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Q3TRM8

- HXK3_MOUSE

UniProt

Q3TRM8 - HXK3_MOUSE

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Protein

Hexokinase-3

Gene

Hk3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Enzyme regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 986ATPSequence Analysis
Nucleotide bindingi540 – 5456ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. hormone binding Source: Ensembl
  5. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: RefGenome
  5. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_253543. Glucose transport.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-3 (EC:2.7.1.1)
Alternative name(s):
Hexokinase type III
Short name:
HK III
Gene namesi
Name:Hk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2670962. Hk3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
  2. mitochondrion Source: MGI
  3. protein complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Hexokinase-3PRO_0000197591Add
BLAST

Proteomic databases

MaxQBiQ3TRM8.
PaxDbiQ3TRM8.
PRIDEiQ3TRM8.

PTM databases

PhosphoSiteiQ3TRM8.

Expressioni

Gene expression databases

BgeeiQ3TRM8.
CleanExiMM_HK3.
ExpressionAtlasiQ3TRM8. baseline and differential.
GenevestigatoriQ3TRM8.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3TRM8.
SMRiQ3TRM8. Positions 35-918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 229197Hexokinase type-1 1Add
BLAST
Domaini235 – 473239Hexokinase type-2 1Add
BLAST
Domaini478 – 674197Hexokinase type-1 2Add
BLAST
Domaini676 – 915240Hexokinase type-2 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 486486RegulatoryAdd
BLAST
Regioni160 – 18627Glucose-bindingSequence AnalysisAdd
BLAST
Regioni487 – 922436CatalyticAdd
BLAST
Regioni602 – 62827Glucose-bindingSequence AnalysisAdd
BLAST

Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 2 hexokinase type-1 domains.Curated
Contains 2 hexokinase type-2 domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiQ3TRM8.
KOiK00844.
OMAiHGTEQGD.
OrthoDBiEOG7S21X5.
PhylomeDBiQ3TRM8.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TRM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATIGPSGLH PGERASVCPH EGVPRPSGSL ELECLQQFKV TRTQLQQIQA
60 70 80 90 100
SLLCSMEQAL KGQDSPAPSV RMLPTYVRST PHGTEQGDFL VLELGATGAS
110 120 130 140 150
LRVLWVTLTG TKECRVEPRS REFVIPQEVI LGAGQQLFDF AARCLSEFLD
160 170 180 190 200
AYPVENQGLK LGFNFSFPCH QTGLDRSTLI SWTKGFRCSG VEGQDVVQLL
210 220 230 240 250
RDAIQRQGTY RIDVVAMVND TVGTMMGCEL GTRPCEVGLI VDTGTNACYM
260 270 280 290 300
EEARHVAALD EDRGRTCVSI EWGSFYDEDA LGPVLTTFDS ALDRESLTPG
310 320 330 340 350
AQRFEKMIGG LYLGELVRLV LVHLTQHGVL FDGCASPALL SQGCILLDHV
360 370 380 390 400
AEMEDTATGT ARVHTILQDL GLSPRASDAE LVQYVCVAVC TRAAQLCAAA
410 420 430 440 450
LAAVLSRLQH SREQQTLQVA VATGGRVFER HPRFLRILKE TVTLLAPNCD
460 470 480 490 500
VSFIPSVDGG GRGVAMVTAV AARLAAHRRI LEETLAPFQL TLEQMTVVQA
510 520 530 540 550
QMREAMIRGL QGEASSLRML PTYVRATPDG SERGDFLALD LGGTNFRVLL
560 570 580 590 600
VRVAEGSVQI INQVYSIPEC RAQGSGQKLF DHIVDCIVDF QKRQGLSGQS
610 620 630 640 650
LPLGFTFSFP CKQLGLDQGI LLNWTKGFNA SGCEGQDVVY LLREAIRRRQ
660 670 680 690 700
AVELNVVAIV NDTVGTMMSC GYDDPRCEMG LIVGTGTNAC YMEELRNVAS
710 720 730 740 750
VPGDSGLMCI NMEWGAFGDD GSLGTLSTRF DTSVDQASIN PGKQRFEKMI
760 770 780 790 800
SGMYLGEIVR HILLHLTNLG VLFRGQKTQC LQARDIFKTK FLSEIESDSL
810 820 830 840 850
ALRQVRAILE DLGLTLTSDD ALMVLEVCQA VSRRAAQLCG AGVAAVVEKI
860 870 880 890 900
RENRGLQELT VSVGVDGTLY KLHPHFSKLV SATVRKLAPQ CTVTFLQSED
910 920
GSGKGAALVT AVACRLTQMA HV
Length:922
Mass (Da):100,101
Last modified:December 6, 2005 - v2
Checksum:i38F4E024630C45E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031A → S in BAE37000. (PubMed:16141072)Curated
Sequence conflicti384 – 3841Y → C in BAE29220. (PubMed:16141072)Curated
Sequence conflicti439 – 4391K → E in BAE29220. (PubMed:16141072)Curated
Sequence conflicti442 – 4421V → I in BAE29007. (PubMed:16141072)Curated
Sequence conflicti509 – 5091G → E in BAE29007. (PubMed:16141072)Curated
Sequence conflicti860 – 8601T → A in BAE29007. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149651 mRNA. Translation: BAE29007.1.
AK149992 mRNA. Translation: BAE29220.1.
AK154603 mRNA. Translation: BAE32706.1.
AK162637 mRNA. Translation: BAE37000.1.
AK171580 mRNA. Translation: BAE42538.1.
CCDSiCCDS26538.1.
RefSeqiNP_001028417.1. NM_001033245.4.
NP_001193319.1. NM_001206390.1.
UniGeneiMm.267479.

