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Protein

Keratin, type I cytoskeletal 26

Gene

Krt26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 26
Alternative name(s):
Cytokeratin-26
Short name:
CK-26
Keratin-26
Short name:
K26
Type I inner root sheath-specific keratin-K25irs2
Gene namesi
Name:Krt26Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444913. Krt26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Keratin, type I cytoskeletal 26PRO_0000312698Add
BLAST

Proteomic databases

MaxQBiQ3TRJ4.
PaxDbiQ3TRJ4.
PeptideAtlasiQ3TRJ4.
PRIDEiQ3TRJ4.

PTM databases

iPTMnetiQ3TRJ4.
PhosphoSiteiQ3TRJ4.

Expressioni

Gene expression databases

BgeeiQ3TRJ4.
CleanExiMM_KRT26.
GenevisibleiQ3TRJ4. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098051.

Structurei

3D structure databases

ProteinModelPortaliQ3TRJ4.
SMRiQ3TRJ4. Positions 302-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7979HeadSequence analysisAdd
BLAST
Regioni80 – 391312RodSequence analysisAdd
BLAST
Regioni80 – 11536Coil 1ASequence analysisAdd
BLAST
Regioni116 – 13722Linker 1Sequence analysisAdd
BLAST
Regioni138 – 22992Coil 1BSequence analysisAdd
BLAST
Regioni230 – 25223Linker 12Sequence analysisAdd
BLAST
Regioni253 – 391139Coil 2Sequence analysisAdd
BLAST
Regioni392 – 45968TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 7856Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA2D. Eukaryota.
ENOG4111D4X. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ3TRJ4.
KOiK07604.
OMAiRYFSVIE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ3TRJ4.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TRJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRFSGRSR VCSRAGSVRL SRGGAGFVAG NVCVGPGAEG SFSCTLGGLS
60 70 80 90 100
SGGSFASEGS GRGSSIGFLN NEPGLFSGNE KVAMQNLNDR LALYLNHVSA
110 120 130 140 150
LEEANTDLEK KIEGWYEKCG PGRGRRLDHD CSRYFSVIED LKRQILSMTT
160 170 180 190 200
CNANLVLQND NARLTADDFK MKYENELALH QSVEADTNGL RRVLDELTLS
210 220 230 240 250
TTDLEIQREA LSEELTYLQK NHEEEMVVLQ NASGGNINVE MNAAPSVDLT
260 270 280 290 300
AMLNNMRAEY EDLAEQNRKD AEASFKEKSA SLQQQISDDA GAATAARNEL
310 320 330 340 350
MELKRNLQTL EIELQSITAM KQSYENSLAE TEGNYYAQLQ QIQEQIGARE
360 370 380 390 400
EQLQQIRTET EGQKLEHEQL LGIKTCLEKE IDTYCNLLDG EEQRSESTSY
410 420 430 440 450
KPKDGKPASE FNDSAEETFA RTVAEELDQL GNLLSLRVHS VEEKSSKISN
460
ITMEQRVPSK AP
Length:462
Mass (Da):51,118
Last modified:October 11, 2005 - v1
Checksum:i2436531C7ECF8412
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971L → Q in BAE21173 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132445 mRNA. Translation: BAE21173.1.
AK162718 mRNA. Translation: BAE37035.1.
AL590991 Genomic DNA. Translation: CAM18788.1.
BC116672 mRNA. Translation: AAI16673.1.
CCDSiCCDS25378.1.
RefSeqiNP_001028569.2. NM_001033397.5.
UniGeneiMm.440509.

Genome annotation databases

EnsembliENSMUST00000100482; ENSMUSP00000098051; ENSMUSG00000075570.
GeneIDi320864.
KEGGimmu:320864.
UCSCiuc007lio.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132445 mRNA. Translation: BAE21173.1.
AK162718 mRNA. Translation: BAE37035.1.
AL590991 Genomic DNA. Translation: CAM18788.1.
BC116672 mRNA. Translation: AAI16673.1.
CCDSiCCDS25378.1.
RefSeqiNP_001028569.2. NM_001033397.5.
UniGeneiMm.440509.

3D structure databases

ProteinModelPortaliQ3TRJ4.
SMRiQ3TRJ4. Positions 302-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098051.

PTM databases

iPTMnetiQ3TRJ4.
PhosphoSiteiQ3TRJ4.

Proteomic databases

MaxQBiQ3TRJ4.
PaxDbiQ3TRJ4.
PeptideAtlasiQ3TRJ4.
PRIDEiQ3TRJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100482; ENSMUSP00000098051; ENSMUSG00000075570.
GeneIDi320864.
KEGGimmu:320864.
UCSCiuc007lio.2. mouse.

Organism-specific databases

CTDi353288.
MGIiMGI:2444913. Krt26.

Phylogenomic databases

eggNOGiENOG410JA2D. Eukaryota.
ENOG4111D4X. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ3TRJ4.
KOiK07604.
OMAiRYFSVIE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ3TRJ4.
TreeFamiTF332742.

Miscellaneous databases

PROiQ3TRJ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TRJ4.
CleanExiMM_KRT26.
GenevisibleiQ3TRJ4. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Neonatal skinImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiK1C26_MOUSE
AccessioniPrimary (citable) accession number: Q3TRJ4
Secondary accession number(s): Q3V1H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.