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Q3TRM8

- HXK3_MOUSE

UniProt

Q3TRM8 - HXK3_MOUSE

Protein

Hexokinase-3

Gene

Hk3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Enzyme regulationi

    Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi93 – 986ATPSequence Analysis
    Nucleotide bindingi540 – 5456ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: RefGenome
    3. glucokinase activity Source: RefGenome
    4. hormone binding Source: Ensembl
    5. mannokinase activity Source: RefGenome

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. cellular glucose homeostasis Source: RefGenome
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: RefGenome
    5. hexose metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-3 (EC:2.7.1.1)
    Alternative name(s):
    Hexokinase type III
    Short name:
    HK III
    Gene namesi
    Name:Hk3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2670962. Hk3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. mitochondrion Source: MGI
    3. protein complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 922922Hexokinase-3PRO_0000197591Add
    BLAST

    Proteomic databases

    MaxQBiQ3TRM8.
    PaxDbiQ3TRM8.
    PRIDEiQ3TRM8.

    PTM databases

    PhosphoSiteiQ3TRM8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TRM8.
    BgeeiQ3TRM8.
    CleanExiMM_HK3.
    GenevestigatoriQ3TRM8.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TRM8.
    SMRiQ3TRM8. Positions 35-918.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 229197Hexokinase type-1 1Add
    BLAST
    Domaini235 – 473239Hexokinase type-2 1Add
    BLAST
    Domaini478 – 674197Hexokinase type-1 2Add
    BLAST
    Domaini676 – 915240Hexokinase type-2 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 486486RegulatoryAdd
    BLAST
    Regioni160 – 18627Glucose-bindingSequence AnalysisAdd
    BLAST
    Regioni487 – 922436CatalyticAdd
    BLAST
    Regioni602 – 62827Glucose-bindingSequence AnalysisAdd
    BLAST

    Domaini

    The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 2 hexokinase type-1 domains.Curated
    Contains 2 hexokinase type-2 domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5026.
    GeneTreeiENSGT00390000017159.
    HOGENOMiHOG000162671.
    HOVERGENiHBG005020.
    InParanoidiQ3TRM8.
    KOiK00844.
    OMAiHGTEQGD.
    OrthoDBiEOG7S21X5.
    PhylomeDBiQ3TRM8.
    TreeFamiTF314238.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TRM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATIGPSGLH PGERASVCPH EGVPRPSGSL ELECLQQFKV TRTQLQQIQA    50
    SLLCSMEQAL KGQDSPAPSV RMLPTYVRST PHGTEQGDFL VLELGATGAS 100
    LRVLWVTLTG TKECRVEPRS REFVIPQEVI LGAGQQLFDF AARCLSEFLD 150
    AYPVENQGLK LGFNFSFPCH QTGLDRSTLI SWTKGFRCSG VEGQDVVQLL 200
    RDAIQRQGTY RIDVVAMVND TVGTMMGCEL GTRPCEVGLI VDTGTNACYM 250
    EEARHVAALD EDRGRTCVSI EWGSFYDEDA LGPVLTTFDS ALDRESLTPG 300
    AQRFEKMIGG LYLGELVRLV LVHLTQHGVL FDGCASPALL SQGCILLDHV 350
    AEMEDTATGT ARVHTILQDL GLSPRASDAE LVQYVCVAVC TRAAQLCAAA 400
    LAAVLSRLQH SREQQTLQVA VATGGRVFER HPRFLRILKE TVTLLAPNCD 450
    VSFIPSVDGG GRGVAMVTAV AARLAAHRRI LEETLAPFQL TLEQMTVVQA 500
    QMREAMIRGL QGEASSLRML PTYVRATPDG SERGDFLALD LGGTNFRVLL 550
    VRVAEGSVQI INQVYSIPEC RAQGSGQKLF DHIVDCIVDF QKRQGLSGQS 600
    LPLGFTFSFP CKQLGLDQGI LLNWTKGFNA SGCEGQDVVY LLREAIRRRQ 650
    AVELNVVAIV NDTVGTMMSC GYDDPRCEMG LIVGTGTNAC YMEELRNVAS 700
    VPGDSGLMCI NMEWGAFGDD GSLGTLSTRF DTSVDQASIN PGKQRFEKMI 750
    SGMYLGEIVR HILLHLTNLG VLFRGQKTQC LQARDIFKTK FLSEIESDSL 800
    ALRQVRAILE DLGLTLTSDD ALMVLEVCQA VSRRAAQLCG AGVAAVVEKI 850
    RENRGLQELT VSVGVDGTLY KLHPHFSKLV SATVRKLAPQ CTVTFLQSED 900
    GSGKGAALVT AVACRLTQMA HV 922
    Length:922
    Mass (Da):100,101
    Last modified:December 6, 2005 - v2
    Checksum:i38F4E024630C45E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031A → S in BAE37000. (PubMed:16141072)Curated
    Sequence conflicti384 – 3841Y → C in BAE29220. (PubMed:16141072)Curated
    Sequence conflicti439 – 4391K → E in BAE29220. (PubMed:16141072)Curated
    Sequence conflicti442 – 4421V → I in BAE29007. (PubMed:16141072)Curated
    Sequence conflicti509 – 5091G → E in BAE29007. (PubMed:16141072)Curated
    Sequence conflicti860 – 8601T → A in BAE29007. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK149651 mRNA. Translation: BAE29007.1.
    AK149992 mRNA. Translation: BAE29220.1.
    AK154603 mRNA. Translation: BAE32706.1.
    AK162637 mRNA. Translation: BAE37000.1.
    AK171580 mRNA. Translation: BAE42538.1.
    CCDSiCCDS26538.1.
    RefSeqiNP_001028417.1. NM_001033245.4.
    NP_001193319.1. NM_001206390.1.
    UniGeneiMm.267479.

