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Protein

Malic enzyme

Gene

Me1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821Proton donorUniRule annotation
Active sitei153 – 1531Proton acceptorUniRule annotation
Metal bindingi225 – 2251Divalent metal cationUniRule annotation
Metal bindingi226 – 2261Divalent metal cationUniRule annotation
Metal bindingi249 – 2491Divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malic enzymeUniRule annotation
Gene namesi
Name:Me1Imported
Synonyms:Mod1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97043. Me1.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ3TQP6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034989.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 240182malicInterPro annotationAdd
BLAST
Domaini250 – 502253Malic_MInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the malic enzymes family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
GeneTreeiENSGT00390000000754.
HOVERGENiHBG000746.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TQP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLICEDLAF TLEERQQLNI HGLLPPCIIS QELQVLRIIK NFERLNSDFD
60 70 80 90 100
RYLLLMDLQD RNEKLFYSVL MSDVEKFMPI VYTPTVGLAC QQYSLAFRKP
110 120 130 140 150
RGLFISIHDK GHIASVLNAW PEDVVKAIVV TDGERILGLG DLGCNGMGIP
160 170 180 190 200
VGKLALYTAC GGVNPQQCLP ITLDVGTENE ELLKDPLYIG LRHRRVRGPE
210 220 230 240 250
YDAFLDEFME AASSKYGMNC LIQFEDFANR NAFRLLNKYR NKYCTFNDDI
260 270 280 290 300
QGTASVAVAG LLAALRITKN KLSDQTVLFQ GAGEAALGIA HLVVMAMEKE
310 320 330 340 350
GLSKENARKK IWLVDSKGLI VKGRASLTEE KEVFAHEHEE MKNLEAIVQK
360 370 380 390 400
IKPTALIGVA AIGGAFTEQI LKDMAAFNER PIIFALSNPT SKAECSAEQC
410 420 430 440 450
YKVTKGRAIF ASGSPFDPVT LPDGRTLFPG QGNNSYVFPG VALGVVACGL
460 470 480 490 500
RHIDDKVFLT TAEVISQQVS DKHLQEGRLY PPLNTIRGVS LKIAVKIVQD
510 520 530 540 550
AYKEKMATVY PEPQNKEEFV SSQMYSTNYD QILPDCYPWP AEVQKIQTKV

NQ
Length:552
Mass (Da):61,481
Last modified:October 11, 2005 - v1
Checksum:i5F8E86740072DC03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159811 Genomic DNA. No translation available.
CT025628 Genomic DNA. No translation available.
AK163403 mRNA. Translation: BAE37336.1.
RefSeqiNP_001185862.1. NM_001198933.1.
UniGeneiMm.148155.

Genome annotation databases

EnsembliENSMUST00000185374; ENSMUSP00000140887; ENSMUSG00000032418.
GeneIDi17436.
UCSCiuc009qxr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159811 Genomic DNA. No translation available.
CT025628 Genomic DNA. No translation available.
AK163403 mRNA. Translation: BAE37336.1.
RefSeqiNP_001185862.1. NM_001198933.1.
UniGeneiMm.148155.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034989.

Proteomic databases

PeptideAtlasiQ3TQP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000185374; ENSMUSP00000140887; ENSMUSG00000032418.
GeneIDi17436.
UCSCiuc009qxr.2. mouse.

Organism-specific databases

CTDi4199.
MGIiMGI:97043. Me1.

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
GeneTreeiENSGT00390000000754.
HOVERGENiHBG000746.

Miscellaneous databases

ChiTaRSiMe1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiSM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EggImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TQP6_MOUSE
AccessioniPrimary (citable) accession number: Q3TQP6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.