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Q3TRM8

- HXK3_MOUSE

UniProt

Q3TRM8 - HXK3_MOUSE

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Protein
Hexokinase-3
Gene
Hk3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Enzyme regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 986ATP Reviewed prediction
Nucleotide bindingi540 – 5456ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. hormone binding Source: Ensembl
  5. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: RefGenome
  5. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-3 (EC:2.7.1.1)
Alternative name(s):
Hexokinase type III
Short name:
HK III
Gene namesi
Name:Hk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2670962. Hk3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
  2. mitochondrion Source: MGI
  3. protein complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Hexokinase-3
PRO_0000197591Add
BLAST

Proteomic databases

MaxQBiQ3TRM8.
PaxDbiQ3TRM8.
PRIDEiQ3TRM8.

PTM databases

PhosphoSiteiQ3TRM8.

Expressioni

Gene expression databases

ArrayExpressiQ3TRM8.
BgeeiQ3TRM8.
CleanExiMM_HK3.
GenevestigatoriQ3TRM8.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ3TRM8.
SMRiQ3TRM8. Positions 35-918.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 229197Hexokinase type-1 1
Add
BLAST
Domaini235 – 473239Hexokinase type-2 1
Add
BLAST
Domaini478 – 674197Hexokinase type-1 2
Add
BLAST
Domaini676 – 915240Hexokinase type-2 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 486486Regulatory
Add
BLAST
Regioni160 – 18627Glucose-binding Reviewed prediction
Add
BLAST
Regioni487 – 922436Catalytic
Add
BLAST
Regioni602 – 62827Glucose-binding Reviewed prediction
Add
BLAST

Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.

Sequence similaritiesi

Belongs to the hexokinase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiQ3TRM8.
KOiK00844.
OMAiHGTEQGD.
OrthoDBiEOG7S21X5.
PhylomeDBiQ3TRM8.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TRM8-1 [UniParc]FASTAAdd to Basket

« Hide

MATIGPSGLH PGERASVCPH EGVPRPSGSL ELECLQQFKV TRTQLQQIQA    50
SLLCSMEQAL KGQDSPAPSV RMLPTYVRST PHGTEQGDFL VLELGATGAS 100
LRVLWVTLTG TKECRVEPRS REFVIPQEVI LGAGQQLFDF AARCLSEFLD 150
AYPVENQGLK LGFNFSFPCH QTGLDRSTLI SWTKGFRCSG VEGQDVVQLL 200
RDAIQRQGTY RIDVVAMVND TVGTMMGCEL GTRPCEVGLI VDTGTNACYM 250
EEARHVAALD EDRGRTCVSI EWGSFYDEDA LGPVLTTFDS ALDRESLTPG 300
AQRFEKMIGG LYLGELVRLV LVHLTQHGVL FDGCASPALL SQGCILLDHV 350
AEMEDTATGT ARVHTILQDL GLSPRASDAE LVQYVCVAVC TRAAQLCAAA 400
LAAVLSRLQH SREQQTLQVA VATGGRVFER HPRFLRILKE TVTLLAPNCD 450
VSFIPSVDGG GRGVAMVTAV AARLAAHRRI LEETLAPFQL TLEQMTVVQA 500
QMREAMIRGL QGEASSLRML PTYVRATPDG SERGDFLALD LGGTNFRVLL 550
VRVAEGSVQI INQVYSIPEC RAQGSGQKLF DHIVDCIVDF QKRQGLSGQS 600
LPLGFTFSFP CKQLGLDQGI LLNWTKGFNA SGCEGQDVVY LLREAIRRRQ 650
AVELNVVAIV NDTVGTMMSC GYDDPRCEMG LIVGTGTNAC YMEELRNVAS 700
VPGDSGLMCI NMEWGAFGDD GSLGTLSTRF DTSVDQASIN PGKQRFEKMI 750
SGMYLGEIVR HILLHLTNLG VLFRGQKTQC LQARDIFKTK FLSEIESDSL 800
ALRQVRAILE DLGLTLTSDD ALMVLEVCQA VSRRAAQLCG AGVAAVVEKI 850
RENRGLQELT VSVGVDGTLY KLHPHFSKLV SATVRKLAPQ CTVTFLQSED 900
GSGKGAALVT AVACRLTQMA HV 922
Length:922
Mass (Da):100,101
Last modified:December 6, 2005 - v2
Checksum:i38F4E024630C45E5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031A → S in BAE37000. 1 Publication
Sequence conflicti384 – 3841Y → C in BAE29220. 1 Publication
Sequence conflicti439 – 4391K → E in BAE29220. 1 Publication
Sequence conflicti442 – 4421V → I in BAE29007. 1 Publication
Sequence conflicti509 – 5091G → E in BAE29007. 1 Publication
Sequence conflicti860 – 8601T → A in BAE29007. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK149651 mRNA. Translation: BAE29007.1.
AK149992 mRNA. Translation: BAE29220.1.
AK154603 mRNA. Translation: BAE32706.1.
AK162637 mRNA. Translation: BAE37000.1.
AK171580 mRNA. Translation: BAE42538.1.
CCDSiCCDS26538.1.
RefSeqiNP_001028417.1. NM_001033245.4.
NP_001193319.1. NM_001206390.1.
UniGeneiMm.267479.

Genome annotation databases

EnsembliENSMUST00000052949; ENSMUSP00000051215; ENSMUSG00000025877.
ENSMUST00000126234; ENSMUSP00000123233; ENSMUSG00000025877.
GeneIDi212032.
KEGGimmu:212032.
UCSCiuc007qpr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK149651 mRNA. Translation: BAE29007.1 .
AK149992 mRNA. Translation: BAE29220.1 .
AK154603 mRNA. Translation: BAE32706.1 .
AK162637 mRNA. Translation: BAE37000.1 .
AK171580 mRNA. Translation: BAE42538.1 .
CCDSi CCDS26538.1.
RefSeqi NP_001028417.1. NM_001033245.4.
NP_001193319.1. NM_001206390.1.
UniGenei Mm.267479.

3D structure databases

ProteinModelPortali Q3TRM8.
SMRi Q3TRM8. Positions 35-918.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3TRM8.

Proteomic databases

MaxQBi Q3TRM8.
PaxDbi Q3TRM8.
PRIDEi Q3TRM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052949 ; ENSMUSP00000051215 ; ENSMUSG00000025877 .
ENSMUST00000126234 ; ENSMUSP00000123233 ; ENSMUSG00000025877 .
GeneIDi 212032.
KEGGi mmu:212032.
UCSCi uc007qpr.2. mouse.

Organism-specific databases

CTDi 3101.
MGIi MGI:2670962. Hk3.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi Q3TRM8.
KOi K00844.
OMAi HGTEQGD.
OrthoDBi EOG7S21X5.
PhylomeDBi Q3TRM8.
TreeFami TF314238.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Miscellaneous databases

NextBioi 373427.
PROi Q3TRM8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3TRM8.
Bgeei Q3TRM8.
CleanExi MM_HK3.
Genevestigatori Q3TRM8.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone and Bone marrow.

Entry informationi

Entry nameiHXK3_MOUSE
AccessioniPrimary (citable) accession number: Q3TRM8
Secondary accession number(s): Q3TAX6, Q3UDP1, Q3UEA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi