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Protein

YEATS domain-containing protein 2

Gene

Yeats2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 2
Gene namesi
Name:Yeats2
Synonyms:Kiaa1197
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2447762. Yeats2.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  • mitotic spindle Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14071407YEATS domain-containing protein 2PRO_0000076367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei446 – 4461PhosphoserineBy similarity
Modified residuei462 – 4621PhosphoserineBy similarity
Modified residuei464 – 4641PhosphoserineBy similarity
Modified residuei470 – 4701PhosphoserineBy similarity
Modified residuei472 – 4721PhosphoserineCombined sources
Modified residuei477 – 4771PhosphothreonineBy similarity
Modified residuei534 – 5341PhosphoserineBy similarity
Modified residuei573 – 5731PhosphoserineBy similarity
Cross-linki590 – 590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei625 – 6251PhosphoserineBy similarity
Cross-linki1095 – 1095Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3TUF7.
MaxQBiQ3TUF7.
PaxDbiQ3TUF7.
PRIDEiQ3TUF7.

PTM databases

iPTMnetiQ3TUF7.
PhosphoSiteiQ3TUF7.

Expressioni

Gene expression databases

BgeeiQ3TUF7.
CleanExiMM_YEATS2.
GenevisibleiQ3TUF7. MM.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228952. 3 interactions.
IntActiQ3TUF7. 3 interactions.
STRINGi10090.ENSMUSP00000111222.

Structurei

3D structure databases

ProteinModelPortaliQ3TUF7.
SMRiQ3TUF7. Positions 205-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 318111YEATSPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili54 – 8027Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi792 – 82837Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 YEATS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000155538.
HOVERGENiHBG062745.
InParanoidiQ3TUF7.
OMAiPIPKIHG.
OrthoDBiEOG70PBX3.
PhylomeDBiQ3TUF7.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 2 hits.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TUF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ESSARDAAVQ KIETIIKEQF
60 70 80 90 100
ALEMKNKEHE IDVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGLK
110 120 130 140 150
TFDPMAFNHP AIKKFLESPS RSSSPTNQRS ETPSANHSES DSLSQHNDFL
160 170 180 190 200
SDKDNNSNVD VEERPPSTGE QRPSRKAGRD TSSISGSHKR ELRNADLTGD
210 220 230 240 250
ETSRLFVKKT IVVGNVSKYI PPDKREENDQ STHKWMVYVR GSRREPSINH
260 270 280 290 300
FVKKVWFFLH PSYKPNDLVE VREPPFHLTR RGWGEFPVRV QVHFKDSQNK
310 320 330 340 350
RIDIIHNLKL DRTYTGLQTL GAETVVDVEL HRHSLGEDSV YPQSSESDVC
360 370 380 390 400
DAPPPTLTLP AAVKASAVAQ SPEPAAAAPV GEGFPETTEA ERHSTFYSLP
410 420 430 440 450
SSLERTPTKV TTAQKVTFSS HGNSAFQPIA SSCKIVPQSQ VPNPESPGKS
460 470 480 490 500
FQPITMSCKI VSGSPISTPS PSPLPRTPTS TPVHLKQGTA SSGVSNPHVI
510 520 530 540 550
VDKPGQVIGA STPSTGSPTS KLPVASQASQ GTGSPIPKIH GSSFLTSTVK
560 570 580 590 600
QEESLFASMP PLCPIGSHPK VQSPKAVTGG LGAFTKVIIK QEPGEAPHVS
610 620 630 640 650
TTGAASQSAF PQYVTVKGGH MIAVSPQKQV ISAGEGTTQS PKIAPSKVVG
660 670 680 690 700
VPVGSALPST VKQAVAISSG QILVAKASSS VTKAVGPKQV VTQGVAKAIV
710 720 730 740 750
SGGGGTIVAQ PVQTLTKTQV TAAGPQKSGS QGSVMATLQL PATNLANLAN
760 770 780 790 800
LPPGTKLYLT TNSKNPSGKG KLLLIPQGAI LRATNNANLQ SGSAAAGGSG
810 820 830 840 850
SSGAGGGSGG GGGSGAGGTP STSGPGGGPQ HLTYTSYILK QTPQGTFLVG
860 870 880 890 900
QPSPQTPGKQ LTTASVVQGT LGVSSSSAQG QQTLKVISGQ KTTLFTQAAT
910 920 930 940 950
AGQASLLKLP DNTLKSVPAA PQLAKPGTTM LRVAGGVITA APSPAVAFSA
960 970 980 990 1000
NGAVHQSEGS TPVSSSVGSI IKTPGQPQVC VSQATMATCK GPAAVAGTAA
1010 1020 1030 1040 1050
SLVSAPSSIS GKATVSGLLK VHSAQSSPQQ AVLTIPSQLK PLSINTSGGV
1060 1070 1080 1090 1100
QTVLMPVNKV VQSFSTSKLP TTVLPISVPN QAAPSSAPVA IAKVKTEPET
1110 1120 1130 1140 1150
PGPNCISQEN QVAVKTEESS ELSNYVIKVD HLETIQQLLT AVVKKIPLIT
1160 1170 1180 1190 1200
AKGDDASCFS AKSLEQYYGW NIGKRRAAEW QRAMTVRKVL QEILEKNPRF
1210 1220 1230 1240 1250
HHLTPLKTKH IAHWCRCHGY TPPDPESLRH DGDSIEDVLT QIDSEPECLS
1260 1270 1280 1290 1300
SFSTADDLCR KLEDLQQFQK REPENEEEVD ILSLSEPLKT NIKKEQEEKQ
1310 1320 1330 1340 1350
EEMRFYLPPT PGSGFVGDIT QKIGITLQPV ALHRNMYASV VEDMILKATE
1360 1370 1380 1390 1400
QLVSDILRQA LAVGYQTASP NRIPKEITVS NIHQAICNIP FLDFLTNKHM

