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Protein
Submitted name:

Origin recognition complex subunit 6

Gene

Orc6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. DNA-dependent DNA replication Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_274616. Activation of ATR in response to replication stress.
REACT_293164. Removal of licensing factors from origins.
REACT_297337. CDC6 association with the ORC:origin complex.
REACT_304291. Assembly of the ORC complex at the origin of replication.
REACT_315933. Orc1 removal from chromatin.
REACT_336670. Assembly of the pre-replicative complex.
REACT_343561. CDT1 association with the CDC6:ORC:origin complex.
REACT_346857. E2F-enabled inhibition of pre-replication complex formation.
REACT_351504. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Submitted name:
Origin recognition complex subunit 6Imported
Gene namesi
Name:Orc6Imported
Synonyms:Orc6lImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1929285. Orc6.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: MGI
  2. nuclear origin of replication recognition complex Source: InterPro
  3. nucleus Source: MGI
  4. origin recognition complex Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3TQX1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034132.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000007370.
HOVERGENiHBG007876.
KOiK02608.

Family and domain databases

InterProiIPR020529. ORC6_met/pln.
[Graphical view]
ProDomiPD315657. Origin_recog_cplx_su6-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q3TQX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYQSCLKSF ECLLGLNSNV GIRDLAVQFS CTEAVNLAAE ILQSYESGLP
60 70 80 90 100
ETQRADLDLS RPLFTTAALL SACKILKIKV DKTKMITASG VKKAILDRLC
110 120 130 140 150
KQLEKIGQQI NRDSADLARP ALKRKKPEFS PTLKKKEPGL EPPAKEIEVI
160 170 180
ETLHKLPKDE DLTQDYEEWK RKILENAAKA QTATAE
Length:186
Mass (Da):20,741
Last modified:October 11, 2005 - v1
Checksum:i5B1FEC395AF1C532
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134854 Genomic DNA. No translation available.
AK163256 mRNA. Translation: BAE37261.1.
RefSeqiNP_001157263.1. NM_001163791.1.
NP_062690.2. NM_019716.2.
UniGeneiMm.29709.

Genome annotation databases

EnsembliENSMUST00000170141; ENSMUSP00000126925; ENSMUSG00000031697.
GeneIDi56452.
KEGGimmu:56452.
UCSCiuc009mpq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134854 Genomic DNA. No translation available.
AK163256 mRNA. Translation: BAE37261.1.
RefSeqiNP_001157263.1. NM_001163791.1.
NP_062690.2. NM_019716.2.
UniGeneiMm.29709.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170141; ENSMUSP00000126925; ENSMUSG00000031697.
GeneIDi56452.
KEGGimmu:56452.
UCSCiuc009mpq.2. mouse.

Organism-specific databases

CTDi23594.
MGIiMGI:1929285. Orc6.

Phylogenomic databases

GeneTreeiENSGT00390000007370.
HOVERGENiHBG007876.
KOiK02608.

Enzyme and pathway databases

ReactomeiREACT_274616. Activation of ATR in response to replication stress.
REACT_293164. Removal of licensing factors from origins.
REACT_297337. CDC6 association with the ORC:origin complex.
REACT_304291. Assembly of the ORC complex at the origin of replication.
REACT_315933. Orc1 removal from chromatin.
REACT_336670. Assembly of the pre-replicative complex.
REACT_343561. CDT1 association with the CDC6:ORC:origin complex.
REACT_346857. E2F-enabled inhibition of pre-replication complex formation.
REACT_351504. Activation of the pre-replicative complex.

Miscellaneous databases

ChiTaRSiOrc6. mouse.
NextBioi312672.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3TQX1.

Family and domain databases

InterProiIPR020529. ORC6_met/pln.
[Graphical view]
ProDomiPD315657. Origin_recog_cplx_su6-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TQX1_MOUSE
AccessioniPrimary (citable) accession number: Q3TQX1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 29, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.