Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3TTM4 (Q3TTM4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Axl MGI 1347244
OrganismMus musculus (Mouse) EMBL BAE36301.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length530 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307

Contains 1 protein kinase domain.

Contains protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
   LigandATP-binding SAAS SAAS008266
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase RuleBase RU000307 SAAS SAAS008266
Gene Ontology (GO)
   Biological_processapoptotic cell clearance

Inferred from mutant phenotype PubMed 18804096. Source: MGI

blood vessel remodeling

Inferred from mutant phenotype PubMed 16627783. Source: MGI

cell maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to extracellular stimulus

Inferred from direct assay PubMed 10322635. Source: MGI

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-alpha

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

dendritic cell differentiation

Inferred from electronic annotation. Source: Ensembl

enzyme linked receptor protein signaling pathway

Inferred from genetic interaction PubMed 9395235. Source: MGI

erythrocyte homeostasis

Inferred from mutant phenotype PubMed 18188450. Source: MGI

forebrain cell migration

Inferred from genetic interaction PubMed 18787040. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 16627783. Source: MGI

natural killer cell differentiation

Inferred from genetic interaction PubMed 16751775. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16627783. Source: MGI

negative regulation of dendritic cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of lymphocyte activation

Inferred from genetic interaction PubMed 11452127. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 18787040. Source: MGI

negative regulation of tumor necrosis factor production

Inferred from genetic interaction PubMed 16831897. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 19463168. Source: MGI

organ regeneration

Inferred from electronic annotation. Source: Ensembl

ovulation cycle

Inferred from genetic interaction PubMed 18787040. Source: MGI

phagocytosis

Inferred from genetic interaction PubMed 19602523. Source: MGI

platelet activation

Inferred from mutant phenotype PubMed 15650770. Source: MGI

positive regulation of cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell differentiation

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from mutant phenotype PubMed 16627783. Source: MGI

secretion by cell

Inferred from mutant phenotype PubMed 15650770. Source: MGI

spermatogenesis

Inferred from genetic interaction PubMed 10227296PubMed 19602523. Source: MGI

substrate adhesion-dependent cell spreading

Inferred from mutant phenotype PubMed 15650770. Source: MGI

vagina development

Inferred from genetic interaction PubMed 18393392. Source: MGI

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatidylserine binding

Inferred from electronic annotation. Source: Ensembl

protein heterodimerization activity

Inferred from physical interaction PubMed 18787040. Source: MGI

protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE36301.1

Sequences

Sequence LengthMass (Da)Tools
Q3TTM4 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: F88AA1D09D7EEE3D

FASTA53059,159
        10         20         30         40         50         60 
LGYRLAYRGQ DTPEVLMDIG LTREVTLELR GDRPVANLTV SVTAYTSAGD GPWSLPVPLE 

        70         80         90        100        110        120 
PWRPGQGQPL HHLVSEPPPR AFSWPWWYVL LGALVAAACV LILALFLVHR RKKETRYGEV 

       130        140        150        160        170        180 
FEPTVERGEL VVRYRVRKSY SRRTTEATLN SLGISEELKE KLRDVMVDRH KVALGKTLGE 

       190        200        210        220        230        240 
GEFGAVMEGQ LNQDDSILKV AVKTMKIAIC TRSELEDFLS EAVCMKEFDH PNVMRLIGVC 

       250        260        270        280        290        300 
FQGSDREGFP EPVVILPFMK HGDLHSFLLY SRLGDQPVFL PTQMLVKFMA DIASGMEYLS 

       310        320        330        340        350        360 
TKRFIHRDLA ARNCMLNENM SVCVADFGLS KKIYNGDYYR QGRIAKMPVK WIAIESLADR 

       370        380        390        400        410        420 
VYTSKSDVWS FGVTMWEIAT RGQTPYPGVE NSEIYDYLRQ GNRLKQPVDC LDGLYALMSR 

       430        440        450        460        470        480 
CWELNPRDRP SFAELREDLE NTLKALPPAQ EPDEILYVNM DEGGSHLEPR GAAGGADPPT 

       490        500        510        520        530 
QPDPKDSCSC LTAADVHSAG RYVLCPSTAP GPTLSADRGC PAPPGQEDGA 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE36301.1.
Tissue: Testis EMBL BAE36301.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK161294 mRNA. Translation: BAE36301.1.
UniGeneMm.4128.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1347244. Axl.

Phylogenomic databases

HOVERGENHBG006346.
InParanoidQ3TTM4.

Gene expression databases

ArrayExpressQ3TTM4.
BgeeQ3TTM4.
GenevestigatorQ3TTM4.

Family and domain databases

InterProIPR003961. Fibronectin_type3.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAXL. mouse.
SOURCESearch...

Entry information

Entry nameQ3TTM4_MOUSE
AccessionPrimary (citable) accession number: Q3TTM4
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)