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Q3TTY5

- K22E_MOUSE

UniProt

Q3TTY5 - K22E_MOUSE

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Protein

Keratin, type II cytoskeletal 2 epidermal

Gene

Krt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei450 – 4501StutterSequence Analysis

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. keratinization Source: Ensembl
  2. keratinocyte activation Source: Ensembl
  3. keratinocyte migration Source: Ensembl
  4. keratinocyte proliferation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 2 epidermal
Alternative name(s):
Cytokeratin-2e
Short name:
CK-2e
Epithelial keratin-2e
Keratin-2 epidermis
Keratin-2e
Short name:
K2e
Type-II keratin Kb2
Gene namesi
Name:Krt2Imported
Synonyms:K2e, Krt2-17Imported, Krt2aBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96699. Krt2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. keratin filament Source: InterPro
  5. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Defects in Krt2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth. Hyperkeratoses and shedding of the outer layers of the epidermis (molting) are observed in later weeks.

Keywords - Diseasei

Disease mutation, Ichthyosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Keratin, type II cytoskeletal 2 epidermalPRO_0000283763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3TTY5.
PaxDbiQ3TTY5.
PRIDEiQ3TTY5.

PTM databases

PhosphoSiteiQ3TTY5.

Expressioni

Tissue specificityi

Expressed mainly in the middle spinous and granular cells of the epidermis of adult tail, nipple and footsole skin. Also found in ear.3 Publications

Developmental stagei

Induction occurs during the first 2 weeks after birth, being first observed in the epidermis of tail then the footpad and later in the ear.1 Publication

Gene expression databases

BgeeiQ3TTY5.
CleanExiMM_KRT2.
GenevestigatoriQ3TTY5.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Associates with KRT10.1 PublicationCurated

Protein-protein interaction databases

BioGridi201033. 7 interactions.
IntActiQ3TTY5. 1 interaction.
MINTiMINT-1867051.
STRINGi10090.ENSMUSP00000023712.

Structurei

3D structure databases

ProteinModelPortaliQ3TTY5.
SMRiQ3TTY5. Positions 199-338, 365-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 198198HeadSequence AnalysisAdd
BLAST
Regioni199 – 508310RodSequence AnalysisAdd
BLAST
Regioni199 – 23436Coil 1ASequence AnalysisAdd
BLAST
Regioni235 – 25319Linker 1Sequence AnalysisAdd
BLAST
Regioni254 – 34592Coil 1BSequence AnalysisAdd
BLAST
Regioni346 – 36924Linker 12Sequence AnalysisAdd
BLAST
Regioni370 – 508139Coil 2Sequence AnalysisAdd
BLAST
Regioni509 – 707199TailSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 701690Gly-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146769.
GeneTreeiENSGT00760000118796.
HOVERGENiHBG013015.
InParanoidiQ3TTY5.
KOiK07605.
OMAiTNLDPIF.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TTY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCQISCRSR RGGGGGGGGG FRGFSSGSAV VSGGSRRSNT SFSCISRHGG
60 70 80 90 100
GRGGSGGGGF GSQSLVGLGG YKSISSSVAG NSGGYGGSSF GGSSGFGGGR
110 120 130 140 150
GFGGGQGFGG SGGFGGGSGF GGGQGFGGGS RFGGGSGFGG GGFGGGSFGG
160 170 180 190 200
GRFGGGPGGF GGPGGFPGGG IHEVSVNQSL LQPLDVKVDP EIQNVKSQER
210 220 230 240 250
EQIKTLNNKF ASFIDKVRFL EQQNQVLRTK WELLQQLDVG SRTTNLDPIF
260 270 280 290 300
QAYIGMLKKQ VDRLSAERTS QESELNNMQD LVEDFKKKYE DEINKRTSAE
310 320 330 340 350
NDFVTIKKDV DSCYMDKTEL QARLDILAQE VNFLRTLYDA ELSQLQQDVT
360 370 380 390 400
DTNVILSMDN NRNLDLDSII AEVQNQYEMI AHKSKAESEE LYHSKYEELQ
410 420 430 440 450
VTAVKHGDSL KEIKMEISEL NRTIQRLQGE ISHVKKQCKG VQDSIADAEQ
460 470 480 490 500
RGEHAIKDAR GKLTDLEEAL QQCREDLARL LRDYQELMNT KLSLDVEIAT
510 520 530 540 550
YRKLLEGEEC RMSGDFSDNV SVSITSSTIS SSVASKTGFG SGGQSSGGRG
560 570 580 590 600
SYGGRGGGGG GGSTYGSGGR SSGSRGSGSG SGGGGYSSGG GSRGGSGGGY
610 620 630 640 650
GSGGGSRGGS GGGYGSGGGS GSGGGYSSGG GSRGGSGGGG VSSGGGSRGG
660 670 680 690 700
SSSGGGSRGG SSSGGGGYSS GGGSRGGSSS GGAGSSSEKG GSGSGEGCGS

