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Q3TPX4

- EXOC5_MOUSE

UniProt

Q3TPX4 - EXOC5_MOUSE

Protein

Exocyst complex component 5

Gene

Exoc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

    GO - Molecular functioni

    1. protein N-terminus binding Source: UniProtKB

    GO - Biological processi

    1. exocytosis Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW
    3. vesicle docking Source: InterPro

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.
    REACT_207837. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exocyst complex component 5
    Alternative name(s):
    Exocyst complex component Sec10
    Gene namesi
    Name:Exoc5
    Synonyms:Sec10l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2145645. Exoc5.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 708707Exocyst complex component 5PRO_0000118944Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei122 – 1221PhosphothreonineBy similarity
    Modified residuei395 – 3951PhosphothreonineBy similarity
    Modified residuei405 – 4051PhosphothreonineBy similarity
    Modified residuei412 – 4121PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ3TPX4.
    PaxDbiQ3TPX4.
    PRIDEiQ3TPX4.

    PTM databases

    PhosphoSiteiQ3TPX4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TPX4.
    BgeeiQ3TPX4.
    CleanExiMM_EXOC5.
    GenevestigatoriQ3TPX4.

    Interactioni

    Subunit structurei

    The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity. Interacts with EXOC3L1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi222868. 1 interaction.
    IntActiQ3TPX4. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TPX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili40 – 10162Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC10 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG261139.
    GeneTreeiENSGT00390000012837.
    HOGENOMiHOG000007911.
    HOVERGENiHBG055591.
    InParanoidiQ80VK3.
    OMAiPYTEGQR.
    OrthoDBiEOG7SJD3Z.
    PhylomeDBiQ3TPX4.
    TreeFamiTF314966.

    Family and domain databases

    InterProiIPR009976. Sec10-like.
    [Graphical view]
    PANTHERiPTHR12100. PTHR12100. 1 hit.
    PfamiPF07393. Sec10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3TPX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI    50
    QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD 100
    EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF 150
    TNSEKIKEAA DVIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF 200
    TSAQRRGEVS RMREVAAVLL HFKGYSHCID VYIKQCQEGA YLRNDIFEDA 250
    AILCQRVNKQ VGDIFSNPEA VLAKLIQSVF EIKLQSFVKD QLEECRKSDA 300
    EQYLKSLYDL YTRTTGLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI 350
    EVEIGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG 400
    PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL 450
    VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF 500
    NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI 550
    LAAEQKKTDF KPEDENNVLI QYTNACVKVC VYVRKQVEKI KNSMDGKNVD 600
    TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV 650
    LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS 700
    ARLARHFS 708
    Length:708
    Mass (Da):81,738
    Last modified:July 27, 2011 - v2
    Checksum:i257374EE3EA58356
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti628 – 6281G → D in BAE37611. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK164067 mRNA. Translation: BAE37611.1.
    AK157473 mRNA. Translation: BAE34093.1.
    AK167145 mRNA. Translation: BAE39290.1.
    AK171012 mRNA. Translation: BAE42183.1.
    CH466605 Genomic DNA. Translation: EDL20783.1.
    BC049967 mRNA. Translation: AAH49967.1.
    CCDSiCCDS49474.1.
    RefSeqiNP_997097.1. NM_207214.3.
    UniGeneiMm.31607.

    Genome annotation databases

    EnsembliENSMUST00000162175; ENSMUSP00000125434; ENSMUSG00000061244.
    GeneIDi105504.
    KEGGimmu:105504.
    UCSCiuc007tjv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK164067 mRNA. Translation: BAE37611.1 .
    AK157473 mRNA. Translation: BAE34093.1 .
    AK167145 mRNA. Translation: BAE39290.1 .
    AK171012 mRNA. Translation: BAE42183.1 .
    CH466605 Genomic DNA. Translation: EDL20783.1 .
    BC049967 mRNA. Translation: AAH49967.1 .
    CCDSi CCDS49474.1.
    RefSeqi NP_997097.1. NM_207214.3.
    UniGenei Mm.31607.

    3D structure databases

    ProteinModelPortali Q3TPX4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222868. 1 interaction.
    IntActi Q3TPX4. 2 interactions.

    PTM databases

    PhosphoSitei Q3TPX4.

    Proteomic databases

    MaxQBi Q3TPX4.
    PaxDbi Q3TPX4.
    PRIDEi Q3TPX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000162175 ; ENSMUSP00000125434 ; ENSMUSG00000061244 .
    GeneIDi 105504.
    KEGGi mmu:105504.
    UCSCi uc007tjv.2. mouse.

    Organism-specific databases

    CTDi 10640.
    MGIi MGI:2145645. Exoc5.

    Phylogenomic databases

    eggNOGi NOG261139.
    GeneTreei ENSGT00390000012837.
    HOGENOMi HOG000007911.
    HOVERGENi HBG055591.
    InParanoidi Q80VK3.
    OMAi PYTEGQR.
    OrthoDBi EOG7SJD3Z.
    PhylomeDBi Q3TPX4.
    TreeFami TF314966.

    Enzyme and pathway databases

    Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.
    REACT_207837. Insulin processing.

    Miscellaneous databases

    NextBioi 357738.
    PROi Q3TPX4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TPX4.
    Bgeei Q3TPX4.
    CleanExi MM_EXOC5.
    Genevestigatori Q3TPX4.

    Family and domain databases

    InterProi IPR009976. Sec10-like.
    [Graphical view ]
    PANTHERi PTHR12100. PTHR12100. 1 hit.
    Pfami PF07393. Sec10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spleen.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    5. "Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion."
      Saito T., Shibasaki T., Seino S.
      Biomed. Res. 29:85-91(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EXOC3L1.

    Entry informationi

    Entry nameiEXOC5_MOUSE
    AccessioniPrimary (citable) accession number: Q3TPX4
    Secondary accession number(s): Q80VK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3