    Genome annotation databases

    EnsembliENSMUST00000052949; ENSMUSP00000051215; ENSMUSG00000025877.
    ENSMUST00000126234; ENSMUSP00000123233; ENSMUSG00000025877.
    GeneIDi212032.
    KEGGimmu:212032.
    UCSCiuc007qpr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK149651 mRNA. Translation: BAE29007.1 .
    AK149992 mRNA. Translation: BAE29220.1 .
    AK154603 mRNA. Translation: BAE32706.1 .
    AK162637 mRNA. Translation: BAE37000.1 .
    AK171580 mRNA. Translation: BAE42538.1 .
    CCDSi CCDS26538.1.
    RefSeqi NP_001028417.1. NM_001033245.4.
    NP_001193319.1. NM_001206390.1.
    UniGenei Mm.267479.

    3D structure databases

    ProteinModelPortali Q3TRM8.
    SMRi Q3TRM8. Positions 35-918.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3TRM8.

    Proteomic databases

    MaxQBi Q3TRM8.
    PaxDbi Q3TRM8.
    PRIDEi Q3TRM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052949 ; ENSMUSP00000051215 ; ENSMUSG00000025877 .
    ENSMUST00000126234 ; ENSMUSP00000123233 ; ENSMUSG00000025877 .
    GeneIDi 212032.
    KEGGi mmu:212032.
    UCSCi uc007qpr.2. mouse.

    Organism-specific databases

    CTDi 3101.
    MGIi MGI:2670962. Hk3.

    Phylogenomic databases

    eggNOGi COG5026.
    GeneTreei ENSGT00390000017159.
    HOGENOMi HOG000162671.
    HOVERGENi HBG005020.
    InParanoidi Q3TRM8.
    KOi K00844.
    OMAi HGTEQGD.
    OrthoDBi EOG7S21X5.
    PhylomeDBi Q3TRM8.
    TreeFami TF314238.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Miscellaneous databases

    NextBioi 373427.
    PROi Q3TRM8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TRM8.
    Bgeei Q3TRM8.
    CleanExi MM_HK3.
    Genevestigatori Q3TRM8.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone and Bone marrow.

    Entry informationi

    Entry nameiHXK3_MOUSE
    AccessioniPrimary (citable) accession number: Q3TRM8
    Secondary accession number(s): Q3TAX6, Q3UDP1, Q3UEA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3