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Protein

DNA-directed RNA polymerase subunit

Gene

Polr1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:Polr1aImported
Synonyms:Rpo1-4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1096397. Polr1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ3TU49.

Expressioni

Gene expression databases

GenevisibleiQ3TU49. MM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 649RPOLA_NInterPro annotationAdd BLAST348

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1182 – 1202Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0262. Eukaryota.
COG0086. LUCA.
HOVERGENiHBG017741.
KOiK02999.

Family and domain databases

Gene3Di1.10.132.30. 1 hit.
InterProiView protein in InterPro
IPR015699. DNA-dir_RNA_pol1_lsu.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
IPR038120. Rpb1_funnel_sf.
PANTHERiPTHR19376:SF11. PTHR19376:SF11. 1 hit.
PfamiView protein in Pfam
PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
SMARTiView protein in SMART
SM00663. RPOLA_N. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3TU49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASKHTPWR RLQGISFGMY SAEELKKLSV KSITNPRYVD YLGNPSANGL
60 70 80 90 100
YDLALGPADS KEVCATCVQD FNNCSGHLGH IDLPLTVYNP FLFDKLYLLL
110 120 130 140 150
RGSCLSCHML TCPRAAIYLL ISQLRVLEVG ALQAVYELER ILSRFLEETG
160 170 180 190 200
DPSAFEIQEE LEEYTSKILQ NNLLGSQGTH VKNVCESRSK LVAQFWKTHM
210 220 230 240 250
AAKQCPHCKT GRSVVRKEHN SKLIITYPAT VHKKSDQEGT ELPEGVPEAP
260 270 280 290 300
GIDKAQMGKR GYLTPSSAQE HLFAIWKNEG FFLNYLFSGL DDIGPESSFN
310 320 330 340 350
PSMFFLDFIV VPPSRYRPVN RLGDQMFTNG QTVNLQAVMK DAVLIRKLLA
360 370 380 390 400
LMAQEQKLPC EMTELTIDKE NDSSVAIDRS FLGLLPGPSL TDKLYNIWIR
410 420 430 440 450
LQSHVNIVFD SEMDKLMLEK YPGIRQILEK KEGLFRKHMM GKRVDYAARS
460 470 480 490 500
VICPDMYINT NEIGIPMVFA TKLTYPQPVT PWNVQELRQA VINGPNVHPG
510 520 530 540 550
ASMVINEDGS RTALSSVDAA QREAVAKQLL TPATGAPKPQ GTKVVCRHVK
560 570 580 590 600
NGDILLLNRQ PTLHRPSIQA HRARILPEEK VLRLHYANCK AYNADFDGDE
610 620 630 640 650
MNAHFPQSEL GRAEAYVLAC TDQQYLVPKD GQPLAGLIQD HMVSGANMTI
660 670 680 690 700
RGCFFTREQY MELVYRGLTD KVGRVKLFPP AILKPFPLWT GKQVVSTLLI
710 720 730 740 750
NIIPEDYAPL NLSGKAKIGS KAWVKEKPRP IPDFDPDSMC ESQVIIREGE
760 770 780 790 800
LLCGVLDKAH YGSSAYGLVH CCYEIYGGET SGRVLTCLAR LFTAYLQLYR
810 820 830 840 850
GFTLGVEDIL VKPNADVVRQ RIIEESTQCG PQAVKAALSL PETASCDEIQ
860 870 880 890 900
GKWQDAHLSK DQRDFNMIDM KFKEEVNHYS NEINKACMPL GLHRQFPENN
910 920 930 940 950
LQMMVQSGAK GSTVNTMQIS CLLGQIELEG RRPPLMASGK SLPCFEPYEF
960 970 980 990 1000
TPRAGGFVTG RFLTGIRPPE FFFHCMAGRE GLVDTAVKTS RSGYLQRCII
1010 1020 1030 1040 1050
KHLEGLVIQY DLTVRDSDGS VVQFLYGEDG LDIPKTQFLQ PKQFPFLAGN
1060 1070 1080 1090 1100
YEVIMKSKHL HEVLSRADPQ KVLGHIKAIK KWHHKHSGAL LRKGAFLSFS
1110 1120 1130 1140 1150
QKIQAAVKAL NLKGSIQNGR SPETQQMLQM WYDLDEESRW KYQKRAAPCP
1160 1170 1180 1190 1200
DPSLSVWRPD IYFASVSETF EKKIDDFSQE WAAQAERSYK KSELSLDRLR
1210 1220 1230 1240 1250
TLLQLKWQRS LCDPGEAVGL LAAQSIGEPS TQMTLNTFHF AGRGEMNVTL
1260 1270 1280 1290 1300
GIPRLREILM VASANIKTPM MSVPVFDTKK ALKKVKSLKK RLTRVCLGEV
1310 1320 1330 1340 1350
LQKVDIQESF CMGEKRNKFQ VYELRFQFLP HAYYQQEKCL RPEDILHFME
1360
TRFFKLLMEA T
Length:1,361
Mass (Da):153,562
Last modified:October 11, 2005 - v1
Checksum:iE944F85E084F2F44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1361Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160970 mRNA. Translation: BAE36122.1.
RefSeqiNP_033114.3. NM_009088.3.
UniGeneiMm.135581.

Genome annotation databases

GeneIDi20019.
KEGGimmu:20019.

Similar proteinsi

Entry informationi

Entry nameiQ3TU49_MOUSE
AccessioniPrimary (citable) accession number: Q3TU49
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)