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Q3TVI4

- HEXI2_MOUSE

UniProt

Q3TVI4 - HEXI2_MOUSE

Protein

Protein HEXIM2

Gene

Hexim2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation By similarity.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro
    2. snRNA binding Source: InterPro

    GO - Biological processi

    1. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: InterPro
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein HEXIM2
    Gene namesi
    Name:Hexim2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1918309. Hexim2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Protein HEXIM2PRO_0000305268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei28 – 281PhosphoserineBy similarity
    Modified residuei52 – 521PhosphoserineBy similarity
    Modified residuei75 – 751PhosphoserineBy similarity
    Modified residuei80 – 801PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3TVI4.

    PTM databases

    PhosphoSiteiQ3TVI4.

    Expressioni

    Gene expression databases

    BgeeiQ3TVI4.
    CleanExiMM_HEXIM2.
    GenevestigatoriQ3TVI4.

    Interactioni

    Subunit structurei

    Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ3TVI4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TVI4.
    SMRiQ3TVI4. Positions 186-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1424Interaction with P-TEFbBy similarity
    Regioni225 – 28662Interaction with CCNT1, HEXIM1 and HEXIM2By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili207 – 27670Sequence AnalysisAdd
    BLAST

    Domaini

    The coiled-coil domain mediates oligomerization.By similarity

    Sequence similaritiesi

    Belongs to the HEXIM family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG72325.
    GeneTreeiENSGT00390000002808.
    HOGENOMiHOG000060338.
    HOVERGENiHBG107976.
    InParanoidiQ3TVI4.
    KOiK15189.
    OMAiPCRQVEE.
    PhylomeDBiQ3TVI4.
    TreeFamiTF336851.

    Family and domain databases

    InterProiIPR024872. HEXIM.
    IPR024876. HEXIM2.
    [Graphical view]
    PANTHERiPTHR13469. PTHR13469. 1 hit.
    PTHR13469:SF3. PTHR13469:SF3. 1 hit.
    PfamiPF15313. HEXIM. 1 hit.
    [Graphical view]
    PRINTSiPR02094. HEXIMFAMILY.

    Sequencei

    Sequence statusi: Complete.

    Q3TVI4-1 [UniParc]FASTAAdd to Basket

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    MATVNHTNCN TASPAALEEA KTSGGLRSPQ IAHEPHDFGG SQLLPSGQEI    50
    QSEDEGTVPA GDGSSCNIRG SRTQSPGGCS VEAVLARKKH RRRPSKRKRH 100
    WRPYLELSWA EKQQRDERQS QRASRVREEM FAKGQPLAPY NTTQFLMNDR 150
    DLEEPNLDVL HGPSHSGSGG ENEAGDSDGQ GRAHGEFQQR DFSEAYERYH 200
    TESLQGRSKQ ELVRDYLDLE RRLSQAEQET RRLRQLQGCS SRQPCQQVEE 250
    LAAEVERLRT ENQRLRQENE MWNREGGYCD QEKPASEGTP WPKVEAPFQT 300
    HTGQLGHREA GDR 313
    Length:313
    Mass (Da):35,397
    Last modified:October 11, 2005 - v1
    Checksum:i37DC31F063D7C60A
    GO

    Sequence cautioni

    The sequence BAB30344.1 differs from that shown. Reason: Frameshift at positions 93 and 99.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016624 mRNA. Translation: BAB30344.1. Frameshift.
    AK140145 mRNA. Translation: BAE24255.1.
    AK160110 mRNA. Translation: BAE35634.1.
    AL662804, AL731805 Genomic DNA. Translation: CAM21575.1.
    AL731805, AL662804 Genomic DNA. Translation: CAM22096.1.
    BC026458 mRNA. Translation: AAH26458.1.
    BC115597 mRNA. Translation: AAI15598.1.
    BC115598 mRNA. Translation: AAI15599.1.
    CCDSiCCDS25514.1.
    RefSeqiNP_001123987.1. NM_001130515.1.
    NP_001123988.1. NM_001130516.1.
    NP_081934.1. NM_027658.2.
    XP_006534291.1. XM_006534228.1.
    XP_006534292.1. XM_006534229.1.
    XP_006534293.1. XM_006534230.1.
    XP_006534294.1. XM_006534231.1.
    UniGeneiMm.273871.

    Genome annotation databases

    EnsembliENSMUST00000062530; ENSMUSP00000053678; ENSMUSG00000043372.
    ENSMUST00000107037; ENSMUSP00000102652; ENSMUSG00000043372.
    GeneIDi71059.
    KEGGimmu:71059.
    UCSCiuc007ltp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016624 mRNA. Translation: BAB30344.1 . Frameshift.
    AK140145 mRNA. Translation: BAE24255.1 .
    AK160110 mRNA. Translation: BAE35634.1 .
    AL662804 , AL731805 Genomic DNA. Translation: CAM21575.1 .
    AL731805 , AL662804 Genomic DNA. Translation: CAM22096.1 .
    BC026458 mRNA. Translation: AAH26458.1 .
    BC115597 mRNA. Translation: AAI15598.1 .
    BC115598 mRNA. Translation: AAI15599.1 .
    CCDSi CCDS25514.1.
    RefSeqi NP_001123987.1. NM_001130515.1.
    NP_001123988.1. NM_001130516.1.
    NP_081934.1. NM_027658.2.
    XP_006534291.1. XM_006534228.1.
    XP_006534292.1. XM_006534229.1.
    XP_006534293.1. XM_006534230.1.
    XP_006534294.1. XM_006534231.1.
    UniGenei Mm.273871.

    3D structure databases

    ProteinModelPortali Q3TVI4.
    SMRi Q3TVI4. Positions 186-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3TVI4. 1 interaction.

    PTM databases

    PhosphoSitei Q3TVI4.

    Proteomic databases

    PRIDEi Q3TVI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062530 ; ENSMUSP00000053678 ; ENSMUSG00000043372 .
    ENSMUST00000107037 ; ENSMUSP00000102652 ; ENSMUSG00000043372 .
    GeneIDi 71059.
    KEGGi mmu:71059.
    UCSCi uc007ltp.2. mouse.

    Organism-specific databases

    CTDi 124790.
    MGIi MGI:1918309. Hexim2.

    Phylogenomic databases

    eggNOGi NOG72325.
    GeneTreei ENSGT00390000002808.
    HOGENOMi HOG000060338.
    HOVERGENi HBG107976.
    InParanoidi Q3TVI4.
    KOi K15189.
    OMAi PCRQVEE.
    PhylomeDBi Q3TVI4.
    TreeFami TF336851.

    Miscellaneous databases

    NextBioi 332919.
    PROi Q3TVI4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TVI4.
    CleanExi MM_HEXIM2.
    Genevestigatori Q3TVI4.

    Family and domain databases

    InterProi IPR024872. HEXIM.
    IPR024876. HEXIM2.
    [Graphical view ]
    PANTHERi PTHR13469. PTHR13469. 1 hit.
    PTHR13469:SF3. PTHR13469:SF3. 1 hit.
    Pfami PF15313. HEXIM. 1 hit.
    [Graphical view ]
    PRINTSi PR02094. HEXIMFAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiHEXI2_MOUSE
    AccessioniPrimary (citable) accession number: Q3TVI4
    Secondary accession number(s): Q9D4C7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3