GVTFSFR
Length:707
Mass (Da):70,923
Last modified:October 11, 2005 - v1
Checksum:i464D375DCBA90EF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2469DVGSRTTNL → ACRQPHHKP in CAA52788. (PubMed:7508961)Curated
Sequence conflicti361 – 3611N → T in CAA52788. (PubMed:7508961)Curated
Sequence conflicti439 – 4391K → I in CAA52788. (PubMed:7508961)Curated
Sequence conflicti451 – 4511R → H in CAA52788. (PubMed:7508961)Curated
Sequence conflicti533 – 5331V → M in CAA52788. (PubMed:7508961)Curated
Sequence conflicti562 – 5621Missing in AAI20486. (PubMed:15489334)Curated
Sequence conflicti564 – 5641T → S in CAA52788. (PubMed:7508961)Curated
Sequence conflicti625 – 6251G → GG in AAI20486. (PubMed:15489334)Curated
Sequence conflicti641 – 6411V → A in CAA52788. (PubMed:7508961)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti500 – 5001T → P in IBS. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74784 mRNA. Translation: CAA52788.1.
AK132476 mRNA. Translation: BAE21186.1.
AK161078 mRNA. Translation: BAE36187.1.
AK161098 mRNA. Translation: BAE36194.1.
BC120485 mRNA. Translation: AAI20486.1.
CCDSiCCDS37220.1.
RefSeqiNP_034798.2. NM_010668.2.
UniGeneiMm.358616.

Genome annotation databases

EnsembliENSMUST00000023712; ENSMUSP00000023712; ENSMUSG00000064201.
GeneIDi16681.
KEGGimmu:16681.
UCSCiuc007xub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74784 mRNA. Translation: CAA52788.1 .
AK132476 mRNA. Translation: BAE21186.1 .
AK161078 mRNA. Translation: BAE36187.1 .
AK161098 mRNA. Translation: BAE36194.1 .
BC120485 mRNA. Translation: AAI20486.1 .
CCDSi CCDS37220.1.
RefSeqi NP_034798.2. NM_010668.2.
UniGenei Mm.358616.

3D structure databases

ProteinModelPortali Q3TTY5.
SMRi Q3TTY5. Positions 199-338, 365-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201033. 7 interactions.
IntActi Q3TTY5. 1 interaction.
MINTi MINT-1867051.
STRINGi 10090.ENSMUSP00000023712.

PTM databases

PhosphoSitei Q3TTY5.

Proteomic databases

MaxQBi Q3TTY5.
PaxDbi Q3TTY5.
PRIDEi Q3TTY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023712 ; ENSMUSP00000023712 ; ENSMUSG00000064201 .
GeneIDi 16681.
KEGGi mmu:16681.
UCSCi uc007xub.1. mouse.

Organism-specific databases

CTDi 3849.
MGIi MGI:96699. Krt2.

Phylogenomic databases

eggNOGi NOG146769.
GeneTreei ENSGT00760000118796.
HOVERGENi HBG013015.
InParanoidi Q3TTY5.
KOi K07605.
OMAi TNLDPIF.
OrthoDBi EOG7FV3Q8.
TreeFami TF317854.

Miscellaneous databases

NextBioi 290429.
PROi Q3TTY5.
SOURCEi Search...

Gene expression databases

Bgeei Q3TTY5.
CleanExi MM_KRT2.
Genevestigatori Q3TTY5.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An unusual type-II 70-kilodalton keratin protein of mouse epidermis exhibiting postnatal body-site specificity and sensitivity to hyperproliferation."
    Rentrop M., Nischt R., Knapp B., Schweizer J., Winter H.
    Differentiation 34:189-200(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: NMRI1 Publication.
    Tissue: Foot sole tissue1 Publication.
  2. "The large type II 70-kDa keratin of mouse epidermis is the ortholog of human keratin K2e."
    Herzog F., Winter H., Schweizer J.
    J. Invest. Dermatol. 102:165-170(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: NMRIImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 23-36; 210-216; 288-296 AND 483-491, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "Out of balance: consequences of a partial keratin 10 knockout."
    Reichelt J., Bauer C., Porter R., Lane E., Magin V.
    J. Cell Sci. 110:2175-2186(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KRT10.
  7. Cited for: TISSUE SPECIFICITY.
  8. Cited for: VARIANT IBS PRO-500.

Entry informationi

Entry nameiK22E_MOUSE
AccessioniPrimary (citable) accession number: Q3TTY5
Secondary accession number(s): Q0VBW1, Q61869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3