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Protein

DNA ligase

Gene

Lig1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101789. Lig1.

PTM / Processingi

Proteomic databases

PaxDbiQ3TSU8.
PeptideAtlasiQ3TSU8.
PRIDEiQ3TSU8.

Expressioni

Gene expression databases

GenevisibleiQ3TSU8. MM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini429 – 565DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967. Eukaryota.
COG1793. LUCA.
HOVERGENiHBG005514.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
InterProiView protein in InterPro
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
PfamiView protein in Pfam
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiView protein in PROSITE
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3TSU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KPPARGAKTL SSFFTPRKPA VKTEVKQEES GTLRKEETKG TLDPANYNPS
60 70 80 90 100
KNNYHPIEDA CWKHGQKVPF LAVARTFEKI EEVSARLKMV ETLSNLLRSV
110 120 130 140 150
VALSPPDLLP VLYLSLNRLG PPQQGLELGV GDGVLLKAVA QATGRQLESI
160 170 180 190 200
RAEVAEKGDV GLVAENSRST QRLMLPPPPL TISGVFTKFC DIARLTGSAS
210 220 230 240 250
MAKKMDIIKG LFVACRHSEA RYIARSLSGR LRLGLAEQSV LAALAQAVSL
260 270 280 290 300
TPPGQEFPTA VVDAGKGKTA EARKMWLEEQ GMILKQTFCE VPDLDRIIPV
310 320 330 340 350
LLEHGLERLP EHCKLSPGVP LKPMLAHPTR GVSEVLKRFE EVDFTCEYKY
360 370 380 390 400
DGQRAQIHVL EGGEVKIFSR NQEDNTGKYP DIISRIPKIK HPSVTSFILD
410 420 430 440 450
TEAVAWDREK KQIQPFQVLT TRKRKEVDAS EIQVQVCLYA FDLIYLNGES
460 470 480 490 500
LVRQPLSRRR QLLRENFVET EGEFVFTTSL DTKDTEQIAE FLEQSVKDSC
510 520 530 540 550
EGLMVKTLDV DATYEIAKRS HNWLKLKKDY LDGVGDTLDL VVIGAYLGRG
560 570 580 590 600
KRAGRYGGFL LAAYDEESEE LQAICKLGNG FSDEELEEHH QSLQALVLPT
610 620 630 640 650
PRPYVRIDGA VAPDHWLDPS IVWEVKCADL SLSPIYPAAR GLVDKEKGIS
660 670 680 690
LRFPRFIRVR KDKQPEQATT SNQVASLYRK QSQIQNQQSS DLDSDVEDY
Length:699
Mass (Da):78,100
Last modified:October 11, 2005 - v1
Checksum:i268B06557654190F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161793 mRNA. Translation: BAE36577.1.
RefSeqiNP_034845.2. NM_010715.2.
UniGeneiMm.288179.
Mm.421129.

Genome annotation databases

GeneIDi16881.
KEGGimmu:16881.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ3TSU8_MOUSE
AccessioniPrimary (citable) accession number: Q3TSU8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 5, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)