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Protein

Malic enzyme

Gene

Me1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82Proton donorUniRule annotation1
Active sitei153Proton acceptorUniRule annotation1
Metal bindingi225Divalent metal cationUniRule annotation1
Metal bindingi226Divalent metal cationUniRule annotation1
Metal bindingi249Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malic enzymeUniRule annotation
Gene namesi
Name:Me1Imported
Synonyms:Mod1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97043. Me1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000032418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 240malicInterPro annotationAdd BLAST182
Domaini250 – 502Malic_MInterPro annotationAdd BLAST253

Sequence similaritiesi

Belongs to the malic enzymes family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
GeneTreeiENSGT00390000000754.
HOVERGENiHBG000746.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
InterProiView protein in InterPro
IPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR037062. Malic_N_dom_sf.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiView protein in SMART
SM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00331. MALIC_ENZYMES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TQP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLICEDLAF TLEERQQLNI HGLLPPCIIS QELQVLRIIK NFERLNSDFD
60 70 80 90 100
RYLLLMDLQD RNEKLFYSVL MSDVEKFMPI VYTPTVGLAC QQYSLAFRKP
110 120 130 140 150
RGLFISIHDK GHIASVLNAW PEDVVKAIVV TDGERILGLG DLGCNGMGIP
160 170 180 190 200
VGKLALYTAC GGVNPQQCLP ITLDVGTENE ELLKDPLYIG LRHRRVRGPE
210 220 230 240 250
YDAFLDEFME AASSKYGMNC LIQFEDFANR NAFRLLNKYR NKYCTFNDDI
260 270 280 290 300
QGTASVAVAG LLAALRITKN KLSDQTVLFQ GAGEAALGIA HLVVMAMEKE
310 320 330 340 350
GLSKENARKK IWLVDSKGLI VKGRASLTEE KEVFAHEHEE MKNLEAIVQK
360 370 380 390 400
IKPTALIGVA AIGGAFTEQI LKDMAAFNER PIIFALSNPT SKAECSAEQC
410 420 430 440 450
YKVTKGRAIF ASGSPFDPVT LPDGRTLFPG QGNNSYVFPG VALGVVACGL
460 470 480 490 500
RHIDDKVFLT TAEVISQQVS DKHLQEGRLY PPLNTIRGVS LKIAVKIVQD
510 520 530 540 550
AYKEKMATVY PEPQNKEEFV SSQMYSTNYD QILPDCYPWP AEVQKIQTKV

NQ
Length:552
Mass (Da):61,481
Last modified:October 11, 2005 - v1
Checksum:i5F8E86740072DC03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159811 Genomic DNA. No translation available.
CT025628 Genomic DNA. No translation available.
AK163403 mRNA. Translation: BAE37336.1.
RefSeqiNP_001185862.1. NM_001198933.1.
UniGeneiMm.148155.

Genome annotation databases

EnsembliENSMUST00000185374; ENSMUSP00000140887; ENSMUSG00000032418.
GeneIDi17436.
UCSCiuc009qxr.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3TQP6_MOUSE
AccessioniPrimary (citable) accession number: Q3TQP6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported