Iqgap1

Functionⁱ

GO - Biological processⁱ

regulation of GTPase activity Source: InterPro
signal transduction Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Iqgap1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:1352757. Iqgap1.

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q3TU98.
PeptideAtlas More...PeptideAtlasⁱ	Q3TU98.
PRIDEⁱ	Q3TU98.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030536.
Genevisibleⁱ	Q3TU98. MM.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	227 – 460	Ras-GAPInterPro annotationAdd BLAST		234

Phylogenomic databases

eggNOGⁱ	KOG2128. Eukaryota. COG5261. LUCA.
HOVERGENⁱ	HBG052143.
KEGG Orthology (KO) More...KOⁱ	K16848.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000048. IQ_motif_EF-hand-BS. IPR000593. RasGAP_C. IPR023152. RasGAP_CS. IPR001936. RasGAP_dom. IPR008936. Rho_GTPase_activation_prot.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612. IQ. 3 hits. PF00616. RasGAP. 1 hit. PF03836. RasGAP_C. 1 hit.
SMARTⁱ	View protein in SMART SM00015. IQ. 3 hits. SM00323. RasGAP. 1 hit.
SUPFAMⁱ	SSF48350. SSF48350. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50096. IQ. 3 hits. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q3TU98-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
AITCIQSQWR GYKQKKAYQD RLAYLHSHKD EVVKIQSLAR MHQARKRYRD 
        60         70         80         90        100
RLQYFRDHIN DIIKIQAFIR ANKARDDYKT LINAEDPPMI VVRKFVHLLD 
       110        120        130        140        150
QSDQDFQEEL DLMKMREEVI TLIRSNQQLE NDLNLMDIKI GLLVKNKITL 
       160        170        180        190        200
QDVVSHSKKL TKKNKEQLSD MMMINKQKGG LKALSKEKRE KLEAYQHLFY 
       210        220        230        240        250
LLQTNPTYLA KLIFQMPQNK STKFMDSVIF TLYNYASNQR EEYLLLRLFQ 
       260        270        280        290        300
TALQEEIKSK VDQIQEIVTG NPTVIKMVVS FNRGARGQNA LRQILAPVVK 
       310        320        330        340        350
EIMDDKSLNI KTDPVDIYKS WVNQMESQTG EASKLPYDVT PEQALSHEEV 
       360        370        380        390        400
KTRLDNSIRN MRAVTDKFLS AIVSSVDKIP YGMRFIAKVL KDSLHEKFPD 
       410        420        430        440        450
AGEDELLKII GNLLYYRYMN PAIVAPDAFD IIDLSAGGQL TTDQRRNLGS 
       460        470        480        490        500
IAKMLQHAAS NKMFLGDNAH LSIINEYLSQ SYQKFRRFFQ VACDVPELQD 
       510        520        530        540        550
KFNVDEYSDL VTLTKPVIYI SIGEIINTHT LLLDHQDAIA PEHNDPIHEL 
       560        570        580        590        600
LDDLGEVPTI ESLIGESCGN SNDPNKEALA KTEVSLTLTN KFDVPGDENA 
       610        620        630        640        650
EMDARTILLN TKRLIVDVIR FQPGETLTEI LETPATNEQE AEHQRAMQRR 
       660        670        680        690        700
AIRDAKTPDK MKKSKPMKED NNLSLQEKKE KIQTGLKKLT ELGTVDPKNR 
       710        720        730        740        750
YQELINDIAK DIRNQRRYRQ RRKAELVKLQ QTYSALNSKA TFYGEQVDYY 
       760        770        780        790        800
KSYIKTCLDN LASKGKVSKK PREMKGKKSK KISLKYTAAR LHEKGVLLEI 
       810        820        830        840        850
EDLQANQFKN VIFEIGPTEE VGDFEVKAKF MGVQMETFML HYQDLLQLQY 
       860        870        880
EGVAVMKLFD RAKVNVNLLI FLLNKKFYGK

Length:880

Mass (Da):101,659

Last modified:October 11, 2005 - v1

Checksum:ⁱCF018F72FA615E8B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK160892 mRNA. Translation: BAE36073.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_057930.2. NM_016721.2.
UniGeneⁱ	Mm.207619.

Genome annotation databases

GeneIDⁱ	29875.
KEGGⁱ	mmu:29875.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK160892 mRNA. Translation: BAE36073.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_057930.2. NM_016721.2.
UniGeneⁱ	Mm.207619.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3TU98.
PeptideAtlas More...PeptideAtlasⁱ	Q3TU98.
PRIDEⁱ	Q3TU98.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	29875.
KEGGⁱ	mmu:29875.

Organism-specific databases

CTDⁱ	8826.
MGIⁱ	MGI:1352757. Iqgap1.

Phylogenomic databases

eggNOGⁱ	KOG2128. Eukaryota. COG5261. LUCA.
HOVERGENⁱ	HBG052143.
KEGG Orthology (KO) More...KOⁱ	K16848.

Miscellaneous databases

ChiTaRSⁱ	Iqgap1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030536.
Genevisibleⁱ	Q3TU98. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000048. IQ_motif_EF-hand-BS. IPR000593. RasGAP_C. IPR023152. RasGAP_CS. IPR001936. RasGAP_dom. IPR008936. Rho_GTPase_activation_prot.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612. IQ. 3 hits. PF00616. RasGAP. 1 hit. PF03836. RasGAP_C. 1 hit.
SMARTⁱ	View protein in SMART SM00015. IQ. 3 hits. SM00323. RasGAP. 1 hit.
SUPFAMⁱ	SSF48350. SSF48350. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50096. IQ. 3 hits. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3TU98_MOUSE
Accessionⁱ	Q3TU98Primary (citable) accession number: Q3TU98
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q3TU98 (Q3TU98_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3TU98 (Q3TU98_MOUSE)

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Putative uncharacterized protein

Iqgap1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