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Protein

Microtubule-associated protein 9

Gene

Map9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 9
Alternative name(s):
Aster-associated protein
Gene namesi
Name:Map9
Synonyms:Asap, Mtap9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442208. Map9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002477542 – 646Microtubule-associated protein 9Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei12PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TRR0.
PaxDbiQ3TRR0.
PeptideAtlasiQ3TRR0.
PRIDEiQ3TRR0.

PTM databases

iPTMnetiQ3TRR0.
PhosphoSitePlusiQ3TRR0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033900.
CleanExiMM_MTAP9.
ExpressionAtlasiQ3TRR0. baseline and differential.
GenevisibleiQ3TRR0. MM.

Interactioni

Subunit structurei

Binds to purified microtubules via its C-terminus.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229458. 3 interactors.
IntActiQ3TRR0. 4 interactors.
MINTiMINT-4111611.
STRINGi10090.ENSMUSP00000088535.

Structurei

3D structure databases

ProteinModelPortaliQ3TRR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili442 – 596Sequence analysisAdd BLAST155

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGGW. Eukaryota.
ENOG4111X21. LUCA.
GeneTreeiENSGT00730000111184.
HOVERGENiHBG081953.
InParanoidiQ3TRR0.
KOiK10434.
OMAiEDRNMKN.
OrthoDBiEOG091G07GL.
PhylomeDBiQ3TRR0.
TreeFamiTF328794.

Family and domain databases

InterProiView protein in InterPro
IPR026106. MAP9.
PANTHERiPTHR14739. PTHR14739. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TRR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDEIFSTTL AYTKSPKATK RTSFQDELIR AITARSARQR SSEYSDDFDS
60 70 80 90 100
DEIVSLGEFS DTSTDESLVR KKMNDFHISD DEEKNSPRLS FLKTKKVNRA
110 120 130 140 150
ISNDALDSST PGSEGSSPDA QEDVTGDSLP KSQNDDREVG REIITVKPTP
160 170 180 190 200
RMHPVKRSTS SGETSSGLDA DGHFKPSPQP RSMLKKSSHT EEGVRPGVDK
210 220 230 240 250
EHSISEASAP TPSLPRQNGT ELQTEEKIYS ENLDLEDSLL QSLTSSSFKE
260 270 280 290 300
SPGGCTSPGS QEKVPIKDHD GEPTEIWDSL LSNENEGSSV LVNCVTPELE
310 320 330 340 350
QPKDGQVAAD DLEEEREKGG FTEDDLTTDP LLSTSPSVIT PTEPAEPAKK
360 370 380 390 400
ANEDRNTKNK KTTNNRVSSA SGRLMTSEFL KRSGPTKRSP SAATSSHYLG
410 420 430 440 450
SLKVLDQKQP RKQSLEPDKA DHIRAAVYQE WLEKKNVYLH EMHRIKRIES
460 470 480 490 500
ENLRIQNEQK KAAKREEALA SFEAWKAMKE KEAKRIAAKK RLEEKNKKKT
510 520 530 540 550
EEENAMRKGE ALQAFEKWKE KKLEYLKEKT RREKEYERAK KQKEEEAVAE
560 570 580 590 600
KKKDSLTAFE KWSERKEALL KQKEKEKINE RRKEELKRAE KKDKDKQAIS
610 620 630 640
EYEKWLEKKE RQERIERKQK KRHSFLESET HPPWSPPSRT APSKVF
Length:646
Mass (Da):73,511
Last modified:July 25, 2006 - v2
Checksum:iF5309EDE68557839
GO
Isoform 2 (identifier: Q3TRR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-458: Missing.

Note: No experimental confirmation available.
Show »
Length:616
Mass (Da):69,664
Checksum:iCD703E5F9566DEC5
GO

Sequence cautioni

Q3TRR0: The sequence AAH61216 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Q3TRR0: The sequence AAH87935 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Q3TRR0: The sequence AK147287 differs from that shown. Reason: Frameshift at position 84.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185K → P in BAE36967 (PubMed:16141072).Curated1
Sequence conflicti205S → H in BAE36967 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020039429 – 458Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030527 mRNA. Translation: BAC27004.2.
AK038737 mRNA. Translation: BAC30117.1.
AK135702 mRNA. Translation: BAE22616.1.
AK135823 mRNA. Translation: BAE22678.1.
AK138540 mRNA. Translation: BAE23696.1.
AK147287 mRNA. No translation available.
AK162555 mRNA. Translation: BAE36967.1.
BC061216 mRNA. Translation: AAH61216.1. Sequence problems.
BC087935 mRNA. Translation: AAH87935.1. Sequence problems.
CCDSiCCDS38461.1. [Q3TRR0-1]
RefSeqiNP_001074699.1. NM_001081230.1. [Q3TRR0-1]
XP_006501341.1. XM_006501278.3. [Q3TRR0-1]
UniGeneiMm.271269.

Genome annotation databases

EnsembliENSMUST00000091014; ENSMUSP00000088535; ENSMUSG00000033900. [Q3TRR0-1]
ENSMUST00000195640; ENSMUSP00000142206; ENSMUSG00000033900. [Q3TRR0-1]
GeneIDi213582.
KEGGimmu:213582.
UCSCiuc008pow.1. mouse. [Q3TRR0-1]
uc012cqt.1. mouse. [Q3TRR0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAP9_MOUSE
AccessioniPrimary (citable) accession number: Q3TRR0
Secondary accession number(s): Q3UUD1
, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: August 30, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot