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Q3TSU8

- Q3TSU8_MOUSE

UniProt

Q3TSU8 - Q3TSU8_MOUSE

Protein

DNA ligase

Gene

Lig1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome

    GO - Biological processi

    1. DNA ligation Source: RefGenome
    2. DNA recombination Source: UniProtKB-KW
    3. DNA repair Source: MGI
    4. DNA replication Source: MGI
    5. double-strand break repair via nonhomologous end joining Source: MGI
    6. lagging strand elongation Source: RefGenome
    7. response to hydrogen peroxide Source: MGI

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:Lig1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:101789. Lig1.

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome
    2. mitochondrion Source: RefGenome
    3. nucleus Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ3TSU8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3TSU8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG005514.
    InParanoidiQ3TSU8.
    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3TSU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    KPPARGAKTL SSFFTPRKPA VKTEVKQEES GTLRKEETKG TLDPANYNPS    50
    KNNYHPIEDA CWKHGQKVPF LAVARTFEKI EEVSARLKMV ETLSNLLRSV 100
    VALSPPDLLP VLYLSLNRLG PPQQGLELGV GDGVLLKAVA QATGRQLESI 150
    RAEVAEKGDV GLVAENSRST QRLMLPPPPL TISGVFTKFC DIARLTGSAS 200
    MAKKMDIIKG LFVACRHSEA RYIARSLSGR LRLGLAEQSV LAALAQAVSL 250
    TPPGQEFPTA VVDAGKGKTA EARKMWLEEQ GMILKQTFCE VPDLDRIIPV 300
    LLEHGLERLP EHCKLSPGVP LKPMLAHPTR GVSEVLKRFE EVDFTCEYKY 350
    DGQRAQIHVL EGGEVKIFSR NQEDNTGKYP DIISRIPKIK HPSVTSFILD 400
    TEAVAWDREK KQIQPFQVLT TRKRKEVDAS EIQVQVCLYA FDLIYLNGES 450
    LVRQPLSRRR QLLRENFVET EGEFVFTTSL DTKDTEQIAE FLEQSVKDSC 500
    EGLMVKTLDV DATYEIAKRS HNWLKLKKDY LDGVGDTLDL VVIGAYLGRG 550
    KRAGRYGGFL LAAYDEESEE LQAICKLGNG FSDEELEEHH QSLQALVLPT 600
    PRPYVRIDGA VAPDHWLDPS IVWEVKCADL SLSPIYPAAR GLVDKEKGIS 650
    LRFPRFIRVR KDKQPEQATT SNQVASLYRK QSQIQNQQSS DLDSDVEDY 699
    Length:699
    Mass (Da):78,100
    Last modified:October 11, 2005 - v1
    Checksum:i268B06557654190F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK161793 mRNA. Translation: BAE36577.1.
    RefSeqiNP_034845.2. NM_010715.2.
    UniGeneiMm.288179.
    Mm.421129.

    Genome annotation databases

    GeneIDi16881.
    KEGGimmu:16881.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK161793 mRNA. Translation: BAE36577.1 .
    RefSeqi NP_034845.2. NM_010715.2.
    UniGenei Mm.288179.
    Mm.421129.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q3TSU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16881.
    KEGGi mmu:16881.

    Organism-specific databases

    CTDi 3978.
    MGIi MGI:101789. Lig1.

    Phylogenomic databases

    HOVERGENi HBG005514.
    InParanoidi Q3TSU8.
    KOi K10747.

    Miscellaneous databases

    NextBioi 290882.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3TSU8.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.

    Entry informationi

    Entry nameiQ3TSU8_MOUSE
    AccessioniPrimary (citable) accession number: Q3TSU8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)