Genome annotation databases

EnsembliENSMUST00000052949; ENSMUSP00000051215; ENSMUSG00000025877.
ENSMUST00000126234; ENSMUSP00000123233; ENSMUSG00000025877.
GeneIDi212032.
KEGGimmu:212032.
UCSCiuc007qpr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149651 mRNA. Translation: BAE29007.1 .
AK149992 mRNA. Translation: BAE29220.1 .
AK154603 mRNA. Translation: BAE32706.1 .
AK162637 mRNA. Translation: BAE37000.1 .
AK171580 mRNA. Translation: BAE42538.1 .
CCDSi CCDS26538.1.
RefSeqi NP_001028417.1. NM_001033245.4.
NP_001193319.1. NM_001206390.1.
UniGenei Mm.267479.

3D structure databases

ProteinModelPortali Q3TRM8.
SMRi Q3TRM8. Positions 35-918.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3TRM8.

Proteomic databases

MaxQBi Q3TRM8.
PaxDbi Q3TRM8.
PRIDEi Q3TRM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052949 ; ENSMUSP00000051215 ; ENSMUSG00000025877 .
ENSMUST00000126234 ; ENSMUSP00000123233 ; ENSMUSG00000025877 .
GeneIDi 212032.
KEGGi mmu:212032.
UCSCi uc007qpr.2. mouse.

Organism-specific databases

CTDi 3101.
MGIi MGI:2670962. Hk3.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi Q3TRM8.
KOi K00844.
OMAi HGTEQGD.
OrthoDBi EOG7S21X5.
PhylomeDBi Q3TRM8.
TreeFami TF314238.

Enzyme and pathway databases

UniPathwayi UPA00242 .
Reactomei REACT_253543. Glucose transport.

Miscellaneous databases

NextBioi 373427.
PROi Q3TRM8.
SOURCEi Search...

Gene expression databases

Bgeei Q3TRM8.
CleanExi MM_HK3.
ExpressionAtlasi Q3TRM8. baseline and differential.
Genevestigatori Q3TRM8.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone and Bone marrow.

Entry informationi

Entry nameiHXK3_MOUSE
AccessioniPrimary (citable) accession number: Q3TRM8
Secondary accession number(s): Q3TAX6, Q3UDP1, Q3UEA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3