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Unreviewed, UniProtKB/TrEMBL Q3TQ39 (Q3TQ39_MOUSE)

Last modified January 19, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Protein kinase C, alpha EMBL CAM15233.1
Submitted name:
    Putative uncharacterized protein EMBL BAE37546.1
Gene names
Name: Prkca MGI 97595
ORF Names: RP23-145G23.2-004 EMBL CAM15233.1
OrganismMus musculus (Mouse) EMBL BAE37546.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Spearmint SPM000961

Sequence similarities

Contains 1 AGC-kinase C-terminal domain.

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Ontologies

Keywords
   LigandATP-binding Spearmint SPM000961
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase Spearmint SPM000961
Transferase
Gene Ontology (GO)
   Biological processcellular calcium ion homeostasis

Inferred from mutant phenotype. Source: MGI

chondrocyte differentiation

Inferred from direct assay. Source: MGI

inactivation of MAPK activity

Inferred from mutant phenotype. Source: MGI

induction of apoptosis by intracellular signals

Inferred from mutant phenotype. Source: MGI

induction of positive chemotaxis

Inferred from mutant phenotype. Source: MGI

negative regulation of cell proliferation

Inferred from genetic interaction. Source: MGI

negative regulation of glucose import

Inferred from mutant phenotype. Source: MGI

negative regulation of insulin receptor signaling pathway

Inferred from mutant phenotype. Source: MGI

negative regulation of protein amino acid phosphorylation

Inferred from mutant phenotype. Source: MGI

neutrophil chemotaxis

Inferred from mutant phenotype. Source: MGI

positive regulation of inflammatory response

Inferred from mutant phenotype. Source: MGI

positive regulation of protein amino acid phosphorylation

Inferred from mutant phenotype. Source: MGI

protein amino acid phosphorylation

Inferred from direct assay. Source: MGI

regulation of muscle contraction

Inferred from mutant phenotype. Source: MGI

regulation of peptidyl-tyrosine phosphorylation

Inferred from mutant phenotype. Source: MGI

regulation of the force of heart contraction

Inferred from mutant phenotype. Source: MGI

   Cellular componentmitochondrion

Inferred from direct assay. Source: MGI

nucleus

Inferred from direct assay. Source: MGI

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

calcium-dependent protein kinase C activity

Inferred from direct assay. Source: MGI

protein binding

Inferred from physical interaction. Source: MGI

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q3TQ39-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: D54E2ED5B9B682ED

FASTA24828,449
        10         20         30         40         50         60 
MKRQVQMQSQ LWKAREGFYA AEISIGLFFL HKRGIIYRDL KLDNVMLDSE GHIKIADFGM 

        70         80         90        100        110        120 
CKEHMMDGVT TRTFCGTPDY IAPEIIAYQP YGKSVDWWAY GVLLYEMLAG QPPFDGEDED 

       130        140        150        160        170        180 
ELFQSIMEHN VSYPKSLSKE AVSICKGLMT KHPAKRLGCG PEGERDVREH AFFRRIDWEK 

       190        200        210        220        230        240 
LENREIQPPF KPKVCGKGAE NFDKFFTRGQ PVLTPPDQLV IANIDQSDFE GFSYVNPQFV 


HPILQSAV

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References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE37546.1.
Tissue: Cerebellum EMBL BAE37546.1.
[2]Holt K.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK163950 mRNA. Translation: BAE37546.1.
AL645535 Genomic DNA. Translation: CAM15233.1.
IPIIPI00652220.
UniGeneMm.222178

3D structure databases

SMRQ3TQ39. Positions 18-242.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3TQ39.

Proteomic databases

PRIDEQ3TQ39.

Genome annotation databases

EnsemblENSMUST00000100302; ENSMUSP00000097875; ENSMUSG00000050965; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:97595. Prkca.

Phylogenomic databases

HOVERGENQ3TQ39.

Gene expression databases

ArrayExpressQ3TQ39.
BgeeQ3TQ39.
GenevestigatorQ3TQ39.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015745. PKC.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_cat_dom.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
[Graphical view]
PANTHERPTHR22985:SF86. PKC. 1 hit.
PfamPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00133. S_TK_X. 1 hit.
[Graphical view]
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ3TQ39_MOUSE
AccessionPrimary (citable) accession number: Q3TQ39
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 19, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information