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Protein

Transcription factor YY2

Gene

Yy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.1 Publication

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 284C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 341C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-MMU-381033 ATF6 (ATF6-alpha) activates chaperones
R-MMU-8874211 CREB3 factors activate genes

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor YY2
Alternative name(s):
Yin and yang 2
Short name:
YY-2
Gene namesi
Name:Yy2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3837947 Yy2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237611 – 378Transcription factor YY2Add BLAST378

Proteomic databases

MaxQBiQ3TTC2
PaxDbiQ3TTC2
PeptideAtlasiQ3TTC2
PRIDEiQ3TTC2

PTM databases

iPTMnetiQ3TTC2
PhosphoSitePlusiQ3TTC2

Expressioni

Tissue specificityi

Weakly expressed by neuronal and glial cells in the cerebral cortex. Expressed by Purkinje cells and in the granular layers of the cerebellum. Expressed in all layers of spermatocytes in testis but not detected in sperm cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000046873
ExpressionAtlasiQ3TTC2 baseline and differential
GenevisibleiQ3TTC2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070112

Structurei

3D structure databases

ProteinModelPortaliQ3TTC2
SMRiQ3TTC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 113Mediates transcriptional activationBy similarityAdd BLAST75
Regioni243 – 378Mediates transcriptional repressionBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the YY transcription factor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 284C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 341C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00510000048066
ENSGT00910000144128
HOGENOMiHOG000008232
HOVERGENiHBG006823
InParanoidiQ3TTC2
KOiK09201
OrthoDBiEOG091G03FM
PhylomeDBiQ3TTC2
TreeFamiTF106493

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q3TTC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASETEKLLC LNTESAEIPA DFVELLPPDN IGDIEAVSLE TSVGQTIEVY
60 70 80 90 100
GDVGVDWAHG SQYHSPVIAL QPLVGSSLSS RDHDKEMFVV QTREEEVVGY
110 120 130 140 150
QDSDNLLFSP EFGSQMVLPV NEDDYLQPTT ASFTGFLAAE NGQGELSPYE
160 170 180 190 200
GNLCGLTTFI EAGAEESVNA DLGDKQWEQK QIDGLDGEFP FTMWDDVNEK
210 220 230 240 250
EDPIAEEQAG ESPPDYSEYM TGKKFPPEGI PGIDLSDPKQ LAEFTSMRPK
260 270 280 290 300
KPKGDFPRPI ACSHKGCEKM FKDNSAMRKH LHIHGPRVHV CAECGKAFVE
310 320 330 340 350
SSKLKRHQLV HTGEKPYQCT FEGCGRRFSL DFNLRTHVRI HTGDKPFVCP
360 370
FDACNKKFAQ STNLKSHILT HVKNKNDQ
Length:378
Mass (Da):42,031
Last modified:October 11, 2005 - v1
Checksum:i8B2E3C9BDFD0FC36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327R → H in BAC29297 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF688658 Genomic DNA Translation: ABS18955.1
AK036071 mRNA Translation: BAC29297.1
AK161451 mRNA Translation: BAE36403.1
CCDSiCCDS53233.1
RefSeqiNP_001092193.1, NM_001098723.1
UniGeneiMm.37577
Mm.491276

Genome annotation databases

EnsembliENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736
ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873
GeneIDi100073351
KEGGimmu:100073351
UCSCiuc012hra.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTYY2_MOUSE
AccessioniPrimary (citable) accession number: Q3TTC2
Secondary accession number(s): Q8CBG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health