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Q3TSU8

- Q3TSU8_MOUSE

UniProt

Q3TSU8 - Q3TSU8_MOUSE

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Protein

DNA ligase

Gene

Lig1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: RefGenome
  3. DNA recombination Source: UniProtKB-KW
  4. DNA repair Source: MGI
  5. DNA replication Source: MGI
  6. double-strand break repair via nonhomologous end joining Source: MGI
  7. lagging strand elongation Source: RefGenome
  8. response to hydrogen peroxide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101789. Lig1.

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. mitochondrion Source: RefGenome
  3. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ3TSU8.

Expressioni

Gene expression databases

GenevestigatoriQ3TSU8.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG005514.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TSU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KPPARGAKTL SSFFTPRKPA VKTEVKQEES GTLRKEETKG TLDPANYNPS
60 70 80 90 100
KNNYHPIEDA CWKHGQKVPF LAVARTFEKI EEVSARLKMV ETLSNLLRSV
110 120 130 140 150
VALSPPDLLP VLYLSLNRLG PPQQGLELGV GDGVLLKAVA QATGRQLESI
160 170 180 190 200
RAEVAEKGDV GLVAENSRST QRLMLPPPPL TISGVFTKFC DIARLTGSAS
210 220 230 240 250
MAKKMDIIKG LFVACRHSEA RYIARSLSGR LRLGLAEQSV LAALAQAVSL
260 270 280 290 300
TPPGQEFPTA VVDAGKGKTA EARKMWLEEQ GMILKQTFCE VPDLDRIIPV
310 320 330 340 350
LLEHGLERLP EHCKLSPGVP LKPMLAHPTR GVSEVLKRFE EVDFTCEYKY
360 370 380 390 400
DGQRAQIHVL EGGEVKIFSR NQEDNTGKYP DIISRIPKIK HPSVTSFILD
410 420 430 440 450
TEAVAWDREK KQIQPFQVLT TRKRKEVDAS EIQVQVCLYA FDLIYLNGES
460 470 480 490 500
LVRQPLSRRR QLLRENFVET EGEFVFTTSL DTKDTEQIAE FLEQSVKDSC
510 520 530 540 550
EGLMVKTLDV DATYEIAKRS HNWLKLKKDY LDGVGDTLDL VVIGAYLGRG
560 570 580 590 600
KRAGRYGGFL LAAYDEESEE LQAICKLGNG FSDEELEEHH QSLQALVLPT
610 620 630 640 650
PRPYVRIDGA VAPDHWLDPS IVWEVKCADL SLSPIYPAAR GLVDKEKGIS
660 670 680 690
LRFPRFIRVR KDKQPEQATT SNQVASLYRK QSQIQNQQSS DLDSDVEDY
Length:699
Mass (Da):78,100
Last modified:October 11, 2005 - v1
Checksum:i268B06557654190F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161793 mRNA. Translation: BAE36577.1.
RefSeqiNP_034845.2. NM_010715.2.
UniGeneiMm.288179.
Mm.421129.

Genome annotation databases

GeneIDi16881.
KEGGimmu:16881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161793 mRNA. Translation: BAE36577.1 .
RefSeqi NP_034845.2. NM_010715.2.
UniGenei Mm.288179.
Mm.421129.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q3TSU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16881.
KEGGi mmu:16881.

Organism-specific databases

CTDi 3978.
MGIi MGI:101789. Lig1.

Phylogenomic databases

HOVERGENi HBG005514.
KOi K10747.

Miscellaneous databases

NextBioi 290882.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3TSU8.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.

Entry informationi

Entry nameiQ3TSU8_MOUSE
AccessioniPrimary (citable) accession number: Q3TSU8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)