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Protein

Keratin, type I cytoskeletal 26

Gene

Krt26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 26
Alternative name(s):
Cytokeratin-26
Short name:
CK-26
Keratin-26
Short name:
K26
Type I inner root sheath-specific keratin-K25irs2
Gene namesi
Name:Krt26Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444913. Krt26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126981 – 462Keratin, type I cytoskeletal 26Add BLAST462

Proteomic databases

MaxQBiQ3TRJ4.
PaxDbiQ3TRJ4.
PeptideAtlasiQ3TRJ4.
PRIDEiQ3TRJ4.

PTM databases

iPTMnetiQ3TRJ4.
PhosphoSitePlusiQ3TRJ4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075570.
CleanExiMM_KRT26.
GenevisibleiQ3TRJ4. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098051.

Structurei

3D structure databases

ProteinModelPortaliQ3TRJ4.
SMRiQ3TRJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 79HeadSequence analysisAdd BLAST79
Regioni80 – 391RodSequence analysisAdd BLAST312
Regioni80 – 115Coil 1ASequence analysisAdd BLAST36
Regioni116 – 137Linker 1Sequence analysisAdd BLAST22
Regioni138 – 229Coil 1BSequence analysisAdd BLAST92
Regioni230 – 252Linker 12Sequence analysisAdd BLAST23
Regioni253 – 391Coil 2Sequence analysisAdd BLAST139
Regioni392 – 459TailSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 78Gly-richSequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA2D. Eukaryota.
ENOG4111D4X. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ3TRJ4.
KOiK07604.
OMAiRYFSVIE.
OrthoDBiEOG091G087I.
PhylomeDBiQ3TRJ4.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TRJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRFSGRSR VCSRAGSVRL SRGGAGFVAG NVCVGPGAEG SFSCTLGGLS
60 70 80 90 100
SGGSFASEGS GRGSSIGFLN NEPGLFSGNE KVAMQNLNDR LALYLNHVSA
110 120 130 140 150
LEEANTDLEK KIEGWYEKCG PGRGRRLDHD CSRYFSVIED LKRQILSMTT
160 170 180 190 200
CNANLVLQND NARLTADDFK MKYENELALH QSVEADTNGL RRVLDELTLS
210 220 230 240 250
TTDLEIQREA LSEELTYLQK NHEEEMVVLQ NASGGNINVE MNAAPSVDLT
260 270 280 290 300
AMLNNMRAEY EDLAEQNRKD AEASFKEKSA SLQQQISDDA GAATAARNEL
310 320 330 340 350
MELKRNLQTL EIELQSITAM KQSYENSLAE TEGNYYAQLQ QIQEQIGARE
360 370 380 390 400
EQLQQIRTET EGQKLEHEQL LGIKTCLEKE IDTYCNLLDG EEQRSESTSY
410 420 430 440 450
KPKDGKPASE FNDSAEETFA RTVAEELDQL GNLLSLRVHS VEEKSSKISN
460
ITMEQRVPSK AP
Length:462
Mass (Da):51,118
Last modified:October 11, 2005 - v1
Checksum:i2436531C7ECF8412
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197L → Q in BAE21173 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132445 mRNA. Translation: BAE21173.1.
AK162718 mRNA. Translation: BAE37035.1.
AL590991 Genomic DNA. Translation: CAM18788.1.
BC116672 mRNA. Translation: AAI16673.1.
CCDSiCCDS25378.1.
RefSeqiNP_001028569.2. NM_001033397.5.
UniGeneiMm.440509.

Genome annotation databases

EnsembliENSMUST00000100482; ENSMUSP00000098051; ENSMUSG00000075570.
GeneIDi320864.
KEGGimmu:320864.
UCSCiuc007lio.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132445 mRNA. Translation: BAE21173.1.
AK162718 mRNA. Translation: BAE37035.1.
AL590991 Genomic DNA. Translation: CAM18788.1.
BC116672 mRNA. Translation: AAI16673.1.
CCDSiCCDS25378.1.
RefSeqiNP_001028569.2. NM_001033397.5.
UniGeneiMm.440509.

3D structure databases

ProteinModelPortaliQ3TRJ4.
SMRiQ3TRJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098051.

PTM databases

iPTMnetiQ3TRJ4.
PhosphoSitePlusiQ3TRJ4.

Proteomic databases

MaxQBiQ3TRJ4.
PaxDbiQ3TRJ4.
PeptideAtlasiQ3TRJ4.
PRIDEiQ3TRJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100482; ENSMUSP00000098051; ENSMUSG00000075570.
GeneIDi320864.
KEGGimmu:320864.
UCSCiuc007lio.2. mouse.

Organism-specific databases

CTDi353288.
MGIiMGI:2444913. Krt26.

Phylogenomic databases

eggNOGiENOG410JA2D. Eukaryota.
ENOG4111D4X. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ3TRJ4.
KOiK07604.
OMAiRYFSVIE.
OrthoDBiEOG091G087I.
PhylomeDBiQ3TRJ4.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ3TRJ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075570.
CleanExiMM_KRT26.
GenevisibleiQ3TRJ4. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C26_MOUSE
AccessioniPrimary (citable) accession number: Q3TRJ4
Secondary accession number(s): Q3V1H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.