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Protein

Exocyst complex component 5

Gene

Exoc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Gene namesi
Name:Exoc5
Synonyms:Sec10l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2145645. Exoc5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001189442 – 708Exocyst complex component 5Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei395PhosphothreonineBy similarity1
Modified residuei405PhosphothreonineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TPX4.
MaxQBiQ3TPX4.
PaxDbiQ3TPX4.
PeptideAtlasiQ3TPX4.
PRIDEiQ3TPX4.

PTM databases

iPTMnetiQ3TPX4.
PhosphoSitePlusiQ3TPX4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061244.
CleanExiMM_EXOC5.
ExpressionAtlasiQ3TPX4. baseline and differential.
GenevisibleiQ3TPX4. MM.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1.By similarity1 Publication

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi222868. 1 interactor.
IntActiQ3TPX4. 2 interactors.
STRINGi10090.ENSMUSP00000125434.

Structurei

3D structure databases

ProteinModelPortaliQ3TPX4.
SMRiQ3TPX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 101Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3745. Eukaryota.
ENOG410XSQQ. LUCA.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiQ3TPX4.
KOiK19984.
OMAiMCAICDV.
OrthoDBiEOG091G03RW.
PhylomeDBiQ3TPX4.
TreeFamiTF314966.

Family and domain databases

InterProiIPR033960. EXOC5/Sec10.
IPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PTHR12100:SF0. PTHR12100:SF0. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TPX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI
60 70 80 90 100
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD
110 120 130 140 150
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF
160 170 180 190 200
TNSEKIKEAA DVIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF
210 220 230 240 250
TSAQRRGEVS RMREVAAVLL HFKGYSHCID VYIKQCQEGA YLRNDIFEDA
260 270 280 290 300
AILCQRVNKQ VGDIFSNPEA VLAKLIQSVF EIKLQSFVKD QLEECRKSDA
310 320 330 340 350
EQYLKSLYDL YTRTTGLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI
360 370 380 390 400
EVEIGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG
410 420 430 440 450
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL
460 470 480 490 500
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF
510 520 530 540 550
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI
560 570 580 590 600
LAAEQKKTDF KPEDENNVLI QYTNACVKVC VYVRKQVEKI KNSMDGKNVD
610 620 630 640 650
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV
660 670 680 690 700
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS

ARLARHFS
Length:708
Mass (Da):81,738
Last modified:July 27, 2011 - v2
Checksum:i257374EE3EA58356
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti628G → D in BAE37611 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164067 mRNA. Translation: BAE37611.1.
AK157473 mRNA. Translation: BAE34093.1.
AK167145 mRNA. Translation: BAE39290.1.
AK171012 mRNA. Translation: BAE42183.1.
CH466605 Genomic DNA. Translation: EDL20783.1.
BC049967 mRNA. Translation: AAH49967.1.
CCDSiCCDS49474.1.
RefSeqiNP_997097.1. NM_207214.3.
UniGeneiMm.31607.

Genome annotation databases

EnsembliENSMUST00000162175; ENSMUSP00000125434; ENSMUSG00000061244.
GeneIDi105504.
KEGGimmu:105504.
UCSCiuc007tjv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164067 mRNA. Translation: BAE37611.1.
AK157473 mRNA. Translation: BAE34093.1.
AK167145 mRNA. Translation: BAE39290.1.
AK171012 mRNA. Translation: BAE42183.1.
CH466605 Genomic DNA. Translation: EDL20783.1.
BC049967 mRNA. Translation: AAH49967.1.
CCDSiCCDS49474.1.
RefSeqiNP_997097.1. NM_207214.3.
UniGeneiMm.31607.

3D structure databases

ProteinModelPortaliQ3TPX4.
SMRiQ3TPX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222868. 1 interactor.
IntActiQ3TPX4. 2 interactors.
STRINGi10090.ENSMUSP00000125434.

PTM databases

iPTMnetiQ3TPX4.
PhosphoSitePlusiQ3TPX4.

Proteomic databases

EPDiQ3TPX4.
MaxQBiQ3TPX4.
PaxDbiQ3TPX4.
PeptideAtlasiQ3TPX4.
PRIDEiQ3TPX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162175; ENSMUSP00000125434; ENSMUSG00000061244.
GeneIDi105504.
KEGGimmu:105504.
UCSCiuc007tjv.2. mouse.

Organism-specific databases

CTDi10640.
MGIiMGI:2145645. Exoc5.

Phylogenomic databases

eggNOGiKOG3745. Eukaryota.
ENOG410XSQQ. LUCA.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiQ3TPX4.
KOiK19984.
OMAiMCAICDV.
OrthoDBiEOG091G03RW.
PhylomeDBiQ3TPX4.
TreeFamiTF314966.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiExoc5. mouse.
PROiQ3TPX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061244.
CleanExiMM_EXOC5.
ExpressionAtlasiQ3TPX4. baseline and differential.
GenevisibleiQ3TPX4. MM.

Family and domain databases

InterProiIPR033960. EXOC5/Sec10.
IPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PTHR12100:SF0. PTHR12100:SF0. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC5_MOUSE
AccessioniPrimary (citable) accession number: Q3TPX4
Secondary accession number(s): Q80VK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.