DNA ligase - Mus musculus (Mouse)

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Q3TSU8 (Q3TSU8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 64. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

Name:

Lig1 MGI 101789

Organism

Mus musculus (Mouse) EMBL BAE36577.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	699 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW double-strand break repair via nonhomologous end joining Inferred from mutant phenotype PubMed 21655080. Source: MGI lagging strand elongation Inferred from Biological aspect of Ancestor. Source: RefGenome response to hydrogen peroxide Inferred from mutant phenotype PubMed 21390131. Source: MGI
Cellular_component	chromosome Inferred from Biological aspect of Ancestor. Source: RefGenome mitochondrion Inferred from Biological aspect of Ancestor. Source: RefGenome nucleus Inferred from direct assay PubMed 9001252. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL BAE36577.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q3TSU8 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 268B06557654190F
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FASTA

699

78,100

        10         20         30         40         50         60 
KPPARGAKTL SSFFTPRKPA VKTEVKQEES GTLRKEETKG TLDPANYNPS KNNYHPIEDA 

        70         80         90        100        110        120 
CWKHGQKVPF LAVARTFEKI EEVSARLKMV ETLSNLLRSV VALSPPDLLP VLYLSLNRLG 

       130        140        150        160        170        180 
PPQQGLELGV GDGVLLKAVA QATGRQLESI RAEVAEKGDV GLVAENSRST QRLMLPPPPL 

       190        200        210        220        230        240 
TISGVFTKFC DIARLTGSAS MAKKMDIIKG LFVACRHSEA RYIARSLSGR LRLGLAEQSV 

       250        260        270        280        290        300 
LAALAQAVSL TPPGQEFPTA VVDAGKGKTA EARKMWLEEQ GMILKQTFCE VPDLDRIIPV 

       310        320        330        340        350        360 
LLEHGLERLP EHCKLSPGVP LKPMLAHPTR GVSEVLKRFE EVDFTCEYKY DGQRAQIHVL 

       370        380        390        400        410        420 
EGGEVKIFSR NQEDNTGKYP DIISRIPKIK HPSVTSFILD TEAVAWDREK KQIQPFQVLT 

       430        440        450        460        470        480 
TRKRKEVDAS EIQVQVCLYA FDLIYLNGES LVRQPLSRRR QLLRENFVET EGEFVFTTSL 

       490        500        510        520        530        540 
DTKDTEQIAE FLEQSVKDSC EGLMVKTLDV DATYEIAKRS HNWLKLKKDY LDGVGDTLDL 

       550        560        570        580        590        600 
VVIGAYLGRG KRAGRYGGFL LAAYDEESEE LQAICKLGNG FSDEELEEHH QSLQALVLPT 

       610        620        630        640        650        660 
PRPYVRIDGA VAPDHWLDPS IVWEVKCADL SLSPIYPAAR GLVDKEKGIS LRFPRFIRVR 

       670        680        690 
KDKQPEQATT SNQVASLYRK QSQIQNQQSS DLDSDVEDY

« Hide

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE36577.1. Tissue: Testis EMBL BAE36577.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK161793 mRNA. Translation: BAE36577.1.
IPI	IPI00473314.
RefSeq	NP_034845.2. NM_010715.2.
UniGene	Mm.288179. Mm.421129.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3TSU8.
Proteomic databases
PRIDE	Q3TSU8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	16881.
KEGG	mmu:16881.
Organism-specific databases
CTD	3978.
MGI	MGI:101789. Lig1.
Phylogenomic databases
HOVERGEN	HBG005514.
InParanoid	Q3TSU8.
KO	K10747.
Gene expression databases
ArrayExpress	Q3TSU8.
Genevestigator	Q3TSU8.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290882.
SOURCE	Search...

Entry information

Entry name

Q3TSU8_MOUSE

Accession

Primary (citable) accession number: Q3TSU8

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information