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Protein
Submitted name:

Protein S (Alpha)

Gene

Pros1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein S (Alpha)Imported
Gene namesi
Name:Pros1Imported
ORF Names:mCG_128002Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1095733. Pros1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501084329725 – 675Sequence analysisAdd BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi126 ↔ 143PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi161 ↔ 171PROSITE-ProRule annotation
Disulfide bondi638 ↔ 665PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ3TR66.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022912.

Structurei

3D structure databases

SMRiQ3TR66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 87GlaInterPro annotationAdd BLAST47
Domaini117 – 155EGF-likeInterPro annotationAdd BLAST39
Domaini157 – 200EGF-likeInterPro annotationAdd BLAST44
Domaini201 – 238EGF-likeInterPro annotationAdd BLAST38
Domaini243 – 283EGF-likeInterPro annotationAdd BLAST41
Domaini299 – 475LAM_G_DOMAINInterPro annotationAdd BLAST177
Domaini484 – 665LAM_G_DOMAINInterPro annotationAdd BLAST182

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IGF6. Eukaryota.
ENOG410ZTGU. LUCA.
HOVERGENiHBG051702.
KOiK03908.
OMAiWNMVSVE.
OrthoDBiEOG091G02L2.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiView protein in InterPro
IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
IPR033189. PROS1.
PANTHERiPTHR24040:SF6. PTHR24040:SF6. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PRINTSiPR00001. GLABLOOD.
SMARTiView protein in SMART
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3TR66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLSARFRV LLACLALVIP VSETNFLSKE RASQVLVRKR RANTLFEETM
60 70 80 90 100
KGNLERECIE ELCNKEEARE VFENNPETDY FYPKYLGCLG AFRVGSFHAA
110 120 130 140 150
RQSANAYPDL RSCVKAISDQ CDPIPCNEDG YLACQDGQAA FTCFCKPGWQ
160 170 180 190 200
GDRCQYDVNE CKDPSNVNGG CSQICDNTPG SYHCSCKRGF AMLPNKKDCK
210 220 230 240 250
DLDECALKPS VCGTAVCKNI PGDFECECPD GYRYDPSSKS CKDVDECSEN
260 270 280 290 300
MCAQLCVNFP GGYSCYCDGK KGFKLAQDQK SCEGIPVCLS LDLDKNYELL
310 320 330 340 350
YLAEQFAGVV LYLKFRLPDI TRFSAEFDFR TYDSEGIILY AESLDHSNWL
360 370 380 390 400
LIALRDGKIE VQFKNEFSTQ ITTGGNVINN GIWNMVSVEE LDDSVSIKIA
410 420 430 440 450
KEAVMNINKL GSLFKPTDGF LDTKIYFAGL PRKVESALIK PINPRLDGCI
460 470 480 490 500
RGWNLMKQGA LGAKEIIEGK QNKHCFLNVE KGSYYPGSGI AQFSIDYNNV
510 520 530 540 550
TNAEGWQMNV TLNIRPSTGT GVMLALVSGG TVPFALSLVD SRSGTSQDIV
560 570 580 590 600
VFVENSVVAR LEAVSLCSDQ QSQLKCNVNR NGLELWTPLR KDVIYSKDLQ
610 620 630 640 650
RQLAVLDKAM KRTVATYLGG IPDISFSATP VNAFYSGCME VNINGVQLDL
660 670
DEAISKHKDI RAHSCPSVRK IQKNF
Length:675
Mass (Da):74,934
Last modified:October 11, 2005 - v1
Checksum:i79D51203E85AF31F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128316 mRNA. Translation: AAI28317.1.
AK145501 mRNA. Translation: BAE26474.1.
AK163032 mRNA. Translation: BAE37164.1.
CH466521 Genomic DNA. Translation: EDK98237.1.
RefSeqiNP_035303.1. NM_011173.3.
UniGeneiMm.127156.

Genome annotation databases

GeneIDi19128.
KEGGimmu:19128.

Similar proteinsi

Entry informationi

Entry nameiQ3TR66_MOUSE
AccessioniPrimary (citable) accession number: Q3TR66
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation