SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3TPX4

- EXOC5_MOUSE

UniProt

Q3TPX4 - EXOC5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Exocyst complex component 5

Gene
Exoc5, Sec10l1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane By similarity.

GO - Molecular functioni

  1. protein N-terminus binding Source: UniProtKB

GO - Biological processi

  1. exocytosis Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
  3. vesicle docking Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_207837. Insulin processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Gene namesi
Name:Exoc5
Synonyms:Sec10l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2145645. Exoc5.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 708707Exocyst complex component 5PRO_0000118944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei122 – 1221Phosphothreonine By similarity
Modified residuei395 – 3951Phosphothreonine By similarity
Modified residuei405 – 4051Phosphothreonine By similarity
Modified residuei412 – 4121Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TPX4.
PaxDbiQ3TPX4.
PRIDEiQ3TPX4.

PTM databases

PhosphoSiteiQ3TPX4.

Expressioni

Gene expression databases

ArrayExpressiQ3TPX4.
BgeeiQ3TPX4.
CleanExiMM_EXOC5.
GenevestigatoriQ3TPX4.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity. Interacts with EXOC3L1.1 Publication

Protein-protein interaction databases

BioGridi222868. 1 interaction.
IntActiQ3TPX4. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3TPX4.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 10162 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the SEC10 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG261139.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiQ80VK3.
OMAiPYTEGQR.
OrthoDBiEOG7SJD3Z.
PhylomeDBiQ3TPX4.
TreeFamiTF314966.

Family and domain databases

InterProiIPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TPX4-1 [UniParc]FASTAAdd to Basket

« Hide

MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI    50
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD 100
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF 150
TNSEKIKEAA DVIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF 200
TSAQRRGEVS RMREVAAVLL HFKGYSHCID VYIKQCQEGA YLRNDIFEDA 250
AILCQRVNKQ VGDIFSNPEA VLAKLIQSVF EIKLQSFVKD QLEECRKSDA 300
EQYLKSLYDL YTRTTGLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI 350
EVEIGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG 400
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL 450
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF 500
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI 550
LAAEQKKTDF KPEDENNVLI QYTNACVKVC VYVRKQVEKI KNSMDGKNVD 600
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV 650
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS 700
ARLARHFS 708
Length:708
Mass (Da):81,738
Last modified:July 27, 2011 - v2
Checksum:i257374EE3EA58356
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti628 – 6281G → D in BAE37611. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK164067 mRNA. Translation: BAE37611.1.
AK157473 mRNA. Translation: BAE34093.1.
AK167145 mRNA. Translation: BAE39290.1.
AK171012 mRNA. Translation: BAE42183.1.
CH466605 Genomic DNA. Translation: EDL20783.1.
BC049967 mRNA. Translation: AAH49967.1.
CCDSiCCDS49474.1.
RefSeqiNP_997097.1. NM_207214.3.
UniGeneiMm.31607.

Genome annotation databases

EnsembliENSMUST00000162175; ENSMUSP00000125434; ENSMUSG00000061244.
GeneIDi105504.
KEGGimmu:105504.
UCSCiuc007tjv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK164067 mRNA. Translation: BAE37611.1 .
AK157473 mRNA. Translation: BAE34093.1 .
AK167145 mRNA. Translation: BAE39290.1 .
AK171012 mRNA. Translation: BAE42183.1 .
CH466605 Genomic DNA. Translation: EDL20783.1 .
BC049967 mRNA. Translation: AAH49967.1 .
CCDSi CCDS49474.1.
RefSeqi NP_997097.1. NM_207214.3.
UniGenei Mm.31607.

3D structure databases

ProteinModelPortali Q3TPX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222868. 1 interaction.
IntActi Q3TPX4. 2 interactions.

PTM databases

PhosphoSitei Q3TPX4.

Proteomic databases

MaxQBi Q3TPX4.
PaxDbi Q3TPX4.
PRIDEi Q3TPX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000162175 ; ENSMUSP00000125434 ; ENSMUSG00000061244 .
GeneIDi 105504.
KEGGi mmu:105504.
UCSCi uc007tjv.2. mouse.

Organism-specific databases

CTDi 10640.
MGIi MGI:2145645. Exoc5.

Phylogenomic databases

eggNOGi NOG261139.
GeneTreei ENSGT00390000012837.
HOGENOMi HOG000007911.
HOVERGENi HBG055591.
InParanoidi Q80VK3.
OMAi PYTEGQR.
OrthoDBi EOG7SJD3Z.
PhylomeDBi Q3TPX4.
TreeFami TF314966.

Enzyme and pathway databases

Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_207837. Insulin processing.

Miscellaneous databases

NextBioi 357738.
PROi Q3TPX4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3TPX4.
Bgeei Q3TPX4.
CleanExi MM_EXOC5.
Genevestigatori Q3TPX4.

Family and domain databases

InterProi IPR009976. Sec10-like.
[Graphical view ]
PANTHERi PTHR12100. PTHR12100. 1 hit.
Pfami PF07393. Sec10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion."
    Saito T., Shibasaki T., Seino S.
    Biomed. Res. 29:85-91(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EXOC3L1.

Entry informationi

Entry nameiEXOC5_MOUSE
AccessioniPrimary (citable) accession number: Q3TPX4
Secondary accession number(s): Q80VK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi