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Protein

F-box only protein 31

Gene

Fbxo31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31
Gene namesi
Name:Fbxo31
ORF Names:MNCb-2609
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1354708 Fbxo31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492601 – 507F-box only protein 31Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei264Phosphoserine; by ATMBy similarity1

Post-translational modificationi

Phosphorylation by ATM following gamma-irradiation results in its stabilization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3TQF0
PaxDbiQ3TQF0
PRIDEiQ3TQF0

PTM databases

iPTMnetiQ3TQF0
PhosphoSitePlusiQ3TQF0

Expressioni

Gene expression databases

BgeeiENSMUSG00000052934
ExpressionAtlasiQ3TQF0 baseline and differential
GenevisibleiQ3TQF0 MM

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218134, 1 interactor
STRINGi10090.ENSMUSP00000057573

Structurei

3D structure databases

ProteinModelPortaliQ3TQF0
SMRiQ3TQF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 96F-boxPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the FBXO31 family.Curated

Phylogenomic databases

eggNOGiENOG410IFQE Eukaryota
ENOG410XPRQ LUCA
GeneTreeiENSGT00390000001368
HOGENOMiHOG000112543
HOVERGENiHBG071549
InParanoidiQ3TQF0
KOiK10308
OMAiPQAFEEM
OrthoDBiEOG091G0N70
PhylomeDBiQ3TQF0
TreeFamiTF331818

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR026941 FBXO31
PANTHERiPTHR10706:SF126 PTHR10706:SF126, 1 hit
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TQF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR
60 70 80 90 100
CSLLELPPEL LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE
110 120 130 140 150
YGVCENLRKL EITGVSCRDV YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV
160 170 180 190 200
DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI HLMERKSATV ECMYGHKGPH
210 220 230 240 250
NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW GRTLEDIFHE
260 270 280 290 300
HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL
310 320 330 340 350
EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN
360 370 380 390 400
ELSRIVLEVR EQVRQEQEAG EGAAPPREPS AKAADGPPAK DGKEPGGGAE
410 420 430 440 450
AAEQSASSGQ GQPFVLPVGV SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE
460 470 480 490 500
RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV QATFQNAAAP SPQAFDEMLR

NIQSLTS
Length:507
Mass (Da):57,191
Last modified:October 11, 2005 - v1
Checksum:iCF6880553F5ABB0C
GO

Sequence cautioni

The sequence AAH26929 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA95069 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207V → L in AAH26929 (PubMed:15489334).Curated1
Sequence conflicti313R → W in BAA95069 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163641 mRNA Translation: BAE37434.1
BC026929 mRNA Translation: AAH26929.1 Different initiation.
AB041586 mRNA Translation: BAA95069.1 Different initiation.
CCDSiCCDS52693.1
RefSeqiNP_598526.3, NM_133765.4
UniGeneiMm.24829

Genome annotation databases

EnsembliENSMUST00000059018; ENSMUSP00000057573; ENSMUSG00000052934
GeneIDi76454
KEGGimmu:76454
UCSCiuc009nrv.3 mouse

Similar proteinsi

Entry informationi

Entry nameiFBX31_MOUSE
AccessioniPrimary (citable) accession number: Q3TQF0
Secondary accession number(s): Q8K1A7, Q9JJC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 11, 2005
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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