSMUSP00000053678.

PTM databases

iPTMnetiQ3TVI4.
PhosphoSitePlusiQ3TVI4.

Proteomic databases

MaxQBiQ3TVI4.
PaxDbiQ3TVI4.
PeptideAtlasiQ3TVI4.
PRIDEiQ3TVI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062530; ENSMUSP00000053678; ENSMUSG00000043372.
ENSMUST00000107037; ENSMUSP00000102652; ENSMUSG00000043372.
GeneIDi71059.
KEGGimmu:71059.
UCSCiuc007ltp.2. mouse.

Organism-specific databases

CTDi124790.
MGIiMGI:1918309. Hexim2.

Phylogenomic databases

eggNOGiENOG410IH8I. Eukaryota.
ENOG4111K9Z. LUCA.
GeneTreeiENSGT00390000002808.
HOGENOMiHOG000060338.
HOVERGENiHBG107976.
InParanoidiQ3TVI4.
KOiK15189.
OMAiPCRQVEE.
OrthoDBiEOG091G0Y9A.
PhylomeDBiQ3TVI4.
TreeFamiTF336851.

Miscellaneous databases

PROiQ3TVI4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043372.
CleanExiMM_HEXIM2.
ExpressionAtlasiQ3TVI4. baseline and differential.
GenevisibleiQ3TVI4. MM.

Family and domain databases

InterProiIPR024872. HEXIM.
[Graphical view]
PfamiPF15313. HEXIM. 1 hit.
[Graphical view]
PRINTSiPR02094. HEXIMFAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiHEXI2_MOUSE
AccessioniPrimary (citable) accession number: Q3TVI4
Secondary accession number(s): Q9D4C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.