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Q3TPX4 (EXOC5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Gene names
Name:Exoc5
Synonyms:Sec10l1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length708 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane By similarity.

Subunit structure

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity. Interacts with EXOC3L1. Ref.5

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the SEC10 family.

Ontologies

Keywords
   Biological processExocytosis
Protein transport
Transport
   Cellular componentCytoplasm
   DomainCoiled coil
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processexocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

vesicle docking

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

   Molecular_functionprotein N-terminus binding

Inferred from physical interaction Ref.5. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 708707Exocyst complex component 5
PRO_0000118944

Regions

Coiled coil40 – 10162 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1221Phosphothreonine By similarity
Modified residue3951Phosphothreonine By similarity
Modified residue4051Phosphothreonine By similarity
Modified residue4121Phosphoserine By similarity

Experimental info

Sequence conflict6281G → D in BAE37611. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3TPX4 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 257374EE3EA58356

FASTA70881,738
        10         20         30         40         50         60 
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI QELQIMDERI 

        70         80         90        100        110        120 
QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD EHISYVATKV CHLGDQLEGV 

       130        140        150        160        170        180 
NTPRQRAVEA QKLMKYFNEF LDGELKSDVF TNSEKIKEAA DVIQKLHLIA QELPFDRFSE 

       190        200        210        220        230        240 
VKSKIASKYH DLECQLIQEF TSAQRRGEVS RMREVAAVLL HFKGYSHCID VYIKQCQEGA 

       250        260        270        280        290        300 
YLRNDIFEDA AILCQRVNKQ VGDIFSNPEA VLAKLIQSVF EIKLQSFVKD QLEECRKSDA 

       310        320        330        340        350        360 
EQYLKSLYDL YTRTTGLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI EVEIGYLKSR 

       370        380        390        400        410        420 
SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG PSIDTHGETF LSQEVVVNLL 

       430        440        450        460        470        480 
QETKQAFERC HRLSDPSDLP RNAFRIFTIL VEFLCIEHID YALETGLAGI PSSDSRNANL 

       490        500        510        520        530        540 
YFLDVVQQAN TIFHLFDKQF NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL 

       550        560        570        580        590        600 
NCMIGQMKHI LAAEQKKTDF KPEDENNVLI QYTNACVKVC VYVRKQVEKI KNSMDGKNVD 

       610        620        630        640        650        660 
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV LHLFDTLHAL 

       670        680        690        700 
CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS ARLARHFS 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Spleen.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[5]"Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion."
Saito T., Shibasaki T., Seino S.
Biomed. Res. 29:85-91(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EXOC3L1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK164067 mRNA. Translation: BAE37611.1.
AK157473 mRNA. Translation: BAE34093.1.
AK167145 mRNA. Translation: BAE39290.1.
AK171012 mRNA. Translation: BAE42183.1.
CH466605 Genomic DNA. Translation: EDL20783.1.
BC049967 mRNA. Translation: AAH49967.1.
CCDSCCDS49474.1.
RefSeqNP_997097.1. NM_207214.3.
UniGeneMm.31607.

3D structure databases

ProteinModelPortalQ3TPX4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid222868. 1 interaction.
IntActQ3TPX4. 2 interactions.

PTM databases

PhosphoSiteQ3TPX4.

Proteomic databases

MaxQBQ3TPX4.
PaxDbQ3TPX4.
PRIDEQ3TPX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000162175; ENSMUSP00000125434; ENSMUSG00000061244.
GeneID105504.
KEGGmmu:105504.
UCSCuc007tjv.2. mouse.

Organism-specific databases

CTD10640.
MGIMGI:2145645. Exoc5.

Phylogenomic databases

eggNOGNOG261139.
GeneTreeENSGT00390000012837.
HOGENOMHOG000007911.
HOVERGENHBG055591.
InParanoidQ80VK3.
OMAPYTEGQR.
OrthoDBEOG7SJD3Z.
PhylomeDBQ3TPX4.
TreeFamTF314966.

Enzyme and pathway databases

ReactomeREACT_147847. Translocation of Glut4 to the Plasma Membrane.
REACT_209837. Membrane Trafficking.

Gene expression databases

ArrayExpressQ3TPX4.
BgeeQ3TPX4.
CleanExMM_EXOC5.
GenevestigatorQ3TPX4.

Family and domain databases

InterProIPR009976. Sec10-like.
[Graphical view]
PANTHERPTHR12100. PTHR12100. 1 hit.
PfamPF07393. Sec10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio357738.
PROQ3TPX4.
SOURCESearch...

Entry information

Entry nameEXOC5_MOUSE
AccessionPrimary (citable) accession number: Q3TPX4
Secondary accession number(s): Q80VK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot