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Protein
Submitted name:

Putative uncharacterized protein

Gene

Axl

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphatidylserine binding Source: MGI
  3. protein heterodimerization activity Source: MGI
  4. protein tyrosine kinase activity Source: MGI

GO - Biological processi

  1. apoptotic cell clearance Source: MGI
  2. blood vessel remodeling Source: MGI
  3. cell maturation Source: Ensembl
  4. cellular response to extracellular stimulus Source: MGI
  5. cellular response to hydrogen peroxide Source: Ensembl
  6. cellular response to interferon-alpha Source: MGI
  7. cellular response to lipopolysaccharide Source: MGI
  8. dendritic cell differentiation Source: Ensembl
  9. enzyme linked receptor protein signaling pathway Source: MGI
  10. erythrocyte homeostasis Source: MGI
  11. forebrain cell migration Source: MGI
  12. inflammatory response Source: MGI
  13. natural killer cell differentiation Source: MGI
  14. negative regulation of apoptotic process Source: MGI
  15. negative regulation of dendritic cell apoptotic process Source: MGI
  16. negative regulation of interferon-gamma production Source: MGI
  17. negative regulation of lymphocyte activation Source: MGI
  18. negative regulation of neuron apoptotic process Source: MGI
  19. negative regulation of tumor necrosis factor production Source: MGI
  20. neuron migration Source: MGI
  21. organ regeneration Source: Ensembl
  22. ovulation cycle Source: MGI
  23. peptidyl-tyrosine phosphorylation Source: MGI
  24. phagocytosis Source: MGI
  25. platelet activation Source: MGI
  26. positive regulation of cytokine-mediated signaling pathway Source: MGI
  27. positive regulation of natural killer cell differentiation Source: MGI
  28. protein kinase B signaling Source: MGI
  29. secretion by cell Source: MGI
  30. spermatogenesis Source: MGI
  31. substrate adhesion-dependent cell spreading Source: MGI
  32. vagina development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:AxlImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1347244. Axl.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3TTM4.
ExpressionAtlasiQ3TTM4. baseline and differential.
GenevestigatoriQ3TTM4.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG006346.

Family and domain databases

InterProiIPR003961. FN3_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TTM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LGYRLAYRGQ DTPEVLMDIG LTREVTLELR GDRPVANLTV SVTAYTSAGD
60 70 80 90 100
GPWSLPVPLE PWRPGQGQPL HHLVSEPPPR AFSWPWWYVL LGALVAAACV
110 120 130 140 150
LILALFLVHR RKKETRYGEV FEPTVERGEL VVRYRVRKSY SRRTTEATLN
160 170 180 190 200
SLGISEELKE KLRDVMVDRH KVALGKTLGE GEFGAVMEGQ LNQDDSILKV
210 220 230 240 250
AVKTMKIAIC TRSELEDFLS EAVCMKEFDH PNVMRLIGVC FQGSDREGFP
260 270 280 290 300
EPVVILPFMK HGDLHSFLLY SRLGDQPVFL PTQMLVKFMA DIASGMEYLS
310 320 330 340 350
TKRFIHRDLA ARNCMLNENM SVCVADFGLS KKIYNGDYYR QGRIAKMPVK
360 370 380 390 400
WIAIESLADR VYTSKSDVWS FGVTMWEIAT RGQTPYPGVE NSEIYDYLRQ
410 420 430 440 450
GNRLKQPVDC LDGLYALMSR CWELNPRDRP SFAELREDLE NTLKALPPAQ
460 470 480 490 500
EPDEILYVNM DEGGSHLEPR GAAGGADPPT QPDPKDSCSC LTAADVHSAG
510 520 530
RYVLCPSTAP GPTLSADRGC PAPPGQEDGA
Length:530
Mass (Da):59,159
Last modified:October 11, 2005 - v1
Checksum:iF88AA1D09D7EEE3D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161294 mRNA. Translation: BAE36301.1.
UniGeneiMm.4128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161294 mRNA. Translation: BAE36301.1.
UniGeneiMm.4128.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1347244. Axl.

Phylogenomic databases

HOVERGENiHBG006346.

Miscellaneous databases

ChiTaRSiAxl. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TTM4.
ExpressionAtlasiQ3TTM4. baseline and differential.
GenevestigatoriQ3TTM4.

Family and domain databases

InterProiIPR003961. FN3_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ3TTM4_MOUSE
AccessioniPrimary (citable) accession number: Q3TTM4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 1, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.