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Q3TPX4

- EXOC5_MOUSE

UniProt

Q3TPX4 - EXOC5_MOUSE

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Protein

Exocyst complex component 5

Gene

Exoc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  1. protein N-terminus binding Source: UniProtKB

GO - Biological processi

  1. exocytosis Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
  3. vesicle docking Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_207837. Insulin processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Gene namesi
Name:Exoc5
Synonyms:Sec10l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2145645. Exoc5.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 708707Exocyst complex component 5PRO_0000118944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei122 – 1221PhosphothreonineBy similarity
Modified residuei395 – 3951PhosphothreonineBy similarity
Modified residuei405 – 4051PhosphothreonineBy similarity
Modified residuei412 – 4121PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TPX4.
PaxDbiQ3TPX4.
PRIDEiQ3TPX4.

PTM databases

PhosphoSiteiQ3TPX4.

Expressioni

Gene expression databases

BgeeiQ3TPX4.
CleanExiMM_EXOC5.
ExpressionAtlasiQ3TPX4. baseline and differential.
GenevestigatoriQ3TPX4.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1.By similarity1 Publication

Protein-protein interaction databases

BioGridi222868. 1 interaction.
IntActiQ3TPX4. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3TPX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 10162Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG261139.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiQ3TPX4.
OMAiPYTEGQR.
OrthoDBiEOG7SJD3Z.
PhylomeDBiQ3TPX4.
TreeFamiTF314966.

Family and domain databases

InterProiIPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TPX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI
60 70 80 90 100
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD
110 120 130 140 150
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF
160 170 180 190 200
TNSEKIKEAA DVIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF
210 220 230 240 250
TSAQRRGEVS RMREVAAVLL HFKGYSHCID VYIKQCQEGA YLRNDIFEDA
260 270 280 290 300
AILCQRVNKQ VGDIFSNPEA VLAKLIQSVF EIKLQSFVKD QLEECRKSDA
310 320 330 340 350
EQYLKSLYDL YTRTTGLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI
360 370 380 390 400
EVEIGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG
410 420 430 440 450
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL
460 470 480 490 500
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF
510 520 530 540 550
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI
560 570 580 590 600
LAAEQKKTDF KPEDENNVLI QYTNACVKVC VYVRKQVEKI KNSMDGKNVD
610 620 630 640 650
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV
660 670 680 690 700
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS

ARLARHFS
Length:708
Mass (Da):81,738
Last modified:July 27, 2011 - v2
Checksum:i257374EE3EA58356
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti628 – 6281G → D in BAE37611. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164067 mRNA. Translation: BAE37611.1.
AK157473 mRNA. Translation: BAE34093.1.
AK167145 mRNA. Translation: BAE39290.1.
AK171012 mRNA. Translation: BAE42183.1.
CH466605 Genomic DNA. Translation: EDL20783.1.
BC049967 mRNA. Translation: AAH49967.1.
CCDSiCCDS49474.1.
RefSeqiNP_997097.1. NM_207214.3.
UniGeneiMm.31607.

Genome annotation databases

EnsembliENSMUST00000162175; ENSMUSP00000125434; ENSMUSG00000061244.
GeneIDi105504.
KEGGimmu:105504.
UCSCiuc007tjv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164067 mRNA. Translation: BAE37611.1 .
AK157473 mRNA. Translation: BAE34093.1 .
AK167145 mRNA. Translation: BAE39290.1 .
AK171012 mRNA. Translation: BAE42183.1 .
CH466605 Genomic DNA. Translation: EDL20783.1 .
BC049967 mRNA. Translation: AAH49967.1 .
CCDSi CCDS49474.1.
RefSeqi NP_997097.1. NM_207214.3.
UniGenei Mm.31607.

3D structure databases

ProteinModelPortali Q3TPX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222868. 1 interaction.
IntActi Q3TPX4. 2 interactions.

PTM databases

PhosphoSitei Q3TPX4.

Proteomic databases

MaxQBi Q3TPX4.
PaxDbi Q3TPX4.
PRIDEi Q3TPX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000162175 ; ENSMUSP00000125434 ; ENSMUSG00000061244 .
GeneIDi 105504.
KEGGi mmu:105504.
UCSCi uc007tjv.2. mouse.

Organism-specific databases

CTDi 10640.
MGIi MGI:2145645. Exoc5.

Phylogenomic databases

eggNOGi NOG261139.
GeneTreei ENSGT00390000012837.
HOGENOMi HOG000007911.
HOVERGENi HBG055591.
InParanoidi Q3TPX4.
OMAi PYTEGQR.
OrthoDBi EOG7SJD3Z.
PhylomeDBi Q3TPX4.
TreeFami TF314966.

Enzyme and pathway databases

Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_207837. Insulin processing.

Miscellaneous databases

ChiTaRSi Exoc5. mouse.
NextBioi 357738.
PROi Q3TPX4.
SOURCEi Search...

Gene expression databases

Bgeei Q3TPX4.
CleanExi MM_EXOC5.
ExpressionAtlasi Q3TPX4. baseline and differential.
Genevestigatori Q3TPX4.

Family and domain databases

InterProi IPR009976. Sec10-like.
[Graphical view ]
PANTHERi PTHR12100. PTHR12100. 1 hit.
Pfami PF07393. Sec10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion."
    Saito T., Shibasaki T., Seino S.
    Biomed. Res. 29:85-91(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EXOC3L1.

Entry informationi

Entry nameiEXOC5_MOUSE
AccessioniPrimary (citable) accession number: Q3TPX4
Secondary accession number(s): Q80VK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3