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Protein

Keratin, type I cytoskeletal 26

Gene

Krt26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 26
Alternative name(s):
Cytokeratin-26
Short name:
CK-26
Keratin-26
Short name:
K26
Type I inner root sheath-specific keratin-K25irs2
Gene namesi
Name:Krt26Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444913 Krt26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126981 – 462Keratin, type I cytoskeletal 26Add BLAST462

Proteomic databases

MaxQBiQ3TRJ4
PaxDbiQ3TRJ4
PeptideAtlasiQ3TRJ4
PRIDEiQ3TRJ4

PTM databases

iPTMnetiQ3TRJ4
PhosphoSitePlusiQ3TRJ4

Expressioni

Gene expression databases

BgeeiENSMUSG00000075570
CleanExiMM_KRT26
GenevisibleiQ3TRJ4 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Structurei

3D structure databases

ProteinModelPortaliQ3TRJ4
SMRiQ3TRJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 395IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 79HeadSequence analysisAdd BLAST79
Regioni80 – 115Coil 1ASequence analysisAdd BLAST36
Regioni116 – 137Linker 1Sequence analysisAdd BLAST22
Regioni138 – 229Coil 1BSequence analysisAdd BLAST92
Regioni230 – 252Linker 12Sequence analysisAdd BLAST23
Regioni253 – 391Coil 2Sequence analysisAdd BLAST139
Regioni392 – 459TailSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 78Gly-richSequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA2D Eukaryota
ENOG4111D4X LUCA
GeneTreeiENSGT00910000144130
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ3TRJ4
KOiK07604
OMAiRYFSVIE
OrthoDBiEOG091G087I
PhylomeDBiQ3TRJ4
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TRJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRFSGRSR VCSRAGSVRL SRGGAGFVAG NVCVGPGAEG SFSCTLGGLS
60 70 80 90 100
SGGSFASEGS GRGSSIGFLN NEPGLFSGNE KVAMQNLNDR LALYLNHVSA
110 120 130 140 150
LEEANTDLEK KIEGWYEKCG PGRGRRLDHD CSRYFSVIED LKRQILSMTT
160 170 180 190 200
CNANLVLQND NARLTADDFK MKYENELALH QSVEADTNGL RRVLDELTLS
210 220 230 240 250
TTDLEIQREA LSEELTYLQK NHEEEMVVLQ NASGGNINVE MNAAPSVDLT
260 270 280 290 300
AMLNNMRAEY EDLAEQNRKD AEASFKEKSA SLQQQISDDA GAATAARNEL
310 320 330 340 350
MELKRNLQTL EIELQSITAM KQSYENSLAE TEGNYYAQLQ QIQEQIGARE
360 370 380 390 400
EQLQQIRTET EGQKLEHEQL LGIKTCLEKE IDTYCNLLDG EEQRSESTSY
410 420 430 440 450
KPKDGKPASE FNDSAEETFA RTVAEELDQL GNLLSLRVHS VEEKSSKISN
460
ITMEQRVPSK AP
Length:462
Mass (Da):51,118
Last modified:October 11, 2005 - v1
Checksum:i2436531C7ECF8412
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197L → Q in BAE21173 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132445 mRNA Translation: BAE21173.1
AK162718 mRNA Translation: BAE37035.1
AL590991 Genomic DNA No translation available.
BC116672 mRNA Translation: AAI16673.1
CCDSiCCDS25378.1
RefSeqiNP_001028569.2, NM_001033397.5
UniGeneiMm.440509

Genome annotation databases

EnsembliENSMUST00000100482; ENSMUSP00000098051; ENSMUSG00000075570
GeneIDi320864
KEGGimmu:320864
UCSCiuc007lio.2 mouse

Similar proteinsi

Entry informationi

Entry nameiK1C26_MOUSE
AccessioniPrimary (citable) accession number: Q3TRJ4
Secondary accession number(s): Q3V1H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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