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Protein
Submitted name:

Putative uncharacterized protein

Gene

Ncstn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • endopeptidase activity Source: MGI

GO - Biological processi

  • beta-amyloid metabolic process Source: MGI
  • epithelial cell proliferation Source: MGI
  • membrane protein ectodomain proteolysis Source: MGI
  • myeloid cell homeostasis Source: MGI
  • positive regulation of catalytic activity Source: MGI
  • protein processing Source: MGI
  • T cell proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:NcstnImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1891700. Ncstn.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of plasma membrane Source: MGI
  • lysosomal membrane Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3TV74.
ExpressionAtlasiQ3TV74. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003550.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG006497.

Family and domain databases

InterProiIPR008710. Nicastrin.
[Graphical view]
PANTHERiPTHR21092. PTHR21092. 1 hit.
PfamiPF05450. Nicastrin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TV74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VTYPEWQSPE EDLNFVTDTA KALANVATVL ARALYELAGG TNFSSSIQAD
60 70 80 90 100
PQTVTRLLYG FLVRANNSWF QSILKHDLRS YLDDRPLQHY IAVSSPTNTT
110 120 130 140 150
YVVQYALANL TGKATNLTRE QCQDPSKVPN ESKDLYEYSW VQGPWNSNRT
160 170 180 190 200
ERLPQCVRST VRLARALSPA FELSQWSSTE YSTWAESRWK DIQARIFLIA
210 220 230 240
SKELEFITLI VGFSTLVFSL IVTYCINAKA DVLFVAPREP GAVSY
Length:245
Mass (Da):27,681
Last modified:October 11, 2005 - v1
Checksum:i8657AE58D46829B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160338 mRNA. Translation: BAE35745.1.
UniGeneiMm.218203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160338 mRNA. Translation: BAE35745.1.
UniGeneiMm.218203.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003550.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1891700. Ncstn.

Phylogenomic databases

HOVERGENiHBG006497.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3TV74.
ExpressionAtlasiQ3TV74. baseline and differential.

Family and domain databases

InterProiIPR008710. Nicastrin.
[Graphical view]
PANTHERiPTHR21092. PTHR21092. 1 hit.
PfamiPF05450. Nicastrin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Embryonic body between diaphragm region and neckImported.

Entry informationi

Entry nameiQ3TV74_MOUSE
AccessioniPrimary (citable) accession number: Q3TV74
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.