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Q3TUU1 (Q3TUU1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Nedd4 MGI 97297
OrganismMus musculus (Mouse) EMBL BAE35880.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412

Ontologies

Gene Ontology (GO)
   Biological_processT cell activation

Inferred from mutant phenotype PubMed 18931680. Source: MGI

adaptive immune response

Inferred from mutant phenotype PubMed 18931680. Source: MGI

blood vessel morphogenesis

Inferred from mutant phenotype PubMed 20026598. Source: MGI

development involved in symbiotic interaction

Inferred from electronic annotation. Source: Ensembl

endocardial cushion development

Inferred from mutant phenotype PubMed 20026598. Source: MGI

glucocorticoid receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of sodium ion transport

Inferred from direct assay PubMed 10212229. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20026598. Source: MGI

negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

Inferred from electronic annotation. Source: Ensembl

neuromuscular junction development

Inferred from mutant phenotype PubMed 19345204. Source: MGI

neuron projection development

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 20026598. Source: MGI

positive regulation of nucleocytoplasmic transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein catabolic process

Inferred from direct assay PubMed 11748237. Source: MGI

progesterone receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

protein monoubiquitination

Inferred from direct assay PubMed 21920314. Source: MGI

protein targeting to lysosome

Inferred from electronic annotation. Source: Ensembl

protein ubiquitination

Inferred from direct assay PubMed 9182527. Source: MGI

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Inferred from mutant phenotype PubMed 18931680. Source: MGI

receptor catabolic process

Inferred from electronic annotation. Source: Ensembl

receptor internalization

Inferred from electronic annotation. Source: Ensembl

regulation of membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of potassium ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

regulation of synapse organization

Inferred from mutant phenotype PubMed 19345204. Source: MGI

transmission of virus

Inferred from electronic annotation. Source: Ensembl

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cell cortex

Inferred from electronic annotation. Source: Ensembl

chromatin

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 14973438. Source: MGI

cytosol

Inferred from direct assay PubMed 19794060PubMed 9182527. Source: MGI

membrane

Inferred from direct assay PubMed 14973438. Source: MGI

nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

ubiquitin ligase complex

Inferred from physical interaction PubMed 11042109. Source: MGI

   Molecular_functionproline-rich region binding

Inferred from physical interaction PubMed 11748237PubMed 9305852. Source: MGI

sodium channel inhibitor activity

Inferred from direct assay PubMed 10212229. Source: MGI

ubiquitin-protein ligase activity

Inferred from direct assay PubMed 11717310PubMed 9182527. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3TUU1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 431CBD3C24FFB788

FASTA39845,106
        10         20         30         40         50         60 
MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 

        70         80         90        100        110        120 
HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT 

       130        140        150        160        170        180 
KTIKKSLNPK WNEEILFRVL PQRHRILFEV FDENRLTRDD FLGQVDVPLY PLPTENPRME 

       190        200        210        220        230        240 
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT 

       250        260        270        280        290        300 
HLPHPPEPSP LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 

       310        320        330        340        350        360 
AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV QTHLAEEFNT 

       370        380        390 
RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLP 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE35880.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK160570 mRNA. Translation: BAE35880.1.
UniGeneMm.279923.

3D structure databases

ProteinModelPortalQ3TUU1.
SMRQ3TUU1. Positions 75-211, 250-281.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ3TUU1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97297. Nedd4.

Phylogenomic databases

HOVERGENHBG079466.
InParanoidQ3TUU1.

Gene expression databases

ArrayExpressQ3TUU1.
BgeeQ3TUU1.
GenevestigatorQ3TUU1.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
IPR001202. WW_dom.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEPS50004. C2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEDD4. mouse.
SOURCESearch...

Entry information

Entry nameQ3TUU1_MOUSE
AccessionPrimary (citable) accession number: Q3TUU1
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)