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Q3TTM4

- Q3TTM4_MOUSE

UniProt

Q3TTM4 - Q3TTM4_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Axl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphatidylserine binding Source: Ensembl
    3. protein heterodimerization activity Source: MGI
    4. protein tyrosine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic cell clearance Source: MGI
    2. blood vessel remodeling Source: MGI
    3. cell maturation Source: Ensembl
    4. cellular response to extracellular stimulus Source: MGI
    5. cellular response to hydrogen peroxide Source: Ensembl
    6. cellular response to interferon-alpha Source: Ensembl
    7. cellular response to lipopolysaccharide Source: Ensembl
    8. dendritic cell differentiation Source: Ensembl
    9. enzyme linked receptor protein signaling pathway Source: MGI
    10. erythrocyte homeostasis Source: MGI
    11. forebrain cell migration Source: MGI
    12. inflammatory response Source: MGI
    13. natural killer cell differentiation Source: MGI
    14. negative regulation of apoptotic process Source: MGI
    15. negative regulation of dendritic cell apoptotic process Source: Ensembl
    16. negative regulation of interferon-gamma production Source: Ensembl
    17. negative regulation of lymphocyte activation Source: MGI
    18. negative regulation of neuron apoptotic process Source: MGI
    19. negative regulation of tumor necrosis factor production Source: MGI
    20. neuron migration Source: MGI
    21. organ regeneration Source: Ensembl
    22. ovulation cycle Source: MGI
    23. phagocytosis Source: MGI
    24. platelet activation Source: MGI
    25. positive regulation of cytokine-mediated signaling pathway Source: Ensembl
    26. positive regulation of natural killer cell differentiation Source: Ensembl
    27. protein kinase B signaling Source: MGI
    28. secretion by cell Source: MGI
    29. spermatogenesis Source: MGI
    30. substrate adhesion-dependent cell spreading Source: MGI
    31. vagina development Source: MGI

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:AxlImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1347244. Axl.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TTM4.
    BgeeiQ3TTM4.
    GenevestigatoriQ3TTM4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG006346.
    InParanoidiQ3TTM4.

    Family and domain databases

    InterProiIPR003961. Fibronectin_type3.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3TTM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    LGYRLAYRGQ DTPEVLMDIG LTREVTLELR GDRPVANLTV SVTAYTSAGD    50
    GPWSLPVPLE PWRPGQGQPL HHLVSEPPPR AFSWPWWYVL LGALVAAACV 100
    LILALFLVHR RKKETRYGEV FEPTVERGEL VVRYRVRKSY SRRTTEATLN 150
    SLGISEELKE KLRDVMVDRH KVALGKTLGE GEFGAVMEGQ LNQDDSILKV 200
    AVKTMKIAIC TRSELEDFLS EAVCMKEFDH PNVMRLIGVC FQGSDREGFP 250
    EPVVILPFMK HGDLHSFLLY SRLGDQPVFL PTQMLVKFMA DIASGMEYLS 300
    TKRFIHRDLA ARNCMLNENM SVCVADFGLS KKIYNGDYYR QGRIAKMPVK 350
    WIAIESLADR VYTSKSDVWS FGVTMWEIAT RGQTPYPGVE NSEIYDYLRQ 400
    GNRLKQPVDC LDGLYALMSR CWELNPRDRP SFAELREDLE NTLKALPPAQ 450
    EPDEILYVNM DEGGSHLEPR GAAGGADPPT QPDPKDSCSC LTAADVHSAG 500
    RYVLCPSTAP GPTLSADRGC PAPPGQEDGA 530
    Length:530
    Mass (Da):59,159
    Last modified:October 11, 2005 - v1
    Checksum:iF88AA1D09D7EEE3D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK161294 mRNA. Translation: BAE36301.1.
    UniGeneiMm.4128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK161294 mRNA. Translation: BAE36301.1 .
    UniGenei Mm.4128.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1347244. Axl.

    Phylogenomic databases

    HOVERGENi HBG006346.
    InParanoidi Q3TTM4.

    Miscellaneous databases

    ChiTaRSi AXL. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TTM4.
    Bgeei Q3TTM4.
    Genevestigatori Q3TTM4.

    Family and domain databases

    InterProi IPR003961. Fibronectin_type3.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.

    Entry informationi

    Entry nameiQ3TTM4_MOUSE
    AccessioniPrimary (citable) accession number: Q3TTM4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)