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Protein

Transcription factor YY2

Gene

Yy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 284C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 341C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-MMU-174800. Chylomicron-mediated lipid transport.
R-MMU-381033. ATF6 (ATF6-alpha) activates chaperones.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor YY2
Alternative name(s):
Yin and yang 2
Short name:
YY-2
Gene namesi
Name:Yy2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3837947. Yy2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237611 – 378Transcription factor YY2Add BLAST378

Proteomic databases

MaxQBiQ3TTC2.
PaxDbiQ3TTC2.
PeptideAtlasiQ3TTC2.
PRIDEiQ3TTC2.

PTM databases

iPTMnetiQ3TTC2.
PhosphoSitePlusiQ3TTC2.

Expressioni

Tissue specificityi

Weakly expressed by neuronal and glial cells in the cerebral cortex. Expressed by Purkinje cells and in the granular layers of the cerebellum. Expressed in all layers of spermatocytes in testis but not detected in sperm cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000091736.
ExpressionAtlasiQ3TTC2. baseline and differential.
GenevisibleiQ3TTC2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070112.

Structurei

3D structure databases

ProteinModelPortaliQ3TTC2.
SMRiQ3TTC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 113Mediates transcriptional activationBy similarityAdd BLAST75
Regioni243 – 378Mediates transcriptional repressionBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the YY transcription factor family.Curated
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 284C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 341C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048066.
ENSGT00760000118771.
HOGENOMiHOG000008232.
HOVERGENiHBG006823.
InParanoidiQ3TTC2.
KOiK09201.
OrthoDBiEOG091G03FM.
PhylomeDBiQ3TTC2.
TreeFamiTF106493.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR017114. TF_Yin_yang.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PIRSFiPIRSF037113. TF_Yin_yang. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TTC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASETEKLLC LNTESAEIPA DFVELLPPDN IGDIEAVSLE TSVGQTIEVY
60 70 80 90 100
GDVGVDWAHG SQYHSPVIAL QPLVGSSLSS RDHDKEMFVV QTREEEVVGY
110 120 130 140 150
QDSDNLLFSP EFGSQMVLPV NEDDYLQPTT ASFTGFLAAE NGQGELSPYE
160 170 180 190 200
GNLCGLTTFI EAGAEESVNA DLGDKQWEQK QIDGLDGEFP FTMWDDVNEK
210 220 230 240 250
EDPIAEEQAG ESPPDYSEYM TGKKFPPEGI PGIDLSDPKQ LAEFTSMRPK
260 270 280 290 300
KPKGDFPRPI ACSHKGCEKM FKDNSAMRKH LHIHGPRVHV CAECGKAFVE
310 320 330 340 350
SSKLKRHQLV HTGEKPYQCT FEGCGRRFSL DFNLRTHVRI HTGDKPFVCP
360 370
FDACNKKFAQ STNLKSHILT HVKNKNDQ
Length:378
Mass (Da):42,031
Last modified:October 11, 2005 - v1
Checksum:i8B2E3C9BDFD0FC36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327R → H in BAC29297 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF688658 Genomic DNA. Translation: ABS18955.1.
AK036071 mRNA. Translation: BAC29297.1.
AK161451 mRNA. Translation: BAE36403.1.
CCDSiCCDS53233.1.
RefSeqiNP_001092193.1. NM_001098723.1.
UniGeneiMm.37577.
Mm.491276.

Genome annotation databases

EnsembliENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736.
ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873.
GeneIDi100073351.
KEGGimmu:100073351.
UCSCiuc012hra.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF688658 Genomic DNA. Translation: ABS18955.1.
AK036071 mRNA. Translation: BAC29297.1.
AK161451 mRNA. Translation: BAE36403.1.
CCDSiCCDS53233.1.
RefSeqiNP_001092193.1. NM_001098723.1.
UniGeneiMm.37577.
Mm.491276.

3D structure databases

ProteinModelPortaliQ3TTC2.
SMRiQ3TTC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070112.

PTM databases

iPTMnetiQ3TTC2.
PhosphoSitePlusiQ3TTC2.

Proteomic databases

MaxQBiQ3TTC2.
PaxDbiQ3TTC2.
PeptideAtlasiQ3TTC2.
PRIDEiQ3TTC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736.
ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873.
GeneIDi100073351.
KEGGimmu:100073351.
UCSCiuc012hra.2. mouse.

Organism-specific databases

CTDi404281.
MGIiMGI:3837947. Yy2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00510000048066.
ENSGT00760000118771.
HOGENOMiHOG000008232.
HOVERGENiHBG006823.
InParanoidiQ3TTC2.
KOiK09201.
OrthoDBiEOG091G03FM.
PhylomeDBiQ3TTC2.
TreeFamiTF106493.

Enzyme and pathway databases

ReactomeiR-MMU-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-MMU-174800. Chylomicron-mediated lipid transport.
R-MMU-381033. ATF6 (ATF6-alpha) activates chaperones.

Miscellaneous databases

PROiQ3TTC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091736.
ExpressionAtlasiQ3TTC2. baseline and differential.
GenevisibleiQ3TTC2. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR017114. TF_Yin_yang.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PIRSFiPIRSF037113. TF_Yin_yang. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYY2_MOUSE
AccessioniPrimary (citable) accession number: Q3TTC2
Secondary accession number(s): Q8CBG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.