GRLNEDQ
Length:1,407
Mass (Da):148,950
Last modified:January 10, 2006 - v2
Checksum:iE5530016D1846E2E
GO
Isoform 2 (identifier: Q3TUF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1305: NIKKEQEEKQEEMRF → SASVVNLLFVCSKET
     1306-1407: Missing.

Note: No experimental confirmation available.
Show »
Length:1,305
Mass (Da):137,310
Checksum:i3A83B91FCB81F47A
GO
Isoform 3 (identifier: Q3TUF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:1,354
Mass (Da):142,996
Checksum:i0B5FCE3250F4E6CE
GO

Sequence cautioni

The sequence AAH57045.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC65745.3 differs from that shown.The sequence differs from that shown because it is derived from pre-RNA.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101L → V in BAC65745 (PubMed:12693553).Curated
Sequence conflicti1162 – 11621K → E in BAE36014 (PubMed:16141072).Curated
Sequence conflicti1294 – 12941K → R in BAE36014 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 3. 1 PublicationVSP_017006Add
BLAST
Alternative sequencei1291 – 130515NIKKE…EEMRF → SASVVNLLFVCSKET in isoform 2. 1 PublicationVSP_017007Add
BLAST
Alternative sequencei1306 – 1407102Missing in isoform 2. 1 PublicationVSP_017008Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160791 mRNA. Translation: BAE36014.1.
AK122463 Transcribed RNA. Translation: BAC65745.3. Sequence problems.
BC042768 mRNA. Translation: AAH42768.1.
BC057045 mRNA. Translation: AAH57045.1. Different initiation.
CCDSiCCDS28043.1. [Q3TUF7-3]
CCDS49790.1. [Q3TUF7-1]
RefSeqiNP_001028409.2. NM_001033237.2. [Q3TUF7-3]
NP_001139402.1. NM_001145930.1. [Q3TUF7-1]
XP_006521965.1. XM_006521902.2. [Q3TUF7-1]
UniGeneiMm.390895.

Genome annotation databases

EnsembliENSMUST00000090052; ENSMUSP00000087506; ENSMUSG00000041215. [Q3TUF7-3]
ENSMUST00000115560; ENSMUSP00000111222; ENSMUSG00000041215. [Q3TUF7-1]
GeneIDi208146.
KEGGimmu:208146.
UCSCiuc007ypj.2. mouse. [Q3TUF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160791 mRNA. Translation: BAE36014.1.
AK122463 Transcribed RNA. Translation: BAC65745.3. Sequence problems.
BC042768 mRNA. Translation: AAH42768.1.
BC057045 mRNA. Translation: AAH57045.1. Different initiation.
CCDSiCCDS28043.1. [Q3TUF7-3]
CCDS49790.1. [Q3TUF7-1]
RefSeqiNP_001028409.2. NM_001033237.2. [Q3TUF7-3]
NP_001139402.1. NM_001145930.1. [Q3TUF7-1]
XP_006521965.1. XM_006521902.2. [Q3TUF7-1]
UniGeneiMm.390895.

3D structure databases

ProteinModelPortaliQ3TUF7.
SMRiQ3TUF7. Positions 205-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228952. 3 interactions.
IntActiQ3TUF7. 3 interactions.
STRINGi10090.ENSMUSP00000111222.

PTM databases

iPTMnetiQ3TUF7.
PhosphoSiteiQ3TUF7.

Proteomic databases

EPDiQ3TUF7.
MaxQBiQ3TUF7.
PaxDbiQ3TUF7.
PRIDEiQ3TUF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090052; ENSMUSP00000087506; ENSMUSG00000041215. [Q3TUF7-3]
ENSMUST00000115560; ENSMUSP00000111222; ENSMUSG00000041215. [Q3TUF7-1]
GeneIDi208146.
KEGGimmu:208146.
UCSCiuc007ypj.2. mouse. [Q3TUF7-1]

Organism-specific databases

CTDi55689.
MGIiMGI:2447762. Yeats2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000155538.
HOVERGENiHBG062745.
InParanoidiQ3TUF7.
OMAiPIPKIHG.
OrthoDBiEOG70PBX3.
PhylomeDBiQ3TUF7.
TreeFamiTF314586.

Miscellaneous databases

NextBioi372166.
PROiQ3TUF7.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TUF7.
CleanExiMM_YEATS2.
GenevisibleiQ3TUF7. MM.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 2 hits.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Head.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-497.
    Tissue: Brain.
  3. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-1407 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 991-1407 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain and Mammary gland.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Spleen and Testis.

Entry informationi

Entry nameiYETS2_MOUSE
AccessioniPrimary (citable) accession number: Q3TUF7
Secondary accession number(s): Q6PGF8, Q80TI2, Q8CG86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: March 16, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.