Q3TUU1 (Q3TUU1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE35880.1

Gene names

Name:

Nedd4 MGI 97297

Organism

Mus musculus (Mouse) EMBL BAE35880.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. SAAS SAAS008973 RuleBase RU003412

Ontologies

Gene Ontology (GO)
Biological_process	T cell activation Inferred from mutant phenotype PubMed 18931680. Source: MGI adaptive immune response Inferred from mutant phenotype PubMed 18931680. Source: MGI blood vessel morphogenesis Inferred from mutant phenotype PubMed 20026598. Source: MGI development involved in symbiotic interaction Inferred from electronic annotation. Source: Compara endocardial cushion development Inferred from mutant phenotype PubMed 20026598. Source: MGI glucocorticoid receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of sodium ion transport Inferred from direct assay PubMed 10212229. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 20026598. Source: MGI negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Inferred from electronic annotation. Source: Compara neuromuscular junction development Inferred from mutant phenotype PubMed 19345204. Source: MGI neuron projection development Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from mutant phenotype PubMed 20026598. Source: MGI positive regulation of nucleocytoplasmic transport Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of protein catabolic process Inferred from direct assay PubMed 11748237. Source: MGI progesterone receptor signaling pathway Inferred from electronic annotation. Source: Compara protein monoubiquitination Inferred from direct assay PubMed 21920314. Source: MGI protein targeting to lysosome Inferred from electronic annotation. Source: Compara protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from mutant phenotype PubMed 18931680. Source: MGI receptor catabolic process Inferred from electronic annotation. Source: Compara receptor internalization Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from electronic annotation. Source: Compara regulation of potassium ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara regulation of synapse organization Inferred from mutant phenotype PubMed 19345204. Source: MGI transmission of virus Inferred from electronic annotation. Source: Compara ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cell cortex Inferred from electronic annotation. Source: Compara chromatin Inferred from electronic annotation. Source: Compara cytosol Inferred from direct assay PubMed 19794060PubMed 9182527. Source: MGI membrane Inferred from direct assay PubMed 14973438. Source: MGI nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara ubiquitin ligase complex Inferred from physical interaction PubMed 11042109. Source: MGI
Molecular_function	sodium channel inhibitor activity Inferred from direct assay PubMed 10212229. Source: MGI ubiquitin-protein ligase activity Inferred from direct assay PubMed 11717310PubMed 9182527. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3TUU1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 431CBD3C24FFB788	FASTA	398	45,106
	10 20 30 40 50 60 MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 70 80 90 100 110 120 HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT 130 140 150 160 170 180 KTIKKSLNPK WNEEILFRVL PQRHRILFEV FDENRLTRDD FLGQVDVPLY PLPTENPRME 190 200 210 220 230 240 RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT 250 260 270 280 290 300 HLPHPPEPSP LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 310 320 330 340 350 360 AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV QTHLAEEFNT 370 380 390 RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLP

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE35880.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK160570 mRNA. Translation: BAE35880.1.
IPI	IPI00462445.
UniGene	Mm.279923.
3D structure databases
ProteinModelPortal	Q3TUU1.
SMR	Q3TUU1. Positions 75-211, 250-281.
ModBase	Search...
Proteomic databases
PRIDE	Q3TUU1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97297. Nedd4.
Phylogenomic databases
HOVERGEN	HBG079466.
InParanoid	Q3TUU1.
Gene expression databases
ArrayExpress	Q3TUU1.
Bgee	Q3TUU1.
Genevestigator	Q3TUU1.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR001202. WW_dom. [Graphical view]
Pfam	PF00168. C2. 1 hit. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NEDD4. mouse.
SOURCE	Search...

Entry information

Entry name

Q3TUU1_MOUSE

Accession

Primary (citable) accession number: Q3TUU1

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	May 29, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)