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Protein
Submitted name:

Prolactin, isoform CRA_b

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Prolactin, isoform CRA_bImported
Gene namesi
Name:PrlImported
ORF Names:mCG_15525Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97762. Prl.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500770226331 – 227Sequence analysisAdd BLAST197

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000021342.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TT66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNSQGSAQ KGTLLLLLIS NLLFCQNVQP LPICSAGDCQ TSLRELFDRV
60 70 80 90 100
VILSHYIHTL YTDMFIEFDK QYVQDREFMV KVINDCPTSS LATPEDKEQA
110 120 130 140 150
LKVPPEVLLN LILSLVQSSS DPLFQLITGV GGIQEAPEYI LSRAKEIEEQ
160 170 180 190 200
NKQLLEGVEK IISQAYPEAK GNGIYFVWSQ LPSLQGVDEE SKILSLRNTI
210 220
RCLRRDSHKV DNFLKVLRCQ IAHQNNC
Length:227
Mass (Da):25,658
Last modified:October 11, 2005 - v1
Checksum:iCF99840CA760FA7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133645 mRNA. Translation: BAE21763.1.
AK161553 mRNA. Translation: BAE36459.1.
AK161594 mRNA. Translation: BAE36481.1.
CH466561 Genomic DNA. Translation: EDL32453.1.
RefSeqiNP_001157002.1. NM_001163530.1.
UniGeneiMm.1270.

Genome annotation databases

GeneIDi19109.
KEGGimmu:19109.
UCSCiuc007pxc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133645 mRNA. Translation: BAE21763.1.
AK161553 mRNA. Translation: BAE36459.1.
AK161594 mRNA. Translation: BAE36481.1.
CH466561 Genomic DNA. Translation: EDL32453.1.
RefSeqiNP_001157002.1. NM_001163530.1.
UniGeneiMm.1270.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19109.
KEGGimmu:19109.
UCSCiuc007pxc.2. mouse.

Organism-specific databases

CTDi5617.
MGIiMGI:97762. Prl.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
KOiK05439.

Miscellaneous databases

ChiTaRSiPrl. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021342.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TT66_MOUSE
AccessioniPrimary (citable) accession number: Q3TT66
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.