Rock2

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processⁱ

positive regulation of centrosome duplication Source: InterPro
regulation of actin cytoskeleton organization Source: InterPro
Rho protein signal transduction Source: InterPro
smooth muscle contraction Source: InterPro

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Rock2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:107926. Rock2.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q3TR46.
PeptideAtlas More...PeptideAtlasⁱ	Q3TR46.
PRIDEⁱ	Q3TR46.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020580.
Genevisibleⁱ	Q3TR46. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3TR46.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	92 – 354	Protein kinaseInterPro annotationAdd BLAST		263
Domainⁱ	357 – 425	AGC-kinase C-terminalInterPro annotationAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0612. Eukaryota. ENOG410XR1Q. LUCA.
HOVERGENⁱ	HBG107817.
KEGG Orthology (KO) More...KOⁱ	K17388.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR029878. ROCK2. IPR008271. Ser/Thr_kinase_AS.
PANTHERⁱ	PTHR22988:SF40. PTHR22988:SF40. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q3TR46-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRPPPTGKM PGAPETAPGD GAGAGRQRKL EALIRDPRSP INVESLLDGL 
        60         70         80         90        100
NSLVLDLDFP ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR 
       110        120        130        140        150
GAFGEVQLVR HKASQKVYAM KLLSKFEMIK RSDSAFFWEE RDIMAFANSP 
       160        170        180        190        200
WVVQLFCAFQ DDRYLYMVME YMPGGDLVNL MSNYDVPEKW AKFYTAEVVL 
       210        220        230        240        250
ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD ETGMVHCDTA 
       260        270        280        290        300
VGTPDYISPE VLKSQGGDGY YGRECDWWSV GVFLFEMLVG DTPFYADSLV 
       310        320        330        340        350
GTYSKIMDHK NSLCFPEDTE ISKHAKNLIC AFLTDREVRL GRNGVEEIKQ 
       360        370        380        390        400
HPFFKNDQWN WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP 
       410        420        430 
KAFVGNQLPF IGFTYFRENL LLSDSPPCRE NDAIQT

Length:436

Mass (Da):49,418

Last modified:October 11, 2005 - v1

Checksum:ⁱD6AA01528EE18D20

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	436	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK163082 mRNA. Translation: BAE37184.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033098.2. NM_009072.2.
UniGeneⁱ	Mm.276024.

Genome annotation databases

GeneIDⁱ	19878.
KEGGⁱ	mmu:19878.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK163082 mRNA. Translation: BAE37184.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033098.2. NM_009072.2.
UniGeneⁱ	Mm.276024.

3D structure databases

ProteinModelPortalⁱ	Q3TR46.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3TR46.
PeptideAtlas More...PeptideAtlasⁱ	Q3TR46.
PRIDEⁱ	Q3TR46.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	19878.
KEGGⁱ	mmu:19878.

Organism-specific databases

CTDⁱ	9475.
MGIⁱ	MGI:107926. Rock2.

Phylogenomic databases

eggNOGⁱ	KOG0612. Eukaryota. ENOG410XR1Q. LUCA.
HOVERGENⁱ	HBG107817.
KEGG Orthology (KO) More...KOⁱ	K17388.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020580.
Genevisibleⁱ	Q3TR46. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR029878. ROCK2. IPR008271. Ser/Thr_kinase_AS.
PANTHERⁱ	PTHR22988:SF40. PTHR22988:SF40. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3TR46_MOUSE
Accessionⁱ	Q3TR46Primary (citable) accession number: Q3TR46
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - Q3TR46 (Q3TR46_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